Serenagen Review – Does It Contain Natural Ingredients?

Metagenics Serenagen is a natural dietary supplement that claims to contain traditional Chinese herbs that aid in stress, depression, and anxiety management.

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In This Review

What is Serenagen?

Serenagen by Metagenics is a natural dietary supplement for stress management. It utilizes traditional herbs used in Chinese medicine for individuals suffering from anxiety disorders or high-stress levels.

It is a natural alternative to antidepressants for decreasing the risk of side effects.

The formulation targets the different organs and systems in the body involved with stress response helping the user cope and relax.

How Does It Rate?

Overall Rating: 3.7

Value for Cost

3.7/5Value for Cost
Return Policy

3.6/5Return Policy


Brand Highlights

  • Stress management formula based on traditional Chinese medicine*
  • Each 2-tablet dose features herbs with a long history of use*
  • Adaptogens may support the body in adjusting to various stressful environmental challenges
  • This product is non-GMO, gluten-free, and vegetarian
  • Covered by the Metagenics, Inc. 60-Day

Key Ingredients

  • Rehmannia root
  • Schisandra fruit
  • Jujube Fruit
  • Dong Quai Root
  • Chinese Asparagus root


  • Serenagen only contains natural ingredients
  • It includes relaxing herbs that have been used for centuries in traditional Chinese medicine


  • There is no clinical evidence that it actually works
  • Serenagen is not effective for acute cases of anxiety
  • The existence of negative feedback indicates that it’s not effective for everyone. It could be because the instructions were not followed correctly, or the product itself has the problem
  • There is no money-back guarantee offer
  • There is no clinical evidence proving the effectiveness or safety of the active ingredients provided on the product’s website

How Does Serenagen Work?

Metagenics Serenagen uses a combination of herbs and traditional Chinese ingredients for nourishing and ‘quieting’ the heart according to the product’s website.

The dietary supplement uses herbs that help manage stress by helping the user to relax. It works by relaxing the body and the mind of the user, helping address anxiety disorders.

The Formula contains adaptogenic herbs or those that promote the balance of physiological processes, helping the user attain homeostasis.

It primarily works on the organs and systems that are directly connected to the stress response of the body.

Serenagen Ingredients – Are they Safe & Effective?

When looking at Serenagen reviews, it is important to scrutinize the ingredients within its formula.

Rehmannia root

– Rehmannia is a kind of plant. The plant’s roots are used to create medication. Rehmannia is widely found in Traditional Chinese Medicine herbal mixtures.

As per ReserchRehmannia is used to treat anemia, renal illness, obesity, diabetes, and a variety of other ailments[1].

Schisandra fruit

– Schisandra is a fruit extract that has a long history of usage in traditional Chinese medicine to treat liver diseases and stomach issues, and as a tonic to increase energy. It is also utilized in a variety of tiredness and sleep formulae[2].

Jujube Fruit

– Because of its great nutritional and health properties, the fruits of Ziziphus jujuba, also known as jujube, red date, or Chinese date, are used as fresh or dried food and as traditional medicine across the world as per ncbi[3].

Dong Quai Root

– Angelica sinensis, often known as dong quai or female ginseng, is a Chinese herb from the Apiaceae family. Angelica sinensis thrives in East Asia’s chilly high-altitude highlands. The plant’s yellowish-brown root is gathered in the fall and has been utilized for thousands of years in Chinese medicine[4].

Chinese Asparagus root

– Chinese asparagus is derived from the plant’s root and is used in traditional Chinese Medicine as a tonic, expectorant, and to treat a range of ailments, including liver and airway inflammatory disorders[5].

Serenagen Video Review

Serenagen Review – YouTube (Video Credit: YouTube)

Serenagen FAQs

Q : Is Serenagen Right for You?

A : If you are looking for a natural solution to your high levels of stress or slight anxiety disorder, this may be the product for you.

However, if you are suffering from severe psychological problems or are taking antidepressants or other medications for psychological disorders, you need to consult your healthcare professional before taking this supplement.

Q: Is Serenagen Safe?

A: Serenagen is relatively safe, and only uses clinically tested natural ingredients for stress relief. However, if you have any psychological disorder, medical problem or are currently taking medication of any kind, you need to consult your primary healthcare provider prior to use.

Q: How Long Is Serenagen Recommended?

A: The use of Serenagen depends on a case-by-case basis, although it is safe. The formula was designed only for the short-term relief of anxiety disorders.

If the problem persists after a few months, it would be best to consult your healthcare professional for the appropriate treatment.

Q: What are the dosage instructions for Serenagen?

A: Take one serving (two tablets) two to three times a day depending on your needs or use as directed by your healthcare provider. Keep tightly closed in a cool, dry place.

The stress relief supplement is formulated without soy, gluten, wheat, dairy products, nuts, egg, tree nuts, fish, shellfish, coloring, sweeteners, and preservatives.

Q: What are the warnings associated with Serenagen?

A : You need to be careful while using any medication or supplement. Following are the warnings associated with Serenagen.

  • Do not use this supplement if you are pregnant or nursing.
  • Keep out of the reach of children and follow suggested use carefully.
  • Overdosing only increases the chance of side effects.
  • In case of any adverse effects, discontinue use and consult your physician immediately.

Q: How are the Serenagen Reviews given by the consumers?

A: Reading the Consumer reviews is important before sitting to a particular product. Here We share some Metagenics Serenagen reviews so you can get a better idea of what customers really think about these Depression Pills.

It was really effective at first. It still works after a few months, but not as well as it did previously. I believe it varies from individual to person. However, the product is excellent. ~ Review by Vera Cabral

One was relaxing but did not result in a complete night’s sleep; also, if I took more than one, I became agitated. I’ve had more success with the cortisol manager. ~ Review by Chelsea davis

(Above reviews have been sourced from Amazon)

Q: What is the cost of Serenagen?

A: The product comes in 2 sizes:

  • $23.16 for 60 Tablets
  • $59.03 for 180 Tablets

Q: Where to buy Metagenics Serenagen?

A: This product can be purchased through e-commerce website like amazon, walmart.

Serenagen Alternatives

Products Cost Range Key Ingredients
Stress Support $29.95 L-Theanine, Passion Flower, Valerian, Lemon Balm
Gabatrol $19.47 L-Glycine, GABA, L-Theanine, Taurine, Bioperine
Optimood $32.95 BCM95, 5-HTP, Ashwagandha, Rhodiola, L-Theanine, Bacopa
Anxie-T $36.99 GABA,Kava Kava, L-Theanine, Theombrine, Ashwagandha

Seller info

  • Address: 25 Enterprise Ste 200 Aliso Viejo, CA, US, 92656
  • Contact: +1 800-692-9400

Serenagen Review – Final Verdict

Overall, Serenagen is an excellent product worth trying if you’re suffering from anxiety now and then. It can also be used for stress management or just to help you relax.

However, if you have moderate to severe anxiety or any other psychological problem, it would be best to consult a healthcare professional for the appropriate treatment.

Depression and anxiety are common disorders that can make daily tasks extremely challenging. Some estimates allege that approximately one in ten Americans suffer from some level of depression and/or anxiety. Symptoms of anxiety and depression include ongoing feelings of sadness accompanied by unease, irritability, tension, and nervousness. While some people require medication to deal with these occasionally crippling symptoms, others may find an all-natural product helpful. An all natural relaxation supplement should promote healthy neurological function. All ingredients should be clinically proven to reduce feelings of anxiousness, sadness, unease, irritability, tension, and nervousness.

Below you'll find some of the most effective natural nervousness relief supplements on the market today, in our opinion.

Our Top Depression Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned depression supplements based on the available research:

VitaPost Stress Support | Ashwagandha & Chamomile
Supports Daily Stress*Gold Star Evidence
Keeps Mind Positive*Gold Star Evidence
Prevents Chronic Stress*Gold Star Evidence
Provides Relaxation*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Restilen | Stress Relief and Relaxation
Maintains a Positive Mood*Gold Star Evidence
Reduces Stress Symptoms*Strong Evidence
Combats Fatigue*Gold Star Evidence
Boosts Energy Levels*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
NuviaLab Relax | Stress Relief Mood Support
Promotes Relaxation*Gold Star Evidence
Supports Calmness*Strong Evidence
Improves Quality of Sleep*Strong Evidence
Enhances Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Serenagen

Serenagen Review – Does It Contain Natural Ingredients?

Customer Reviews & Ratings

5.0 out of 5

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  1. Renee

    My doctor suggested that I take Metagenics Serenagen. I’m in the process of going through menopause. Hot flashes, low mood, interrupted sleep, and constantly having to get up to urinate throughout the night. Sometimes every hour. I went to a urologist, who prescribed a prescription drug, which, incidentally made me feel very tired and headachy. When I went to my integrative doctor, she was not happy about the prescription medicine and requested I use Serenagen. That and black cohosh. I was not expecting much. But, much to my surprise, I immediately noticed (within two weeks) that I was no longer getting up to urinate as much. From a normal 8 times to maybe up to 2 times – or less. I thought it was a fluke, but after 6 weeks, things have been consistent. Another benefit is that I overall feel a lot better. I wake up with more energy and my mood seems better, happier. (Menopause struggles). My hot flashes went from 100% to 1%. (Probably due to the black cohosh.) This supplement formula has been a very positive experience for me. I’m grateful that my integrative doctor believes in non-traditional medicine And traditional medicine. She uses both.
    This assessment is based on 6 weeks of taking Serenagen and black cohosh. Not sure if I plateaued or if more improvement is on the horizon.
    Question… are there long term negative side effects to continue this supplement on a long term basis.

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5 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology
[2] Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism
[3] A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection
[4] Dong Quai
[5] Antidepressant-like effect of a standardized hydroethanolic extract of Asparagus adscendens in mice

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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