The Best Joint Pain Supplements (2022) – Learn The Science

The best joint pain supplements for 2022 to deal with achy joints and inflammation.

Which Joint Pain Supplements Really Work?

Joint pain is most often a result of diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), and other conditions affecting the joints.

The Best Joint Pain Supplements (2022) – Learn The Science
Some people use supplements to try to help manage joint pain from arthritis. Shutterstock Images

According to the Centers for Disease Control and Prevention (CDC[1]), approximately 22.7% of people in the U.S. were told by a doctor to have some form of arthritis.

But despite its high prevalence, treatment for arthritis is limited to relieving the symptoms such as Osteoarthritis and inflammation without directly addressing the disease. This is exactly why a lot of people turn to alternative remedies such as joint pain supplements to find some relief.

In order to manage the joint pain, relieves any kind of discomfort, and improve flexibility people usually opt for the best supplement for joint pain.

Why Do My Joints Hurt?

Joints are vital parts of the human body that are needed for adequate movement. When joints hurt, a large number of issues may be contributing to the symptoms experienced.

In addition to pain, other symptoms like tenderness, stiffness and swelling may also be present.

WebMD[2] explains that the cause of painful joints can vary from simple injuries to more serious health conditions, such as osteoarthritis, bursitis, rheumatoid arthritis and gout.

Even though rare, it should be noted that cancer within the joints can also cause such symptoms to become present.

What’s good for joint pain? Here’s a look at 11 of the best joint supplements and what the existing research says about them.

How to Choose the Best Joint Pain Supplements?

Choosing the best joint supplements or best joint support supplements is not easy. This is mostly because there is an abundance of joint pain supplements, joint reliefs, joint pills on the market with most of them not offering any true measurable benefits.

Because most of these products are designed as dietary supplements, they don’t undergo rigorous FDA testing making their ingredient safety and efficiency highly debatable.

Furthermore, the studies on common ingredients in supplements for joint pain are inconclusive and contradictory, as stated in a review on bone and joint supplements published in Pharmacy and Therapeutics.

So choosing the best joint pain supplements will largely depend on your own research and trust regarding these products.

The 14 Best Joint Pain Supplements for women and men

Considering ingredients quality and efficiency, label transparency, product reviews, we’ve picked out 10 of the best joint supplements in terms of safety and efficiency.

#1 Projoint Plus

Projoint Plus is a dietary joint supplement, which is formulated to assist with alleviating pain in your joints. This supplement contains a potent dose of ingredients that have been scientifically proven to provide relief in the symptoms experienced following an injury, as well as caused by arthritis.

Age-related deterioration, which is usually caused by wear and tear over the years, can also have a significant impact on a person’s life. This supplement will also assist with reducing the symptoms caused by these problems.

The joint supplement is in the form of a capsule that can be taken with or without a meal. It also contains ingredients that assist with the delivery of the active ingredients into the bloodstream; thus providing faster results.

This product can be purchased from the official website at $29.95 for a packet of sixty pills. This formula also offered a 60-day money-back guarantee. There is a lack of information regarding the manufacturers of Projoint Plus, and specific dosage instructions are also not provided on the page that describes the benefits of the product.

With sixty capsules found in each container; however, the user would most likely be required to take two capsules daily – more accurate dosage instructions can be found on the product’s label.

Read more about Projoint Plus here.

#2 Joint N-11

Joint N-11 by Zenith Labs is a natural bone and joint health supplement containing active ingredients developed to support and promote healthy flexibility and mobility.

This joint supplement is considered an all-natural diet formula that alleviates joint pain, stiffness, and inflammation. It also claims to restore mobility of the knees, hips, and back, prevent signs of aging such as memory loss, abnormal blood sugar, and heart problems.

This is the best joint supplement for knees pain that contains natural ingredients that are also helpful in joint pain. Some of the ingredients include turmeric root, Bioperine, ginger root, bail and rosemary leaves, and soy lecithin. However, this product is said to contain high antioxidants, which help treat degenerative joint disease. The supplement also boosts the body’s defenses and speeds up healing.

For the best results, it is recommended to take two capsules per day with breakfast.

Read more about Joint N-11 and Joint N-11 here

#3 Turmeric Curcumin Plus

Turmeric curcumin plus is a superfood designed to help people with little or no time in paying attention to their diet or lifestyle stay in shape both in mind and body. The product contains a potent ingredient called turmeric, which has a long history in ancient remedies for its antioxidant and anti-inflammatory properties[6].

Turmeric curcumin plus features a unique blend of natural ingredients, which helps users relieve joint pain, increase cognitive performance, foster brain health, and anti-inflammatory response. Also, it may be a great support to achieving your weight loss goal, as it has antioxidant properties to help boost your body’s metabolism. These are the best pills for joint pain, knee pain. However, individuals may experience different results with the supplement.

Read more about Turmeric Curcumin Plus here.

#4 1MD KrillMD

KrillMD is a krill oil nutritional supplement manufactured by 1MD. This product contains krill oil derived from the Antarctic krill. It uses Multi-Stage Oil extraction (MSO) technology, which increases its bioavailability and absorption. 1MD KrillMD also consists of omega-3 (DHA and EPA), astaxanthin, and lipids (phospholipids). These ingredients are naturally derived from krill oil.

This nutritional supplement uses exclusive Antarctic krill oil, sourced from sustainable sources, and has proven to be just as productive as fish oil. This blend of omega-3 bound to krill lipids with the powerful antioxidant astaxanthin creates a great product that is not on the market today.

This product contains mollusks, which could set off an allergic reaction to those who have allergies to it. Other than that, there may not be many side effects associated with 1MD KrillMD. This does not necessarily mean that you may not experience any other side effects.

As a dietary supplement, it is recommended to take two (2) capsules per day or as recommended by a healthcare specialist.

Read more about 1MD KrillMD here

#5 MoveMD

This dietary supplement MoveMD is a natural joint supplement rich in antioxidants that provide you with immediate pain relief, promotes healing and repair, and other health benefits. This best joint pain relief supplement also contains anti-inflammatory substances that relieve swelling and pain associated with arthritis.

The product is the best medicine for knee pain said to relieve symptoms within about seven days of regular use of the supplement. It also claims that the body will be supplied with the necessary nutrients in an appropriate ratio and help relieve the symptoms of pain and joint stiffness. MoveMD is the good answer to the question of what to take for knee pain?

The supplement is in the form of a capsule that can be taken with or without a meal. It also contains ingredients that are said to assist with delivering the active ingredients into the bloodstream, thus providing faster results.

MoveMD dietary supplement can be purchased from the official website at $50 for a bottle. There are claims that there is a 90-day money-back guarantee on the product. It is recommended to take one capsule per day, preferably in the morning, on an empty stomach.

Read more about MoveMD here

#6 Instaflex

Endorsed by famous football player Doug Flutie, Instaflex is bound to offer at least some benefits to people with arthritis. Instaflex ingredients label Unlike most joint supplements, Instaflex Advanced does not include Chondroitin and Glucosamine but rather relies on other scientifically proven substances. This product contains a unique form of Boswellia extract labeled AprèsFlex, resveratrol, a polyphenol, UC-II Collagen, Black pepper extract, Hyaluronic acid, and, lastly, turmeric was added due to its fairly known anti-inflammatory properties.

The product has been developed to provide numerous benefits to the user, such as a reduction in the discomfort that is often experienced when joints become painful, as well as significant improvements in flexibility within the joints that are affected.

One particular aspect that makes Instaflex Advanced quite a popular product is the fact that the manufacturer claims the product will provide a significant improvement in the symptoms experienced by the user within the first seven days of usage.

Instaflex Advanced has recently introduced a new trial program, where the user can gain access to a 14-day trial of the product to see if it works for them. After that, the customer will be required to pay a monthly fee of $69.99 and a shipping fee of $4.99. Instaflex is available on amazon.

The product is conveniently shipped each month automatically to the customer; thus avoiding running out of these supplements.

Read more about Instaflex reviews here.

#7 Osteo Bi-Flex

This product is unique and one of the best top-rated joint supplements of 2022 that offers benefits not just to the joints but also surrounding muscles. Another thing that makes this product unique is that the product tablets are 80% smaller than other similar joint support supplements.

Big pills are often difficult to swallow, which can make a supplement inconvenient. With the smaller design in mind, users can easily take the supplement wherever they are to experience the numerous advantages that Osteo Bi-Flex can offer them.

Osteo Bi-Flex is also suitable for those with gluten sensitivity and shellfish allergies. As far as the ingredients are concerned, the product contains glucosamine, type-II collagen, 5-LOXIN Advanced, and MSM. Osteo Bi-Flex has been developed in such a way to provide fast and effective relief of joint-related symptoms.

According to the manufacturer of the product, if a user closely follows the dosage instructions provided on the packaging, they are expected to experience a significant reduction in pain, inflammation, and discomfort within the first seven days. After the early seven days, the symptoms will become even more reduced – long-term use will assist with improving flexibility and range of motion in the joints that are affected as well.

Read more about Osteo Bi-Flex here.

#8 Beneflex

While Glucosamine is known to be one of the most popular joint support ingredients found in nature, it most certainly does not work for everyone. Beneflex is the best joint supplement because that focuses on introducing the user’s body to the latest advancements in natural sciences. Instead of including Glucosamine in their formula, the manufacturer has taken a look at natural substances that can provide more effective results.

Additionally, Beneflex does not utilize any filler, which means the entire capsule is filled with beneficial substances that will assist with improving joint-related symptoms – according to the manufacturer’s website, within as little as one week.

The ingredients that make Beneflex so beneficial include a specialized UC-II Collagen, which has gone through numerous scientific trials and studies and was proven to effectively improve overall joint health[7]. Other ingredients include ApresFlex, a specialized extract of the Boswellia Serrata plant, as well as Turmeric and Hyaluronic Acid. The product can be purchased at numerous locations, including, the world’s most popular online retailer.

When looking at the product’s listing at various online locations, we could find mostly positive reviews from users who have used the product in the past to assist with reducing pain and inflammation in their joints, as well as for improving the overall flexibility of their bones.

Read more about Beneflex here.

#9 Osteojuv

OsteJuv’s main purpose is to improve joint lubrication as it contains high concentrations of hyaluronic acid. The manufacturers of OsteoJuv claim the product is capable of treating pain from different types of arthritis and works on all joints in the body. Besides improving joint lubrication, this product is said to reduce inflammation, which is another contributing factor to pain and joint damage.

With improvements in lubrication and a reduction in inflammation, the user is expected to experience improved comfort and range of motion in the joints that have been affected by these symptoms.

The primary ingredients found in Osteojuv include Hyaluronic Acid, Chondroitin, Glucosamine, Calcium, and Gelatin. It should be noted that the combination of Chondroitin and Glucosamine has been proven to work more effectively than any one of these ingredients used separately. This is the best glucosamine chondroitin joint lubrication supplement on market.

The product comes in the form of a dietary capsule and should be taken once per day – a total of two tablets need to be taken each morning.

The product claims to provide effective results in a relatively short period of time, but continued usage will offer the user the most benefits. It should be noted that individuals who are allergic to shellfish should avoid using Osteojuv.

Read more about OsteoJuv here.

#10 Flexacil Ultra

What to take for joint pain? The manufacturers of Flexacil Ultra claim that this product contains the best-selling formula for joint pain relief available on the market today. It also contains ginger root and horsetail leaf extracts. This effect is due to the apparent ability of the horsetail plant to downregulate the levels of TNF-? Which causes inflammation in RA.

In addition to the horsetail leaf extracts and ginger root extracts, Flexacil Ultra also contains a combination of Glucosamine and Chondroitin – while these ingredients often fail to produce effective results when used alone, they have been proven to offer a significant improvement in joint-related symptoms when used together.

One particular factor about Flexacil Ultra that sets it aside from many competing best joint supplements is the fact that this product does not only aim to provide relief in pain and inflammation symptoms experienced by the user.

In addition to reducing the severity of these symptoms, the product also aims to assist the body in repairing the cartilage that has been damaged. When the cartilage is repaired, joint-related symptoms will gradually start to improve. The user will also begin to experience improvements in flexibility, comfort, and range of motion within these joints. It is the best supplement for knee cartilage.

Read more about Flexacil Ultra here.

#11 Lyprinol

Another potent option for individuals suffering from joint pain that is accompanied by inflammation is Lyprinol. This product is unique and contains a specialized natural marine lipid extract. The extract consists of a unique omega-3 fatty acids formulation, combined with relatively rare lipid groups.

The product has gone through numerous scientific studies, as well as clinical trials, and has been proven to provide the user with practical anti-inflammatory effects. This particular supplement is useful for a variety of conditions that include inflammation as a symptom – this includes various types of arthritis, including osteoarthritis and rheumatoid arthritis.

In addition to treating symptoms caused by arthritis and other joint-related issues, Lyprinol is also useful in treating many different conditions, such as asthma.

The product comes in capsule form. When starting to use this product, the user is advised to take up to four of these capsules daily for up to six weeks. Two of these capsules should be taken in the morning, and another two at night. It is advised to take Lyprinol supplements with a meal.

After the first six weeks, the user is advised to lower their dose to a maximum of two capsules daily – this will be for maintenance.

Read more about Lyprinol here.

#12 Arthro 7

The manufacturers of Arthro 7 claim their product can help relieve joint discomfort, promote joint mobility, nourish joint cartilage, and promote joint mobility. The product contains collagen, bromelain, CMO (cetyl myristoleate) which is a type of fatty acid, MSM, lipase, turmeric, Gelatin, silicon dioxide, titanium dioxide, and magnesium stearate. Also vitamin C best vitamin for bones and joints, knee pain, arthritis.

The manufacturer claims that more than eight million bottles of their Arthro-7 product have been sold to date and that the supplement has helped millions of people overcome common symptoms that affect their joints.

Furthermore, the product does not contain any pharmaceutical drugs and is free of GMOs, shellfish, and gluten. According to the manufacturer of Arthro-7, users typically start to experience results when they have used to produce for two weeks as a daily joint support supplement.

Arthro-7 is an affordable best joint supplement that can be taken without experiencing any significant side effects. Most users report that the supplement tends to work relatively quickly and that it does provide them with the benefits promoted by the manufacturer.

A special offer can be utilized, which provides the customer with a constant supply of the product to ensure they never run out of the supplement. By taking advantage of the special offer, the customer will pay $33.30 per one-month supply of the supplement.

Read more about Arthro 7 here.

#13 Vital 3

Vital three is different from other joint pain supplements because it comes in a drop dispenser. This product was also tested in clinical trials and was described as a good addition to other arthritis medications, as explained on the product website.

The collagen in Vital three is said to improve joint lubrication and cushion, which aids in its repair. This is an important feature to look for in joint support supplements as the breakdown of cartilage and joints is the primary cause of pain, as well as inflammation and other particular symptoms that people tend to experience.

The fact that Vital 3 does not only focus on relieving the symptoms but also targets the cause of the symptoms makes the product much more efficient than many of the other choices on the market. Vital3 is the best supplement for joints and ligaments.

Vital 3 is not just a random product on the market. This is the best joint health supplement that has scientific evidence to back up the claims made by the product’s manufacturer. In fact, ten different clinical trials have been conducted on human subjects – and the results were quite impressive amongst all of the clinical trials that were conducted by the scientists behind this powerful formula.

Read more about Vital 3 here.

#14 Flexitrinol

Flexitrinol is an innovative joint health supplement, specially designed to reduce joint pains, improve flexibility, and promote overall joint health. It is made of powerful and high-quality ingredients that help to make your joint strength and reduce the pain. It also helps to prevent inflammation, which is the main cause of joint pain and also further damage to the affected joints.

The product does not utilize any pharmaceutical drugs or harmful chemicals, but rather solely relies on nature to provide a potent formula that is virtually free of any potential side effects.

Flexitrinol ingredients are Flaxseed oil, and Omega fatty acid complex (Omega 3, 6, and 9), MSM, vitamin C which is the best vitamin for joints pain and stiffness, Glucosamine HCL, and Chondroitin Sulfate.

Thousands of people have utilized Flexitrinol, and the majority of these individuals have reported positive effects after taking the supplement daily over a few weeks. This joint support supplement is very affordable, with a special offer currently offering a one-month supply of Flexitrinol at the price of $39.99.

It should also be noted that Flexitrinol has undergone several laboratory tests and clinical trials to provide evidence that the supplement is safe for long-term use and effective in producing the results it claims to provide.

Read more about Flexitrinol reviews here.

How do Joint Pain Supplements Work?

Joint pain products contain ingredients that are believed to mainly reduce inflammation and repair joint structure.

The supplements for joint pain are meant to be taken orally, and the ingredients that enter the bloodstream are believed to improve collagen synthesis, inhibiting the synthesis of proteins that can cause joint cartilage destruction, and reduce inflammation and pain.

Some joint supplements also improve joint lubrication by affecting the synovial fluid of the joints. This efficiency can depend greatly on the quality of the ingredients, their molecular weight, and their ability to enter the bloodstream.

Also, these joint support supplements are not regulated by the U.S. Food and Drug Administration so read labels carefully.

CAUTION: Before choosing a supplement, talk with your doctor or pharmacist about other medications you’re taking so they can check for potential interactions. Some joint health supplements can interact with certain medications, such as blood thinners.

Taking Joint Pain Supplements

Taking Joint Pain Supplements

Things to Consider When Taking Joint Pain Supplements

Most joint pain supplements you see on the market are derived from natural ingredients and are completely safe. This also means you probably won’t have any side effects, which is common with prescription treatments for arthritis.

Talk to your doctor before taking these supplements for joint pain, especially if you are currently taking other medications.

In terms of quality, the Arthritis Foundation recommends that you choose the products from the most reputable national brands and be wary of low-cost alternatives that claim to have the same ingredients at a fraction of the price.

Another thing you need to consider before taking supplements is label transparency, i.e., that all ingredients are listed including binding ones. This is important, especially if you have certain allergies and want to make sure you don’t have an allergic reaction to any of the ingredients in your joint pain supplement.

Popular Ingredients in Joint Pain Supplements

The two most popular ingredients in joint pain supplements are glucosamine for joint pain and chondroitin.

A 2018 study published in the Annals of Rheumatoid Diseases even suggested that 800 mg of chondroitin sulfate taken daily was equal in providing joint pain relief as a daily 200-mg dose of Celebrex (celecoxib).

Both ingredients are essential constituents of healthy joint cartilage tissue. Their efficiency in repairing the joints is limited to laboratory studies.

Other popular ingredients are hyaluronic acid which is a part of the synovial fluid, diacerein, Avocado–soybean unsaponifiable (ASU), S-adenosylmethionine, Indian frankincense (Boswellia), capsaicin, turmeric, etc.

Some of these ingredients are believed to help improve joint cartilage structure and speed up a repair, and others function as natural anti-inflammatories and pain relievers.

Bone Joint Health Info

Bone Joint Health Info


Joint pain is a daily reality of a great number of people with arthritis. While medical experts are on the search for effective treatments of arthritis, patients rely on natural supplements for joint pain and bones to find at least some relief.

While the effectiveness of dietary supplements in the treatment of arthritis pain is elusive, some studies are speaking in favor of some of these best supplements for arthritis and ingredients.

The best way to honestly know if a joint supplement will work for you is to try it out for yourself.

[1] Arthritis Related Statistics
[2] causes of joint pain
[3] Chondroitin sulfate as good as widely used anti-inflammatory for knee osteoarthritis
[4] Supplements for Arthritis, Osteoarthritis
[5] Arthritis Foundation: "Tip-offs to Rip-offs, Common Therapies to Consider, Supplement Guide-Osteoarthritis, Supplements to Avoid."
[6] Natural Standard: "The Authority on Integrative Medicine."
[7] Robert Bonakdar, MD, director of pain management at Scripps Center for Integrative Medicine.
[8] Harvard Health Publications: "Online Medical Dictionary."
[9] BMJ-British Medical Journal. "Popular supplements to combat joint pain do not work, study finds." ScienceDaily. ScienceDaily, 17 September 2010.
[10] Arthritis
[11] Reginster, J.; Dudler, J.; Blicharski. T. et al. Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Annal Rheum Dis. 2018:19(4):409-12. DOI: 10.1136/annrheumdis-2016-210860.
[12] Codie A. Primeau, Bryn O. Zomar, Lyndsay E. Somerville, Ishita Joshi, J. Robert Giffin, Jacquelyn D. Marsh, Health Economic Evaluations of Hip and Knee Interventions in Orthopaedic Sports Medicine: A Systematic Review and Quality Assessment, Orthopaedic Journal of Sports Medicine, 10.1177/2325967120987241, 9, 3, (232596712098724), (2022).
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Dr. Sarah Brewer, MSc, MA, RN

Dr. Sarah Brewer is qualified from Cambridge University with degrees in Natural Sciences, Medicine, and Surgery. She is an award-winnin

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links."This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."