Wellsprings Serenity Cream Reviews: Does It Really Work?

A natural, bioidentical progesterone cream used for the relief of menopause symptoms and other conditions related to hormone imbalance known as Serenity Cream.

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In This Review

What is Wellsprings Serenity Natural Progesterone Cream?

Wellsprings Serenity Natural Progesterone Cream is a bioidentical progesterone cream used by women to alleviate the uncomfortable symptoms of menopause. Marketed as an alternative to Hormone Replacement Therapy, the active ingredient in this cream is natural progesterone, a hormone that declines after age 40.

Low progesterone symptoms include irritability, fatigue, irregular or frequent menstruation, low sex drive, hot flashes, insomnia, weight gain, and mood swings. Each 2.1 oz jar of Serenity contains 1,260 mg of bioidentical USP Pharmaceutical grade Natural Progesterone extracted from plant saponins.

How Does It Rate?

Overall Rating: 3.7
Wellsprings Serenity Natural Progesterone CreamWellsprings Serenity Natural Progesterone Cream


Value for Cost

3.8/5Value for Cost
Return Policy

3.7/5Return Policy


Brand Highlights

  • Wellsprings Serenity Natural Progesterone Cream is manufactured by Wellsprings.
  • According to the company, this menopause product has been chosen by both doctors and women for over 20 years as the best alternative to HRT.
  • Users of Serenity allegedly report experiencing relief in their menopause symptoms and an improvement in their quality of life without any side effects.

Key Ingredients

  • Bioidentical Progesterone
  • Grapefruit Seed Extract
  • Aloe Barbadensis


  • Manufacturer’s website includes a comprehensive list of ingredients, as well as clear instructions on how to use this product, user testimonials, and a FAQ page
  • This cream is fragrance free, not tested on animals, and free from common allergens
  • Natural progesterone has been prescribed since the 1930s to treat menopause related symptoms
  • There have been no reported side effects associated with natural progesterone
  • In contrast with taking progesterone orally, over 90 percent of the hormone is absorbed by the body during transdermal application


  • Wellsprings no longer offers Serenity in the United States
  • Some users have criticized this cream for containing progesterone without oestrogen

How Does It Work?

In contrast with taking a progesterone supplement, Wellsprings Serenity Natural Progesterone Cream contains an advanced liposomal formula that allows for 97-100 percent progesterone absorption by the skin. The cream should be applied each morning and evening to the fatty tissue areas of the body, including the thighs, hips, buttocks, upper arms, and lower abdomen. The cream should be massaged into a different body part each time it is applied.

The manufacturer recommends using a double dosage –1/4 teaspoon instead of 1/8 teaspoon) during the first month of application. Each 1/8 teaspoon contains 15 mg of natural progesterone.


*All individuals are unique. Your results can and will vary.

According to the manufacturer, a healthy woman will naturally produce 20-25 mg of progesterone during the second half of her monthly menstrual cycle, so this cream attempts to mimic the body’s natural production of progesterone.

Wellsprings Serenity Natural Progesterone Cream Ingredients – Are they Safe & Effective?

Per every 60gm jar of this cream, there is:

Bio-Identical Progesterone.

According to studies this has been extracted from plant saponins and helps combat symptoms of low progesterone-like low sex drive, irritability, hot flashes, mood swings, weight gain, insomnia, and fatigue[1].

Grapefruit Seed Extract

Relieves hot flashes experienced at menopause. According to the study, it is also effective in improving the physical and psychological symptoms of the menopause[2].

Aloe Barbadensis

Studies Suggests that Aloe vera gel has the tendency to rehydrate the body that may reverse the symptoms of menopause[3].

Other ingredients in the formula include – Deionized Water, Caprylic/Capric Triglyceride, Glycerin, Leaf Juice, Progesterone, Phenoxyethanol, Sodium PCA, Methyl Glucose Sesquistearate, Aminomethyl Propanol, Carbomer, Tocopheryl Acetate, Caprylyl Glycol, Sorbic Acid, Cetyl Alcohol, Glyceryl Stearate, Isopropyl Myristate, Stearic Acid, Sodium, Hyaluronate, PEG-20 Methyl Glucose Sesquistearate, and Xanthan Gum.


Q: How Much Does Wellsprings Serenity Natural Progesterone Cream Cost?

A: The cost of Wellsprings Serenity Natural Progesterone Cream is £26.99.

Q: Is the Serenity Cream Vegan?

A: The Serenity Smoothing Cream is vegan, gluten-free, non-GMO, and cruelty-free.

Q: Where you can buy Wellsprings Serenity Natural Progesterone Cream?

A: You can buy the product from its official website and online retailers.

Q: Where is Wellspring Company Located?

A: Postal Address:
Eros House
Grand Rue, St Martins
Guernsey, GY4 6LQ
United Kingdom

Q: What are the similar products to Wellsprings Serenity Natural Progesterone Cream?

A: The similar products include Amberen, Estrovera, and Serenol.


*All individuals are unique. Your results can and will vary.

Final Verdict

Wellsprings’ website offers a wealth of information on their natural progesterone cream, including a detailed list of ingredients and user testimonials.

Although it does not offer deals when more than one jar of cream is ordered, the manufacturer accepts PayPal as a billing option and the natural menopause supplement is shipped the same or the next working day. Wellsprings Serenity Natural Progesterone Cream is no longer offered in the United States.

Fortunately, natural therapies for menopausal symptoms such as weight gain, hot flashes, night sweats, decreased libido, and mood swings are available. Since many women experience weight gain during menopause, many natural menopause supplements contain herbs and botanicals that support a healthy metabolism. Menopause supplements should be evaluated on proven ingredients, ability to reduce hot flashes and night sweats, ability to provide hormonal balance and boost libido and its overall value.

Below you’ll find some of the most effective menopause supplements on the market today, in our opinion.

Our Top Menopause Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned menopause supplements and vitamins based on the available research:

NuviaLab Meno | Menopause Support Formula
Reduce Hot Flashes and Irritability*Gold Star Evidence
Eliminate Difficulties In Falling Asleep*Gold Star Evidence
Counteract Feelings of Fatigue and Tiredness*Strong Evidence
Support Regulation of Hormonal Activity*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Amberen | Best Multi-Symptom Menopause Relief Supplement
Reduces Hot Flashes*Gold Star Evidence
Helps Restore Hormonal Balance*Gold Star Evidence
Better Sleep*Strong Evidence
Mood Improvement*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Giddy + Health Menopause Support | Supplements Backed By Science
Boost Mood & Cognition*Gold Star Evidence
Reduces Menopausal Symptoms*Gold Star Evidence
Improves Markers of Menopause*Strong Evidence
Optimized Nutrition Absorption*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Estroven Complete Multi-Symptom Menopause Relief
Reduces Menopause Symptoms*Gold Star Evidence
Reduces Night Sweats*Gold Star Evidence
Improve Energy*Strong Evidence
Support Mood Swings*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Wellsprings Serenity Natural Progesterone Cream

Wellsprings Serenity Cream Reviews: Does It Really Work?

Customer Reviews & Ratings

4.5 out of 5

Review this Product

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  1. lynda

    twenty-1 creme VS capsule
    I love the Twenty – 1 creme and it works wonders for me however I was thinking to switch to capsules. But would like to see some reviews on that particularly. And if I was to switch could I just go straight into taking the capsule once I’m done with the cream.
  2. Anna Bel

    Wonder cream
    I have used Wellsprings Serenity cream for a year now and can report an amazing difference to my health and wellbeing.

    I suffered terribly with night sweats and insomnia for years. At 51 I had my last period and it all went downhill from there.

    I developed vulval skin problems. Itching and sweating like never before. I couldn’t sleep for more than 2 hours at a time, however tired I became. My hair started to fall out and my overall skin condition was excessive dryness and flaking.

    In desperation, I trawled the internet for months. Researching everything, and finally came up with the choice to try Wellsprings Serenity cream.

    Wow! within a few months, people were complimenting me on how well I was looking, even to the degree of one person asking, Have you had work done with a wink in her eye. My mood was so much better, I started to feel energised and my skin complaints were gone. It did take a few months, but the difference in me is amazing! I have energy, my sleep has improved and is of better quality. My hair has stopped falling out and my skin is glowing. I cannot say that it will work for you as it has me, but what I can say, is 100% give it a go. I would not be without this cream now. I did not change any other part of my lifestyle while trying the cream. My supplements were as they had always been, this way I could give it an honest chance.

    My daughter had 10 years of IVF which left her bloated, lardy and irritable and with terrible skin and horrendous headaches. She was told she had estrogen dominance from all the medication given to her during the IVF episodes… She tried the cream too, but with a break for her period, and has never looked back. her gynecologist has been blown away by the change in my daughter’s mood and appearance.

    Two generations of a woman taking Wellsprings and transformed must count for something.

    If you are otherwise healthy, but suffering from the symptoms that progesterone cream may be able to help you with. Give it a go. If you want one make that we would recommend, then Wellsprings Serenity is the one to try.

    For people worrying about getting the correct measure…We went on eBay and purchased a set of cooks measuring spoons that had a 1/8th measure in the set.

    Hope that helps anyone out there, pondering on what to do.

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Wellsprings Serenity Natural Progesterone Cream
Bioidentical Progesterone, Grapefruit Seed Extract, and Aloe Barbadensis.

3 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Fugh-Berman A, Bythrow J. Bioidentical hormones for menopausal hormone therapy: variation on a theme. J Gen Intern Med. 2007 Jul;22(7):1030-4. doi: 10.1007/s11606-007-0141-4. Epub 2007 Mar 7. PMID: 17549577; PMCID: PMC2219716.
[2] Grapeseed Extract Improves Menopause Symptoms | NHRI. (2022). Retrieved 23 December 2022, from https://www.naturalhealthresearch.org/grapeseed-extract-improves-menopause-symptoms/
[3] Poordast T, Ghaedian L, Ghaedian L, Najib FS, Alipour S, Hosseinzadeh M, Vardanjani HM, Salehi A, Hosseinimehr SJ. Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial. J Ethnopharmacol. 2021 Apr 24;270:113760. doi: 10.1016/j.jep.2020.113760. Epub 2020 Dec 28. PMID: 33383112.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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