Zyprexa Review – Does It Work and Is It Safe To Use?

Zyprexa (olanzapine) is an atypical antipsychotic medication used in the treatment of bipolar disorder, schizophrenia, and treatment-resistant depression.

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In This Review

What Is Zyprexa?

Zyprexa (olanzapine) is a drug primarily used for treating mental or mood conditions like schizophrenia and bipolar disorder. It can also be used in combination with other prescription drugs for treating clinical depression. One of the most remarkable benefits of this drug is its ability to decrease hallucinations and help the user think more clearly.

It can also decrease agitation and help the user become more active and participate in normal daily activities. The drug is used in patients at least 13 years of age.

How Does It Rate?

Overall Rating: 3.7

Value for Cost

3.7/5Value for Cost
Return Policy

3.6/5Return Policy


Brand Highlights

  • Identify the mechanism of action of olanzapine.
  • Summarize the approved and off-label indications for olanzapine therapy.
  • Review the adverse event profile for olanzapine.
  • Outline the importance of collaboration and communication among interprofessional team members to improve outcomes and treatment efficacy for patients who might benefit from therapy with olanzapine.

Key Ingredients

  • Gelatin
  • Mannitol
  • Aspartame
  • Sodium methyl hydroxybenzoate
  • Sodium propyl hydroxybenzoate


  • Zyprexa works in treating mood and mental conditions
  • There are many patients with mental and/or mood conditions who already benefited or continues to benefit from the drug
  • It is available all over the world
  • The drug can be taken with or without food


  • It is connected to numerous side effects
  • Zyprexa cannot be mixed with certain medications
  • It shouldn’t be taken by people who have certain medical conditions like liver disease, heart disease and diabetes
  • Over dosage can lead to serious side effects

How Does Zyprexa Works?

Zyprexa primarily works in the brain affecting different neurotransmitters specifically serotonin (5HT) and dopamine. These are neurotransmitters that are directly connected to the mood and behavior of the user among other things.

Psychotic problems are associated with too much activity of neurotransmitters in the brain the most common of which is dopamine. Schizophrenia is directly connected to the abnormally high activity of dopamine in the brain, leading to delusions and hallucinations.

Zyprexa works by blocking receptors that dopamine act on to prevent the over-activity of dopamine and help control schizophrenia. The drug also works as a mood stabilizer in those with bipolar disorder.

Zyprexa Ingredients – Are They safe & Effective?


– Gelatin contains the amino acid glycine, which is considered an ‘inhibitory neurotransmitter’. That means it essentially exhibits some of the same Characteristics of anti-anxiety and anti-depressant meds—but without the side effects.[1]


– Mannitol helps you make more urine and to lose salt and excess water from your body. It treats swelling from heart, kidney, or liver disease. As per Article, It also treats swelling around the brain or in the eyes.[2]


– As per Research an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia.[3]

Sodium propyl hydroxybenzoate

– Propyl 4-hydroxybenzoate and its sodium salt are also used as an antimicrobial preservative in orally administered Medicinal Products for human use.[4]

Zyprexa FAQ

Q : The Side Effects of Zyprexa

A : Zyprexa shouldn’t be used in psychotic conditions that are connected to dementia. It may cause sudden death, heart failure, or pneumonia when used by older adults that have conditions related to dementia. The drug may cause weight gain, high cholesterol or triglycerides especially when used by young adults or teenagers.

This is the reason blood tests need to be performed regularly and physician visits should be regular when taking this drug. Zyprexa can also cause high blood sugar so you need to be very careful if you are diabetic. This is the reason it is usually not prescribed for people with diabetes.

Zyprexa may also impair a person’s ability to think or react so you have to be very careful when doing anything that requires you to be alert like operating heavy machinery. Do not drink alcohol while taking the drug. Taking it increases the risk of dehydration or overheating so you need to drink plenty of fluids when exercising or if the weather is hot.

Q : What Will be Dosage for Zyprexa?

A : Do not take Zyprexa in smaller or larger amounts or for a longer time period than recommended. It is usually taken only once daily because of the long half-life of the drug.

Q : What are the Warnings for Zyprexa?

A : If you are pregnant, lactating, have any medical condition or are taking medication, consult your physician. Zyprexa can cause serious side effects, especially when the user is suffering from certain medical conditions or when combined with other medications. Follow your physician’s instructions carefully and never adjust dosage unless otherwise specified by your physician. If your symptoms don’t improve or worsen, contact your physician for the appropriate action.

Q: Can you get hallucinations with taking olanzapine with oxcarbazepine?

A : Olanzapine may induce a worsening of hallucinations in a psychotic disorder with substantial affective component and therefore its use should be carefully evaluated in such cases.

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Final Verdict – Zyprexa

Overall, Zyprexa appears to be just like any other drug which comes with a long list of potential side effects. It is mostly for treating schizophrenia and bipolar symptoms but can also be used in combination with other medications for treating certain cases of depression. If your problem is an only slight depression, it may be better to take other over-the-counter products like dietary supplements for the problem. You just need to choose a product carefully and make sure it is both safe and effective.

Depression and anxiety are common disorders that can make daily tasks extremely challenging. Some estimates allege that approximately one in ten Americans suffer from some level of depression and/or anxiety. Symptoms of anxiety and depression include ongoing feelings of sadness accompanied by unease, irritability, tension, and nervousness. While some people require medication to deal with these occasionally crippling symptoms, others may find an all-natural product helpful. An all natural relaxation supplement should promote healthy neurological function. All ingredients should be clinically proven to reduce feelings of anxiousness, sadness, unease, irritability, tension, and nervousness.

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Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Zyprexa

Zyprexa Review – Does It Work and Is It Safe To Use?

Customer Reviews & Ratings

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  1. Andrea Marcoulis

    I have type 1 brittle diabetes from taking Zyprexa .
    I developed type 1 Diabetes after taking Zyprexa for 2 years prescribed for depression and anxiety. There is no family history going back 3 generations. I am a very slender woman, so my Dr didn’t recognize the symptoms. I suffered from severe neuropathy and vision problems and was in a coma and not expected to live. There was a class action suit against Eli Lily The settlement was close to 1 billion dollars in 2007. I got $11,000 for a life-threatening disease. This drug should not be on the market.

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28 Tablets
Gelatin, Mannitol, Aspartame, Sodium methyl hydroxybenzoate and Sodium propyl hydroxybenzoate

4 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705715/
[2] Vortioxetine (Brintellix): A New Serotonergic Antidepressant https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296590/
[3] Aspartame https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227014/
[4] Optimization of entrapment efficiency and release of clindamycin in microsponge based gel https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639917/

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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