In This Review

Overview About Antidepressants

Antidepressants are drugs that are used to treat significant depression, chronic pain, anxiety disorders, and addiction. However, there is debate over their effectiveness in treating adult depression, and data suggests that they may end up doing more harm than good. Life throws you curveballs, and often, these trials take their toll on you. You can’t eat, sleep, smile, or even normally function. You just want to be alone and one by one, you see things in a negative light.

It could be depression. What should you do? It may be time for you to admit that you need help. People are in constant search of help, especially when it comes to coping with anxiety. Antidepressants can help your body adjust to the drastic changes you’re going through.

While there is a variety of products to choose from, you deserve the ones that have been scientifically proven to work. While there are numerous supplements promoted as natural or herbal antidepressants, it is essential to recognise that their efficiency and safety may differ. St. John’s wort, S-adenosylmethionine (SAMe), omega-3 fatty acids, and 5-HTP (5-hydroxytryptophan) are some often discussed supplements for treating the symptoms of depression. Before you learn more about these , you should also know more about how these work.

You should also learn about why you go through depression, that it’s okay to admit that you need help, and how these products can help you.

Types of Antidepressants

Antidepressants come in a variety of forms that are routinely used to treat depression and related illnesses.

Selective Serotonin Reuptake Inhibitors (SSRIs):

The most often prescribed antidepressants are SSRIs. They act by preventing serotonin reabsorption (reuptake) in the brain, which helps to boost serotonin levels, a neurotransmitter related with mood control. Sertraline (Zoloft), escitalopram (Lexapro), paxil (Prozac), and paroxetine (Paxil) are examples of SSRIs.

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs):

SNRIs boost serotonin levels as well, but they also impact norepinephrine, a neurotransmitter that regulates mood regulation. Venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) are examples of SNRIs.

Tricyclic Antidepressants (TCAs):

TCAs were among the first-generation antidepressants. They act by preventing serotonin and norepinephrine reuptake. TCAs, while effective, have greater adverse effects than newer antidepressants, and they are commonly prescribed when other therapies have failed. Nortriptyline (Pamelor), amitriptyline (Elavil) and imipramine (Tofranil) are examples of TCAs.

Monoamine Oxidase Inhibitors (MAOIs):

These are an old class of antidepressants that operate by blocking an enzyme called monoamine oxidase, or MAO. This enzyme is responsible for the breakdown of serotonin, dopamine and norepinephrine. MAOIs are often used when other antidepressants have failed to work due to potential interactions with specific foods and drugs. MAOIs such as phenelzine (Nardil) and tranylcypromine (Parnate) are examples.

A Typical Antidepressants:

This category includes antidepressants that don’t fit into the other classes. They work through various mechanisms and often have different side effect profiles. Examples include mirtazapine (Remeron), bupropion (Wellbutrin), and trazodone (Desyrel).

It is extremely important to remember that the choice of antidepressant is influenced by personal factors such as symptoms, medical history, and potential drug interactions. A qualified healthcare professional is able to determine the most appropriate antidepressant for a specific individual.

How We Research & Select the Best Antidepressant Supplements?

We search for scientific literature and reputable sources that evaluate the effectiveness and safety of various antidepressant supplements. This includes looking for evidence-based systematic reviews, meta-analyses, and randomised controlled trials (RCTs). We also refer to various reputable medical journals that are good sources for scientific studies, such as PubMed and the Cochrane Library.

Expert’s Advice On Antidepressants Supplement

According to the Robert Johnson, MD, FCCP, antidepressant medications are a valuable tool for treating depression and other mood disorders. They work by altering the balance of chemicals in the brain, which can help alleviate symptoms such as sadness, anxiety, and lack of energy.

Our Top Picks



The Best Antidepressants Medications of 2024

Depression is a common mental health problem that can affect people of all ages and their backgrounds. This is where antidepressant supplements can help. In this article, we will explore the numerous supplements and the potential benefits they could provide for those who would like to manage their depression symptoms.


Jarrow Formulas SAMe | Best Energy Pill


Jarrow Formulas SAMe

(3.5/5) 341 REVIEWS

  • Form: Tablets
  • Quantity: 60 Tablets
  • Dosage: 1 Tablet Per Day
  • Ingredients: S-adenosyl Methionine, Cellulose, Glyceryl Behenate, Magnesium Stearate, Silicon Dioxide
  • Usage: Joint Health, Brain Metabolism and Mood, Liver Function
  • Safety: Non GMO, Glutan Free, Vegan.
  • Return Policy: 60 Days.
  • Company Info: +1-866-459-4154,

Best Supplement to Boost Mood star-3.4.1

“I’ve tried numerous different kinds of SAMe, but this one from Jarrow is the finest. It’s incredibly efficient and effective. It significantly improves my mood; I refer to it as my happy pill. I have recommended Jarrow SAMe to several people, and they all enjoy it. I definitely recommend the 400 mg if you need aid with your mood, and it’s also good for joint health and brain function, but something about it is making my stomach hurt, and I’m not sure if it’s the Sam-e itself or the mannitol that is one of its ingredients.” – Claudia S.

Jarrow formula contains 400 mg of SAMetosylate disulfate. The biologically active form of SAMe is the S,S structure. To maintain 68-80% S,S SAMe, this formula is manufactured naturally by fermentation and processed without the use of artificial solvents.

colan Some research [1] suggests that SAMe supplementation may have antidepressant properties and could be beneficial for individuals with depression. It has been shown to be just as successful as various antidepressant medications in alleviating depressive symptoms. Additionally, SAMe may have a faster onset of action compared to traditional antidepressants.

SAMe promotes the growth of healthy connective tissue. Furthermore, SAMe metabolism promotes glutathione synthesis, which is essential for antioxidant actions and liver functions. A vegan diet with Jarrow formula could help create a healthier and more sustainable future. Phosphatidylcholine and neurotransmitters like dopamine, norepinephrine, and serotonin are synthesised by SAMe methylation processes. To ensure a biologically active product, the formula is prepared at low temperatures and enteric-coated.

Official Website


NOW Supplements Saffron | Best Antidepressant for Energy and Motivation


NOW Supplements Saffron

(3.5/5) 1 REVIEWS

  • Form: Capsules
  • Quantity: 60 Capsules
  • Dosage: 1 Capsule Twice Daily With Food
  • Ingredients: S-adenosyl Methionine, Cellulose, Glyceryl Behenate, Magnesium Stearate, Silicon Dioxide
  • Usage: May Help Maintain a Positive Mood and Relaxed Attitude
  • Safety: UL Certified, Non GMO, Vegan
  • Return Policy: 60 Days.
  • Company Info: 244 Knollwood Drive, Bloomingdale, IL 60108, +1-888-669-3663

It is the Natural Mood Boosterstar-3.4.1

“Now Supplements Saffron capsules are average in size. This stuff is fantastic; it has helped me overcome my sadness and boosted my mood. This vitamin performs exactly what it says it does, and the results are evident. If you’re trying to lose weight, this tablet will help. Now ordering again for her and for myself too. Amazing what nature can give us. No extra hidden ingredients, pure spice. ” – Brittany

NOW Supplements Saffron is a dietary supplement produced by NOW Foods. Saffron is a spice made from the Crocus sativus flower. It has traditionally been used in herbal medicine to boost mood, promote calm sleep, and enhance cognitive function. That’s why it is one of the best rated antidepressants.

colan According to Frontiersin [2] , saffron may boost a happy mood, a calm attitude, and peaceful sleep. Saffron extract may also help improve cognitive function and dopamine levels. However, the precise mechanisms by which saffron works are unknown.

Supplements by NOW Saffron contains 50mg of saffron extract per capsule and is non-GMO, vegan, and gluten-free. It is recommended to take one capsule daily, with food. Consult your healthcare provider before starting any dietary supplement, especially when you have a health condition or are taking medications. Dietary supplements should never be taken in place of a healthy diet and lifestyle. NOW Supplements Saffron is designed to give a standardised dose of saffron extract, ensuring a constant amount of active components in each serving.

Official Website


Nature Made SAM-e Complete | Best Supplement for Mood and Energy

Nature Made SAM-e Complete

Nature Made SAM-e Complete

(4.5/5) 6 REVIEWS

  • Form: Tablets
  • Quantity: 36 Tablets
  • Dosage: Take 2 Drops One to Three Times Daily
  • Ingredients: S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Mannitol
  • Usage: Help restore a healthy mood in as little as 7-14 days when taken daily†
  • Safety: No Artificial Flavors, No Preservatives, Gluten Free
  • Return Policy: NA
  • Company Info: Nature Made, P.O. Box 8531, West Hills, CA 91309-9903, +1-800-276-2878

The Strongest Pain Killerstar-3.5.1

“I’ve been taking SAM-E from Life Extensions for a few years, but I ran out recently and switched to Nature Made. I’m very glad I did because the improvement in quality and pain relief were immediate. Nature Made SAM-E is really good in comparison to other makers, and the blister packets are robust enough not to open easily. I am very happy with this new brand and will continue to buy SAM-E from Nature Made.” – Albert

Nature Made SAM-e Complete is a dietary supplement containing SAM-e (s-adenosylmethionine), a naturally occurring molecule in the body that is involved in the creation, activation, and breakdown of various chemicals in the body, including neurotransmitters like dopamine and serotonin. SAM-e is known to help support a healthy mood, promote joint health, and may naturally decrease with physical activity and age.

colan According to Dovepress [3] ,SAMe has been studied for its potential benefits in treating mood disorders such as depression. It is thought to improve the access of neurotransmitters such as serotonin and norepinephrine, which are important in mood and emotion regulation.

Nature Made SAM-e Complete is specifically formulated to restore a healthy mood and promote joint comfort, and it has been clinically proven to work in as little as 7-14 days when taken daily. Nature Made SAM-e is available in tablets, sourced from high-quality ingredients, gluten-free,and contains no artificial flavors or preservatives. The SAM-e in Nature Made SAM-e Complete is thought to work by increasing the availability of neurotransmitters like dopamine and serotonin, which are important for regulating mood and emotions. SAM-e has also been proven to enhance the formation of compounds known as proteoglycans, which aid in joint health and reduce inflammation. It’s important to note that taking any dietary supplement, including Nature Made SAM-e Complete, should be done under the guidance of a healthcare professional. SAM-e can interact with certain medications, and it may not be suitable for everyone. Additionally, the effectiveness of SAM-e for mood support and joint health may vary depending on individual factors.
Official Website


St. John’s Wort Supplement | Best Depression Supplements


St. John’s Wort Supplement

(3.6/5) 304 REVIEWS

  • Form: Capsules
  • Quantity: 120 Capsules
  • Dosage: Take Two Capsules Daily
  • Ingredients: St. John’s Wort, Vegetable capsule (HPMC), Rice Flour
  • Usage: High-intensity Support for Cardiovascular Health, Mood Health, and Optimal Immune Function
  • Safety: Non-GMO, 100% Vegan, Gluten Free, Manufactured in the USA
  • Return Policy: NA
  • Company Info: PO Box 1574 Folsom, CA 95763,

Skin is Burning and Itchystar-3.4.1

“I started taking St. John’s Wort supplements for depression. After only a couple of days, my skin felt like it had been chemically burned (yeah, I know how that feels), and my eyelids were very sensitive. It turns out that St. John’s Wort causes acute sensitivity in those with pale skin. It was causing my skin to literally cook from the inside out. It was excruciatingly painful. I immediately stopped taking it.” – Lyra

St. John’s Wort (Hypericum perforatum) is an herbal supplement that is primarily used for its potential antidepressant and mood-enhancing effects. While its exact mechanisms of action are not fully understood, several components in St. John’s Wort are believed to contribute to its therapeutic effects.

colanAccording to Systematic Reviews Journal [4] St. John’s Wort’s is effective in treating a variety of diseases such as depression, stress, anxiety, and sleep disorders. It was found to be more effective than placebo and comparable to typical antidepressant drugs for mild to moderate depression.

St. John’s wort is promoted as a treatment for depression, attention deficit hyperactivity disorder (ADHD), menopausal symptoms, somatic symptom disorder (a condition in which a person experiences severe, exaggerated concern over physical symptoms), obsessive-compulsive disorder, andother disorders. Although the exact mechanism by which St. John’s Wort works is unknown, it is suspected to impact the levels of certain neurotransmitters in the brain, such as serotonin, dopamine, and norepinephrine. These ingredients have been shown to have an impact on mood and emotional well-being. Although St. John’s Wort may be beneficial in treating mild to severe depression, further research is needed to completely appreciate its possible benefits and risks. It is important to note that some depression supplements like St. John’s Wort, can interact with other medications and supplements and should not be used without first consulting with a healthcare professional.


Gaia Herbs Emotional Balance | Best Supplements for Stress Anxiety and Depression


Gaia Herbs Emotional Balance

(4.5/5) 56 REVIEWS

  • Form: Capsules
  • Quantity: 60 Capsules
  • Dosage: Take 1 Capsule 3 Times Daily
  • Ingredients: Vegetable Glycerin, Water, Vegan Capsule (Hypromellose) and Sunflower Lecithin
  • Usage: Helps the Body Cope With Stress to Support a Balanced Mindset
  • Safety: Vegan Soy-Free, Soy-Free Purity-Tested, Purity-Tested Dairy-Free
  • Return Policy: 45-Days
  • Company Info: +1-800-831-7780,

This Product Causes High Blood Pressurestar-3.4.1

“If you do research into the side effects of St. John’s Wort, you’ll discover that it can raise blood pressure. It is the best antidepressant for anxiety and can also induce rashes, light sensitivity, and sexual problems in certain people. Though I had to abandon Mood Uplift, I’m not suggesting that Gaia Herbs Emotional Balance you shouldn’t try it; nevertheless, as with medications, know what you’re getting into. By the way, if you’re looking for a quick stress reliever, a decent valerian-chamomile-hops combination would be exactly the thing. Temporary relief is preferable to no relief. And it may just get you through until the sun breaks through the clouds. – Roy

Gaia Herbs Emotional Balance is an herbal supplement that is thoughtfully formulated with St. John’s Wort, Ginkgo, Gotu Kola, and other mood-supporting herbs to help your body cope with stress and support emotional balance. The specific mechanisms by which it works are not clear-cut since traditional herbal medicine uses a holistic approach to managing wellness issues.

colanAccording to the Springer Link [5], Vegetable Glycerin is a relaxing substance that can help quiet an overworked mind. It minimizes the impact of stress on both our physical and emotional well-being by promoting a relaxed state. colan-1

The ingredients in Emotional Balance have been traditionally used to help the body manage stress, support a balanced mood, and promote a positive outlook. For example, St. John’s Wort has been traditionally used for its calming effects, and Ginkgo is believed to help support cognitive function and mood. Gotu Kola is also believed to have a positive impact on stress and anxiety levels. You should always talk to your healthcare provider before starting to take any new supplement, especially when taking other medications or suffering from health issues.
Official Website


Garden of Life Dr. Formulated Probiotics Mood | Best Supplement for Energy


Garden of Life Dr. Formulated Probiotics Mood

(4.6/5) 34 REVIEWS

  • Form: Capsules
  • Quantity: 60 Capsules
  • Dosage: Take 2 Capsules a Day
  • Ingredients: Organic Ashwagandha (Root), Aurorablue(R) Organic Blueberry Complex (Organic Alaska Blueberry (Fruit)
  • Usage: Promotes Emotional Well-Being, Relaxation and Digestive Balance
  • Safety: Third-party Certified, Non-GMO and Gluten-free
  • Return Policy: 60-Days
  • Company Info: +1-800-365-7709 ,

Get’s Duplicate Product, Expensivestar-3.4.1

“I’ve been receiving Garden of Life Dr. Formulated Probiotics Mood for quite some time and have discovered that EVERY shipment contains defective capsules ranging from 5-10 capsules that are empty and/or half full, while many of the other capsules are too loose or cut to survive the stomach. Because the capsules are all so thin, weak, and poorly sealed, stomach acids will be able to eliminate all of the germs. Garden of Life has a high reputation, yet the quality of this product is ALWAYS drastically degraded, rendering its benefits almost meaningless. I’ll try to remember for the next time. – Anita L. Adams

Garden of Life Dr. Formulated Probiotics Mood+ is a unique probiotic formula that includes clinically studied strains to support mood, as well as organic ashwagandha and organic blueberries to help reduce stress. The specific methods by which it operates are unknown, as research into the gut-brain axis and probiotics continues. However, evidence indicates that gut flora may influence mood and emotions and taking probiotics may help maintain a balanced mood and reduce stress levels.

colanAccording to the African Journals Online (AJOL) [6], suggests that ashwagandha is renowned for its ability to combat stress and anxiety by regulating the production of cortisol, the primary stress hormone. By promoting a state of calmness and relaxation, it can help restore emotional balance and improve overall well-being.colan-1

Furthermore, ashwagandha has traditionally been used for its soothing qualities and helps relieve tension and anxiety. Blueberries, especially organic blueberries, are abundant in antioxidants along with additional nutrients that may aid general health and well-being.

Although probiotics can be useful to many people, they may not work for everyone and should not be taken in place of regular medical care. Before beginning to take probiotics, like with any supplement, consult with your healthcare professional.
Official Website


Integrative Therapeutics 5-HTP | Best Vitamins for Sleep and Anxiety


Integrative Therapeutics 5-HTP

(3.5/5) 121 REVIEWS

  • Form: Capsules
  • Quantity: 60 Capsules
  • Dosage: Take 1 Capsule One to Three Times Daily Before Meals
  • Ingredients: L-5-hydroxytryptophan
  • Usage: Provides Nutritional Support for Normal Sleep and Mood.
  • Safety: FDA Approved, Dairy Free, Vegan, Gluten Free
  • Return Policy: 60-Days
  • Company Info: 825 Challenger Drive, Green Bay, WI 54311 +1-800-931-1709

Best Sleep Supplementstar-3.4.1

“Integrative Therapeutics 5-HTP Improves Sleep To aid sleep, I take 5-HTP an hour before bed. It is one of the natural alternatives to the antidepressant trazadone that I utilise. I also buy sublingual melatonin to put under my tongue before night. It allows me to fall asleep quickly and sleep deeply; in the morning, I don’t feel fatigued or the urge to sleep longer; and I feel active throughout the day. This mixture generally gets me a good night’s sleep. Very helpful. Calming and restful.”. – Dawn M.

Integrative Therapeutics 5-HTP (5-hydroxytryptophan) is a nutritional supplement that contains 50 mg of 5-HTP per capsule. 5-HTP is an immediate precursor of serotonin and provides nutritional support for proper sleep and mood. This ingredient is an amino acid that occurs naturally and is a precursor to the neurotransmitter serotonin. 5-HTP dietary supplements aid in the increase of serotonin levels in the brain. Because serotonin regulates mood and behavior, 5-HTP may improve sleep, mood, anxiety, hunger, and pain sensitivity. L-5-HTP has an incredible ability to impact the generation of serotonin in the brain, which in turn plays an important role in controlling sleep-wake cycles.

colanAccording to the Molecular Sciences[7], L-5-HTP enhances serotonin levels, promotes a sense of relaxation, and supports the body’s natural sleep rhythms. This allows you to fall asleep faster, sleep deeper, and wake up feeling refreshed and revitalized.colan-1

5-HTP is thought to work by raising serotonin levels in the brain, improving mood and alleviating anxiety and depression symptoms. 5-HTP is not found in food, like tryptophan is. After 6 weeks of taking 5-HTP, all 15 subjects studied reported less anxiety. Taking 5-HTP before going to bed is the optimum time. 5-HTP is a relaxing supplement that can help you maintain a healthy sleep pattern.

However, because research on the benefits of 5-HTP is still underway, the particular processes through which Integrative Therapeutics 5-HTP operates are not totally established. It’s crucial to remember that 5-HTP can interact with some drugs and should never be taken without seeing a doctor. Before beginning any new supplement or prescription, it is always advisable to consult with your healthcare professional.

Integrative Therapeutics 5-HTP is free of sugar, salt, wheat, gluten, maize, soy, dairy products, artificial colouring, artificial flavoring, preservatives, and animal-derived substances.
Official Website


Slogar 5-HTP | Natural Mood Stabilizer


Slogar 5-HTP

(3.4/5) 1 REVIEWS

  • Form: Capsules
  • Quantity: 90 Capsules
  • Dosage: Take One (1) Vegetable Capsule Twice Daily
  • Ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate.
  • Usage: Helps to Promote Both a Positive Mood and a State of Relaxation.
  • Safety: Non-GMO, Vegan, Gluten-Free, Dairy-Free
  • Return Policy: 14-Days
  • Company Info: 500 Willow Tree Road Leonia, NJ 07605 United States, +1-201-944-2311,

Best Mood Enhancers Supplementstar-3.4.1

“Slogar 5-HTP product contains 5-HTP derived from natural sources. 5-HTP aids in the creation of serotonin in the brain. This composition promotes both a good mood and a feeling of relaxation. Both the package and the size are convenient. It’s a high-quality product that assists me with my sleep problems and stress management. – Richard

5-HTP dietary supplements help raise serotonin levels in the brain. Since serotonin helps regulate mood and behavior, 5-HTP may have a positive effect on sleep, mood, anxiety, appetite, and pain sensation. Solgar 5HTP Complex Capsules is a complex formulated to help those individuals coping with modern day stresses that may be affecting sleep or mood balance. This unique formula is designed to help you switch off from a busy day and aid a restful sleep in just 1-2 capsules a day. 5-HTP supports your brain’s production of serotonin. This formulation helps to promote both a positive mood and a state of relaxation. Solgar 5-HTP Complex capsules are formulated to help with natural mood support.

colanAccording to the MDPI [8], a person’s magnesium status is strongly linked to stress levels, with stress and hypomagnesemia amplifying each other’s deleterious effects. It inhibits the function of more stimulating neurotransmitters while binding to calming receptors, resulting in a more serene and restful state.colan-1

Solgar 5-HTP Complex pills are designed to provide natural mood support. 5-HTP is a precursor that aids in the creation of serotonin. Serotonin, sometimes known as the “feel good” neurotransmitter, regulates mood, sleep, and appetite. To boost a happy mood and state of relaxation, this formulation blends naturally derived 5-HTP standardised Griffonia simplicifolia with magnesium, Vitamin B6, P-5-P (the active form of Vitamin B6), and the herb Valerian. It may aid in the maintenance of healthy sleep patterns, mood, hormone balance, and a general sense of well-being. It is ideal for those who require support in times of stress, without the risk of becoming dependent.
Official Website


Pure Encapsulations Zinc | Best Collagen Supplement


Pure Encapsulations Zinc

(3.4/5) 74 REVIEWS

  • Form: Capsules
  • Quantity: 60 Capsules
  • Dosage: Take 1 Capsule, 1-2 Times Daily, With a Meal
  • Ingredients: Zinc (as Zinc Picolinate)
  • Usage: Promotes collagen formation and healthy tissue development
  • Safety: Gluten Free, GMO Free, Vegan Vegetarian
  • Return Policy: 30-Days
  • Company Info: Pure Encapsulations, LLC 490 Boston Post Road Sudbury, MA 01776, +1-800-753-2277,

Immune System Booster Vitaminsstar-3.4.1

“Zinc Picolinate Supplement for Immune System Support, Growth and Development, and Wound Healing. But Pure Encapsulations Zinc made me sick, and I don’t think that’s the fault of the manufacturer; it LOOKS like a wonderful product; it could just be that I’m sensitive to zinc? So… I’m not sure… I’m giving it three stars. – Lisa

The Pure Encapsulations Zinc supplement supports the body’s natural defense system and immune function Zinc also aids in wound healing and the absorption of B vitamins. Zinc 30 by Pure Encapsulations is a convenient supplement that you can take to boost your zinc levels. Each vegetable capsule provides zinc picolinate‚ a highly bioavailable form of the mineral that may strengthen your immune system and keep you from getting sick as often. In addition‚ Zinc 30 also contains vitamin C (in the form of ascorbyl palmitate) to support the absorption of zinc. Each bottle of Zinc 30 by Pure Encapsulations contains 180 capsules‚ which can last for three months‚ depending on your dosage.

colanResearch [9], has shown in numerous studies about zinc that it supports a robust immune system and is essential for the growth and function of immune cells such as neutrophils, natural killer cells, and T-cells. These cells are responsible for identifying and eliminating harmful pathogens, providing a formidable defense against infections

Zinc plays an important role in supporting the body’s defense system, and is related to the normal absorption and actions of the B vitamins. Pure Encapsulations Zinc 15 is designed to support the body’s natural defense system as well as enhance digestion and metabolism of important vitamins, minerals, carbohydrates and other essential nutrients. Zinc is essential for over two dozen enzymes involved in digestion and metabolism, including carbonic anhydrase, which is vital to tissue respiration. Zinc 30 by Pure Encapsulations® provides well-tolerated zinc in a capsule form. Bound to picolinic acid, the body can absorb and process the zinc well.
Official Website


Brintellix Antidepressants Supplement | Best Supplements for Depression


Brintellix Antidepressants Supplement

(3.4/5) 145 REVIEWS

  • Form: Tablets
  • Quantity: 30 Tablets
  • Dosage: Take 1 Capsule Daily
  • Ingredients: Vortioxetine Hydrobromide, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Magnesium Stearate, Polyethylene Glycol, Iron Oxide Red
  • Usage: Treat Severe Depression
  • Safety: FDA Approved
  • Return Policy: 30-Days
  • Company Info: +1-877-825-3327

It help with depressionstar-3.4.1

“I switched from Pistiq to Brintellix over a few weeks and suffered 8/10 anxiety, tingling sensations, vivid dreams, and sleepless nights. I persisted because most reviewers claimed that if you got past the first two weeks, everything would be OK. After three weeks, the anxiousness was completely gone. I felt terrific, excellent, until I nearly had four accidents while driving and understood I was simply not awake. I was taking 10 mg, and the advice to increase it to 20mg did not sit well with me. My feelings were best described as fatigued and manic at the same time. Unfocused and verbally agitated. This medicine helps some people, but I couldn’t wait to come off of it.– Lisa

Brintellix Antidepressant Tablet is an immediate-release tablet for oral administration. It contains the beta polymorph of vortioxetine hydrobromide, an antidepressant. The drug is manufactured by Takeda Pharmaceuticals and H. Lundbeck. It looks like a white component in powder form that is soluble in water.

It works through two mechanisms of action – one is the receptor activity modulation and the other is reuptake inhibition. Some of the inactive ingredients include magnesium stearate, microcrystalline cellulose, mannitol, hydroxypropyl cellulose, and sodium starch glycolate. Thefilm coating consists of hypromellose, titanium dioxide, iron oxide red, iron oxide yellow, and polyethylene glycol.

colanAccording to theNational Library of Medicine [10], Vortioxetine is a medication used to treat depression in adults. Vortioxetine refers to a class of medications known as serotonin modulators. It works mainly by promoting the amount of serotonin, a molecule that occurs naturally in the brain and aids in the maintenance of mental balance.

It’s an FDA-approved drug that’s known to treat severe depression. Studies show that those who have taken Brintellix are less likely to suffer from depression. The drug is effective in reducing major depressive disorder in cases where even the first-line drugs had failed.

This serotonin inhibitor comes in different dosages, and the prices are still under approval. Hence, the drug is still not available in generic form. Some possible side-effects include a headache, dizziness, vomiting, diarrhea, and nausea.
Read Reviews


Abilify Antidepressant Tablet | Top Depression Medication


Abilify Antidepressant Tablet

(3.4/5) 14 REVIEWS

  • Form: Capsules
  • Quantity: 30 Capsules
  • Dosage: Take 1 Time Per Day With or Without Food
  • Ingredients: Aripiprazole, Aspartame, Calcium Silicate, Magnesium Stearat, Microcrystalline Cellulose
  • Usage: Treatment of manic or mixed episodes associated with Bipolar
  • Safety: Active Ingredient, Japanese Company, FDA Approved
  • Return Policy: 30-Days
  • Company Info: +1-888-922-4543

Treatment of Manic Depressionstar-3.4.1

“Abilify has made me very joyful. My doctor prescribed 2 mg in addition to the 20 mg of Abilify Aripiprazole. I’ve been depressed since my hubby died two years ago. This past January, I observed that I wasn’t getting out of bed or coming home from work and just sleeping. I despised everything and adopted an “I don’t care” attitude. I was crying all the time and began to miss work. I awoke feeling really joyful after taking Abilify. I’m awake, and life appears to be returning to normal! I understand that everyone is different, but it works for me.– Maggie

Abilify, aripiprazole, is classified as anantipsychotic medication, although it is also used as an antidepressant. It has been proven to have antidepressant properties and is used in depression treatments as well. It is designed to readjust the actions of chemicals found in the brain.

It is approved by the United States Food and Drug Administration (FDA) to treat the symptoms of psychotic conditions such as schizophrenia, bipolar disorder, aggression, mood swings, temper tantrums, irritability, self-injury, and other major depressive problems in adults. It is also approved as complementary medicine to treat depression in addition to antidepressants.

colanStudies [11] have shown that Aripiprazole has been proven to be beneficial in lowering depression symptoms when taken with other antidepressants. colan-1

It works by making the dopamine receptors work properly instead of shutting them down, as some antidepressants do. The drug was developed in Otsuka, Japan by a pharmaceutical company and marketed jointly by Otsuka America and Bristol-Meyers Squibb. Health insurance often covers the drug, but without it, the bottle costs around $250.

It is one of the most popular medications for depression in the United States. Some people have experienced side-effects such as weakness, nausea, constipation, headache, insomnia, etc. But these side-effects are temporary during the treatment and do not seem to cause any permanent damage.
Read Reviews


Zanaprin Tablets | Best Stress Reducer Supplement

Zanaprin Tablets

Zanaprin Tablets

(3.5/5) 34 REVIEWS

  • Form: Tablets
  • Quantity: 30 Tablets
  • Dosage: Take 1 Tablets Daily
  • Ingredients: Vitamin B-1 (thiamine HCl), Vitamin B-2 (riboflavin), Niacinamide, Vitamin B-6 (pyridoxine HCl), Folic Acid, Vitamin B-12 (cyanocobalamin)
  • Usage: Help With Social Anxiety, Stress, Insomnia, Panic Attacks
  • Safety: Manufactured in GMP and NSF Certified
  • Return Policy: 30-Days
  • Company Info: +1-888-606-1002,

Best Medication for Insomniastar-3.4.1

“I’ve struggled with anxiety for years, but Zanaprin has provided me with the relief I’ve been searching for. It’s truly remarkable. Zanaprin has made a noticeable difference in my overall mood and well-being. Zanaprin is now a staple in my daily routine. It has helped me combat my occasional sleeplessness and treatment for insomnia. It relaxes me without any grogginess the next day.– Enrique

Zanaprin is manufactured by a company called Lazarus Labs which is a fairly well-known company in the supplement industry. Lazarus Labs manufactures a wide variety of natural supplements, with Zanaprin being a particularly popular product from this company.

The product was designed to help with social anxiety, stress, insomnia, panic attacks, and toincrease mental alertness and cognitive functioning. This makes Zanaprin an all-in-one solution for individuals who experience problems with their mental wellbeing.

This product contains only natural ingredients, making it a safer solution than some of the pharmaceutical options that are available to individuals suffering from the symptoms that the supplement claims to treat.

colanAccording to the Nyaspubs [12] Thiamine deficiency has been linked to neurological disorders such as cognitive deficiencies and encephalopathy during the previous century.colan-1

The main ingredient in this product is phenibut (beta-phenyl-gamma-aminobutyric acid) whose mechanisms are similar to GABA, meaning that it works by calming the central nervous system.

Even though many of the ingredients have shown promising results in clinical trials, it should be noted that the product may not work for everyone – a number of unsatisfied customer testimonials can be found on product listings where Zanaprin is sold on the internet.

There are, however, some positive reviews that claim the product is effective in providing the particular benefits claimed by the manufacturer. Thus, those suffering from mild anxiety and depression could benefit from this unique treatment.
Read Reviews


Symetrin Antidepressant Tablet | Best Mood Booster Supplements

Symetrin Antidepressant Tablet

Symetrin Antidepressant Tablet

(3.4/5) 41 REVIEWS

  • Form: Tablets
  • Quantity: 30 Tablets
  • Dosage: Take 1 Tablet, 2 Times Daily
  • Ingredients: Sensoril, Libifem, Vitamin D, Vitamin B6
  • Usage: Relieve Feelings of Sadness and Irritability
  • Safety: Natural Ingredients, Imported from USA
  • Return Policy: NA
  • Company Info: NA

Treat Mood Swings From Depressionstar-3.4.1

“My life has literally been saved by Symetrin Antidepressant Tablet. (as well as the life of my family). I was self-critical and mistreated others. I was irritable and dissatisfied for no apparent reason. My mood swings have subsided as a result of this medication, and I feel more in control. I am now a very happy person who can deal with daily life and its obstacles. I have an ADHD son, and I am learning to be more patient with him. I don’t feel like “killing” everyone in my vicinity. I’m much better at balancing job and family responsibilities without breaking down emotionally. Thank you very much!– Anna E

Symetrin is a natural anti-depressant that is primarily being promoted as a mood enhancer. The product is mainly promoted to a female audience. The manufacturer of Symetrin claims that the product will not only help to provide the female user with a significant boost in their mood but also help to reduce the mental symptoms that come during PMS and menopause.

colanSeveral studies have investigated the antidepressant properties of Sensoril. One study published in the Clinicaltrials [13] evaluated Sensoril’s effectiveness in alleviating sadness and anxiety symptoms. When compared to the placebo group, the Sensoril-treated group exhibited significant reductions in both depression and anxiety symptoms.

The product contains patented formulas that were clinically tested for their safety and efficiency, namely Sensoril and Libefem. Sensoril contains the herb Ashwagandha that a clinical study published in the Journal of Alternative and Complementary Medicine found to be effective in reducing stress and anxiety.

Libifem is a specialized extract of the Trigonella foenum-graecum Seed Extract herb that a clinical trial published in Phytotherapy Research found improved hormonal balance in women and increased libido and sexual functioning.

Symetrin also contains two other ingredients, vitamin B6 and vitamin D which are two of the most important vitamins for normal mood regulation and nervous system functioning. Symetrin comes with a 30-day free trial and no side-effects have been associated with this natural antidepressant. The product does not contain any ingredients that may cause addiction and this is one of the few supplements on the market that holds scientific evidence to back up the claims made about the product.
Read Reviews

How to Choose the Best and Safest Antidepressant?


While selecting the best and safest antidepressant for your needs, understand the importance of finding the right medication to help manage depression and improve your mental well-being. With numerous options available on the market, we are here to assist you in making an informed decision that can positively impact your life.

Understanding Antidepressants: A Brief Overview

Before delving into the process of choosing the best and safest antidepressant, it is crucial to understand what these medications are and how they work. Antidepressants are prescription drugs designed to alleviate symptoms of depression, such as persistent sadness, loss of interest, and feelings of hopelessness.

There are several classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and others. Each class has its unique mechanism of action and potential side effects. It is essential to work closely with a qualified healthcare professional to determine the most suitable option for your specific needs.

Dr. Roberts emphasizes the critical role antidepressants play in treating depression. These drugs have the ability to restore emotional equilibrium and improve the standard of life for persons suffering from depression by targeting their brain’s chemical abnormalities.

Step 1: Consultation with a Healthcare Professional

The first and most crucial step in choosing the best and safest antidepressant is to consult with a healthcare professional. Only a licensed medical practitioner can assess your condition, consider your medical history, and recommend the most appropriate treatment plan. This step is essential to ensure your safety and optimize the effectiveness of the medication.

During your consultation, be prepared to discuss your symptoms, any previous treatments you have tried, and any known allergies or sensitivities. Honesty and open communication with your healthcare provider are paramount in making the best possible choice for your mental health.

Step 2: Assessing Your Needs and Preferences

Once you have consulted with a healthcare professional, it is time to assess your specific needs and preferences. This step involves considering various factors that can influence your treatment experience and overall well-being. Some important considerations include:

Efficacy: Discuss with your healthcare provider the efficacy rates of different antidepressants, especially those proven effective for treating your specific type of depression. Consider the success rates, the average time it takes to see improvement, and any potential factors that may affect the medication’s effectiveness.

Side Effects: It is crucial to be aware of potential side effects associated with antidepressant medications. While they can vary between individuals, understanding common side effects and their severity is important to make an informed decision. Your healthcare provider can guide you through this information, helping you weigh the risks and benefits of each option.

Drug Interactions:Inform your healthcare provider about any other medications, supplements, or herbal remedies you are currently taking. Certain combinations of medications can lead to adverse effects or reduced efficacy. Your healthcare provider will assess potential drug interactions and recommend an antidepressant that minimizes these risks.

Safety Profile: Antidepressants can have varying safety profiles, and some may carry a higher risk of certain adverse events. Discuss with your healthcare provider any pre-existing medical conditions, such as heart disease or liver problems, as well as any lifestyle factors that may influence your choice.

Patient Experience: Consider your own preferences regarding factors such as dosing frequency, method of administration (e.g., pills, capsules, or liquid), and potential lifestyle restrictions. Some individuals prefer once-daily dosing, while others may benefit from a more flexible dosing schedule. Your preferences can play a role in ensuring treatment adherence and overall satisfaction.

Step 3: Regular Monitoring and Adjustments

Choosing the best and safest antidepressant is not a one-time decision; it requires ongoing monitoring and potential adjustments. It is crucial to maintain regular communication with your healthcare provider

Antidepressants Stats

The percentage of Americans taking antidepressants has nearly doubled between 1999 and 2012 according to a report published in Journal of the American Medical Association[14] (JAMA).

What this means is that more and more people are likely to try alternative remedies for their depression.

And while antidepressants do help mitigate depression, they do come with their own set of side effects and risks.

Antidepressants reduce the number of blood platelets which increases a person’s risk of internal bleeding.

Furthermore, when taking drugs or even herbs that increase serotonin levels, antidepressant use may lead to serotonin syndrome which is a potentially fatal condition.

For all these reasons, many depression sufferers are looking for other ways to fight depression.

According to an article published in the Harvard Mental Health Letter[15], antidepressants can make depressive symptoms even worse in the beginning and may even lead to adverse health outcomes.

What Are The Top 5 Antidepressants

Antidepressants treat moderate to severe depression. Although these don’t cure depression itself, it helps stave off the symptoms so that you can better cope with the emotions within you [16].

The five well-known, FDA-approved SSRIs to treat depression are:

  1. Citalopram (Celexa)
  2. Escitalopram (Lexapro)
  3. Fluoxetine (Prozac)
  4. Paroxetine (Paxil)
  5. Sertraline (Zoloft)

How are you able to get over the so-called funk you feel when you lack sleep or when you start to panic for no apparent reason.
The depression aid you’re taking can range from any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Tricyclic antidepressants (TCAs)
  • Monoamine oxidase inhibitors (MAOIs)

More commonly prescribed antidepressants include trazodone, mirtazapine (Remeron), vortioxetine (Trintellix), vilazodone (Viibryd) and bupropion (Wellbutrin SR, Wellbutrin XL, others). Bupropion is one of the few antidepressants not frequently associated with sexual side effects.

There are those that have taken the alternative approach and have opted for modalities that don’t require a doctor’s prescription.

While there are still questions and debates surrounding these options, there are those who swear by them.

The list of possible approaches includes psychotherapy, electroconvulsive therapy, acupuncture, sleep therapy exercise, and bright light exposure.

Whatever the case may be, an antidepressant works on your mental health.

Though some may come with side effects, doctors urge that you take these under close supervision so that the medical professional can take immediate steps when needed.

How Do Antidepressants Work?

As already explained, antidepressants work mainly by boosting the levels of the neurotransmitter serotonin in the brain. Depression is considered to be a result of chemical imbalances in the brain with low serotonin being the main culprit.

Studies show that antidepressants are effective in moderate and severe cases of depression[17], but not in milder cases. Those suffering from mild depression may turn to antidepressants as a way to mitigate the symptoms associated with mood disorders such as panic attacks, anxiety, insomnia, low mood, low energy, and body aches.

Note: If you currently take a prescription antidepressant, talk to your doctor before making any changes to your medication.

When To See a Doctor?

As stated, antidepressants give your body a boost of specific chemicals that react with the hormones in you.

There are numerous studies surrounding this subject, and the goal of every expert is to find one that comes with the right blend of chemicals.

Some have honed in on the serotonin levels and believe that in order for the product to work, it must bring the levels back to normal.

While the meds can increase or lower serotonin levels within a matter of hours, it takes weeks before it can truly make a difference.

Moreover, the kind of drug prescribed will differ from one person to the next. The doctor may give you the medicine based on the following:

  • The Type of Depression you are Going Through – If you feel as if you need an energy boost, then the antidepressant prescribed should stimulate your body. It also works the other way around. If, for instance, you’ve been losing sleep, then you might need one that comes with a sedative effect.
  • The Side Effects You Need to Consider – Talk to your doctor about your condition and see which brand your body responds to best.
  • The Medicine that Works best Based on Your Medical History – This is when you discuss your depression and whether or not it runs in your family. Doctors might even consider what worked best for a relative.
  • The Way The Medicine Interacts with Other Drugs – Give a list of medicines you’re currently taking to avoid any medication interactions.

Myths and Facts About Anti-depressants

There are certain myths associated with the consumption of anti-depressants that are hugely infamous. Some people believe these baseless facts and avoid treatment altogether making it worse. Let’s see some of those fears and analyze the facts.

Myth: Antidepressants will only make you forget your worries and won’t help to solve them.

Fact: Antidepressants will neither make you forget things nor will solve your problems. When you are depressed, you perceive your problems in a much bigger way than they actually are.

Antidepressants enhance your ability to think clearly and approach your problems with clarity. It will remove the cloud that is blocking your clear view and help you see things as they are.

This, in turn, helps you to deal with the problems in a much more efficient way.

Myth: Antidepressants rob your ability to feel and put you in an emotionless state

Fact: Antidepressants are a way to positively stimulate your mind to resume proper functioning and make you feel yourself again.

There are rare cases of people feeling emotionless but that might be due to high dosages or consuming a specific antidepressant.

This can be controlled by reducing the dosage or trying a different one with proper consulting. In most cases, if taken the right quantity, it won’t alter your personality or freeze your emotions.

Myth: Antidepressants make you gain weight

Fact: Every tablet or medication has its own side-effects and so does antidepressants. There are many other medications for various other treatments that cause weight gain.

To a certain extent, it is true that the best antidepressant for weight loss causes variations in your weight. While some antidepressants make you gain weight, the effect will mostly be temporary. Once you are off of the medication, you will likely return to your normal body weight through diet and exercise.

Myth: The safest antidepressants for young adults are for lifetime. Once you start, you can’t stop.

Fact: For first-timers, once you are on medication in the initial stage, you need to continue the medication for a period of six months to nine months.

Once your situation is under control, you can consult your doctor and stop the medication or gradually decrease the dosage.

The latter is the most advised as getting off of medication abruptly can develop issues like nausea, dizziness, and headaches.

Do Antidepressants Cause Side-Effects?

Several antidepressants for anxiety have been associated with a risk of experiencing certain side-effects, which is something that people need to take into account when they are considering starting this medication to help them improve their state-of-mind.

The safety and possibility of side-effects can be discussed with a professional healthcare provider, and when side-effects do appear, then the user can discuss this with their healthcare provider in order to change their dosage or the type of antidepressant they are using.

According to Mayoclinic[18], common side-effects that people tend to experience when taking antidepressants include nausea, fatigue, drowsiness, dry mouth, constipation,increased appetite, weight gain, insomnia and, in some individuals, a significant reduction in their sex drive.

What Are the Key Ingredients in Antidepressants Supplements?

In today’s fast-paced society, where stress and worry are common, it’s critical to prioritize our mental health. While traditional pharmaceutical choices have long been the go-to solution for people seeking relief from depression and other similar problems, many people have turned to natural alternatives: antidepressant supplements. These supplements provide a comprehensive approach to mental health by utilizing the power of carefully selected substances to enhance mental equilibrium and overall well-being. In this comprehensive guide, we explore the top ingredients found in ineffective antidepressant supplements, empowering you to make informed choices for your mental wellness.

1. St. John’s Wort: Nature’s Sunshine

St. John’s Wort, scientifically known as Hypericum perforatum, has gained significant recognition as a powerful natural remedy for depressive symptoms. This herb has several active compounds, like hypericin and hyperforin, which interact together to strengthen neurotransmitters in the brain and control mood. Numerous studies suggest that it is profitable in managing symptoms of mild-moderate to serious depression, which has made it an increasingly popular option amongst those seeking antidepressant alternatives.

2. Saffron: The Golden Spice for Mood Enhancement

Renowned for its culinary uses, saffron (Crocus sativus) also offers impressive mental health benefits. This vibrant spice contains a high concentration of safranal, crocin, and other bioactive compounds that contribute to its antidepressant properties. Based on research, saffron may raise serotonin levels in the brain, boosting a pleasant mood and alleviating depression symptoms. Saffron in your food or supplements containing saffron can be an excellent method to improve your mental health.

3. Omega-3 Fatty Acids: Nourishing the Brain

For proper brain function, it’s necessary to ingest DHA and eicosapentaenoic acid, which are both omega-3 fatty acids. It contains high amounts of fatty acids such as salmon, mackerel, and even sardines. These acids are typically found in oily fish. Efficient signal transmission between neurons is possible due to omega-3 fatty acids which are necessary for both the function and structure of brain cells. In addition, high-quality fish oil tablets might be a practical approach to increase your omega-3 consumption and support mental wellness.

4. Rhodiola Rosea: Nature’s Stress Buster

Rhodiola rosea is a flowering plant native to arctic regions and has long been revered for its adaptogenic properties. This herb helps the body adapt to and resist various stressors, including emotional stress. By modulating stress hormone levels, such as cortisol, Rhodiola rosea can enhance mood, reduce fatigue, and alleviate symptoms of depression and anxiety. Including Rhodiola rosea supplements in your daily routine can provide valuable support for managing stress and promoting mental resilience.

5. Ashwagandha: The Herb of Tranquility

Ashwagandha (Withania somnifera) is an ancient Ayurvedic herb widely recognized for its calming and rejuvenating properties. It acts as an adaptogen, helping the body cope with stress and anxiety. Ashwagandha contains compounds known as withanolides, which have been shown to regulate neurotransmitters like serotonin and gamma-aminobutyric acid (GABA), promoting a sense of calm and well-being. Adding ashwagandha supplements to your wellness regimen may offer a natural solution for alleviating depression symptoms.

6. B Vitamins: Nourishing the Nervous System

The B vitamins like B6 (pyridoxine), B1 (thiamine), and B12 (cobalamin), play a crucial role in maintaining a healthy nervous system. These vitamins are involved in the synthesis of neurotransmitters, such as serotonin and dopamine, which are necessary for mood regulation. A deficiency in B vitamins can contribute to feelings of depression and fatigue. Support your mental health by adding B vitamin-rich foods like whole grains, legumes, and leafy greens into your diet, or taking daily a high-quality B complex supplement.

7. L-Theanine: Calming the Mind

L-Theanine, an amino acid found largely in green tea leaves, has distinct relaxation-promoting characteristics. It increases the production of alpha brain waves, which are connected with a relaxed, alert state. L-Theanine also increases levels of neurotransmitters that have a soothing impact on the mind, such as serotonin, dopamine, and gamma-aminobutyric acid (GABA). Including L-theanine supplements in your routine will help you reduce stress, boost attention, and sleep better.

8. 5-HTP: The Serotonin Precursor

5-HTP is a naturally occurring chemical found in the seeds of the African plant Griffonia simplicifolia. This molecule is essential as a precursor to serotonin, a neurotransmitter that regulates many bodily activities, including sleep, mood, and appetite. It is possible to increase the amount of serotonin in the nervous system by taking 5-HTP supplements daily. This increase in serotonin can potentially provide relief from symptoms associated with depression and anxiety. The reactions and impacts of 5-HTP may change from person to person.

Consult with a professional whoy can offer important advice based on your unique needs and circumstances, considering any existing prescriptions. This is crucial to ensure that 5-HTP is compatible with your situation and to avoid any potential interactions or adverse effects.

Remember to always prioritize your health and well-being by seeking professional advice before starting any new supplements or treatments.

Product Comparison

Here’s a short comparison of our top recommendations to make your decision easier:

St. John’s Wort Supplement NOW Supplements Saffron Garden of Life Dr. Formulated Probiotics Mood Pure Encapsulations Zinc Gaia Herbs Emotional Balance
Rating star-3.4-1 star-3.4-1 star-3.4-1 star-3.4-1 star-3.4-1
Cost $24.99 $19.78 $29.99 $15.00 $28.67
Dosage Take Two Capsules Daily 1 Capsule Twice Daily With Food Take 2 Capsules a Day Take 1 Capsule, 1-2 Times Daily, With a Meal Take 1 Capsule 3 Times Daily
Usage High-intensity Support for Cardiovascular Health, Mood Health, and Optimal Immune Function May Help Maintain a Positive Mood and Relaxed Attitude Promotes Emotional Well-Being, Relaxation and Digestive Balance Promotes collagen formation and healthy tissue development Helps the Body Cope With Stress to Support a Balanced Mindset
Return Policy NA 60-Days 60-Days 30-Days 45-Days
Pros Non-GMO, 100% Vegan, Gluten Free, Manufactured in the USA UL Certified, Non GMO, Vegan Third-party Certified, Non-GMO and Gluten-free Gluten Free, GMO Free, Vegan Vegetarian Vegan Soy-Free, Soy-Free Purity-Tested, Purity-Tested Dairy-Free
Review Best Natural Antidepressants It is the Natural Mood Booster Best Probiotics for People on Antidepressants Immune System Booster Vitamins This Product Causes High Blood Pressure!
Shop Now

Frequently Asked Questions

Q: What Are the Best Vitamins for Antidepressants?

A: The best vitamins for antidepressants are Vitamin D, B Vitamins, Omega-3 Fatty Acids, Magnesium, Vitamin C, and Zinc.

Q: What’s the Best Herb for Anxiety and Depression?

A: St. John’s Wort, Lavender, Chamomile, Ashwagandha, Passionflower (Passiflora incarnate), and Lemon Balm are common herbs for anxiety and depression.

Q: Can I Take Antidepressant Supplements With Prescription Medications?

A: It’s crucial to consult with your healthcare provider before combining antidepressant supplements with prescription medications. Some supplements may interact with drugs, reducing their efficacy or producing bad side effects. Based on your individual situation and medical history, your healthcare practitioner can provide personalized recommendations.

Q: Are Antidepressant Supplements Safe to Use?

A: Generally, antidepressant supplements are considered safe when used as directed. However, it is critical to contact a healthcare practitioner before incorporating any new supplement into your regimen, especially if you have any previous health issues or are using prescription medications. Your healthcare provider can assess potential interactions, provide personalized recommendations, and ensure their safety.

Q: How Long Does It Take for Antidepressant Supplements to Work?

A: The time it takes for antidepressant supplements to work depends on the individual and the specific supplement utilized. In some circumstances, you may notice significant improvements in a few weeks, while others may require several weeks or even months before significant changes are observed. Consistency and patience are key when incorporating supplements into your mental health regimen.

Q: Are There Any Side Effects Associated With Antidepressant Supplements?

A: While antidepressant pills are generally well taken, some people may experience negative effects. Digestion problems, dizziness, headaches, and allergic responses are all common adverse effects. It is critical to carefully read product labels, follow suggested dosing directions, and report any adverse reactions to your healthcare physician.

Q: What is the Best Time to Take Antidepressants?

A: Antidepressants are sometimes best when taken in the morning due to their potential side effects.

Q: Can Antidepressant Medications Be Addictive?

A: Antidepressants are not considered addictive,yet when people stop taking them, they may experience unpleasant side effects. These may include issues with mood, cognition, and eyesight.

Q: Can Antidepressant Supplements Replace Professional Treatment?

A: Antidepressant supplements should not be used instead of medical treatment for depression or other mental illnesses. They should be viewed as complementary approaches that can potentially support overall well-being. When you suffer from severe depressive symptoms, it is critical that you seek professional assistance from a certified healthcare specialist. They can provide a comprehensive assessment, determine an appropriate treatment plan, and offer ongoing support.


In conclusion, antidepressant vitamin supplements provide a natural and holistic approach to mental wellness, harnessing the power of carefully selected ingredients. Including these supplements in your daily routine, in addition to a nutritious diet and professional supervision, can help you live a more balanced and satisfying life.
Everyone’s needs differ, so contact a healthcare expert before beginning any new supplement program. Antidepressants are types of drugs that help with severe cases of depression but not with milder ones.

Antidepressants for women usually work through the same mechanisms as do prescription medications -by boosting the levels of serotonin in the brain. But antidepressants have an additional advantage of addressing other issues that may be causing depression besides low serotonin levels. Many of these antidepressants, for instance, mitigate stress, anxiety, insomnia, and nutritional deficiencies. All these factors could be at the root of depression. The antidepressants reviewed here are good examples of products that address depression from multiple angles.

These products reduce stress, central nervous system activity, cortisol release, and enhance brain neurotransmitter synthesis and support overall brain health. All of this makes antidepressants a better and safer alternative to fighting depression.

Was this article helpful?


Morganne Skinner, BSN, RN

Morganne Skinner began her nursing career in the surgical-trauma intensive care unit, where she served as a charge nurse and earned a c

18 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S. doi: 10.1093/ajcn/76/5.1158S. PMID: 12420702.
[2] van Ballegooijen, Adriana J., et al. "The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review." Int. J. Endocrinol., vol. 2017, 12 Sept. 2017, doi:10.1155/2017/7454376.
[3] Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat. 2011;7(Suppl 1):9-13. doi: 10.2147/NDT.S19619. Epub 2011 May 31. PMID: 21750623; PMCID: PMC3131098.
[4] Apaydin, E.A., Maher, A.R., Shanman, R. et al. A systematic review of St. John’s wort for major depressive disorder. Syst Rev 5, 148 (2016).
[5] Vena, A., Howe, M., Cao, D. et al. The role of E-liquid vegetable glycerin and exhaled aerosol on cue reactivity to tank-based electronic nicotine delivery systems (ENDS). Psychopharmacology 236, 2083–2092 (2019).
[6] Singh, N., et al. "An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda." 1., vol. 8, no. 5S, 2011, doi:10.4314/ajtcam.v8i5S.9.
[7] Maffei, M.E. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int. J. Mol. Sci. 2021, 22, 181.
[8] Pickering, G.; Mazur, A.; Trousselard, M.; Bienkowski, P.; Yaltsewa, N.; Amessou, M.; Noah, L.; Pouteau, E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients 2020, 12, 3672.
[9] Prasad, Ananda S. "Zinc in Human Health: Effect of Zinc on Immune Cells." Mol. Med., vol. 14, no. 5, May. 2008, pp. 353-7, doi:10.2119/2008-00033.Prasad.
[10] D'Agostino A, English CD, Rey JA. Vortioxetine (brintellix): a new serotonergic antidepressant. P T. 2015 Jan;40(1):36-40. PMID: 25628505; PMCID: PMC4296590.
[11] Pae, CU., Serretti, A., Patkar, A.A. et al. Aripiprazole in the Treatment of Depressive and Anxiety Disorders. CNS Drugs 22, 367–388 (2008).
[12] Satoshi Kida, Roles of Essential Nutrients in Memory Performance and Their Mechanisms??????????????????????????, Nippon Eiyo Shokuryo Gakkaishi, 10.4327/jsnfs.76.87, 76, 2, (87-94), (2023).
[13] "A Clinical Trial to Study the Effects of Sensoril® for Patients With Generalized Anxiety Disorder - Full Text View -" Mar. 2011,
[14] Marcus SC, Olfson M. National Trends in the Treatment for Depression From 1998 to 2007. Arch Gen Psychiatry. 2010;67(12):1265–1273. doi:10.1001/archgenpsychiatry.2010.151
[15] Depression - Harvard Health. (2023, May 16). Retrieved from
[16] " [Internet]." Depression: How effective are antidepressants? Institute for Quality and Efficiency in Health Care (IQWiG), 18 June 2020,
[17] Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA. 2010 Jan 6;303(1):47-53. doi: 10.1001/jama.2009.1943. PMID: 20051569; PMCID: PMC3712503.
[18] "Antidepressants: Get tips to cope with side effects." Mayo Clinic, 12 Sept. 2019,

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."