Neprinol Reviews: Does This Supplement Give You the Best Results?

Neprinol is a joint pain supplement that aids in blood purification, appropriate joint and circulation function, as well as reduces symptoms of fatigue.

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In This Review

Overview Of Neprinol

Are you also feeling the aging effects on your body? Do you sometimes feel uneasy, tired, or feel heavy? After a certain age, this is obvious. As we grow older, our natural enzyme production decreases. This led to a wide range of health concerns. Therefore, we need a powerful combination of enzymes and nutrients that can help us get back our vitality and well-being.

That’s where Neprinol comes in – a unique supplement designed to support your body’s essential needs. In this blog, we’ll explore the supplement Neprinol, we’ll understand the science behind this innovative supplement, find the roles of different enzymes and how they can benefit your body.

What is Neprinol?

Neprinol is a product that claims to cleanse the blood while also lessening aches and pains due to everyday activity. It intends to support the cleansing of blood, proper joint and circulatory function by decreasing excess fibrin and fibrinolytic activity through a blend of systemic enzymes. Other claims by this product include helping with fatigue and discomfort, poor circulation, elevated blood viscosity, and delayed healing.

How Does Neprinol Rate?

Overall Rating: 3.8

Value for Cost

3.9/5Value for Cost

3.7/5Return policy


Brand Highlights

  • Neprinol is manufactured by Arthur Andrew Medical, a company founded in 2003, who have 15 products that claim to help with joint relief and digestive enzymes for women, children, and even pets.
  • The company focuses on enzyme and probiotic-based dietary supplements for digestive issues, immune complications, poor circulation, hormone imbalance, and joint and muscle pain.


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*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Magnesium
  • Proprietary Blend Neprinol AFD
  • Systemic and Lipollytic Enzyme blend: Serrapeptase, Nattokinase, Lipase
  • Neprinol Protease Blend
  • Neprinol Enzyme and Cofactor Blend


  • This product may lessen aches and pains by the support of clean blood and proper joint and circulatory function.
  • According to the manufacturer’s website, Nattokinase is associated with maintaining normal blood viscosity and normal cardiovascular health, while Serrepeptase is a protein digesting enzyme that can support health fibrin concentrations.
  • Papain may promote healing and inflammation from overexertion.
  • The other ingredients are known for promoting a healthy cardiovascular system and immune system.


  • This product may seem expensive compared to other joint products.
  • Manufacturer suggests supplementing for at least one month, with optimal results expected within one to three months, though some may find the timeframe lengthy.
  • One of the ingredients, Serrapeptase, should not be taken with blood thinners such as Warfarin or aspirin, as it may increase the risk of bleeding or bruising.
  • The manufacturer warns not to take this product if you are also taking anti-coagulants or if you are pregnant or nursing.

How Does Neprinol Work?

Neprinol contains a blend of systemic, vegan-friendly enzymes, which work towards breaking down debris in the blood like excess fibrin and other unwanted proteins.

The ingredients serve to support normal inflammatory levels and are similar to other digestive enzymes. But, these specific ingredients target the bloodstream, not the gastrointestinal tract.

The cleansing of the blood is claimed to support healthy cardiovascular and liver function, while also maintaining a healthy inflammatory response for everyday activity.

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Neprinol Ingredients – Are they Safe & Effective?

Neprinol Supplement Facts

Neprinol Supplement Facts

Neprinol is a dairy, gluten, and soy-free product, as stated by the manufacturer. The following are the ingredients that constitute this product:


– Magnesium is known to strengthen the bones and improve cartilage consistency. A study published in PubMed suggests that lower magnesium intake was linked to increased pain and decreased functionality in knee osteoarthritis, especially in those with limited fiber intake[1].

Proprietary Blend Neprinol AFD

– This proprietary blend is designed to safeguard joints against fibrin-related damage. It comprises various enzymes and compounds specifically tailored to promote joint health and support inflammation management.

Systemic and Lipollytic Enzyme blend: Serrapeptase, Nattokinase, Lipase

– A natural enzyme compound that assists in certain biochemical reactions related to the joints. Additionally, research published in the journal Medicine indicates that systemic enzyme supplementation reduces cough and breathlessness, while also decreasing supplemental oxygen requirements in patients with pulmonary fibrosis[2].

Neprinol Protease Blend

– Protease is derived from Serratia, B. subtilis and A. oryzae – Another compound that is lauded for its ability to fight inflammation. The journal Arthritis Research & Therapy discusses the role of proteases in maintaining the balance of cartilage and bone in a healthy state, highlighting their significant involvement in conditions such as RA, OA, and spondyloarthritis[3].

Neprinol Enzyme and Cofactor Blend

– Amla, Papain, Bromelain, Rutin, Coenzyme Q10 – This compound has a direct effect on blood vessels which can reduce the appearance and cause of spider veins and bruising.

READ NEXTArthrozene and What Is Relief?



*All individuals are unique. Your results can and will vary.

Benefits of Neprinol

  • Better Digestion: Neprinol can help your body break down the food you eat more effectively, making it easier for your body to absorb the nutrients from that food.
  • Improved Circulation: The ingredients in Neprinol can help keep your blood flowing smoothly throughout your body, preventing it from becoming too thick or sluggish.
  • Reduced Discomfort: If you experience occasional aches or discomfort in your joints, especially after physical activity, Neprinol may help reduce that discomfort and support quicker recovery.
  • Boosted Energy Levels: By supporting better nutrient absorption and circulation, Neprinol can potentially help you feel more energetic and less fatigued throughout the day.
  • Faster Healing: The enzymes in Neprinol may assist your body’s natural healing processes, allowing you to recover more quickly from minor injuries or physical stress.
  • Stronger Immunity: Certain components in Neprinol are believed to support a healthy immune system, helping your body fight off illnesses more effectively.
  • Side Effects of Neprinol

  • Digestive Issues: Neprinol may lead to bloating, gas, or diarrhea, particularly when consumed on an empty stomach or in high doses.
  • Allergic Reactions: With enzymes derived from plants and microbes, some individuals may experience allergic reactions, manifesting as rash, itching, or difficulty breathing.
  • Interactions with Medications: Components in Neprinol, can interact with certain medications, potentially impacting their effectiveness or leading to side effects.
  • Stomach Irritation: The enzymes present in Neprinol might cause stomach upset or irritation, especially when taken without food or in larger doses.
  • Neprinol Questions and Answers

    Q: What Is Neprinol Good For?

    A: Neprinol is beneficial for promoting cardiovascular health and supporting the body’s natural inflammation response due to its enzyme blend, aiding in overall wellness and vitality.

    Q: How Should You take Neprinol?

    A: Neprinol recommended dosage is two to three capsules per day for maintenance, four to six capsules for increased support, and nine capsules per day for therapeutic purposes. The capsules should be taken with eight ounces of water on an empty stomach.

    It is recommended that the capsules be taken at least one hour prior to eating or two hours after a meal.

    Q: How Much Does Neprinol Cost?

    A: There are three options in which to purchase Neprinol: 90 capsules for $55.00, 150 capsules for $85.00, or 300 capsules for $145.00. New customers can get a 10% off coupon and the manufacturer offers free shipping within the United States.

    Q: Does Neprinol Lower Cholesterol?

    A: Neprinol is mainly utilized as a systemic enzyme supplement and might aid in promoting healthy circulation, yet its specific effect on cholesterol reduction remains unclear. Seeking advice from a healthcare provider is recommended for tailored recommendations regarding cholesterol management.

    Q: What Are the Ingredients in Neprinol?

    A: Neprinol contains a blend of systemic enzymes, including serrapeptase, nattokinase, bromelain, papain, and other proteolytic enzymes, as well as coenzymes and cofactors such as magnesium and Amla.

    Q: Are there any alternatives to Neprinol?

    A: Yes, there are multiple supplements on the market such as Purity H.A. Joint Formula, Lunaflex PM and Inflama-Care.

    Q: What is Neprinol’s Return Policy?

    A: Unopened items purchased directly from the manufacturer can be returned or exchanged within 30 days of the purchase date for a full refund or exchange.

    Q: Does Neprinol Offer a Free Trial?

    A: Neprinol does not offer a free trial but does give a 10% off coupon for new purchasers.


    Pro Joint Plus

    *All individuals are unique. Your results can and will vary.

    What Do the Neprinol Reviews Say?

    The Neprinol reviews show a range of opinions about how well it works, with some users believing it’s effective while others are uncertain. Here are a few reviews of Neprinol from Amazon.

    Good Product

    – I don’t know if there is anything that is supposed to feel different after having taken this product for a while. I take it to maintain optimum health. I selected this brand after researching many Nattokinase brands. I haven’t experienced anything negative by taking it. ~ Phillip

    A decent standard formulation for non-specific use

    But if you really need to be using systemic enzymes (serrapeptase, nattokinase, and NAC) for fibrin control (usually associated with immune system problems/), use a combination of the full-strength individual products. I use a combination of the three mentioned above that is than 10-15 times stronger than their strength in this formula, as may be required depending on the seriousness of your problem. My wife, however, loves this product for daily use. ~ Vincent Bartone

    Just not for me

    49 y/o male Ironman and thought this may be a good idea to take my heavy training load. Noticed little effect after taking for 2+ months. Gonna assume I’m at a point in my life where I do not yet need this kind of supplement. Am sure it’s a quality product just not right time for me. Maybe in 20 years ?.

    Neprinol Review – Final Verdict

    Neprinol offers a blend of systemic enzymes to support healthy levels of fibrin and other debris in the blood. This is claimed to cleanse the blood to support cardiovascular and liver functions, as well as joint function.

    The use of this product for some consumers may be limited as there is no certainty that pregnant or nursing women may use the product safely. There is also a warning for individuals who are taking anti-coagulants and it is recommended that they do not take this product without consulting their physician.

    There may be similar joint relief products out there for these individuals who are looking for a product to assist with blood cleansing and joint, circulation, and immune system support. Neosporin is one of the joint pain relief products which give effective results.

    Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

    Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

    Our Top Joint Pain Relief Choices

    Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

    JointXL Plus - Joint Health Formula
    Reduces Joint Pain & Soreness*Gold Star Evidence
    Enhances Comfort & Mobility*Gold Star Evidence
    Prevents Joint Degeneration*Gold Star Evidence
    Supports Tissue Repair *Strong Evidence
    Rating Breakdown
    Support for Claims:
    Ingredient Safety:
    Value for the Price:
    Brand Transparency:
    Overall Rating: 4.9
    BioDynamix Joint Genesis | Doctor Formulated
    Reduces Pain and Stiffness*Gold Star Evidence
    Improves Joint Lubrication*Gold Star Evidence
    Supports Joint Function*Gold Star Evidence
    Relieves Inflammation & Discomfort*Strong Evidence
    Rating Breakdown
    Support for Claims:
    Ingredient Safety:
    Value for the Price:
    Brand Transparency:
    Overall Rating: 4.9
    ProJoint Plus - VitaPost | Premium Joint Support
    Supports Cartilage Health*Gold Star Evidence
    Supports Joint Health*Gold Star Evidence
    Lubricates Stiff Joints*Strong Evidence
    Supports Joint Mobility*Gold Star Evidence
    Rating Breakdown
    Support for Claims:
    Ingredient Safety:
    Value for the Price:
    Brand Transparency:
    Overall Rating: 4.9
    Relief Factor | Best Pain Relief Supplement
    Relief Aches and Pains*Gold Star Evidence
    Reduces Inflammation*Strong Evidence
    Protect Joints Damage*Strong Evidence
    Support Immune System*Gold Star Evidence
    Rating Breakdown
    Support for Claims:
    Ingredient Safety:
    Value for the Price:
    Brand Transparency:
    Overall Rating: 4.8

    Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

    Customer Reviews for Neprinol

    Neprinol Reviews: Does This Supplement Give You the Best Results?

    Customer Reviews & Ratings

    4.5 out of 5

    Review this Product

    Leave a review and share your experience with others.

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    1. Gretchen Fletcher

      Finally no hip pain!
      I ordered a bottle of Neprinol when I was desperate for relief from arthritis in my hip. I could hardly walk and was afraid I would need a hip replacement or would end up as a cripple with a walker. I took it for about a week and my pain went away completely.

      I thought maybe it had just cleared up on its own, so I didn’t reorder Neprinol when I finished the bottle. Then a week or so later, the pain came back. I ordered a second bottle and lo and behold! The pain went away and is completely gone. I will never be without this amazing miracle product, even though I don’t really understand how or why it works.

    2. Lydia

      My joints were swelling
      The first time it happened to me I was really scared. I didn’t have any joint condition like arthritis that I knew of and my joints had never swelled up like that before. The swelling was in my wrists and when I went to see a specialist about it she told me that it was due to inflammation and that if I didn’t treat it right away, it would soon turn into full-blown arthritis. So, I started taking Neprinol and it has not only stopped the swelling but has kept my joints protected from inflammation and arthritis too.

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    Neprinol Ques and Ans

    • Q: Cramps every day! with taking 3. Will taking just 1 do any good? Thanks

      A: You should follow the recommended dosage of Neprinol, take 2-3 capsules per day for maintenance, 4-6 pills for increased support, and 9 capsules per day for therapeutic purposes. On an empty stomach, take two capsules with eight ounces of water. The capsules should be consumed at least an hour before or two hours after a meal. After following the above instructions, consult your doctor if you still have cramps.

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    Arthur + Andrew
    PRICE (in USD)
    90 capsules
    Magnesium and Proprietary Blend Neprinol AFD

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      3 Sources

      We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

      [1] Magnesium -
      [2] Effects of Systemic Enzyme Supplements on Symptoms and Quality of Life in Patients with Pulmonary Fibrosis -
      [3] Proteinases in the joint: clinical relevance of proteinases in joint destruction -

      **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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