By Joan Raynor on October 22, 2013   Last Modified: July 4, 2015

Brintellix Review – How Safe and Effective is This Antidepressant?

Brintellix Review – How Safe and Effective is This Antidepressant?
Expert Rating: 4 / 5.0
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What is Brintellix?

Last September 30, 2013, the US Food and Drug Administration approved Brintellix (generic vortioxetine) to be used for the treatment of major depression, a condition that is characterized by symptoms such as insomnia, low mood, difficulty of concentration, loss of interest, fatigue and changes in appetite. Brintellix is a new class of antidepressant drug that is manufactured by Takeda Pharmaceuticals and H. Lundbeck.

Key Ingredient

Brintellix

The active ingredient in Brintellix is the antidepressant vortioxetine hydrobromide. It appears as a white to slightly beige powder substance that is soluble (slightly) in water. The inactive ingredients in Brintellix are: microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, mannitol, sodium starch glycolate and film coating which consists of titanium dioxide, polyethylene glycol, iron oxide red, iron oxide yellow and hypromellose.

Advantages

  • Research and clinical studies involving this drug show that it is effective in alleviating MDD (Major Depressive Disorder) even for patients who failed to respond to first line drugs
  • As according to a clinical trial called REVIVE, Brintellix is more effective than agomelatine (another type of antidepressant) and is much better tolerated
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Disadvantages

  • Has side effects
  • This drug is not yet available in generic form
  • Further research about this drug is necessary since it is still new. Brintellix has not proven itself yet to be better than existing antidepressant therapies
  • As like other antidepressants, Brintellix may also increase the risk for suicidal thoughts

Who Should Take Brintellix?

Brintellix is only indicated for patients diagnosed as having MDD or Major Depressive Disorder. Thus, it is not recommended for patients suffering from other types of psychiatric disorders.

Will Brintellix Show Results?

Although the drug has already been approved by FDA, there is still no 100% guarantee that this drug will perform well in a real clinical setting and in the market as well. As of the moment, results regarding this drug are only from the clinical researches conducted by its manufacturers. Thus far, results show that Brintellix will be a promising antidepressant. According to Lundbeck, during its clinical studies, Brintellix has shown better efficacy versus the placebo used.

Is Brintellix Right for You?

Since Brintellix is a new drug and not much has been exposed to the public and the entire medical community regarding its effectiveness and action, determining whether Brintellix is right for you can be difficult. You wouldn’t want to guess which drug will work for you, would you? As of this time, Brintellix might not be a very good first choice for an antidepressant. Even psychiatrists and health care professionals as of the moment are thinking twice before prescribing this drug to their patients, not just because it is expensive but because more clinical findings that support it efficacy must be released.

Side Effects of Brintellix

The most common side effects that were reported with the use of this drug are:

  • Headache
  • Dizziness
  • Diarrhea
  • Vomiting
  • Nausea
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Caution

  • Risk for Suicide: Taking Brintellix, as like other antidepressants, may increase the risk for suicidal thoughts and attempts and it may also worsen the clinical symptoms of major depression. Family, friends and caregivers of patients suffering from MDD and who are taking this drug are advised to monitor the patient attentively and to apply suicidal precautions.
  • Risk for Serotonin Syndrome: The use of Brintellix, as with other antidepressants like SNRIs and SSRIs can cause a potentially life threatening condition called as serotonin syndrome which is characterized by mental status changes, neuromuscular symptoms and/or gastrointestinal symptoms. If such symptoms occur, discontinue the drug at once and consult a health professional.
  • Brintellix must not be taken together with MAOIs (another class of antidepressant).
  • Individuals with known hypersensitivity to one of Brintellix’s components should not take the drug.

Final Verdict

Brintellix is a very promising drug in treating major depression. It is different from the other types of drugs used to treat depression and it works using two mechanisms of action which are: a) receptor activity modulation and b) reuptake inhibition. Thus, this drug is a much more improved version of the first line agents used to treat the psychiatric disorder. However, it doesn’t necessarily follow that because this drug is new, it is already effective. This product still has a lot to prove to the public in the following years. As of the moment, until further confirmation from public reviews about the effectiveness of this product has been published, it is wise to stick to what professionals already trust.

On the other hand, for more information regarding products or medications used to treat depression, below is a helpful list of product reviews:

Depression is a common problem today. There are numerous supplements that claim to address this particular problem. Not all brands are created equal, and so reading customer testimonials, thorough research and rigorous evaluation by experts, we have consolidated and ranked today’s top anti-depressants. The criteria we used are: potential to reduce symptoms of depression, potential to reduce anxiety, potential to restore healthy serotonin levels, quality of ingredients and ability to improve overall physical and mental well-being. Below are the finest natural anti-depressants available on the today’s market.

Rating
Our Top Depression Choices
Serelax
Serelax
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
98%
Brintellix
Brintellix
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
92%
True Calm
True Calm
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
91%
Zen Life Supplements Stress And Anxiety Management
Zen Life Supplements
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
90%
Solal Inositol
SOLAL Inositol
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
90%

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.

*Results may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as medical advice. Always consult your doctor before using any supplements.

Disclosure of Material Connection: Some of the links in the post above are "associate sales links." This means if you click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

 
 
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Author

Expert Author : Joan Raynor (Consumer Health Digest)

Joan Raynor, a depression health researcher, has written numerous articles on mental health and illness. She is contributing to ConsumerHealthDigest.com since 2011.

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