VetriScience GlycoFlex 3 Review – Is It Effective For Joint?

Glycoflex 3 is a hip and joint supplement for dogs and increases hind leg strength in dogs also has antioxidants to support your dog’s joint health problems.

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In This Review

What is GlycoFlex 3?

GlycoFlex 3 is manufactured by VetriScience (a Vermont company in business since 1972), who assert that their products have an excellent track record in supporting canine joint health.

It is meant as a dietary supplement for dogs suffering from joint problems due to age, size, or very active lives. This supplement is available through many retailers; at one source we examined and a bag of 120 soft chews was $30.

The supplements have the same formula, although two soft chews contain as much as one tablet, which may be important to your own cost planning.

How Does It Rate?

Overall Rating: 3.7
Vetriscience Glycoflex 3Vetriscience Glycoflex 3


Value for Cost

3.9/5Value for Cost
Return Policy

3.7/5Return Policy


Brand Highlights

  • Brand name is VetriScience.
  • Based in the USA.
  • Glycoflex 3 is a hips and joint pain supplement for dogs
  • Brand claim that it is safe & effective.

Key Ingredients

  • Green-lipped mussel
  • Glucosamine HCl
  • Methylsulfonylmethane
  • DMG
  • Minerals


  • Many ingredients are from natural animal sources.
  • Sold in many retailers online and traditionally.
  • May provide maximum joint support in dogs.
  • Can be used as a follow-up post orthopedic surgeries in dogs.


  • No veterinary research is cited.
  • Not guaranteed to be safe for puppies or pregnant dogs.
  • Contains shellfish compounds (mussel, shrimp, crab).
  • No manufacturer guarantees.

How Does GlycoFlex 3 Work?

This best dog hip and joint supplement contains extracts from New Zealand green-lipped mussels as well as other joint support compounds that are intended to supplement your dog’s normal diet.

It is not a replacement for a wholesome diet, or a multivitamin supplement, although it does contain some minerals.

The supplement is available in tablet and chew-treat formulas, both of which have chicken flavoring that should make it easy to feed to your pet.

GlycoFlex 3
GlycoFlex 3 – Facts

GlycoFlex 3 Ingredients – Are they Safe & Effective?

VetriScience does not list the exact formulation of GlycoFlex 3 on their website. However, we were able to review the product’s label and its active ingredients, which are:

Green-lipped mussel

According to research it is a whole-organism extract from a natural (shellfish) source, intended as a source of amino acids, minerals and other compounds. [1]

Clinical investigations of GLM have indicated that oral doses of green-lipped mussel administered to arthritic dogs for an appropriate time period were associated with reduced joint discomfort and inflammation, as well as improvements in mobility.

Glucosamine HCl

A major component in the formation of cartilage and joint tissue.


A source for sulfur, a key mineral in cell formation.


A metabolic support compound.


The supplement includes calcium, manganese and selenium, all important for the health of joints. You can read more in our Nutra Thrive Reviews.

Alternatives to GlycoFlex 3:

Side Effects

This product has no known side effects when fed correctly, presuming that your pet does not have an allergy to shellfish compounds. If your dog’s digestion tends to be sensitive, VetriScience recommends using the tablet formulation rather than the chewable treat formulation.


Q: Are there other products under the name GlycoFlex?

A: Yes, VetriScience has an entire product line under that name. While all of the products have some similarities, the formulas are different and intended for dogs in different situations, so please be sure to check the labels carefully before you buy.

Q: Does this product contain any possible allergens?

A: The active ingredients for this product include a shellfish extract, and it also contains shrimp and crab extracts, as well as chicken flavoring and brewer’s yeast as an inactive ingredient.

Q: What are the dosage directions of this product?

A: According to manufacturer recommendations:

For the first 4-6 weeks of use, give dogs up to 30 pounds 1/2 tablet daily, 31-60 pounds 1 tablet daily, 61-100 pounds 2 tablets daily, and 101 pounds or higher, 2 and 1/2 tablets daily. After this first 4-6 weeks, halve that – so a 50-pound dog would go from one tablet daily to 1/2 tablet daily. For a small dog, feed 1/2 tablet every other day.

If you choose the soft chew formulation, each chew is equivalent to one-half tablet. For example, a 70-pound dog would be given four chews daily for the first 4-6 weeks, then two chews daily.

If you are feeding more than one tablet’s worth (two chews) daily, the manufacturer recommends dividing it into two doses, one in the morning and the other in the evening.

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GlycoFlex 3 Review – Final Verdict

VetriScience’s website presents GlycoFlex 3 in a very detailed light, and it is available from many reputable retailers. However, they do not provide much scientific backing for their claims, some of which are very precise (“increasing hind leg strength by up to 41% in 4 weeks”), which makes complete trust difficult.

There are many pet supplements on the market today, so be sure to research thoroughly before you make a commitment with your hard-earned money.

Our Top Rated Dog Joint Supplements
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Juve Flex
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GlycoFlex 3

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for GlycoFlex 3

VetriScience GlycoFlex 3 Review – Is It Effective For Joint?

Customer Reviews & Ratings

2.3 out of 5

Review this Product

Leave a review and share your experience with others.

Write a Review

  1. Cynthia

    My dog hates the taste
    My chihuahua loves to eat so when he doesn’t want to eat his food because I added a crushed-up Glycoflex treat to his meal, it breaks my heart. I have tried to mask the Glycoflex treat in ice cream, chicken, and cheese but he just spits it out. There has to be a better alternative to the taste than the current product offers. I would prefer a powder that has no taste.

    I’m on the hunt for something else.

  2. Dr. Barry Reder

    Most unusual effect!
    This is not my first rodeo. I bred Neapolitan Mastiffs for ten years. I follow Dr. Billingsworth BARF diets exclusively. My two-year-old rescue boxer seemed fine…until she started to limp. Which joint or joints were the problem…we could not isolate. I started Glycoflex ‘stage three’ at four tabs per day for 30 days. When ALL limping was gone, I went down to two tabs/day. I strongly dislike testimonial advertisements, however, if this can help your dog, go for it!
  3. Sam

    Glycoflex tablets too hard for dogs to chew
    I originally used the GlycoFlex 3 tablets for my dog several years back and she was willing to eat them and I could half them as suggested for her weight. I went to the chews for a while and then went back to the tablets. I have a very hard time cutting these new pills in half, even using a knife and a hammer on the knife to try to cut them. She refuses to eat these new ones and will remove them from her bowl of food and put them on the floor. She will lick anything off that I have put on them to entice her to eat them. I tried soaking them overnight and they were still too hard for me to cut. I’m sure they hurt her teeth to try to chew them so she just quit trying. I have to wonder if too much of the ‘hardening’ agent was put in this batch. Vetri science will not answer my e-mails with my concerns about their hardness.

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VetriScience GlycoFlex 3 Ques and Ans

  • Q: Is Glycoflex more effective with or without food?

    A: There is no clear consensus on whether GlycoFlex is more effective when taken with or without food. However, GlycoFlex is typically more effective when taken with food. Taking GlycoFlex with a meal or snack helps to optimize its absorption and utilization by the body. It is generally recommended to follow the instructions provided by the manufacturer

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GlycoFlex 3
Soft Chew
120 Soft Chew
Green-lipped mussel, Glucosamine HCl, Methylsulfonylmethane, DMG, and Minerals

1 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.
[1] Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs -

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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