Neprinol Reviews – Does Neprinol Joint Pain Give You the Best Results?

Neprinol is a joint pain supplement that aids in blood purification, appropriate joint and circulation function, as well as reduces symptoms of fatigue.

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In This Review

What is Neprinol?

Neprinol is a product that claims to cleanse the blood while also lessening aches and pains due to everyday activity. It intends to support the cleansing of blood, proper joint and circulatory function by decreasing excess fibrin and fibrinolytic activity through a blend of systemic enzymes. Other claims by this product include helping with fatigue and discomfort, poor circulation, elevated blood viscosity, and delayed healing.

How Does It Rate?

Overall Rating: 4.5

Value for Cost

4.3/5Value for Cost

4.2/5Return policy


Brand Highlights

  • Neprinol is manufactured by Arthur Andrew Medical, a company founded in 2003, who have 15 products that claim to help with joint relief and digestive enzymes for women, children, and even pets.
  • The company focuses on enzyme and probiotic-based dietary supplements for digestive issues, immune complications, poor circulation, hormone imbalance, and joint and muscle pain.


Pro Joint Plus

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Magnesium
  • Proprietary Blend Neprinol AFD
  • Systemic and Lipollytic Enzyme blend: Serrapeptase, Nattokinase, Lipase
  • Neprinol Protease Blend
  • Neprinol Enzyme and Cofactor Blend


  • This product may lessen aches and pains by the support of clean blood and proper joint and circulatory function.
  • According to the manufacturer’s website, Nattokinase is associated with maintaining normal blood viscosity and normal cardiovascular health, while Serrepeptase is a protein digesting enzyme that can support health fibrin concentrations.
  • Papain may promote healing and inflammation from overexertion.
  • The other ingredients are known for promoting a healthy cardiovascular system and immune system.


  • This product may seem expensive compared to other joint products.
  • For some individuals, the manufacturer states that the benefits may be slow and it is recommended to supplement this product for a minimum of one month with the best results occurring between one to three months. This may be too long for users to see results.
  • One of the ingredients, Serrapeptase, has been advised to not be taken with blood thinners, such as Warafin or aspirin, because it may increase the risk of bleeding or bruising[4].
  • The manufacturer warns not to take this product if you are also taking anti-coagulants or if you are pregnant or nursing.

How Does Neprinol Work?

Neprinol contains a blend of systemic, vegan-friendly enzymes, which work towards breaking down debris in the blood like excess fibrin and other unwanted proteins.

The ingredients serve to support normal inflammatory levels and are similar to other digestive enzymes. But, these specific ingredients target the bloodstream, not the gastrointestinal tract.

The cleansing of the blood is claimed to support healthy cardiovascular and liver function, while also maintaining a healthy inflammatory response for everyday activity.

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Neprinol Ingredients – Are they Safe & Effective?

Neprinol is a dairy, gluten, and soy-free product, as stated by the manufacturer. The following are the ingredients that constitute this product:


– Magnesium is known to strengthen the bones[1] and improve cartilage consistency.

Proprietary Blend Neprinol AFD

– This is a special blend that protects the joints against the damages of fibrin.

Systemic and Lipollytic Enzyme blend: Serrapeptase, Nattokinase, Lipase

[2] – A natural enzyme compound that assists in certain biochemical reactions related to the joints.

Neprinol Protease Blend

– Protease is derived from Serratia[3], B. subtilis and A. oryzae – Another compound that is lauded for its ability to fight inflammation.

Neprinol Enzyme and Cofactor Blend

– Amla, Papain, Bromelain, Rutin, Coenzyme Q10 – This compound has a direct effect on blood vessels which can reduce the appearance and cause of spider veins and bruising.

READ NEXTArthrozene and What Is Relief?



*All individuals are unique. Your results can and will vary.

Neprinol Questions and Answers

Q: Are there any alternatives to Neprinol?

A: Yes, there are multiple supplements on the market such as Purity H.A. Joint Formula, Lunaflex PM and Inflama-Care.

Q: How Should You take Neprinol?

A: Neprinol recommended dosage is two to three capsules per day for maintenance, four to six capsules for increased support, and nine capsules per day for therapeutic purposes. The capsules should be taken with eight ounces of water on an empty stomach.

It is recommended that the capsules be taken at least one hour prior to eating or two hours after a meal.

Q: How Much Does Neprinol Cost?

A: There are three options in which to purchase Neprinol: 90 capsules for $54.99, 150 capsules for $84.99, or 300 capsules for $144.99. New customers can get a 10% off coupon and the manufacturer offers free shipping within the United States.

Q: What is Neprinol’s Return Policy?

A: Unopened items purchased directly from the manufacturer can be returned or exchanged within 30 days of the purchase date for a full refund or exchange.

Q: Does Neprinol Offer a Free Trial?

A: Neprinol does not offer a free trial but does give a 10% off coupon for new purchasers.



*All individuals are unique. Your results can and will vary.

Neprinol Review – Final Verdict

Neprinol offers a blend of systemic enzymes to support healthy levels of fibrin and other debris in the blood. This is claimed to cleanse the blood to support cardiovascular and liver functions, as well as joint function.

The use of this product for some consumers may be limited as there is no certainty that pregnant or nursing women may use the product safely. There is also a warning for individuals who are taking anti-coagulants and it is recommended that they do not take this product without consulting their physician.

There may be similar joint relief products out there for these individuals who are looking for a product to assist with blood cleansing and joint, circulation, and immune system support. Neosporin is one of the joint pain relief products which give effective results.

Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

BioDynamix Joint Genesis | Doctor Formulated
Reduces Pain and Stiffness*Gold Star Evidence
Improves Joint Lubrication*Gold Star Evidence
Supports Joint Function*Gold Star Evidence
Relieves Inflammation & Discomfort*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
ProJoint Plus - VitaPost | Premium Joint Support
Supports Cartilage Health*Gold Star Evidence
Supports Joint Health*Gold Star Evidence
Lubricates Stiff Joints*Strong Evidence
Supports Joint Mobility*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Relief Factor | Best Pain Relief Supplement
Relief Aches and Pains*Gold Star Evidence
Reduces Inflammation*Strong Evidence
Protect Joints Damage*Strong Evidence
Support Immune System*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Heal-n-Soothe | Best Joint Pain Formula
Supports Healhty Joints*Gold Star Evidence
Promotes Joint Mobility*Gold Star Evidence
Help in Relieving Joint Pain*Strong Evidence
Supporting Reduction in Joint Pain*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Turmeric Curcumin Plus | High Quality Joint & Muscle Health Formula
Supports Joint Health*Gold Star Evidence
Supports Immune System*Strong Evidence
Antioxidant Support*Strong Evidence
Supports Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Neprinol

Neprinol Reviews – Does Neprinol Joint Pain Give You the Best Results?

Customer Reviews & Ratings

4.5 out of 5

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  1. Gretchen Fletcher

    Finally no hip pain!
    I ordered a bottle of Neprinol when I was desperate for relief from arthritis in my hip. I could hardly walk and was afraid I would need a hip replacement or would end up as a cripple with a walker. I took it for about a week and my pain went away completely.

    I thought maybe it had just cleared up on its own, so I didn’t reorder Neprinol when I finished the bottle. Then a week or so later, the pain came back. I ordered a second bottle and lo and behold! The pain went away and is completely gone. I will never be without this amazing miracle product, even though I don’t really understand how or why it works.

  2. Lydia

    My joints were swelling
    The first time it happened to me I was really scared. I didn’t have any joint condition like arthritis that I knew of and my joints had never swelled up like that before. The swelling was in my wrists and when I went to see a specialist about it she told me that it was due to inflammation and that if I didn’t treat it right away, it would soon turn into full-blown arthritis. So, I started taking Neprinol and it has not only stopped the swelling but has kept my joints protected from inflammation and arthritis too.

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Neprinol Ques and Ans

  • Q: Cramps every day! with taking 3. Will taking just 1 do any good? Thanks

    A: You should follow the recommended dosage of Neprinol, take 2-3 capsules per day for maintenance, 4-6 pills for increased support, and 9 capsules per day for therapeutic purposes. On an empty stomach, take two capsules with eight ounces of water. The capsules should be consumed at least an hour before or two hours after a meal. After following the above instructions, consult your doctor if you still have cramps.

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90 capsules

3 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Magnesium -
[2] Systemic and Lipollytic Enzyme blend: Serrapeptase, Nattokinase, Lipas -
[3] Neprinol Protease Blend -

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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