Pregnenolone Cream Reviews: Are There Any Side Effects?

Pregnenolone Cream is a supplement that helps to provide an array of various health benefits and helps you prevent stress & depression, and skin disorders.

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In This Review

Pregnenolone Cream Overview

This product has many health benefits such as anti-fatigue properties, enhancing memory, treatment of Alzheimer’s disease, skin disorders and trauma, stress management, and boosting immunity. Pregnenolone is a naturally occurring chemical found in the body of humans. They can easily be synthesized in the laboratory and used for medicinal purposes.

In women, the menopause product has been very effective in the control and treatment of health complications such as Endometriosis, Premenstrual Syndrome (PMS), and Fibrocystic Breast Disease. Pregnenolone is used by the body to synthesize hormones that control various body functions hence helping reverse arthritis, aging, depression, allergic reactions, seizures, multiple sclerosis, lupus, and many other disorders.

Pregnenolone exists in two formulations, cream, and capsules and these are easy to use. A Pregnenolone bottle of 60 tablets costs about $12.15. Pregnenolone was allowed in 1994 to be sold over the counter.

How Does It Rate?

Overall Rating: 3.1
Pregnenolone CreamPregnenolone Cream


Value for Cost

3.2/5Value for Cost
Return Policy

3.2/5Return Policy


Brand Highlights

  • Healthy levels of Pregnenolone has been linked with positive support of the immune system, mood and memory.
  • No Parabens, No Soy, No GMO, and Fragrance-Free. Perfect for all skin types and safe for sensitive areas.
  • Contains natural ingredients.
  • 180 Day refund-policy


WellMe MenoRescue

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Diosgenin
  • Silica
  • Hypromellose
  • Magnesium Stearate


  • Pregnenolone is a natural way of increasing the concentration of steroid hormones.
  • Has an anti-aging effect.
  • It is affordable.
  • Pregnenolone is also available in other formulations that are simple and easy to use.
  • It is paraben free.
  • There are positive consumer reviews on Pregnenolone use.
  • It is easily available through the online system.


  • It causes side effects.
  • There are mixed consumer reviews.
  • Testing has not been intensively conducted on animals.
  • It may interact with other medications involving the use of DHEA and estrogen.

How Does Pregnenolone Cream Work?

Pregnenolone is used in the body to synthesize steroid hormones creating a balance in hormonal concentration. Hence the product reverses aging, fatigue, endometriosis, and arthritis. It is also used as an anti-fatigue agent that boosts energy production. It also controls arthritis.

Pregnenolone Cream Ingredients – Are They Safe and Effective?


– It is a six-ring structured compound extracted from wild yam native to the southern USA and Mexico. The conversion of diosgenin to Pregnenolone is carried out in a laboratory. Consumption of pills containing diosgenin (wild yam extract) cannot work because the human body cannot convert it to Pregnenolone[1].


– It is used to prevent caking, strengthen bones and prevent osteoporosis and reduce the risk of cardiovascular disease and stroke. It also helps to make collagen and help the heart and immune system[2].


– It acts as an emulsifier in various vaginal-based gels and helps in reducing the severity of the most bothersome vulvovaginal atrophy symptoms[3].

Magnesium Stearate

– It is used for easier manufacturing and plays a vital role in health by keeping the bones strong. It also reduces unwanted side effects such as insomnia, depression, and anxiety[4].


Over 30 Hormone Solution

*All individuals are unique. Your results can and will vary.


Q: Does It Interact with Other Medications?

A: When the user is taking other hormones like estrogens and DHEA, it is advisable to seek medical advice before using this product. However, experts advise that the DHEA dose should be lowered immediately Pregnenolone consumption starts. But it is important that the two supplements are tried separately to find out the possible reactions that may arise from the use of either of the two.

The use of estrogen together with Pregnenolone can be dangerous because Pregnenolone is readily converted to estrogen. This definitely will cause an abnormal rise in estrogen concentration which may result in adverse side effects. The two servings should not exceed a total of 2 to 3mg.

Q: How to Take Pregnenolone?

A: The recommended dose for every individual varies depending on the age and health of the user. It is, therefore, important to consult healthcare personnel before using Pregnenolone and other natural menopause supplements. For the Pregnenolone cream, a full pump press is applied once a day for not more than 25 consecutive days.

Q: What are the Precautions When Using This Supplement?

A: Pregnenolone is for external use only. It should be kept out of reach of children. Do not use more than 2 to 3mg of Pregnenolone on a daily basis to avoid unknown side effects. This product might not be safe for consumption by pregnant or breastfeeding women. It should be avoided by individuals whose bodies may react to elevated levels of estrogen. The cream should not come into contact with the eyes.

Customers Reviews

Not good enough.

Messy leaks and strong (strawberry) smell. After a few months, we moved on to Vagisil which is better (no mess, no scent) at a much cheaper price.
~ Millie Ramirez.

Also ReadWellsprings Serenity Natural Progesterone Cream


WellMe MenoRescue

*All individuals are unique. Your results can and will vary.

Final Verdict

Pregnenolone is a very effective natural plant-derived menopause supplement that has helped change the lives of individuals suffering from the symptoms of hormone imbalance. It has been used for a long period of time and shown to give results without causing adverse complications.

On the internet, there are comments about Pregnenolone, most of which recommend it for use. It is one formula that has helped manage serious health conditions including Alzheimer’s disease, trauma, skin disorders, memory, and immunity enhancement.

Fortunately, natural therapies for menopausal symptoms such as weight gain, hot flashes, night sweats, decreased libido, and mood swings are available. Since many women experience weight gain during menopause, many natural menopause supplements contain herbs and botanicals that support a healthy metabolism. Menopause supplements should be evaluated on proven ingredients, ability to reduce hot flashes and night sweats, ability to provide hormonal balance and boost libido and its overall value.

Below you'll find some of the most effective menopause supplements on the market today, in our opinion.

Our Top Menopause Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned menopause supplements and vitamins based on the available research:

WellMe MenoRescue | Doctor Formulated
Relieves Symptoms of Menopause*Gold Star Evidence
Supports Hormonal Balance*Gold Star Evidence
Provides All-Day Energy*Strong Evidence
Balance Mood Swings*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Over 30 Hormone Solution | Revolutionary Hormonal Balance
Addresses Hormonal Changes*Gold Star Evidence
Boosts Metabolism*Gold Star Evidence
Enhances Sleep Quality*Strong Evidence
Improves Energy Levels and Vitality*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Amberen | Best Multi-Symptom Menopause Relief Supplement
Reduces Hot Flashes*Gold Star Evidence
Helps Restore Hormonal Balance*Gold Star Evidence
Better Sleep*Strong Evidence
Mood Improvement*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Bonafide Relizen | Menopause Relief Supplements
Cooling Relief From Hot Flashes*Gold Star Evidence
Powerful Hormone-free Relief*Gold Star Evidence
Helping Better Night's Sleep*Strong Evidence
Eliminate The Occurrence Of Night Sweats*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Pregnenolone Cream

Pregnenolone Cream Reviews: Are There Any Side Effects?

Customer Reviews & Ratings

2.0 out of 5

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  1. Diana Morales

    Love the product but....
    I love this product but i have a problem with applicator. When I twist n pull off tab… not cut it all the way.. have to use blade to cut it again many times and hard to squeeze too… also, can’t put it in deep inside. So.. waste a lot. Need to have a better solution.

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Pregnenolone Cream
2.00 Fl Oz
Diosgenin, Silica, Hypromellose and Magnesium Stearate.

4 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Komesaroff PA, Black CV, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001 Jun;4(2):144-50. PMID: 11428178.
[2] Price, C., Koval, K., & Langford, J. (2013). Silicon: A Review of Its Potential Role in the Prevention and Treatment of Postmenopausal Osteoporosis. International Journal Of Endocrinology, 2013, 1-6. doi: 10.1155/2013/316783
[3] Fianu Jonasson, A., Bixo, M., Sundström Poromaa, I., & Åstrom, M. (2020). <p>Safety and Efficacy of an Oxytocin Gel and an Equivalent Gel but Without Hormonal Ingredients (Vagivital<sup>®</sup> Gel) in Postmenopausal Women with Symptoms of Vulvovaginal Atrophy: A Randomized, Double-Blind Controlled Study</p>. Medical Devices: Evidence And Research, Volume 13, 339-347. doi: 10.2147/mder.s265824
[4] Park, H., Parker, G., Boardman, C., Morris, M., & Smith, T. (2011). A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients. Supportive Care In Cancer, 19(6), 859-863. doi: 10.1007/s00520-011-1099-7

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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