In This Review
Overview
Do you suffer from symptoms like fatigue, difficulty losing weight, and unbalanced blood sugar levels? The problem may lie in your liver and gallbladder health.
These key organs play a central role in body detoxification, metabolic wellness, and other health parameters, and poor function can negatively impact your overall well-being. The answer may lie in a potent supplement called UpWellness Ultra Liver.
What is Ultra Liver? This all-natural formula blends 10 science-backed extracts to support liver and gallbladder health, offering benefits like added energy, healthy weight loss, balanced blood sugar levels, stronger immunity, and more.
Does UpWellness Ultra Liver really work? Based on the research, it should be effective for many users. In this review, we look at some of the studies supporting the ingredients and answer all of your product questions. Keep reading for our fact-based evaluation of UpWellness Ultra Liver.
What Is UpWellness Ultra Liver?
Ultra Liver by UpWellness is an all-natural, plant-based supplement formulated by Dr. Joshua Levitt, blending ten potent science-backed ingredients that support liver and gallbladder health.
By enhancing the function of these organs, the formula increases bile production and body detoxification, improving metabolic health to support balanced blood sugar levels, boost energy, curb hunger, and speed up fat-burning for healthy weight loss.
The formula also helps improve fat processing and waste removal, supporting digestive health, and it contains powerful antioxidants and anti-inflammatory agents that help strengthen immunity and enhance brain health, mood, and cognitive function.
Ultra Liver by UpWellness is all-natural, vegan-friendly, and contains no toxic additives or harsh chemicals. It is safe and well-tolerated by most users, and many customers report significant improvements to multiple health parameters with regular intake.
How Does UpWellness Ultra Liver Rate?
UpWellness Ultra LiverBrand Highlights
- UpWellness is highly regarded for its effective, all-natural health supplements.
- There is a 60-day, 100% satisfaction money-back guarantee.
- The company manufactures in an NSF-certified and certified organic U.S. facility.
- There are significant discounts on bulk purchases.
- UpWellness offers free shipping on all orders.
Key Ingredients
- TMG
- Berberine
- NAC
- Milk Thistle
- Schisandra Berry
Pros
- Ultra Liver contains 100% natural ingredients.
- The supplement is physician-formulated.
- UpWellness Ultra Liver is vegan-friendly.
- It has ingredients backed by science for multiple health benefits.
- Ultra Liver is well-tolerated by most users with no serious reported side effects.
Cons
- The Ultra Liver results may vary for different individuals.
- This supplement is only available for purchase online.
About the Manufacturer
The manufacturer of Ultra Liver is a leading health and wellness company called UpWellness, headquartered in Buford, Georgia.
Founded in 2014 by current CEO Jake Carney and a team of expert naturopathic physicians, the brand offers a line of all-natural supplements to support multiple aspects of wellness, including liver health, mood, digestion, and more. Ultra Liver was developed by leading doctor Dr. Joshua Levitt.
The brand values using premium-sourced natural ingredients backed by science and research for their advantages to health. UpWellness places safety at high priority, manufacturing all supplements in an NSF-certified and certified organic facility in the USA.
How Does UpWellness Ultra Liver Work?
Ultra Liver contains ten potent ingredients rich in antioxidants that work to kill free radicals, lower oxidative stress, reduce inflammation, and help repair cellular damage to organs like the liver and gallbladder.
A review published in the World Journal of Gastrointestinal Pharmacology and Therapeutics by Sael Casas-Grajales and Pablo Muriel discussed the benefits of antioxidants in supporting liver health [1].
Improving the function of these organs helps boost body detoxification, as we noted in our Liver Revive review, and it increases bile production. This supports better elimination of waste and fat processing, supporting healthy digestion and metabolic wellness.
A review published in Diabetes Care by Bart Staels and Vivian A Fonseca highlighted the role of bile acids in metabolic regulation [2].
As a result, the formula helps improve digestion, balance blood sugar levels, decrease hunger and cravings, increase energy, and speed up fat-burning for weight management benefits. In addition, the antioxidant-rich blend helps boost the immune system, support brain health, and boost mood.
What Are the UpWellness Ultra Liver Key Ingredients?
These are some of the primary active UpWellness Ultra Liver ingredients:
TMG
The compound trimethylglycine, also called betaine, is rich in antioxidant and anti-inflammatory compounds that support the health of the liver, helping to improve metabolism and support natural-fat-burning for healthy weight loss.
TMF also helps support heart and brain health, prevent insulin resistance, lessen fatigue, and boost muscle strength. An 8-month study of mice published in Gastrointestinal and Liver Physiology by Elango Kathirvel et al concluded that treatment with betaine helps prevent and treat fatty liver and lower insulin resistance [3].
Berberine
This natural, plant-derived compound decreases the liver’s production of glucose, helping to improve insulin resistance, balance blood sugar levels, and boost energy. This helps lessen hunger and cravings, supporting weight management. Berberine also supports heart health, helping to regulate blood pressure and cholesterol levels.
A review published in Nutrients by Anna Koperska et al concluded that there is
a growing amount of evidence confirming the positive effects of BBR on multiple metabolic pathways, such as lipids and glucose metabolism, energy homeostasis, or gut microbiota modulation, which allows us to speculate about the importance of this natural bioactive substance for NAFLD therapy [4].
NAC
N-acetylcysteine is a form of the amino acid cysteine, rich in antioxidant and anti-inflammatory properties, which helps support the health of the liver, gallbladder, and kidneys by repairing cellular damage. It also improves circulation and supports heart health, helping to lower the risk of cardiovascular disease.
A 3-month study published in Hepatitis Monthly by Manouchehr Khoshbaten et al concluded that N-acetylcysteine supplementation helps improve liver function in patients with non-alcoholic fatty liver disease [5].
Milk Thistle
This plant is rich in the flavonoid silymarin, known for its potent hepatoprotective properties and its ability to regenerate liver cells. It helps boost bile production and improve detoxification, balance blood sugar, support digestive health, and strengthen the immune system.
A review published in the National Library of Medicine by C Mulrow et al found support for the hepatoprotective benefits of milk thistle [6].
Schisandra Berry
This red berry has potent antioxidants and anti-inflammatory agents, helping to support liver health and protect the organ from damage. In addition, it supports neural function to help enhance brain health.
A study of rats published in the Journal of Medicinal Food by Hyoung Joon Park et al concluded that Schisandra Chinensis helps prevent non-alcoholic fatty liver disease [7].
How to Take UpWellness Ultra Liver?
Follow these simple instructions for the correct intake of UpWellness Ultra Liver:
- Take two capsules of UpWellness Ultra Liver daily.
- Consume both at once, or take one in the morning and the second in the evening.
- Take the supplements about 1-2 hours after a meal for optimal absorption.
- Follow a consistent daily intake for best results.
- Do not exceed the maximum daily dosage unless directed by a healthcare practitioner.
- Combine usage with a healthy lifestyle, including a nutritious diet, regular exercise, adequate hydration, and stress management. To support organ health, read our article outlining Simple Tips for Optimal Liver Function.
Benefits of UpWellness Ultra Liver
These are the primary UpWellness Ultra Liver benefits:
- Supports Liver and Gallbladder Health – Rich in bioactive agents and antioxidants, the formula supports liver and gallbladder health to help enhance metabolism, balance blood sugar, improve detoxification, and more.
- Supports Healthy Weight Loss – By supporting metabolic health, the formula helps improve food processing, curb hunger and cravings, and speed up fat-burning for weight management support.
- Supports Healthy Blood Sugar Levels – The ingredients improve liver and gallbladder function, supporting metabolic health and helping to balance blood sugar levels.
- Helps Boost Energy – By supporting optimal liver and gallbladder health and helping to balance blood sugar, the formula helps boost daily energy levels.
- Helps Strengthen Immunity – Packed with potent antioxidants that lower oxidative stress and inflammation, the supplement helps repair body-wide cellular damage to support a stronger immune system.
These are some of the secondary benefits of Ultra Liver:
- Supports Digestive Health – By supporting liver health, the formula improves bile production, helping to improve fat digestion and waste removal to enhance digestion.
- Supports Brain Health and Mood – Some of the antioxidant-rich ingredients in the supplement support healthy brain function and improve neurotransmitter synthesis to help boost mood.
What Are the UpWellness Ultra Liver Side Effects?
This supplement is an all-natural product containing safe ingredients and is well-tolerated by most users. Does UpWellness Ultra Liver have any side effects? While adverse effects are rare, in some cases, individuals may experience mild issues like nausea or digestive upset that normally resolve in a few days.
If these issues persist, consult with a healthcare practitioner regarding the ideal dosage and usage. Before taking UpWellness Ultra Liver, check the label carefully to ensure that you do not have an allergy to an ingredient.
Safety
Ultra Liver contains all-natural ingredients and is free of toxic additives and harsh chemicals. It is well-tolerated by most users with no serious reported side effects.
Can I take Ultra Liver if I am vegan? Yes, you can. The supplement is plant-based and suitable for individuals who are vegan or vegetarian.
Can I take Ultra Liver if I’m on medication? As it may have health or medication contraindications, all users need to consult with a healthcare practitioner for approval before use. Generally speaking, the supplement is suitable for individuals who have had gallbladder removal surgery.
The company places safety at a high priority, manufacturing all supplements in an NSF-certified and certified organic facility in the USA.
How Effective Is UpWellness Ultra Liver?
UpWellness Ultra Liver is a natural supplement developed by leading physician Dr. Joshua Levitt. It contains an optimal blend of extracts backed by science for their liver and gallbladder support benefits and multiple other health properties like promoting healthy weight loss, balancing blood sugar, boosting energy, enhancing digestion, and more.
According to the multiple studies we have presented highlighting the benefits of the ingredients to the liver, gallbladder, metabolism, and overall health. The primary ingredient, TMG, has significant evidence for its liver support benefits in particular.
A 2024 study published in the International Journal of Health Sciences and Research by Dhaval Dalal et al found support for the benefits of trimethylglycine in the treatment of non-alcoholic fatty liver disease [8].
The feedback and ratings for this supplement are highly positive overall, with many users reporting significant improvements in liver and gallbladder health, weight loss, energy, digestion, and more.
How Much Does UpWellness Ultra Liver Cost?
UpWellness Ultra Liver is available for purchase on the official website and on Amazon. We highly recommend that users buy from the manufacturer directly to avoid possible imitation brands on the market.
The company offers significant discounts on bulk purchases and free shipping on all orders. In addition, customers can save an extra 10% by signing up for the VIP auto delivery service. This is the price list:
- 1 Bottle – $62.95 + FREE shipping
- 3 Bottles – $55.95/each + FREE shipping
- 6 Bottles – $48.95 each + FREE shipping
UpWellness Ultra Liver FAQs
Q: Who should take Ultra Liver?
A: UpWellness Ultra Liver is designed for adults who want a natural solution to help support liver and gallbladder health, promote healthy weight loss, balance blood sugar, boost energy, improve digestion, and more. Before taking the supplement, consult with a healthcare practitioner for approval.
Q: How long does it take for results?
A: For maximum benefits, take UpWellness Ultra Liver consistently for 12 weeks. However, many users notice improvements in digestion and detoxification within a few days, and experience benefits like weight loss, added energy, and a boost in mood within about 3-4 weeks of regular intake.
Q: What is unique about UpWellness Ultra Liver?
A: UpWellness Ultra Liver contains a uniquely potent blend of science-backed ingredients like TMC, NAC, and milk thistle that support optimal liver and gallbladder health for multiple benefits. The formula is developed by a physician and is superior to many competing brands. In addition, it is offered at a reasonable cost for the market.
Q: Can I buy UpWellness Ultra Liver in stores?
A: No, UpWellness Ultra Liver is not for sale in retail brick-and-mortar stores. You can buy it on the official company website and on Amazon, but we highly recommend purchasing from the manufacturer directly to ensure that you get the real product and can access discounts.
Q: What is the return policy?
A: The company offers a 60-day 100% money-back guarantee on UpWellness Ultra Liver and all of its other products. If you are dissatisfied with the results, contact customer service and file a return. Send the bottles back within 60 days of the order according to their instructions for a full refund of the purchase price.
Q: Can I take Ultra Liver if I had my gallbladder removed?
A: Yes, the product is safe for individuals who have had gallbladder removal surgery. It helps enhance liver and digestive health, improving bile production and quality even following a cholecystectomy (gallbladder removal) procedure.
What Do the UpWellness Ultra Liver Customer Reviews Say?
Ultra Liver by UpWellness is a popular product online, with multiple positive reviews and little critical feedback. On the official website, the supplement received a rating of 4.8 out of 5 stars from 355 users. Customers rave about significant weight loss benefits, added energy, improved digestion, and more.
One of the top 5-star UpWellness Ultra Liver reviews comes from Sharon P., who says the product has had a positive impact on her liver condition:
I’ve never felt any energy for years, but WOW, I sure do now. I’m feeling better than I have in the last 10 years; it’s like night and day. I’m not feeling so bloated and just generally feeling much happier. Thanks for this product. After years of cirrhosis, I really think this just might turn around. Thank you. Thank you. Thank you.
Another enthusiastic 5-star Ultra Liver review is from Joe. M, who is experiencing potent digestive health benefits even after gallbladder surgery:
This has completely changed my gut health. I was having severe digestive issues after having my gallbladder removed, and this has made a 98% improvement.
User Brenda E. rates Ultra Liver 3 stars, citing several health benefits but waiting for even greater results:
Taking Ultra Liver. So far, my morning blood sugar has been coming down from 190 to 179, which has only been week one. I have lost 5lbs and I have never lost weight. I think I am happily shocked. I hope it continues for my good! We shall see.
UpWellness Ultra Liver Review – Conclusion
In the final analysis, Ultra Liver by UpWellness supplement contains a superior blend of science-backed natural extracts and delivers on its promise to help optimize liver and gallbladder health, support steady weight loss, boost energy, balance blood sugar levels, enhance digestion, and more.
Priced reasonably for the high quality of the formula, the supplement offers excellent value for the cost, and the Ultra Liver reviews and ratings are overwhelmingly enthusiastic. Customers cite improvements in health parameters, such as blood sugar, energy levels, mood, digestion, and weight loss, and many highly recommend it to others.
UpWellness Ultra Liver is an all-natural, safe formula free of toxic additives and harsh chemicals, and is well-tolerated by most users. Before taking the supplement, consult with a healthcare practitioner for approval.
Ultra Liver is ideal for individuals who want to enhance their liver and gallbladder health for multiple benefits to well-being. If you are ready to place an order or you want more information, visit the official website for additional details.
Below you'll find some of the most effective Liver Supplements on the market today, in our opinion.
Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned Liver Supplements products based on the available research:
Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.
1 Customer Reviews for UpWellness Ultra Liver

Customer Reviews & Ratings
3.4 out of 5Review this Product
Leave a review and share your experience with others.
Write a Review
Have a Question? Please Tell Us What We Are Missing Here!
Upload Your Video Review
How to record video?
- Prepare your device, ensuring it's charged and has enough storage.
- Find a quiet, well-lit space with natural or good indoor lighting.
- Position your device and frame yourself in the center with head and shoulders visible.
- Introduce yourself, the product, and why you chose it.
- Share your experience, including positives, negatives, and recommendations.
- Test audio and video to ensure they're working properly.
- Keep the video concise, aiming for 1-3 minutes.
- Review your recording for quality and clarity.
- Upload your video.
Video recording details:
- Video duration: 1 - 3 minutes
- Video Quality: Full HD (1080p and above)
- Video format: MP4
- Audio Quality: Clear without background noise
8 Sources
We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.
[2] Bile Acids and Metabolic Regulation: https://pmc.ncbi.nlm.nih.gov/articles/PMC2811459/
[3] Betaine Improves Nonalcoholic Fatty Liver and Associated Hepatic Insulin Resistance: A Potential Mechanism for Hepatoprotection by Betaine: https://pmc.ncbi.nlm.nih.gov/articles/PMC2993168/
[4] Berberine in Non-Alcoholic Fatty Liver Disease—A Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC9459907/
[5] N-Acetylcysteine Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC3270338/
[6] Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary: https://www.ncbi.nlm.nih.gov/books/NBK11896/
[7] Schisandra chinensis Prevents Alcohol-Induced Fatty Liver Disease in Rats: https://pmc.ncbi.nlm.nih.gov/articles/PMC3901324/
[8] Prospective study on safety and efficacy of trimethylglycine in patients with non-alcoholic fatty liver disease with or without fibrosis : https://www.researchgate.net/publication/378297007_Prospective_study_on_safety_and_efficacy_of_trimethylglycine_in_patients_with_non-alcoholic_fatty_liver_disease_with_or_without_fibrosis




This article changed my life!
This article was informative.
I have a medical question.
This article contains incorrect information.
This article doesn’t have the information I’m looking for.
Tyler Jackson