In This Review


Joint health should be top of mind for all adults, but especially if you’re active. Working out can cause cartilage breakdown, which can wear down joints and cause inflammation, loss of movement, and pain over time.

Certain supplements may benefit your joint health and allow you to stay active for an extended period of time. Supplements that reduce inflammation or promote the production of collagen—a protein that supports tendons and ligaments—may be beneficial to your joints.

However, not all joint pills are created equal, so exercise caution when selecting a supplement. As a result, we only included supplements in this roundup that are supported by research and noted where additional research is needed for joint supplements.

A recent study that was conducted within Germany found that over 57.8% of the population seems to suffer from regular joint and musculoskeletal pain, as well as other accompanying symptoms. While there are many potential issues that can lead to joint pain, arthritis is one of the most commonly associated conditions that cause these particular symptoms.

When arthritis develops, the patient’s quality-of-life can be greatly affected in an adverse way, and they may soon start to find that everyday activities become something that seems to be impossible to perform.

A large number of arthritis diseases cannot be cured, but several methods can be utilized to provide a relief of the symptoms caused by such a disease.

Sarah Anzlovar, MS, RDN, LDN says, “The research on supplements for joint health is pretty limited,especially among young, healthy athletes.”

In this post, we would like to take a closer look at arthritis, including the symptoms to look out for, the potential causes of arthritis and the conventional treatment options that are available to a patient diagnosed with one of these diseases.

Why Trust Consumer Health Digest?

We at Consumers Health Digest strive to provide relatively accurate information about vitamins and supplements on the market. We spent hours researching the best glucosamine supplements for arthritis and joint pain. We also looked at the different types of certifications that each product has. As a result, you can put your trust in us!

Researched and Approved

Finally, our reviewers were wowed by a variety of nootropic supplements, but the Physio Flex Pro stood out because it is made from 100% natural ingredients that are powerful enough to keep your joints lubricated in the long and short term. Performance Lab Flex is the best arthritis joint pain supplement of 2023 if you’re willing to spend a little more on glucosamine supplements. This flexibility enhancer allows people to maintain an active lifestyle without causing harm to their bodies.

Our Top Picks

Best Glucosamine Supplements For Joint Pain

Glucosamine supplements are often taken to alleviate the symptoms of arthritis-related joint pain. However, the effectiveness of glucosamine supplements varies from person to person, and more research is required to fully understand their benefits.

Here are some of the best glucosamine supplements for arthritis joint pain based on their popularity and positive customer reviews.


Physio Flex Pro | Best Supplement For Joint Pain


Physio Flex Pro

(4.9/5) 9 REVIEWS
  • Natural Ingredients
  • Physio Approved
  • Reputable Manufacturer
  • Made In The USA
  • FDA Registered Facility
  • Form: Capsules
  • Quantity: 60 Capsules
  • Brand: Physio Flex Pro
  • Dosage: 2 Capsules Per Day
  • Ingredients: Selenium, Methylsulfonylmethane, Glucosamine, Chondroitin
  • Usage: Reduces Pain and Inflammation, Helps Strengthen Bones
  • Safety: FDA Registered Facility, Made in the USA, Non-GMO
  • Refund Policy: 60-Day
  • Company Info: Physio Flex Pro, 10731 Walker Street, Cypress, CA 90630, United States, [email protected]


“After receiving Physio Flex Pro reviews and several months of shoulder and knee inflammation, along with an arthroscopy of my right knee, I can say 90% of my inflammation and pain are gone. I began taking joint relief after my surgery three months ago. I will definitely continue for another 3 months. Very satisfied so far.” – Amber S.


Physio Flex Pro is a pharmaceutical-strength formula designed to help anyone who wants to relieve joint pain, restore joint health and flexibility, and support overall joint wellness. The supplement contains glucosamine, chondroitin, MSM, turmeric, boswellia serrata, and hyaluronic acid, among other natural ingredients.
Glucosamine is a naturally occurring amino sugar found in joint cartilage. It is required for the formation and repair of joint tissues, as well as for the lubrication and cushioning of joints.

colanAccording to Journal of Orthopaedic Surgery and Research[1], “Glucosamine is a natural chemical compound found in both human and animal tissues. It helps in the formation of cartilage in humans and is commonly used as a dietary supplement to treat joint disorders such as osteoarthritis.”colan-1

It is intended to provide all-around joint support by addressing the root causes of joint pain and inflammation. The supplement is intended for people who have joint pain, stiffness, or limited mobility as a result of ageing, overuse, or injury.
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Performance Lab Flex | Best Glucosamine Supplement


Performance Lab Flex

(4.8/5) 105 REVIEWS
  • 100% Natural Ingredients
  • GMP Certified Facility
  • Vegan-friendly Formula
  • 100% Plant-based Capsules
  • FDA Registered Facility
  • Form: Capsules
  • Quantity: 60 Capsules
  • Brand: Performance Lab
  • Dosage: 2 Capsules Per Day
  • Ingredients: Glucosamine Sulfate, Chondroitin Sulfate, MSM, Curcuma Longa, ApresFlex Boswellia Serrata
  • Usage: Nourishes Cartilage, Supports Flexible and Resilient Ligaments
  • Safety: GMP Certified, Non-GMO, Soy Free
  • Refund Policy: 30-Day
  • Company Info: NA


“For many years, I’ve suffered from lower back pain. I’ve noticed some relief since starting to take two tablets per day. However, only time will tell if the long-term benefits are worth it. In the meantime, I’ll order some more. I’ll write another review in about three months.” – Michael J.


Performance Lab Flex is manufactured by Opti-Nutra, a company known for using high-quality, research-backed ingredients in its products. Performance Lab Flex is a dietary supplement designed to support joint health and flexibility.

colanAccording to Aging Clinical and Experimental Research [2], shows that chondroitin sulfate can reduce pain, inflammation, and stiffness in people with osteoarthritis or other forms of joint pain. Chondroitin sulfate is a popular supplement that people often use to help manage joint pain, particularly in the knee. It is a component of human cartilage and, as a supplement, is believed to support the growth and maintenance of cartilage tissue in joints.colan-1

The unique combination of AprèsFlex Boswellia serrata 100 mg, CurcuWIN curcumin 250 mg, glucosamine sulphate 500 mg, Phytodroitin 100 mg, and OptiMSM methylsulfonylmethane (MSM) 100mg in Performance Lab Flex provides longer-lasting joint relief. These ingredients work to promote joint health and mobility by reducing inflammation, supporting healthy connective tissues, and enhancing nutrient absorption. All these ingredients are clinically proven, non-GMO, gluten-free, and allergen-free.

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Doctor’s Best | Best Glucosamine Chondroitin with MSM


Doctor’s Best Glucosamine Chondroitin Msm with OptiMSM

(3.3/5) 660 REVIEWS
  • Form: Capsules
  • Quantity: 240 Capsules
  • Brand: Doctor’s Best
  • Dosage: 4 Capsules Per Day
  • Ingredients: Selenium, Methylsulfonylmethane, Glucosamine, Chondroitin
  • Usage: Helps Support Joint Health, Helps Support Healthy Hair, Skin and Nails
  • Safety: Science-Based Nutrition, Non-GMO, Gluten Free
  • Refund Policy: 60-Day
  • Company Info: NA

Great product for general joint support and maintenance!

“Due to inflammation and spurs, I have stiff joints, muscles, and pain in my ankles and heels. I’ve been taking these supplements for three weeks and have noticed a slight improvement. When I tried to get up and walk, I got an 8 on a scale of 1 to 10. After three weeks of taking these supplements, it is now a 5 – 6. The pain is less severe now, and I no longer need to take pain relievers! Overall, I am very pleased with the product. I was pleased with how the items were packaged and delivered on time!” – Maira

Doctor’s Best Glucosamine Chondroitin MSM with OptiMSM is a dietary supplement containing a combination of three important nutrients: glucosamine, chondroitin, and methylsulfonylmethane (MSM). These nutrients are well-known for their ability to support joint health and reduce inflammation, making them a popular choice for people suffering from joint pain and stiffness.

Glucosamine is a naturally occurring compound in the body that is required for the formation and repair of joint cartilage. It also plays a role in the development of tendons, ligaments, and other connective tissues. MSM provides the bioavailable sulphur required for joint health, hair, skin, and nails. In healthy joints, hyaluronic acid plays an important role in joint fluid cells, tissue hydrodynamics, and physiological functions to support and maintain hydration, elasticity, and microcirculation.

“MSM is a naturally occurring sulfur compound that can help with the decrease of joint inflammation and the promotion of joint health. It may serve as a useful supplement for people suffering from joint pain, but more research is needed to fully understand its effects.” , says Dr. David Heber, MD, PhD

It is formulated to provide the optimal combination of these three nutrients in a convenient and easy-to-take supplement. This supplement is also suitable for vegetarians and is free of gluten and soy.
Official Website


Now Foods Glucosamine | Best Joint Supplement For Athletes


Now Foods Glucosamine

(3.5/5) 123 REVIEWS
  • Form: Tablets
  • Quantity: 60 Tablets
  • Brand: NOW Foods
  • Dosage: 2 Tablets Per Day
  • Ingredients: Glucosamine Sulfate, Chondroitin, MSM
  • Usage: Promote Normal Joint Mobility and Comfort
  • Safety: GMP Certification, Non-GMO, Dairy Free
  • Refund Policy: 30-Day
  • Company Info: 244 Knollwood Drive, Bloomingdale, IL 60108, +1-888-669-3663

Helps the knees.

“Sometimes just a few aches and pains can take a beating with gardening and yard work. Also sent to my sister, who was about ready to go to the doctor and whose knee has quit hurting. It won’t cure if you need surgery, but for “wear and tear” as we age, I highly recommend!” – Lisa D.

The Now Foods Glucosamine and Chondroitin Extra Strength Tablets are a dietary supplement that promotes joint health and mobility. It contains glucosamine and chondroitin, two naturally occurring substances that are required for the formation of healthy cartilage, ligaments, and tendons.

Glucosamine is an amino sugar that is found in cartilage and synovial fluid and aids in joint lubrication. Chondroitin is a complex molecule that is also a component of cartilage. It helps maintain cartilage structural integrity by resisting compression. These two nutrients support joint health by acting synergistically.

It is designed to provide a concentrated dose of these nutrients. Each tablet contains 600mg of chondroitin sulphate and 750mg of glucosamine sulfate. The tablets are also free of common allergens like gluten, soy, and dairy, making them suitable for people who follow a strict diet. It is also appropriate for athletes and active people who want to improve joint health and mobility.

Official Website


Kirkland Signature | Best Glucosamine Chondroitin Supplement


Kirkland Signature Glucosamine & Chondroitin

(4.7/5) 486 REVIEWS
  • Form: Tablets
  • Quantity: 280 Tablets
  • Brand: Kirkland Signature
  • Dosage: 2 Tablets Per Day
  • Ingredients: Glucosamine, Chondroitin Sulfate, Stearic Acid, Magnesium Stearate
  • Usage: Helps Promotes Healthy Cartilage
  • Safety: Gluten Free, Lactose Free
  • Refund Policy: 90-Day
  • Company Info: NA

Good medication but TOO BIG!

“I have used kirkland glucosamine chondroitin for several years, and I will keep using it. I am 78 years old, and I’ve tried various joint supplements in the past, but this one stands out. It has made a remarkable difference in my joint comfort and flexibility. I can now engage in activities I love without worrying about nagging discomfort. The combination of glucosamine and chondroitin is a winning formula. The Kirkland Signature brand delivers quality and affordability, making it a smart choice. The price is excellent. This supplement has definitely helped with the thumb joint pain I had been experiencing from arthritis. This medication is helpful for arthritis pain, and I take two pills daily. However, these pills are very large, and I have trouble swallowing them.” – Kaira

Kirkland Signature Glucosamine and Chondroitin is a dietary supplement that is designed to promote joint health and mobility. It contains two key ingredients: glucosamine and chondroitin.

Glucosamine and chondroitin are naturally occurring compounds that are found in the body and used to build and maintain healthy joint cartilage. Each tablet of Kirkland Signature Glucosamine and Chondroitin contains 1500mg of glucosamine sulfate and 1200mg of chondroitin sulfate.

Their extra-strength tablets help promote healthy cartilage, synovial fluid (the gelatinous substance that surrounds the joints), and ligament tissue, as well as general bodily wellness.  In addition, this product is natural and healthy without added yeast, artificial preservatives, lactose, gluten, hydrogenated oils, GMOs, artificial flavors or colors.

Official Website


Curamin Extra Strength Pain Relief | Best Arthritis Supplements


Curamin Extra Strength Pain Relief

(3.4/5) 145 REVIEWS
  • Form: Tablets
  • Quantity: 60 Tablets
  • Brand: Terry Naturally
  • Dosage: 3 Tablets Per Day
  • Ingredients: Glucosamine, DL-Phenylalanine, Boswellia, Gum Resin Extract, Rhizome Extract
  • Usage: Best For Pain Relief
  • Safety: GMP Certified, Non-GMO, Soy Free
  • Refund Policy: 90-Day
  • Company Info: 955 Challenger Drive, Green Bay, WI 54311, +1-877-575-5155

Relief of arthritis pain!

“A friend told me about this product and how well it has relieved pain for her joints, so I tried it for 2 weeks. I have severe arthritis. It worked so well that I purchased a month’s supply, and this is my third month of using it. I have recommended it to many of my friends, who are also amazed at the relief from pain they experienced using Curamin Extra Strength. Love it!” – Linda

Curamin Extra Strength is a dietary supplement that is marketed as a natural way to relieve pain and inflammation. It contains a blend of botanical ingredients, including glucosamine, curcumin, boswellia, DLPA, and nattokinase, that are said to work together to support a healthy inflammatory response.

Glucosamine is a naturally occurring compound in the body that is required for joint cartilage formation and repair. Turmeric, a spice commonly used in Indian cuisine, contains the active ingredient curcumin. It has been researched for its anti-inflammatory and antioxidant properties, and it has been shown to have potential benefits for a variety of health conditions such as arthritis, depression, and cognitive decline.

colanAccording to BMC Complementary Medicine and Therapies [3], “Boswellia Extract was effective in reducing joint pain and improving physical function in patients with osteoarthritis. Also, it may be helpful in managing symptoms of osteoarthritis and other forms of joint pain.”colan-1

Curamin Extra Strength’s combination of these ingredients is said to provide a powerful natural alternative to over-the-counter pain relievers like ibuprofen and acetaminophen. It is recommended for people who have chronic pain from conditions such as arthritis, fibromyalgia, or back pain.

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Replenex Extra Strength | Best Joint Inflammation Supplement


Melaleuca Replenex Extra Strength

(3.5/5) 234 REVIEWS
  • Form: Tablets
  • Quantity: 90 Tablets
  • Brand: Replenex
  • Dosage: 3 Tablets Per Day
  • Ingredients: Calcium, Glucosamine, Ginger Root Extract, Green Tea Leaf Extract, Bromelain and Papain
  • Usage: Reduce Joint Discomfort, Inflammation, and Stiffness
  • Safety: Gluten Free
  • Refund Policy: 90-Day
  • Company Info: Melaleuca, Inc., 4609 West 65th South, Idaho Falls, ID 83402, (208) 522-0700, [email protected]

This product definitely works.

“This stuff is the best. It’s like Ibuprofen minus the toxic pharmaceutical crap. The drink mix is phenomenal. I thought it would taste like supplements, like shakes from other companies, but this one is literally pink lemonade. I was actually surprised how it did anything considering it didn’t taste gross.” – Michaela C.

Replenex is an organic dietary supplement that promotes overall joint health while also reducing pain and swelling. The product contains a one-of-a-kind combination of key ingredients, including glucosamine HCl, chondroitin sulphate, MSM, and hyaluronic acid.

The main ingredient in Replenex Extra Strength is glucosamine sulfate, a compound found naturally in the body that is essential for the formation of cartilage, the tissue that cushions joints. Glucosamine sulfate has been shown to help reduce pain and improve function in people with osteoarthritis, a degenerative joint disease that is characterized by the breakdown of cartilage. 

colanAccording to Research[4] shows that 63% of the participants who were treated with ginger had a significant reduction in knee pain compared to 50% of the placebo group. The severity of pain and overall improvement of osteoarthritis-related symptoms were also significantly reduced in the group taking ginger compared to the placebo group.colan-1

The formula is also high in antioxidants, which work to destroy free radicals and lower oxidative stress. It may fix damage to the joints and cartilage and protect them from potentially harmful agents.

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Spring Valley Glucosamine Chondroitin | Best Joint Health Supplement


Spring Valley Glucosamine Chondroitin

(3.1/5) 567 REVIEWS
  • Form: Tablets
  • Quantity: 40 Tablets
  • Brand: Spring Valley
  • Dosage: 2 Tablets Per Day
  • Ingredients: Glucosamine HCL, Chondroitin Sulfate
  • Usage: Supports Joint Health
  • Safety: Gluten Free, No Artificial Flavors or Colors
  • Refund Policy: Non-Returnable
  • Company Info: 917 Christi Ln Apt B, Chico CA, 95973, United States

Works good I guess.

“Can’t tell if it works like others have reviewed but their large pills and not as many as other bottles contain. I went for this one as I have elbow pain and high-strength pills are what I need. I take it in the morning when I remember to take it, and it’s been hit or miss with pain. I’m not consistent with it and their “dietary supplement,” so DO NOT TAKE AT NIGHT OR BEFORE BED. It will keep you up and I suggest morning or afternoon to take it.” – Marguax L.

Spring Valley Glucosamine Chondroitin is a dietary supplement that is formulated to support joint health and mobility. It contains a blend of glucosamine sulfate, chondroitin sulfate, and MSM (methylsulfonylmethane)[5], which are known to be effective in promoting healthy joints and reducing joint pain and stiffness.

Glucosamine and chondroitin are naturally occurring compounds that are found in the body and used to build and maintain healthy joint cartilage. Each tablet of Spring Valley Glucosamine Chondroitin contains 1500mg of glucosamine sulfate and 1200mg of chondroitin sulfate. These tablets are free from gluten, artificial colors, artificial flavors, sugar, and lactose.


Move Free Joint Health | Best Joint Supplement


Move Free Joint Health

(4.6/5) 192 REVIEWS
  • Form: Coated Tablets
  • Quantity: 120 Coated Tablets
  • Brand: Move Free
  • Dosage: 3 Tablets Per Day
  • Ingredients: Glucosamine Hydrochloride, Methylsulfonylmethane(MSM), Uniflex, Chondroitin Sulfate
  • Usage: Supports Joint Health, Supports Healthy Cartilage
  • Safety: Gluten Free, No Artificial Flavors or Colors
  • Refund Policy: 30-Day
  • Company Info: Pharmapacks, LLC 1516 Motor Pkwy, Islandia, NY 11749, +1-(888) 532-4574, [email protected]

This stuff really works for me.

“I’m 62, and this is the first product review I’ve ever done. I had problems with my knees for years. I’ve been taking this for several months now, and the difference is phenomenal. Give it a try. It’s a lot cheaper than doctors or surgery. Just be patient, as it takes some weeks for your body to heal itself.” – Mark Jones

Schiff Move Free Ultra is a once-daily nutritional supplement that promotes joint health. According to their website, it provides joint cushioning, increases comfort and range of motion, and aids in cartilage maintenance. They also promote Schiff Move Free Ultra as an alternative to larger, multi-pill supplement programmes, comparing its size to that of the leading glucosamine and chondroitin pills.

It contains a combination of ingredients such as glucosamine, chondroitin, hyaluronic acid, and MSM that work together to reduce joint pain, inflammation, and stiffness while also promoting healthy cartilage and joint function.
Glucosamine is a naturally occurring compound found in the body’s cartilage. It is known to stimulate the formation of new cartilage, which is necessary for the maintenance of healthy joints. Chondroitin is another naturally occurring substance found in cartilage that is known for its ability to reduce inflammation and support cartilage repair and growth.

Move Free Joint Health is designed to be taken on a daily basis to help with joint health and mobility. Two tablets per day are recommended, providing 1500mg of glucosamine hydrochloride, 1200mg of chondroitin sulphate, 3.3mg of hyaluronic acid, and 500mg of MSM. The tablets are easy to take and contain no gluten, dairy, or shellfish.

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Arazo Nutrition Joint Support | Best Supplement For Joint Flexibility


Arazo Nutrition Joint Support

(3.5/5) 267 REVIEWS
  • Form: Tablet
  • Quantity: 180 Tablets
  • Brand: Arazo Nutrition
  • Dosage: 3 Tablets Per Day
  • Ingredients: Glucosamine Sulfate, Chondroitin Sulfate, Boswellia Serrata Extract, Turmeric, Hyaluronic Acid
  • Usage: Joint Support, Stress Relief, Inflammation Management
  • Safety: GMP Certified Facility, Third Party Tested
  • Refund Policy: 60-Day
  • Company Info: 3422 Old Capitol Trail, Suite 941, Wilmington, DE 19808, U.S.A.,
    [email protected]

Joint pain relief.

“It has provided some pain relief from the arthritis that I suffer from, thus allowing me to move more freely. And best of all, this brand is formulated in the USA.” – Cinema Paradiso

Arazo Nutrition Joint Support is a complete dietary supplement for joints. It helps with cartilage repair, joint mobility, joint flexibility, joint structure support, and joint tissue protection. It contains a combination of ingredients such as glucosamine, chondroitin, MSM, turmeric, and Boswellia serrata that work together to reduce joint pain, inflammation, and stiffness while also promoting healthy cartilage and joint function. It helps rebuild and maintain joint flexibility and ease discomforts that come with age, weight, or sports-related stress.

colanAccording to National Library Of Medicine[6], “Using hyaluronic acid to treat joint pain, particularly in the knees, can increase the density of synovial fluid. Hyaluronic acid also helps to relieve pain by delaying further cartilage degradation and forming a protective layer between joints.”colan-1

Arazo Nutrition Joint Support is a daily supplement designed to promote joint health and mobility. Two capsules per day are recommended, providing 1500mg of glucosamine sulfate, 1000mg of chondroitin sulfate, 600mg of MSM, 300mg of turmeric, and 100mg of boswellia serrata. The capsules are easy to take and contain no gluten, soy, or dairy.

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Thorne Glucosamine & Chondroitin | Best Supplement For Knee Cartilage


Thorne Glucosamine & Chondroitin

(5/5) 15 REVIEWS
  • Form: Capsules
  • Quantity: 90 Capsules
  • Brand: Thorne Research
  • Dosage: 1 Capsule Three Times Daily
  • Ingredients: Glucosamine Sulfate, Chondroitin Sulfate
  • Usage: Supports Normal Cartilage Formation
  • Safety: Gluten Free, Dairy Free, Soy Free
  • Refund Policy: 60-Day
  • Company Info: USA, +1-800-228-1966, [email protected]

Seems to be working!

“I’ve been using Thorne Glucosamine & Chondroitin, and it’s been a game-changer for my joint health. I have just finished my first bottle of Thorne’s Glucosamine Sulfate. As someone who enjoys an active lifestyle, I occasionally experience joint discomfort, but this supplement has made a noticeable difference. The combination of glucosamine and chondroitin works synergistically to support my joint flexibility and ease occasional stiffness. It takes weeks for there to be any noticeable effect, if there is going to be one. My knees are feeling less creaky and more tolerant of bending and yoga movements. I’ll stick with it! I appreciate that Thorne is a trusted brand known for their high-quality products. If you’re looking for a reliable supplement to support your joint health, Thorne Glucosamine & Chondroitin is definitely worth considering.”
Hadas G.

Thorne Research is a dietary supplement company that offers a range of health and wellness products, including the Thorne Glucosamine & Chondroitin supplement. This supplement is intended to support joint health and mobility, particularly in those with age-related joint issues or athletes who place a high demand on their joints.

Glucosamine and chondroitin are two naturally occurring compounds in the body that are found primarily in cartilage. They are key components of healthy cartilage, which cushions and protects joints. However, as we get older or put more strain on our joints, the production of these compounds decreases, resulting in joint discomfort and stiffness.

Dr. Kevin R. Stone, Orthopedic Surgeon says, “Joint pain can have a significant impact on one’s quality of life, but it doesn’t have to limit one’s activities. Many people are able to manage their joint pain and continue doing the things they enjoy with the right treatment and lifestyle changes.”

It is made from high-quality, natural ingredients and contains no artificial preservatives, flavors, or colors. It is also free of common allergens like gluten, dairy, and soy, making it suitable for people who follow a strict diet.

Official Website


Nuzena Joint Support | Best Knee Joint Supplement


Nuzena Joint Support

(3.5/5) 678 REVIEWS
  • Form: Capsules
  • Quantity: 60 Capsules
  • Brand: Nuzena
  • Dosage: 3 Capsule Per Day
  • Ingredients: Glucosamine Sulfate, Turmeric Curcumin, Chondroitin Sulfate, Quercetin, Boswellia
  • Usage: Support For Joint and Cartilage Health
  • Safety: Gluten Free, Clinically Proven Ingredients, Non-GMO Formulas
  • Refund Policy: 30-Day
  • Company Info: USA, +1-(855) 888 4151, [email protected]

Good For Knees.

“I loved the formula and was blown away by the results. It helped me be more flexible, and the stiffness on my wrists and knees, especially during the winter months, has reduced significantly. And it’s all natural, so there’s really nothing to dislike. No side effects so far.” – MK

Nuzena Joint Support truly stands as the best joint health supplement, offering natural support for joint health, mobility, and acting as a potent natural anti-inflammatory agent while also nurturing healthy bones and cartilage. This remarkable supplement harnesses the power of a unique blend of natural ingredients, synergistically working together to combat inflammation, stimulate cartilage regeneration, and enhance joint flexibility. Boasting a substantial 1500 mg of glucosamine hydrochloride, a natural compound renowned for its support of joint health, it effectively alleviates joint pain and inflammation, making it a superior choice compared to other supplements available on the market.

colanAccording to National Institutes of Health[7], “Turmeric Curcumin supplementation increased cartilage volume and improved knee function in patients with osteoarthritis. And combination of curcumin and boswellia improved knee function and reduced pain in patients with knee osteoarthritis.”colan-1

It is a well-known health supplement company that offers personal health specialists, clinically proven ingredients, non-GMO products, and ethically sourced items. The company has been praised for its efforts to improve the lives of its customers.

Official Website

What To Look For In Joint Health Supplements?

When shopping for supplements, look for options made with science-backed ingredients in doses that have been clinically shown to deliver the intended results, such as those on this vetted list.


Supplements for joint health are available in a variety of forms, including pills, powders, capsules, and sprays. This will differ depending on the type of supplement. When possible, choose third-party tested supplements to ensure that the form you are using is safe.


It is essential to carefully read a supplement’s ingredient list and nutrition facts panel to determine which ingredients are included and how much of each ingredient is included in relation to the recommended daily value of that ingredient. Please bring the supplement label to your healthcare provider so that they can review the various ingredients in the supplement as well as any potential interactions between these ingredients and other supplements or medications you are taking.


Check the dosage instructions to make sure you’re using the right amount of the supplement to get the desired results.

Brand Reputation

All of the brands on our list have been in the supplement industry for a long time. These leading brands manufacture a variety of supplements that address various aspects of your health.

Most of these companies make supplements that adhere to the Arthritis Foundation’s guidelines for relieving joint pain naturally and safely.

Pricing And Refund Policy

We’ve included a variety of joint supplements to accommodate different people. The best supplement is not the cheapest, but it can improve overall joint health naturally.

Also, all these supplements come with a 100% satisfaction guarantee to safeguard your interests.

Customer Reviews

Read customer reviews to determine the effectiveness of the supplement and whether it has any side effects.

Consult Your Doctor

Before starting any new supplement, it’s always a good idea to consult your doctor or a healthcare professional to ensure it’s safe and suitable for you.

What Is Glucosamine?

Glucosamine supplements are commonly used to alleviate joint pain and stiffness associated with osteoarthritis, which is a degenerative joint disease that affects millions of people worldwide. Glucosamine may help to slow down the progression of osteoarthritis by supporting cartilage health and reducing inflammation in the joints.

According to the Arthritis Foundatio, glucosamine is a natural part of the cartilage that is found within joints – not only within the human body, but also in some animals.

This substance is needed within the human body to assist with the growth and maintenance of the cartilage that supports joints, and also assists with the repair of cartilage that has been damaged or broken down.

When it comes to supplements that contain glucosamine, the substance is usually derived from shellfish shells. This may include the shell of crabs, lobsters or shrimp. In some cases, the substance may also be derived from certain types of vegetables, or be produced in a laboratory. There are also different kinds of glucosamine, including:

It has been found that the use of glucosamine offers improvement in various symptoms experienced by patients who are suffering from arthritis.
The particular areas where glucosamine seems to be most beneficial in include improvements in the overall joint function amongst patients with osteoarthritis, as well as a significant relief of pain in the joints of arthritis patients.


Does Arthritis Joint Pain Really Work?

Arthritis joint pain supplements can help relieve joint pain and stiffness, but their effectiveness varies depending on the ingredients and dosage used, as well as the individual’s condition and response to the supplement.

The treatment of arthritis is quite tricky, since no prescription medication has been developed to cure the disease or completely prevent further breakdown of the cartilage that supports joints in the patient’s body.

Numerous types of medication have been developed to help patients experience relief from the symptoms they are suffering from, as well as to potentially slow down the progression rate of the disease.

The problem that many people face with such medications is that they are known to cause numerous side effects. These side effects can be extremely unpleasant.

Luckily, numerous alternative remedies have been identified that are able to provide patients with a considerable reduction in the severity of their symptoms without having to expose their bodies to pharmaceutical chemicals that may well be dangerous to their health.

One particular natural substance that is often of interest amongst those individuals who are looking for a natural way to reduce their symptoms is glucosamine.

Learn More About: Arthritis And Joint Pain

Let’s start our post by looking at how arthritis can affect your joints and, in turn, cause joint pain. It should be noted first, however, that suffering from joint pain does not automatically make you an arthritis patient.

There are other factors that can lead to joint pain, joint inflammation and other symptoms that may affect your joints. According to Healthline, other factors such as injury to the joints, as well as strains, can lead to joint pain.

Some infectious diseases, including hepatitis, influenza and mumps can cause a person to experience joint pain, and bursitis is another possible cause. In this post, however, we are going to focus primarily on joint pain caused by arthritis diseases.

According to the Arthritis Foundation, there are over 100 types of arthritis that can affect a person’s joints.
These diseases tend to have unique ways of causing joint pain and inflammation, and many can also lead to accompanying symptoms developing as well.

Some of the most common arthritis types that are diagnosed amongst the general population include:


  • This is the most common type of arthritis and tends to affect the largest number of patients ever diagnosed with arthritis.
  • This particular type of arthritis has numerous potential causes, and can cause severe pain in some patients.
  • Treatment is possible for patients with osteoarthritis, but it should be noted that the disease is not considered curable.
  • Treatment options usually aim to reduce pain and inflammation, as well as to reduce the progression rate of the disease.

Rheumatoid Arthritis

  • This is also a relatively common type of arthritis that happens when a patient’s immune system mistakenly starts to attack the patient’s own body – the joints, in particular.
  • Rheumatoid arthritis is classified as an autoimmune disease and can be quite harmful to the human body.
  • Similar to osteoarthritis, rheumatoid arthritis is also not curable, but the progression can be slowed with the use of certain medication that helps to prevent the inflammation in the joints caused by the autoimmune reaction.

Psoriatic Arthritis

  • A less common type of arthritis, as compared to osteoarthritis and rheumatoid arthritis, but still important to be aware of.
  • Psoriatic arthritis is also an autoimmune disease where the immune system attack’s the host’s body – instead of only targeting pathogens, however, the immune system goes awry and attacks healthy joint tissue.
  • In addition to the joints, other areas of the body can also be affected by psoriatic arthritis, including the skin.


  • An inflammatory type of arthritis that is quite different from most other arthritis diseases, such as rheumatoid arthritis and osteoarthritis.
  • With gout, excess amounts of uric acid are not expelled by the body in a timely manner; thus the uric acid starts to build up within the bloodstream.
  • In time, the uric acids start to collect within joints by forming crystals. This is what then causes inflammation and pain symptoms within the joints where the crystals form.
Arthritis And Joint Pain

What Are The Symptoms Of Arthritis?

It is well-known that arthritis causes joint pain, as well as swelling in affected joints – the purpose of our article is, after all, to discuss joint pain caused by arthritis. These, however, are not the only symptoms that can be caused by arthritis.

It should be noted that different types of arthritis cause different symptoms and affects the body in a different way; thus it is relatively hard to provide a complete overview of the symptoms that may signal the development of arthritis.

According to MedicineNet, some common symptoms that rheumatoid arthritis causes, which is often shared amongst other forms of these diseases, include:

  • Fatigue is relatively common amongst individuals with arthritis diseases. The patient may feel tired, weak and like they do not have enough strength to get through the day.
  • In addition to swelling and pain symptoms developing in the joints, other symptoms may also affect the joints. This may include warm sensations in the affected joints, as well as redness and tenderness. Applying joint pain relief cream on the affected area may help to prevent these symptoms. Check for Soothanol X2 Review, as it is designed to work on all kinds of joint pain.
  • Most patients who develop arthritis develop also find that their joints become stiff. This also causes the patient to experience reductions in their range-of-motion and joint flexibility, which can interfere with their day-to-day activities.
  • With some forms of arthritis, severe cases of the disease can lead to joint deformity. This particular symptom can be extremely uncomfortable and also cause severe disabilities.
  • Some patients who develop certain types of arthritis, such as rheumatoid arthritis, may also develop a fever and anemia.
Symptoms Of Arthritis

We will also be taking a look at glucosamine, a natural supplement that has shown promising results when used to treat arthritis-related symptoms and the effects that such a disease can have on joints in the body.

In addition to looking at how glucosamine can be useful, we will also discuss some of the best supplements that contain glucosamine you can use to reduce the symptoms you may be experiencing due to arthritis.

What Causes Arthritis?

When it comes to defining the causes of arthritis, it is quite difficult. Similar to as we discussed with the symptoms of arthritis, the specific causes of arthritis really depend on the specific disease a patient has developed.

There are, however, some common causes that have been associated with the most prevalent types of arthritis diseases, and knowing about these particular causes and risk factors can help a particular individual suffering from joint pain determine if they may be at a risk of arthritis.

Medical News Today explains that there are a couple of risk factors and causes that people need to be aware of when it comes to arthritis.

Not all of these risk factors are associated with the same types of arthritis, but it is still important to consider all of these issues that may increase a person’s risk of developing certain arthritis diseases. The particular possible causes include:

  • Wear-and-tear that occurs over the lifetime of a patient causes joints to gradually break down; thus leading to joint damage and the development of osteoarthritis.
  • Direct injury to a joint in the body, which may cause cartilage to break down, can lead to osteoarthritis, also called degenerative arthritis.
  • Some infections are also known to contribute to the development of arthritis symptoms. This is especially the case with Lyme disease.
  • When the immune system has a dysfunction, it can go awry and attack healthy joints in the patient’s body. This is often referred to as an autoimmune disorder. As we have discussed already, the most common form of such a disorder would be rheumatoid arthritis.
  • Genetics also seem to play a part in the risk factor for certain arthritis diseases, especially osteoarthritis.
Causes Arthritis

Which Ingredients Are The Most Effective For Joint Pain?

There are several ingredients that are commonly used for joint pain. Here are some of the best:


Glucosamine is a natural compound of cartilage, a substance that keeps bones from rubbing together, causing pain and inflammation. It may also help to prevent cartilage breakdown, which can occur with arthritis.


Chondroitin is a molecule found in cartilage that is frequently used in conjunction with glucosamine to alleviate joint pain and improve joint function.

Omega-3 Fatty Acids

Omega-3 fatty acids are found in fish oil and are known for their anti-inflammatory properties. They can help reduce joint pain and stiffness[8].


Turmeric is one of the most popular supplements for treating pain, including osteoarthritic joint pain. Its pain-relieving properties are attributed to curcumin, a chemical compound found in turmeric. Curcumin appears to have anti-inflammatory properties.


Ginger is a root that contains compounds that are anti-inflammatory. It can alleviate joint pain and stiffness.

Product Comparison

To help you decide, here is a brief comparison of our top picks:

Physio Flex Pro Performance Lab Flex Now Foods Glucosamine Curamin Extra Strength Move Free Joint Health
Rating star-4.8 star-4.8 star-3.5-1 star-3.5-1 star-3.1-1
Cost $58.00 $69.00 $15.59 $40.95 $24.47
Dosage 2 Capsules Per Day 2 Capsules Per Day 2 Tablets Per Day 3 Tablets Per Day 3 Tablets Per Day
Usage Reduces Pain and Inflammation Nourishes Cartilage Promote Normal Joint Mobility Best For Pain Relief Supports Joint Health
Return Policy 60-Days 30-Day 30-Day 90-Day 30-Day
Pros FDA Registered Facility Non-GMO, Soy Free GMP Certification, Non-GMO GMP Certified, Non-GMO No Artificial Flavors or Colors
Review Quick Result All in One Joint Supplement Reasonable Deal. Result – Time Consuming May Vary Person to Person
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Frequently Asked Questions

Q. What diet is good for arthritis?

A: As we grow older, our bones naturally weaken. Even if you are eating healthy foods and doing regular exercise, you are still vulnerable to several bone-related problems. A usual complaint that most of you are already suffering from is joint pain, or, to be more specific, arthritis.

Q. What is the best joint supplement for arthritis?

A: Glucosamine and chondroitin are two of the most commonly used arthritis supplements. They are parts of cartilage, which is the substance that cushions the joints.

Q. What can you take to lubricate your joints?

A: Synovial fluid, also known as joint fluid, cushions joints and allows bones and other structures to move freely. Fish oil, glucosamine and chondroitin, methionine, and collagen are all supplements that may help in synovial fluid production.

Q. Which vitamin is the most beneficial for joint health?

A: Daily vitamin consumption is critical for overall health protection. Vitamin D[9] is one of the most beneficial vitamins for joint health. Vitamin D has numerous health benefits, including improved joint health. If you have rheumatoid arthritis, vitamin D is especially important to include in your diet.

Q. Is magnesium helpful for joint pain?

A: Magnesium can help people who suffer from joint pain. Red Algae magnesium, in particular, is a popular ingredient in a variety of joint supplements.

Because of its unique bone-strengthening properties, red algae magnesium is beneficial for joint support. Low magnesium levels are frequently associated with decreased bone density and health, which can lead to a variety of other issues.

Q. Should athletes take a joint supplement?

A: Athletes benefit greatly from joint supplements. Athletes put their bodies through significant strain on a daily basis, whether they are running, lifting, or climbing. Although frequent and intense exercise is extremely beneficial to your body, it can also be taxing on your joints and muscles.

Taking a joint supplement on a daily basis can help you protect your joints and fight cartilage degeneration while pushing your body to perform at its best. The best joint pain supplements contain ingredients that help rebuild damaged tissue and strengthen cartilage, such as glucosamine hydrochloride or chondroitin sulfate.

Q. How much glucosamine should I take daily?

A: The current daily intake recommendation for joint relief is 1,500mg per day. This is the recommended dosage for potentially relieving joint pain and inflammation. Each item on this list contains at least 1,500mg of glucosamine per serving, if not more.

Q. Is it worth taking joint supplements?

A: Joint supplements should not be used in place of a well-balanced diet rich in protein, carbohydrates, fats, fruits, and vegetables. It is also critical to follow an exercise regimen appropriate for your level and get enough rest. Joint supplements may provide additional support if you are not getting enough of certain nutrients. We recommend consulting with your doctor to see if joint supplements are right for you.

Q. Are joint supplements safe?

A: High-quality joint supplements from reputable brands are considered safe to take on a daily basis, but you should always consult with your doctor to ensure they are compatible with your current health plan and personal health concerns.


Arthritis is a problematic group of diseases that can have a detrimental effect on the entire body, as well as on an affected patient’s overall lifestyle.

While the most unfortunate fact about arthritis might be the fact that most forms of these diseases cannot be cured, treatment can help to slow the progression of the damage the disease causes to joints in the patient’s body, as well as help to reduce the severity of the symptoms that the patient is experiencing.

In this article, we have offered a comprehensive overview of arthritis diseases, as well as looked at how Glucosamine supplements can help relieve symptoms without causing any significant side-effects that may be harmful to the patient’s wellbeing. However, if you are looking for joint related supplement then you may explore the best msm supplement.

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Sam Kramer is a Registered Dietitian, Licensed Dietitian Nutritionist, Six Sigma Green Belt Certified, and Certified Sports Nutritionis

9 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Zhu, X., Sang, L., Wu, D. et al. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. J Orthop Surg Res 13, 170 (2018).
[2] Reginster, JY., Veronese, N. Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment. Aging Clin Exp Res 33, 37–47 (2021).
[3] Yu, G., Xiang, W., Zhang, T. et al. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther 20, 225 (2020).
[4] Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, Riva A, Petrangolini G, Iannello G, Nichetti M, Infantino V, Perna S. Clinical trials on pain lowering effect of ginger: A narrative review. Phytother Res. 2020 Nov;34(11):2843-2856. doi: 10.1002/ptr.6730. Epub 2020 May 20. PMID: 32436242; PMCID: PMC7754412.
[5] Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. PMID: 28300758; PMCID: PMC5372953.
[6] Migliore A, Procopio S. Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab. 2015 Jan-Apr;12(1):31-3. doi: 10.11138/ccmbm/2015.12.1.031. PMID: 26136793; PMCID: PMC4469223.
[7] Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017 Oct 22;6(10):92. doi: 10.3390/foods6100092. PMID: 29065496; PMCID: PMC5664031.
[8] Kris-Etherton PM, Richter CK, Bowen KJ, Skulas-Ray AC, Jackson KH, Petersen KS, Harris WS. Recent Clinical Trials Shed New Light on the Cardiovascular Benefits of Omega-3 Fatty Acids. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):171-178. doi: 10.14797/mdcj-15-3-171. PMID: 31687095; PMCID: PMC6822654.
[9] Putman MS, Pitts SA, Milliren CE, Feldman HA, Reinold K, Gordon CM. A randomized clinical trial of vitamin D supplementation in healthy adolescents. J Adolesc Health. 2013 May;52(5):592-8. doi: 10.1016/j.jadohealth.2012.10.270. Epub 2012 Dec 23. PMID: 23608721; PMCID: PMC3634127.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."