Top Rated Joint Pain Supplements of 2022

Here are the top 11 joint pain supplements of 2022 for men and women. Learn which supplements can help ease your joint pain.

Myths and Facts About Joint Supplements

There have been several myths and facts about joint pain supplements. One of the facts is that there are several types of joint pain supplements that help in easing joint pain. It is also a fact that many joint supplements have side effects and some can even make your condition worse.

Some joint supplements can help you feel better temporarily while some can help diminish your symptoms completely.

There are also myths about joint supplements.

Some of the myths include:

  • Myth: Joint pain supplements such as glucosamine benefit everyone who has arthritis.
  • Fact: The truth is glucosamine has been able to benefit some people especially those who have osteoarthritis by stimulating the regrowth of worn-out cartilage
  • Myth: All supplements can help heal arthritis pain.
  • Fact: Not all joint supplements have been able to relieve pain. Some of the joint pain supplements that have been effective contain glucosamine, chondroitin, collagen and Gamma-linolenic acid (GLA)
Top Rated Joint Pain

Joint Pain Supplements Review

Below are The Top Rated Supplements for Joint Pain

#1 Projoint Plus

ProJoint Plus is a natural herbal formula designed to assist you to achieve healthy joints and flexible mobility. It is made of all-natural ingredients that are precursors for the formation of connective tissues such as cartilage, tendons, and the joint lubricating fluid. ProJoint Plus is the best natural joint supplement and joint lubrication supplement.

ProJoint Plus is presented in a container carrying 60 capsules per bottle which equates to 20 servings. This product is FDA approved and has ingredients claimed to have been researched extensively in Harvard Medical School, Mayo Clinic, and Arthritis Clinic.

Taking 3 capsules a day of this ProJoint Plus is associated with cartilage health and joint mobility and healing of the injured joints.

To learn more about Projoint Plus, please click here.

#2 Turmeric Curcumin Plus

Turmeric Curcumin Plus

Turmeric Curcumin Plus

know More About Curcumin Plus

Turmeric Curcumin Plus is a dietary supplement that boosts overall health. The main ingredients turmeric provides anti-inflammatory effects thus reducing swelling and inflammation in the body. Hence, using this supplement can aid in offering relief from joint aches, osteoporosis, and arthritis. It is a natural anti-inflammatory supplement for joint pain.

This formula helps in boosting the immune system due to the antioxidants in the natural product. Also, this supplement promotes a reduction in blood pressure and cholesterol level thus improving overall wellness. In addition, this product boosts the rate of metabolism thus stimulating fat loss. Turmeric Curcumin Plus is best joint supplement for arthritis pain.

This product is available online and costs $23.95 per bottle. Each bottle contains 60 capsules, and the user can take two to four tablets depending on the body requirement.

To learn more about Turmeric Curcumin Plus, please click here.

#3 JOINT N-11

Zenith Labs created this all-natural and nutritional supplement, Joint N-11, to address the main cause of joint pain and stiffness. In addition to offering relief for joint pain, it can help deal with bone and cartilage pain and provides long-lasting and irreparable results.

The manufacturer claims that the purpose of the product is to restore the mobility of the knees, back, and hips and promote bone health. The product is said to be high in antioxidants, which aids in the treatment of osteoarthritis. JOINT N-11 is the best joint pain relief supplement for knees pain and knee cartilage.

The functioning of Joint N-11 revolves around three essential phases, which are building and rehydrating the body’s cartilage, working on the cartilage by repairing damaged cushions in the joints and providing flexibility and tissue activity.

The Joint N-11 supplement is said to contain 11 potent ingredients. These ingredients are Niacinamide as the main ingredient, absorption blend, turmeric root, Bioperine, ginger root, bail and rosemary leaves, soy lecithin, and others.

The manufacturer recommends taking two capsules per day while having breakfast for 90 days. The product can be gotten only on the official website of the manufacturer. It is priced at $49 per bottle.
To learn more about JOINT N-11 review, please click here.

#4 1MD KrillMD

KrillMD, a nutritional supplement with krill oil produced by 1MD, a health and supplements company focused on helping people live healthy lives by making various dietary supplements.

This product is said to contain clinically proven and potent krill oil gotten from Antarctic krill. According to the manufacturer, the product uses multi-stage oil (MSO) extraction technology, which enhances bioavailability and absorption. KrillMD best medicine for joint pain, knee pain.

The ingredients present in the supplement include omega-3 (DHA and EPA, and other ingredients that are naturally derived from krill oil and have been proved to be just as effective and efficient as fish oil.

The product is also said to contain mollusks that could set off an allergic reaction to those who have allergies to it. Other than that, no significant reports of adverse reactions have been claimed to be associated with 1MD KrillMD.

As a dietary supplement, it is recommended to take two (2) capsules a day or as recommended by a healthcare professional. The product can be obtained from the official website of the manufacturer or various online stores.
To learn more about 1MD KrillMD, please click here.

#5 MoveMD

MoveMD is a dietary and joint health supplement that is manufactured to alleviate pain and discomfort in the joint and promote healthy joint.

According to the manufacturer, MoveMD is a potent and straightforward supplement that can lubricate the joints and prevent them from becoming stiff. It’s also said to be high in immune-building antioxidants and other collagen. It is also claimed that the product will treat joint pain and inflammation in less than seven days and improve the flexibility and mobility of the joints.

The active ingredients contained in this best joint health supplement include chicken collagen (type II), Hyaluronic acid, Boswellia Extract, Natural Astaxanthin, and eggshell membrane collagen (type XIV)

The manufacturer claims that the supplement is side-effect-free, and with regular use of the supplement, joint stiffness, pain, and discomfort will no longer be a problem. 

The recommended dose of MoveMD is one capsule a day, taken with a glass of water and with or without food. You can get the product for $ 54.95 on the official website of the manufacturer or in other online stores.
To learn more about MoveMD, please click here.

#6 Joint Advance

Joint Advance is a natural herb formula tailored for the relief of joint health problems. It contains natural herbs, which are easily metabolized by the body cells, this ensures that the toxic effects are manned with ease. Joint Advance is natural and prescription is hardly needed.

It acts best in the short bones of the body such as fingers, knees, and elbows. Manufacturers argue that this product is applicable to all ages and its effectiveness compared to other prescription drugs in pharmacies. Joint Advance is the best joint pill for knee pain, joint pain relief.

Joint Advance formula is available on a wider platform including Amazon. A 90 pills bottle could cost you approximately $39.95 on Amazon. The prices vary slightly on other platforms.

To learn more about Joint Advance, please click here.

#7 Eazol

Eazol Pain Relief is a multifaceted dietary supplement, which relieves several conditions affecting joints. It specifically relieves joint pains, reduces inflammation, and eases the symptoms of rheumatoid arthritis and osteoarthritis. Ingredients used in the Eazol Pain Relief formula are natural and are obtained from natural herbs.

The manufacturer states that the ingredient has scientifically been proven non-toxic to humans. This makes Eazol safe for human use. It can also be used by vegetarians and vegans.

Each ingredient has been shown to act differently but conjointly relieve multiple conditions arising from musculoskeletal aches Eazol Pain relief is encapsulated, and the recommended dosage is two capsules daily with water immediately after meals.

To learn more about Eazol, please click here.

#8 Supple

What is supple for arthritis? Supple is another impressive joint pain supplement. It comes as a delicious drink and also contains glucosamine and chondroitin sulfate. It also contains other nutrients that help improve joint health like vitamin C, vitamin D, B vitamins, and calcium. It is the best glucosamine chondroitin supplement on the market.

The only problem with this product is that it doesn’t contain anti-inflammatory ingredients so it doesn’t offer fast joint pain relief. This is particularly the reason there are some negative customer reviews for Supple online. It would take a few weeks before joint pain relief will be experienced by the user.

There is also some customer feedback saying it isn’t very effective. It is also a little pricey since a 48-day supply costs $99.95 plus shipping.

To learn more about Supple, please click here.

#9 Osteo Bi-Flex

Osteo Bi-Flex is another above-average joint pain supplement offering different formulations for different joint pain problems. It comes in triple strength, double strength, joint & muscle, and many other variations. It is one of the first joint supplements on the market and there are many positive customer feedback and reviews from people who have tried it.

One downside is that there is some customer feedback saying it doesn’t work quickly. It isn’t offered with a money-back guarantee which is another disadvantage of joint medicine. The price of Osteo Bi-Flex is around $20 for a bottle that lasts approximately two months so it is a very affordable and best joint supplement.

To learn more about Osteo Bi-Flex, please click here.

#10 Instaflex Joint Support

Instaflex Joint Support is a high-quality joint supplement which is the reason it is being distributed by renowned supplement retailer GNC. It is also available from other known retailers like Vitamin World,, and It contains glucosamine sulfate, MSM, and a blend of herbs that address joint pain. It is the best joint support supplement.

The problem with this joint supplement is that there are some negative reviews from customers saying joint pain relief takes some time. Also, some of the active ingredients are not really proven to be effective in relieving joint discomfort. One bottle which lasts approximately 30 days is being sold online for $69.99.

To learn more about Instaflex reviews, please click here.

#11 TFX Flex

TFX-Flex is another joint pain supplement being distributed by renowned retailer GNC. It offers a new approach to providing joint pain relief. It claims to be 2X more effective than glucosamine and chondroitin supplements.

Its primary active ingredient is Type II Collagen which is said to be more effective compared to regular glucosamine + chondroitin supplements. It also contains herbs that are known to help relieve joint pain like white willow bark extract, ginger root, Boswellia renin extract, and turmeric root extract.

The problem with this joint supplement is that it is not effective in all cases of joint pain for unknown reasons. There is still not enough evidence that Type II collagen effectively relieves joint pain since there are only very few studies conducted on it. A bottle that lasts approximately one month is being sold for $59.99 on the GNC website.

To learn more about TFX Flex, please click here.

Expert’s Advice on Arthritis Pain

According to Shawn Plank, MD, an integrative medicine physician with the University of Pittsburgh Medical School Centre for Integrative Medicine you need to take a whole-body approach to treat arthritis pain. Plank says that your lifestyle plays a major role in reducing joint pain. It is advisable to lose weight so that it cannot put pressure on joints which can result in joint pains.

You should also regularly get involved in an exercise that will make your muscles strong. Strong muscles are able to support the joints and make them flexible. Taking an anti-inflammatory diet can also be helpful in reducing inflammation. Foods that contain omega-3-fatty acids have anti-inflammatory agents.

Do any joint supplements really work? Plank says that taking joint medication can help in easing arthritis joint pain and to other people supplements can help in providing extra relief that the drugs can’t provide.

You should discuss your condition with your physician so that you can know which supplements suit you. This is because some bone and joint supplements can cause allergies, interact with other drugs, and can have harmful side effects.

Plank recommends the following best supplement for joints pain and ligaments:

  • Glucosamine sulphate/Chondroitin Sulphate: Glucosamine is usually found naturally in the joint cartilage. The supplements are usually made from shells of crabs, shrimps, and lobsters. Glucosamine helps in slowing down the breakdown of cartilage, reduce joint pain and help in improving the joint mobility. Chondroitin is also found in the bone and cartilage. Chondroitin sulfate supplements are usually made from cow trachea and pork by-products. Chondroitin helps in reducing joint pain and inflammation, improving joint function and slowing down the progression of osteoarthritis. Chondroitin also helps in keeping the joints lubricated by helping the cartilage to retain water.
  • Vitamin D3: Vitamin D promotes the absorption of Calcium which is used by the bones. Vitamin D can be found in many types of food such as orange juice, sardine, dairy products, fortified cereals, and egg yolk. Vitamin D can also be made in your body when you are exposed to direct sunlight. Vitamin D can also be found in the form of supplements. It is best vitamins for joint pain and stiffness.
  • Omega 3: Omega 3 fatty acids are found naturally in soybean oil, canola oil, and walnut and some fish such as salmon and tuna. Omega 3 supplements help in the production of chemical acid that helps in controlling joint inflammation.
  • Calcium: Calcium plays a major role in the formation of bones, therefore, you should ensure you have enough Calcium in your body. You can get Calcium from several types of foods but if you are not able to get the Recommended Daily Intake from your diet you should get natural calcium supplements.

Other supplements that have been recommended are:

  • Turmeric
  • Green Tea
  • Ginger
  • S-adenosyl-l-methane (SAMe)
  • Devil’s Claw
  • Methylsulfonylmethane (MSM)
  • Bromelain
  • Vitamin E
  • Stinging Nettle

Can Supplements Cause Joint Pain?

Yet another common myth about joint supplements is that the more you consume certain supplements, the better the effects. Believe it or not, some supplements can cause joint pain.

But, how?

Overconsumption of certain vitamins and minerals can be counterproductive.

Basically, it is more common for the general population to consume some vitamin or mineral in excess than it is to be deficient, especially for people who take vitamin supplements. Some vitamins, such as B-complex and vitamin C, are water-soluble. When you take too much, the body simply expels the excess.

On the other hand, vitamins such as A, D, E, and K all of which are beneficial for joint pain are fat-soluble[1]. Excessive consumption makes the body hold the excess, it doesn’t flush them. This impairs their effect. That’s why doctors advise us to consume only a recommended amount of the best vitamins for joint pain, arthritis, stiffness.

Joint pain supplements help avoid this effect because they contain the precise amount of these vitamins for joints you need, no excess.

Joint Pain Supplements – What to Consider?

Before taking any joint pain supplement you should ensure it has proof of solving your problems, the supplements can be found in large pharmaceuticals, the product has little or no side effects, the product gives you building blocks for the joints and ingredients of the product have been tested and are of quality.

Before you start using joint supplements you should ensure you get the nutrients and best vitamins for joint health from your diet first. This is because many joint supplements or knee supplements have side effects that can result in other complications.


[1] fat soluble vitamins supplements for joint health
[2] Shawn Plank, MD, integrative medicine physician, University of Pittsburgh Medical School Center for Integrative Medicine.
[3] Arthritis Foundation: "Tip-offs to Rip-offs, Common Therapies to Consider, Supplement Guide-Osteoarthritis, Supplements to Avoid."
[4] Natural Standard: "The Authority on Integrative Medicine."
[5] WebMD Medical Reference: "How Much Calcium?"
[6] Rozendaal, R. Annals of Internal Medicine, Feb. 19, 2008, vol 148: pp 268-277.
[7] Robert Bonakdar, MD, director of pain management at Scripps Center for Integrative Medicine.
[8] Harvard Health Publications: "Online Medical Dictionary."
[9] Nieman, D.C., Shanely, R.A., Luo, B. et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 12, 154 (2013).
[10] Arthritis
[11] Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis
[12] Codie A. Primeau, Bryn O. Zomar, Lyndsay E. Somerville, Ishita Joshi, J. Robert Giffin, Jacquelyn D. Marsh, Health Economic Evaluations of Hip and Knee Interventions in Orthopaedic Sports Medicine: A Systematic Review and Quality Assessment, Orthopaedic Journal of Sports Medicine, 10.1177/2325967120987241, 9, 3, (232596712098724), (2022). Crossref
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Evan Jensen, CPT

Evan Jensen is a renowned American Nutritionist, Diet Expert and health writer. He has a master’s degree in journalism, with more

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links."This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."