Which Menopause Supplements Really Work?

All women who live long enough will enter menopause, and two-thirds of those women will experience uncomfortable symptoms related to menopause such as hot flashes, night sweats, mood swings, and vaginal dryness.

Because of certain studies from the Women’s Health Initiative that found that hormone replacement therapy (HRT) carried an increased risk of breast cancer, coronary heart disease, and stroke, many women are reluctant to use HRT to relieve menopause symptoms.

Instead, more and more women are turning to alternative treatments in the form of botanical dietary supplements (BDS) to relieve their symptoms.

One study[1] found that as much as 79% of women with a mean age of 50 years used these supplements to relieve their symptoms, and many of these women did report finding some relief.

The good news with these supplements is that studies show that they genuinely can be useful, and the risks of side-effects are low.

What is the Best Menopause Treatment?

Since every woman has to go through menopause at some stage in her life, hundreds of clinical trials and research studies are continuously being conducted in order to find the most appropriate method for these women to manage the symptoms they experience during this time in their lives.

This has led to the development of many different treatment measures that women can now utilize to help them overcome the unpleasant menopause symptoms.

WebMD[2] explains that the specific type of treatment often also depends on some factors related to the woman who is experiencing these symptoms.

When it comes to a pharmaceutical approach, a woman who still has a uterus will often receive combination HRT (Hormone Replacement Therapy), while a woman who does not have a uterus anymore (those who had undergone a hysterectomy) may only be prescribed a dose of estrogen.

A lot of women do tend to experience adverse reactions to these particular treatment options.

This is a particular reason why natural supplements for menopause are becoming more-and-more popular – these supplements often provide relief of the symptoms experienced by the woman going through menopause, without causing the dreadful side-effects often associated with hormone replacement therapy.

Best Menopause Supplements of 2022

To help you choose the best menopause supplements, we’ve compiled a list of the best quality menopause supplements regarding manufacturer transparency, ingredients quality, and client satisfaction.

Here are the 7 best menopause supplements on the market today:

#1 Amberen

Amberen is manufactured by Lunada Biomedical, which is a company with an overall good rating. This product was also designed to address the common menopause symptoms such as hot flashes, mood swings, irritability, and low libido weight gain, joint pain, headaches, stress, and fatigue.

Amberen is different from your regular menopause supplements in that it contains natural metabolites instead of herbs. The product does not contain synthetic hormones, such as estrogen, but instead relies on natural substances that can assist a woman in dealing with the symptoms that are caused by menopause. Furthermore, the product does not contain soy and has been manufactured with top-quality ingredients.

The aim of the formula introduced by the user’s body through Amberen is to restore a natural balance of hormones, but without utilizing any synthetic hormones, as these are known to contribute to the development of adverse effects. Some ingredients found in Amberen include a series of amino acids, as well as vitamin E, and several beneficial minerals.

The supplement also contains a succinates proprietary blend, which assists with providing a better balance in the body’s ability to produce hormones. It should also be noted that Amberen has been clinically tested for both its effectiveness and its safety.

To learn more about this product, click here.

#2 Profemin

Another excellent supplement for women who are experiencing the symptoms of menopause is Profemin, a product developed by Thera Botanics, a company that produces a wide range of all-natural supplements to address numerous symptoms and problems within the human body. In addition to being promoted as a supplement for menopause, Profemin is also promoted as a supplement to be taken when a woman experience symptoms of perimenopause.

By looking at the reviews on the internet about Profemin, it seems like the majority of women who have used the supplement before are happy with the results they were able to experience. The official website of Profemin promotes the product as a natural alternative to traditional and conventional treatment options, such as hormone replacement therapy.

Even though promoted as an alternative to these treatments, it should be noted that Profemin only utilizes natural ingredients and does not include any synthetic hormones, such as those found in hormone replacement therapy.

The particular ingredients found in Profemin’s formula includes Angelica Gigas, Phlomis Umbrosa, and Cyanchum Wilfordii – these are the only ingredients we found listed, but the product may also include some other ingredients; thus it is advised to consult the product’s label prior to use.

To learn more about this product, click here.

#3 Feminelle

Feminelle is a supplement that has been designed for all women. The product combines various natural ingredients that assist with numerous issues that some women tend to experience. Amongst the numerous conditions the product is known to assist with, menopause is listed – several of the ingredients found in the product might assist with relieving some of the symptoms that a woman may experience while she is going through menopause.

The critical ingredients of Feminelle include Soy Isoflavones, Grape Seed Extract, Glucosamine, Magnesium Stearate, Black Cohosh, Dimethyl Sulfonate, Vitis Vinifera, and Angelica Sinensis. Although many of these ingredients have been tested in separate clinical trials, it should be noted that Feminelle’s specific formula has not yet gone through any scientific studies to prove it is effective in reducing the severity of menopause symptoms.

Additionally, numerous reviews claim that the benefits of the product can be experienced, but at a mild level.

Still, the product contains beneficial natural compounds that may provide relief of symptoms such as a low sex drive, insomnia, mood swings, and hot flashes – symptoms that are very common amongst menopausal women.

To learn more about this product, click here.

#4 Oona Menopause

Oona is a company that takes pride in its traditional approach to treating common female complaints. If you are a lover of all things natural, then this product is definitely for you. The downside to this product is that it is impractical and maybe too pricey considering you need to take two tablets two times daily and that one $29 bottle contains 96 tablets. For those women who are willing to spend a little extra on a natural supplement, Oona Menopause may be an excellent choice.

The product is being promoted to primarily reduce the severity of mood swings and hot flashes caused by menopause, but may also assist with other particular symptoms that some women tend to experience. Such additional symptoms include mild depression, night sweats, tension, and nervousness, as well as sleep disturbances. Oona Menopause contains two proprietary blends. The first proprietary blend provides the user with a 60mg dose of Black Cohosh Root extract, as well as Rhizome extract. The other proprietary blend contains Chaste Tree Berry extract, also known as Vitex Agnus-Castus Berry Extract.

The combination provides a potent formula that assists with reducing the impact that menopause has on a woman’s life.

To learn more about this product, click here.

#5 Menosure

Menosure contains a great number of ingredients which are black cohosh, soy isoflavones, dong Quai, vitex berry, licorice, red clover, sage, squaw vine, blessed thistle, red raspberry extract, wild yam, and false unicorn. If you are looking for a menopause relief product with a lot of beneficial ingredients, then this might be the product of your liking.

Menosure’s effectiveness in reducing the symptoms a woman may experience during menopause is backed by a lot of positive reviews, which can be found at numerous locations on the internet. It should be noted, however, that the Menosure formula has not yet undergone any scientific studies, but many of the individual ingredients found in the product has been proven useful through clinical trials.

One particular unfortunate factor about Menosure for many women who are interested in the product is its price tag. A 60-capsule bottle of this supplement will cost the customer $64.99 – this is considerably pricier than most competing products on the market. On the bright side, Menosure does come with free shipping when the supplement is purchased directly from the product’s official website.

While some of the competitor products come with a money-back guarantee, it should be noted that Menosure does not come with such a warranty; thus if the product does not work, the user loses their money.

To learn more about this product, click here.

#6 Remifemin

Remifemin is being promoted as one of the best natural alternatives to hormone replacement therapy. The product also promotes itself as being a much safer choice when compared to hormone replacement therapy.

The formula primary relies on Black Cohosh, which is a natural substance that does not include any type of estrogen or other hormones, but has been scientifically-proven to assist with the production of certain hormones in the female body[7].

Thus, the product assists in balancing the hormone levels in the female user’s body without having to rely on any synthetically-produced hormones. Unlike many of the natural menopause supplements available on the market today, Remifemin has numerous clinical studies to back up the claims the product makes about its unique formula.

This provides women with peace-of-mind that they are not buying just another supplement that promises them a relief of their symptoms without ever delivering on those promises – but ensures that the customer knows they are buying a reliable product that will offer them real relief.

To learn more about this product, click here.

#7 Estroven

The last menopause supplement on our list is Estroven, an all-natural capsule that is taken once per day to relieve some of the most common issues that menopause causes. The product is promoted primarily to assist with reducing the stress that women tend to undergo when they are going through menopause, as well as to assist with mood swings and memory loss.

Furthermore, the product also claims to assist with reducing hot flashes, night sweats, and more. Estroven is backed by scientific research and also by many positive reviews on the internet, most claiming that the product offers the user fast and effective relief of these common symptoms experienced during menopause.

In addition to the main product, Estroven also has many other supplements on the market that targets additional problems that a woman may experience.

They have a specific product meant to help reduce the sleep disturbances caused by menopause, as well as a specific product that provides a boost of energy through the inclusion of maximum-strength ingredients. Estroven is available at numerous online retailers and is a relatively affordable supplement.

To learn more about this product, click here.

How to Choose the Best Menopause Supplements?

Because most BDS for menopause symptoms rely on similar ingredients, you’ll want to focus on the product manufacturer and quality when choosing your product.

When choosing top rated menopause supplements, make sure that the product manufacturer is reliable and trustworthy. You can easily determine a manufacturer’s trustworthiness by looking at the info provided on their website.

Is there a physical address and contact information?

Are there any details regarding product manufacturing?

The more information was given, the higher the possibility that you are dealing with a responsible company that does not sell ineffective and contaminated products.

You also need to look carefully at the product description, the ingredients listed, and the studies behind their efficiency. When it comes to buying health products, taking safety precautions is of utmost importance.

What to Look for When Choosing Menopause Supplements?

When choosing a menopause supplement, look for ingredients such as black cohosh, red clover, and saint john’s wort. These ingredients were found to be highly effective in peer-reviewed clinical trials. A lot of menopause supplements also contain phytoestrogens from soy and other plants, but their efficiency is still unknown.

Other than that, you will find many different ingredients in menopause supplements that treat symptoms such as hot flashes, night sweats, depression, and vaginal dryness. Because the FDA does not regulate dietary supplements, it can be hard to tell if the ingredients in your product are safe.

However, some products are manufactured in an FDA-approved facility and by the Good Manufacturing Practice (GMP) guidelines, which is a sign that a product is safe for use.

Furthermore, look for products offering a money-back guarantee as this also is a sign that the manufacturer has your safety and satisfaction in mind. This also means you won’t be throwing money away on products that don’t offer any relief.

Menopause and Health

Can Supplements Ease Menopause Symptoms- What Study Says?

There have been countless studies on menopause supplements conducted over the past 50 years. According to one systematic review[3] of the effectiveness of BDS in the treatment of menopausal symptoms, the most extensively studied ingredients for menopause symptom relief are black cohosh and soy.

The efficiency of these ingredients is believed to be due to their estrogenic effect, but recent studies show that this is not the case with black cohosh.

Instead, black cohosh seems to alleviate menopause symptoms by affecting serotonin receptors and thus improving vasomotor functioning and mood.

Soy, on the other hand, contains high amounts of phytoestrogens which are believed to counteract estrogen deficiency seen in menopause[4].

However, the mechanism of action of these phytoestrogens is unknown, and studies on their effectiveness are inconclusive. Other ingredients that may offer relief to some women are red clover, dong Quai, evening primrose, hops, Ginkgo Biloba, Ginseng, valerian, lemon balm, licorice root, and many others.

These ingredients were less studied than black cohosh and soy so their efficiency remains unknown.

Menopause Supplements Work

Do Menopause Supplements Work?

As already mentioned, menopause supplements may work for some women, but because the studies on these products and their ingredients are inconclusive, we cannot know for sure.

What we do know is that women taking these supplements claim they offer relief and these claims often come from clinical trials[5].

Menopause supplements containing black cohosh are most likely to work, but so are those containing other botanicals that affect the hormones, and neurotransmitters.

Some of the botanicals used in menopause supplements address anxiety and depression symptoms, which might directly impact the severity of menopause symptoms.

This is because the severity of hot flashes and night sweats can become worse as a result of depression and anxiety as found in one study[6] published in the journal Menopause.


While hormone replacement therapy remains the standardized treatment for menopause symptoms, many women are wary of their safety and efficiency.

Although natural supplements may seem like a much safer alternative, you still need to check the label carefully before making a purchase.

Also, make sure to do your research and talk to your doctor before taking these supplements as they do affect your body’s functioning.

Facebook youtube pinterest Twitter linkedin

Dr. Anna Cabeca, DO

Dr. Anna Cabeca, a triple board-certified, Emory University-trained physician and hormone expert was diagnosed with early menopause at

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."