Activene Reviews: Does It Soothe and Decrease Muscles and Joint Pain?

Activene is a cream which offers pain relief and anti-inflammatory benefits, promising to ease sore joints and muscles, backaches, bruises, and sprains.

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In This Review

What is Activene?

The promised benefits of Activene Arnica Gel Cream included easing pain and inflammation in swollen joints, muscles, and backs, killing harmful bacteria, and healing small bruises and sprains. It may also provide hydrating and repair benefits to the skin, and boost blood flow.

The product has an average price for the market at the moment on sale, but there are certainly other ingredients they could also have added. Some customer reviews said it was effective, while other users got less benefit.

How Does It Rate?

Overall Rating: 3.3

Value for Cost

3.8/5Value for Cost



Brand Highlights

  • Activene Cream is suitable for adults and children 12 years of age and older.
  • It exudes a potent mint scent for about 15 minutes.
  • Activene Arnica Gel Cream promises not to stain clothing.
  • The manufacturer states that the ingredients are clinically and allergy tested.


Pro Joint Plus

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Menthol
  • MSM
  • Aloe Vera Leaf
  • Carbomer
  • Arnica Montana Flower Extract
  • Tea Tree Leaf Oil
  • Vitamin E


  • Activene may ease muscle, joint, and tendon pain.
  • It could improve nerve function.
  • Activene Cream might decrease redness and inflammation.
  • The product may improve blood circulation.
  • It could moisturize and soften the skin.


  • The cream contains artificial color which could cause skin irritation.
  • Activene focuses on one primary active ingredient.
  • Some users may not like the initial menthol scent.
  • You can’t use it on wounds or damaged skin.

How Does It Work?

The cream has healing properties, through its anti-inflammatory properties which may decrease swelling and redness on the skin, heal skin issues, and ease pain and swelling in the muscles and joints.

A review published in Mediators of Inflammation examined the possible effect of anti-inflammatory cytokines in the development of osteoarthritis [1].

It also contains an organic sulfur which is essential in the building and maintenance of strong joints and cartilage, slowing damage progression, and possibly rebuilding some of the damaged tissue.

A review in the Journal of Bone and Joint Surgery examined the use of sulfur in arthritis treatment, and found some support [2].

Activene has powerful antioxidant potential which abolishes some of the damaging free radicals, resulting in lower levels of oxidative stress.

This promotes repair and healing to the body and skin barrier and strengthens immunity. Activene has antimicrobial properties which could kill bacteria and germs, helping to prevent infection.

A review article in Frontiers in Pharmacology discussed the use of antimicrobial peptides in the treatment of skin wounds and infections [3]. Activene also has some hydrating ingredients which moisturize the skin and eliminate dryness.



*All individuals are unique. Your results can and will vary.

Activene Ingredients – Are they Safe & Effective?

Activene Arnica Gel Cream Supplement Facts
Activene Arnica Gel Cream Supplement Facts

These are some of the key ingredients in Activene:


Menthol is a terpene alcohol from the peppermint plant. When applied topically, it has a cooling, soothing sensation on the skin which may bring relief from inflammation. An article in Phytochemistry discussed the biological properties of menthol [4].

It’s also an analgesic which decreases pain by desensitizing the nerve receptors. It has potent antioxidant benefits which may repair and heal damage to the skin barrier, and it also improves vasodilation and circulation.

A study on rate in Pharmaceutics demonstrated the antioxidant, anti-inflammatory, and wound-healing potential of menthol [5].


This is Methylsulfonylmethane, which is a compound existing naturally in humans, plants, and animals. It’s high in sulfur, which plays a role in joint and cartilage development and maintenance. As highlighted in our JointReflex article, MSM may slow down cartilage breakdown and contribute to the repair of damaged tissue.

A 12-week pilot clinical trial in Osteoarthritis and Cartilage on men and women with knee osteoarthritis concluded that MSM twice daily led to a general improvement in physical function and a decrease in pain [6].

MSM may lower pain and inflammation in the body, including the muscles and joints. It could also lessen stiffness and improve flexibility and mobility.

Tea Tree Oil

Derived from the leaves of the Australian tea tree, this oil has antibacterial and anti-fungal benefits when included in topical products. It may kill microbes on the skin and help to prevent infections.

Tea tree oil is also highly anti-inflammatory, decreases pain and swelling, and has potent antioxidants which could heal and repair skin damage. A research summary in WCET Journal discussed the effectiveness of tee tree oil in chronic wound healing [7].

Frequently Asked Questions (FAQs)

Q: How Do You Apply It?

A: The product is suitable for adults, or children who are 12 and older. Take some of the cream and massage it into the area you want to treat until it’s absorbed, up to 4 times per day.

Do not use Activene Cream on open wounds or damaged skin. Wash your hands carefully with soap and water after each application.

Q: What is the Return Policy?

A: The manufacturer is offering a 100% unconditional money back guarantee. If you’re not happy with the cream, contact customer service for instructions as to how to receive your refund.

Q: Is It Worth It?

A: At the sale price it’s more worth it than at regular cost. Activene provides soothing and healing benefits to some users, and not to others. You may find it effective, but there are also other options which may be more potent.

Q: Where to Buy It?

A: You can purchase Activene Cream from the official website, and you can also get it from a number of other online retailers and stores including Amazon and Walmart. The manufacturer is offering free shipping for orders over $50. The cream is on sale now for $14.97, down from the regular retail cost of $24.97.

Q: What Sets It Apart From the Competition?

A: Activene is not overly unique when it comes to the competition. The formula is normally a bit costly, but now on sale it falls into the average price range. It contains potent organics, but there are other products with more active ingredients on the market.



*All individuals are unique. Your results can and will vary.

Activene Reviews from Customers

The reviews for Activene offered a range of opinions. There were quite a few customers who said it eased joint and muscle pain as well as small aches and sprains, however, some users got less benefit in these areas.

The product seems to be less effective overall for nerve issues. Here are a few of the customer comments about the cream:

Instantaneous Cooling

As the primary massage therapist for a men’s Semi Pro Football team, needed something that was still going to help them function while they healed.

The cooling effect of this cream is almost instantaneous, bringing down their inflammation. The lasting effect per application was about 4.5 hours with one client. Will be purchasing more in the near future. Thanks. – Cindy

Not Effective

Can’t say that it absolutely doesn’t work, been using this for a week or two or three now and have felt zero benefits.

Only guess is that it’s not the kind of pain this product is intended to work on. For this reason, giving the benefit of the doubt and going with 2 stars instead of 1. – Jonathan

It Eases the Pain

Have post herpetic neuralgia, and it helps a little with the burning, achy sensation. Have tried just about everything out there, no magic cure, especially with nerve pain. – GF



*All individuals are unique. Your results can and will vary.

Final Word

Activene is a cream which aims to decrease pain and inflammation in the muscles and joints, heal sprains and bruises, and destroy harmful bacteria. It could also offer hydrating and soothing benefits for the skin. The product is not suitable for open wounds or damaged skin.

The customer reviews for Activene Cream offered different opinions. Many customers liked the cream and found it provided them with healing and soothing benefits. Others said it had little effect on their particular issue. Some liked the scent, while others thought it was too overpowering.

Activene Arnica Gel Cream contains primarily organic ingredients, but it does have artificial color. If you experience a skin reaction to the product, you should stop using it immediately. You may want to check with a dermatologist first before trying a new skin cream.
There are many supplements in the same joint pain category as Blue Stop Max that can perform a similar function and may be a better fit for you, so you should be cautious before making a purchase.

Bones are connected by joints, which allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. Topical joint relief products tend to work more quickly, helping to relieve pain directly in the affected area compared to products taken orally. A topical joint pain relief product should be evaluated on its: potential to block the transportation of pain signals, potential to act as a counterirritant to reduce soreness and Quality of Ingredients* backed by clinical research.

Below you'll find some of the most effective topical joint pain products on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain relief gels, gummies, and creams based on the available research:

Balmorex Pro | Relief and Recovery Cream
Supports Joints, Back, and Muscles*Gold Star Evidence
Reduces Inflammation and Swelling*Gold Star Evidence
Boosts Recovery & Joint Flexibility*Gold Star Evidence
Provides Long-Lasting Pain Relief*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Back to Life | Pain Relief Program
Builds Strong Muscles and Bones*Gold Star Evidence
Increases Flexibility of Joints*Strong Evidence
Reduces Cramps*Strong Evidence
Eases Discomfort in Stiff Areas*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Barker Wellness | Cannabinoid-Infused Products
Nurtures Body & Mind*Gold Star Evidence
Targets Sleep & Focus*Strong Evidence
Wide Range of Products*Gold Star Evidence
Natural and Organic*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Activene

Activene Reviews: Does It Soothe and Decrease Muscles and Joint Pain?

Customer Reviews & Ratings

3.0 out of 5

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  1. Janice H.

    It eases the pain
    I have post-herpetic neuralgia, which somewhat relieves the aching, burning sensation. I’ve pretty much tried everything, but there isn’t a miracle solution, particularly for nerve discomfort.

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3 OZ
Menthol, MSM, Aloe Vera Leaf, Carbomer, Arnica Montana Flower Extract, Tea Tree Leaf Oil, and Vitamin E.

7 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis:
[2] Arthritis : Arthritis 19.Aspx
[3] Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds:
[4] Menthol: A Simple Monoterpene With Remarkable Biological Properties:
[5] The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization:
[6] Efficacy Of Methylsulfonylmethane (MSM) In Osteoarthritis Pain Of The Knee: A Pilot Clinical Trial:
[7] WHAM Evidence Summary: Effectiveness Of Tea Tree Oil In Managing Chronic Wounds:

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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