SAM-e Joint Reviews – Is This Supplement Worth Buying?

SAM-e Joint is a joint supplement used to relieve joint pain and discomfort. The supplement is intended to help reduce inflammation while increasing mobility.

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In This Review

What is SAM-e Joint?

Experiencing issues with your joints can be cause for a lot of pain and discomfort as a person. It dramatically affects the ease to conduct usual daily activities such as walking, ruing, climbing or stretching. Many people consider taking joint relief supplements that can help reduce joint discomfort t and pain. SAM-e Joint is a supplement designed for those seeking relief of pain or discomfort in the joints.

SAM-e Joint is a joint supplement used for the ease of pain and discomfort in the joints. The supplement is designed to help reduce inflammation cases while increasing ease of mobility. With the use of the supplement, one is supposed to have a production and repair of cartilage. It helps with the increase of flexibility in the joints during movement. The supplement also provides liver detoxification and improves mood and brain function.

How Does It Rate?

Overall Rating: 3.5

Value for Cost

3.8/5Value for Cost

3.9/5Return policy


Brand Highlights

  • The company behind the development of CHD SAM-e Joint supplement is known as the Jarrow Formula.
  • The manufacturers claim the product provides joint, liver and brain health support.
  • They argue that the supplement contains all-natural ingredients that work towards the relief of joint pain.
  • The supplement is said to be manufactured under low humidity and low temperature.
  • They claim that the supplement is enteric-coated to maintain it as a biologically active product and is individually blister-packed.


Pro Joint Plus

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • S-Adenosyl Methionine
  • Glucosamine HCL


  • It may offer relief and strength of joints
  • It provides flexibility and mobility
  • May promote better liver function
  • May help improve brain function.


  • The SAM-e Joint supplement contains only two ingredients
  • The supplement lacks on the many natural ingredients known for joint relief

SAM-e Joint Ingredients – Are they Safe & Effective?

525mg of Glucosamine HCL

  • It is a synthesized aminosaccharide. It is an element of joint and intestinal tissue that is part of the synovial fluid production used in the lubrication of joints.

200mg of S-Adenosyl Methionine (from 400mg of SAM-e tosylate disulfate)

  • It is found in living cells. It is a metabolite of methionine which is an essential amino acid. It is a chiral molecule that is in two forms; (S, S) SAM-e and (R, S) SAMe.
  • It is made through natural microbiological fermentation after which it is specially processed without the use of chemical solvents to preserve the 68-80% of (S-S) SAMe.
    The SAM-e Joint supplement has the highest concentration of active S, S Form (68-80% SAM-e).

Other ingredients include; Cellulose, glyceryl behenate, oleic acid, titanium dioxide, stearic acid, silicon dioxide, dextrin, sodium citrate, dextrose, magnesium stearate, and medium chain triglycerides.

How Does SAM-e Joint Work?

The SAM-e Joint supplement works in various ways. It helps in the production of connective tissue through transulfuration for the maintenance of joint strength. It is where vital components of connective tissue such as glucosamine and chondroitin get sulfated by metabolites of SAMe to produce sulfated glycosaminoglycans (GAGAS).

It produces methylation reactions that involve in the synthesis of neurotransmitters such as L-DOPA & Dopamine, and related hormones such epinephrine, phosphatidylcholine, and serotonin to boost brain metabolism.

The metabolism of SAMe helps in the synthesis of glutathione (GSH) and glutathione-dependent enzymes that are part of the body’s endogenous antioxidant network which is vital for promoting liver function such as phase II detoxification.

See Also



*All individuals are unique. Your results can and will vary.


Q: How Much Does SAM-e Joint Cost?

A: SAM-e Joint supplement is available online at about $31.92. Prices of shipment may as well be incurred depending on your address.

Q: SAM-e Joint Joint– Is It Safe?

A: The SAM-e Joint is said to be made from natural ingredients and thus safe for use. It is, however, recommended that one does not exceed the recommended dosage of one tablet, once or twice a day. To avoid unwanted side effects.

The supplement is not to be used by pregnant or nursing mothers, persons with Parkinson’s disease, manic depression, or bipolar disorder. Persons under prescribed medications such as anti-depressants should ensure they first consult with a physician before use.

Q: What Kind of Reviews are Out there for SAM-e Joint?

A: The supplement is widely available online, but the reviews featuring it are scarce. A review mentioned the product to be of high quality in supporting their mood and joint comfort. Some consumers claimed that the supplement did not deliver quite to their expectations.



*All individuals are unique. Your results can and will vary.

SAM-e Joint Review – Final Verdict

SAM-e Joint supplement is a product used mainly for supporting joint relief from pain and discomfort. It enables its users to achieve better mobility and flexibility. The supplement can still be useful for liver detoxification and brain metabolism.

The supplement, however, has just two ingredients in its formulation. There are various ingredients well known in joint support that are not present in the product. Moreover, many other products are offering similar pros to those of SAM-e Joint supplement.

Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

ProJoint Plus - VitaPost | Premium Joint Support
Supports Cartilage Health*Gold Star Evidence
Supports Joint Health*Gold Star Evidence
Lubricates Stiff Joints*Strong Evidence
Supports Joint Mobility*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Relief Factor | Best Pain Relief Supplement
Relief Aches and Pains*Gold Star Evidence
Reduces Inflammation*Strong Evidence
Protect Joints Damage*Strong Evidence
Support Immune System*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Heal-n-Soothe | Best Joint Pain Formula
Supports Healhty Joints*Gold Star Evidence
Promotes Joint Mobility*Gold Star Evidence
Help in Relieving Joint Pain*Strong Evidence
Supporting Reduction in Joint Pain*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Turmeric Curcumin Plus | High Quality Joint & Muscle Health Formula
Supports Joint Health*Gold Star Evidence
Supports Immune System*Strong Evidence
Antioxidant Support*Strong Evidence
Supports Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
1MD MoveMD | Fast-Acting Joint Support
Reduces Joint Discomfort*Gold Star Evidence
Increases Joint Mobility*Strong Evidence
Helps Lubricate Joints*Gold Star Evidence
Support Joint Health*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.7

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for SAM-e Joint

SAM-e Joint Reviews – Is This Supplement Worth Buying?

Customer Reviews & Ratings

3.0 out of 5

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  1. zyan

    Depression! not that much effective!
    At first, everything was wonderful. I felt relief from my depression once the sam-e had time to kick in/process and it was like a weight off my shoulders. My depression didn’t vanish completely, but it was far easier to manage and i felt a marked increase in emotional stability that i hadn’t felt for a long time. However, after a few months of taking sam-e I began to notice side effects. My anxiety became so severe that I could scarcely breathe and was left constantly short of breath and struggling to draw breath, and I was having heart palpitations regularly. I also occasionally suffered from stomach pains. All of this went away after I stopped taking the sam-e, I haven’t taken it since or had the same issues since I stopped taking it. I was taking 400 mg per day of Nature’s Trove sam-e in the mornings before eating.

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SAM-e Joint
SAM-e Joint
60 capsules
Glucosamine HCL and S-Adenosyl Methionine.

2 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Glucosamine HCL -
[2] S-Adenosyl Methionine -

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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