Brintellix (Vortioxetine) Review: How Safe and Effective is This Product?

By on   Last Modified: August 25, 2015

3.7
Expert Rating: 3.7 / 5.0

What is Brintellix?

Brintellix is a product to be used for the treatment of major depression, a condition that is characterized by symptoms such as insomnia, low mood, lack of concentration, general loss of interest, fatigue and changes in appetite. Brintellix is a newer class of antidepressant drug that is manufactured by Takeda Pharmaceuticals and H. Lundbeck.

Key Ingredient

Brintellix

The active ingredient in Brintellix is the antidepressant Vortioxetine Hydrobromide. It appears as a white to slightly beige powder substance that is soluble in water. The inactive ingredients in Brintellix are: microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, mannitol, sodium starch glycolate and film coating which consists of titanium dioxide, polyethylene glycol, iron oxide red, iron oxide yellow and hypromellose.

Advantages

  • Research and clinical studies involving this drug show that it is effective in alleviating MDD (Major Depressive Disorder) even for patients who failed to respond to first line drugs
  • As according to a clinical trial called REVIVE, Brintellix is more effective than Agomelatine (another type of antidepressant) and is much better tolerated

Disadvantages

  • Some side effects are associated with the product
  • This drug is not yet available in generic form
  • Brintellix has not proven itself to be better than existing antidepressant therapies
  • Like other antidepressants, Brintellix may also increase the risk for suicidal thoughts

Who Should Take Brintellix?

Brintellix is only indicated for patients diagnosed as having MDD or Major Depressive Disorder. Thus, it is not recommended for patients suffering from other types of psychiatric disorders.

Will Brintellix Show Results?

Although the drug has been approved by FDA, there is still no 100% guarantee that this drug will perform well in a real clinical setting or with the general market. As of the moment, results regarding this drug are only from the clinical research conducted by its manufacturers. Thus far, results show that Brintellix will be a promising antidepressant. According to Lundbeck, during its clinical studies, Brintellix has shown better efficacy versus the placebo used.

Is Brintellix Right for You?

Brintellix might not be a very good first choice for an antidepressant. Even psychiatrists and health care professionals are thinking twice before prescribing this drug to their patients, not just because it is expensive but because more clinical findings that support its efficacy must be released.

Side Effects of Brintellix

The most common side effects that were reported with the use of this drug are:

  • Headache
  • Dizziness
  • Diarrhea
  • Vomiting
  • Nausea
  • Risk for Suicide: Taking Brintellix, as like other antidepressants, may increase the risk for suicidal thoughts and attempts and it may also worsen the clinical symptoms of major depression. Family, friends and caregivers of patients suffering from MDD and who are taking this drug are advised to monitor the patient attentively and to apply suicidal precautions.
  • Risk for Serotonin Syndrome: The use of Brintellix, as with other antidepressants like SNRIs and SSRIs can cause a potentially life threatening condition called as serotonin syndrome which is characterized by mental status changes, neuromuscular symptoms and/or gastrointestinal symptoms. If such symptoms occur, discontinue the drug at once and consult a health professional.
  • Brintellix must not be taken together with MAOIs (another class of antidepressant).
  • Individuals with known hypersensitivity to one of Brintellix’s components should not take the drug.

Final Verdict

Brintellix is a reasonably promising drug in treating major depression. It is different from the other types of drugs used to treat depression and it works using two mechanisms of action which are: a) receptor activity modulation and b) reuptake inhibition. Thus, this drug is a much more improved version of the first line agents used to treat the psychiatric disorder. However, it doesn’t necessarily follow that because this drug is relatively new, it is already effective. This product still has a lot to prove to the public in the next few years. As of the moment, until further confirmation from public reviews about the effectiveness of this product has been published, it is wise to stick to known medications that professionals trust and recommend.

Depression is a common problem today. There are numerous supplements that claim to address this particular problem. Not all brands are created equal, and so reading customer testimonials, thorough research and rigorous evaluation by experts, we have consolidated and ranked today's top anti-depressants. The criteria we used are: potential to reduce symptoms of depression, potential to reduce anxiety, potential to restore healthy serotonin levels, quality of ingredients and ability to improve overall physical and mental well-being. Below are the finest natural anti-depressants available on the todays market.

Rating
Our Top Depression Choices
Serelax
Serelax
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
98%
Brintellix
Brintellix
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
85%
True Calm
True Calm
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
81%
Nerve Tonic
Nerve Tonic
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
75%
Zen Life Supplements Stress And Anxiety Management
Zen Life Supplements
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
70%

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.

*Results may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as medical advice. Always consult your doctor before using any supplements.

Disclosure of Material Connection: Some of the links in the post above are "associate sales links." This means if you click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

 
Author

Expert Author : Joan Raynor (Consumer Health Digest)

Joan Raynor, a depression health researcher, has written numerous articles on mental health and illness. She is contributing to ConsumerHealthDigest.com since 2011.

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