Conolidine Review – Is Conolidine The Best Joint Supplement?

Explore Conolidine, a supplement claiming to restore natural pain relief with tabernaemontana divaricate, targeting chronic pain's root cause effectively.

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In This Review

Overview of Conolidine

Chronic pain takes the joy of living and to regain calmness from the agony it causes may be all you ever wish in life. Well, Conolidine claims to be the pain support supplement to help you out.

Featuring a unique blend of two natural ingredients to make the supposed revolutionary formula, Conolidine claims to help in the management of chronic pain and body wellness by alleviating pain, and muscle and joint inflammation.

However, with only two ingredients, it is still not clear if this supplement can actually offer the claimed health benefits. There is limited research or clinical studies to support Conolidine’s efficiency claims therefore raising doubts as far as its potency claims are concerned.

Join us as we explore the science behind Conolidine supplement, look into its health benefit claims, and ingredients’ efficiency claims, and decide whether or not it is worth investing in your time and money.

What is Conolidine?

Claims to be formulated using drug-free certified natural ingredients (plant alkaloids) to provide a solution to chronic pain without worrying about addiction.

Conolidine claims to be a revolutionary formula designed to manage chronic pain, alleviate muscle and joint inflammation, provide relief from nerve pain and discomfort, enhance joint flexibility and mobility, and support a sense of relaxation and well-being.

This health supplement combines two powerful ingredients; piperine and tabernaemontana divaricate (pinwheel flower extract) to help you manage chronic pain and boost the body’s overall health and wellness.

How Does Conolidine Rate?

Overall Rating: 3.7

Value for Cost

3.4/5Value for Cost

3.6/5Return Policy


Brand Highlights

  • Features 100% plant-based natural ingredients and compounds
  • Manufactured in GMP-certified and FDA-approved facilities
  • Non-habit forming and zero side effects
  • Backed by 100% money-back guarantee


JointXL Plus

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Piperine
  • Tabernaemontana divaricate (Pinwheel flower extract)


  • May help manage chronic pain
  • Claims to relieve muscle and joint inflammation
  • Provide relief from nerve pain and discomfort
  • It may help enhance joint flexibility and mobility
  • Improve sleep quality and disturbances related to pain
  • May support a sense of relaxation and wellbeing


  • Does not come with a free trial offer
  • Contains only two ingredients which might not offer the efficiency it claims
  • Results are likely to vary from one user to the other
  • You can only purchase it online through the official website

Who is the Manufacturer of Conolidine?

There is not much information available online to tell us who the manufacturer of Conolidine is.

What is currently known is that the supplement was launched by GRD Labs as a new morphine alternative.

The supplement is designed using drug-free ingredients to help people manage chronic pain without worrying about addiction.

How Does Conolidine Work?

Conolidine is packed with a powerful blend of 2 plant-based and natural compounds, each chosen for its potential benefit on pain relief. The ingredients build on each other to relieve pain in different parts of the body.

The formula features piperine and tibernaemontana divaricate (pinwheel flower extract) that work to reduce muscle and joint inflammation, calm nerve pain and discomfort, ease joint flexibility and mobility, raise sleep quality and pain-related disturbances, and support a sense of relaxation and wellbeing.

Conolidien is designed to restore your body’s natural internal painkiller flow, hence naturally killing pain safely and quickly at any age, thanks to tabernaemontana divaricate (pinwheel flower extract). It supposedly targets the origin and addresses the root cause of chronic pain.

Tabernemontan divaricate is packed with powerful pain-reliever properties making it highly versatile as it can treat a number of ailments including joint and muscle pain, joint stiffness, headaches, and inflammation. This plant-based ingredient offers holistic health benefits that go beyond pain relief as it also works to improve the body’s overall health and wellness.

A research study published in Signal Transduction and Targeted Therapy shows that pinwheel flower has analgesic effects thanks to alkaloids, the primary active compound in this ingredient traditionally known to be efficient in managing and relieving pain. [1]

Another key ingredient in Conolidine is piperine, a bioactive compound present in black pepper. According to research published in the Asian Pacific Journal of Tropical Biomedicine, piperine works to enhance the absorption of nutrients and various compounds in the body. [2]

In this case, it enhances the Conolidine’s bioavailability, hence enabling the body to effectively absorb and efficiently utilize tabernaemountana divaricate extract’s pain-relieving benefits.

Apart from the absorption-boosting properties, piperine also possesses antioxidant and anti-inflammatory effects, which may further contribute to pain relief and body wellness by reducing oxidative stress and inflammation. This is according to a publication in Current Topic on Medicine Chemistry. [3]



*All individuals are unique. Your results can and will vary.

Conolidine Ingredients – Are They Safe And Effective?

Conolidine contains only two key ingredients of which are discussed below in detail with supporting links to scientific research:


Piperine is a bioactive compound found in black pepper and it is commonly known for pungent flavor. However, it has also been recognized for its inspiring medicinal ability. It works to enhance nutrient and compound absorption in the body. This ingredient has also been discussed in our review of the Nuzena Turmeric Curcumin + Joint Pain Reliever supplement.

A research study published in Beni Suef University Journal of Basic Applied Science notes that piperine has shown the ability to alter drug bioavailability, metabolizing enzymes, and gastrointestinal disorders. [4]

Tabernaemontana Divaricate (Pinewheel Flower Extract)

Taberbaemontana divaricate also referred to as pinwheel flower extract is also a key ingredient used in the formulation of conolidine supplement. Tabernaemontana divaricate extract has been studied and found to offer health benefits that extend beyond chronic pain relief.

A research study published in Anesthesiology and Pain Medicine looked into the health benefits of tabernaemontan divaricate supplements on pain relief and overall health. [5]

Benefits of Conolidine

Conolidine purports to offer the following health benefits:

Helps to reduce chronic pain naturally: Cololidine has been purposely designed to help manage chronic pain. It contains powerful ingredients that work in synergy to naturally melt away pain and offer comfort.

May help eliminate joint and muscle inflammation: Apart from relieving pain, the ingredients’ medicinal properties have been found to have effect on joint and muscle inflammation.

May help promote joint flexibility and mobility: Conolidine has also been found to promote flexibility in the joints hence leading to easy mobility.

May help relieve nerve pain and discomfort: Apart from relieving joint pain, the supplement has also been found to help with nerve pain relief and ease the discomfort that comes with it.

Promote a sense of relaxation and wellbeing: Since Conolidine relieves you from chronic pain it assures you a sense of relaxation and wellbeing.

Boost healthier immune function: Conolidine is said to offer a holistic approach to health, making it an ideal supplement for boosting immune function.

May help with quick recovery from exertion: Conolidine is designed for use by people of all ages. If you are an athlete or actively participate in sports, you can use Conolidine to help you recover fast from muscle and joint strain or pain, especially after extensive workouts or exercise.


Pro Joint Plus

*All individuals are unique. Your results can and will vary.

Conolidine FAQs

Q: Does Conolidine Have a Return Policy?

A: Conolidine comes with a 90-day 100% money-back guarantee to secure your purchase. If you are not satisfied with the results or you feel that the supplement is not working to help you achieve your desired results, you can return your order within the specified period in exchange for your full purchase price.

Q: Where Can I Buy Conolidine?

A: The product is currently available for purchase online through the official website only. It is not available on any online retail shop or in drug stores.

Q: Does Conolidine Have Any Side Effects?

A: According to the manufacturer, Conolidine is formulated using natural ingredients and plant-based compound to target the root cause of pain without causing side effects. However, we cannot completely rely on the manufacturer’s words to rule out the possibility of side effects.

As always, it is always advisable to first consult with your doctor about the safety concerns of any supplement before adding it to your health routine especially if you are on medication or you have an underlying health condition.

Some compounds or natural ingredients may also interact with other supplements which is another reason why you should consult your healthcare provider before committing to this product. By doing this, you will help prevent any unforeseen health risks.

Q: How Should You Take Conolidine?

A: One bottle of Conolidine contains 30 ML liquid to take you for a month. According to the manufacturer, you should put one drop of Conolidine under your tongue and let it rest there for at least one minute before swallowing.

For optimal results, you are advised to ensure consistent use of Conolidine because skipping doses may reduce endorphin flow, hence leading to the recurrence of pain symptoms.

Q: What Sets Conolidine From the Competition?

A: Unlike other traditional painkillers, Conolidine works naturally to optimize endorphin flow to get rid of pain without causing side effects.
It acts through a natural mechanism to help the body manage pain, making it the most sustainable and safe form of relieving pain compared to other painkillers.

Q: How Much Does Conolidine Cost?

A: The price of Conolidine as given on the official website is as follows:

  • 1 bottle costs – $29
  • 3 bottles cost $87 ($29 each)
  • 6 bottles $174 ($29 each)

What Do the Customer Reviews Say About Conolidine?

Since this product doesn’t sell on key retailer sites yet, we only managed to randomly sample customer reviews from other independent websites, and here is what some users had to say about Conolidine:

Jenifer says

My mom insisted that I buy her Conlidine after a friend recommended it to her. She is in her mid-60s and has been struggling with joint stiffness for months now which has to some extent affected her mobility. She finds it difficult to get in and out of bed unless she is supported. I bought her this stuff three weeks ago and I am amazed with the results. Her knee joints are more flexible and her mobility has also improved.

Penny says

If you are looking for a painkiller you can trust, this one is a sure bet. I use it after my workouts and it helps me recover fast. I highly recommend it.

Thomas says

Compared to other painkillers I have tried, this one seems to be more efficient.

Don says

It worked great at first but my second order is not that effective. I have no idea what happened but I may be forced to try something else because it seems the manufacturer can’t maintain the product’s quality. I feel so betrayed by this.

Charles says

It is not different from other painkillers. I have used it as instructed and gives only short-term relief from pain. I was hoping it would work differently to offer long-term relief but no. So, I guess I won’t be purchasing it again.



*All individuals are unique. Your results can and will vary.

Conolidine Reviews – Conclusion

Conolidine claims to be a powerful and reliable health supplement that can effectively alleviate pain and promote the body’s overall health and wellness.

It purports to contain drug-free ingredients sourced naturally from medicinal herbs and clinically tested and proven to offer comprehensive solutions to chronic pain and the body’s overall health.

However, given that this supplement contains only two ingredients which also have insufficient clinical support it is not clear whether it can offer the claimed comprehensive solution of chronic pain and other mentioned health concerns.

So, before investing in this supplement and making it part of your daily health routine, we recommend doing further research or consulting with a healthcare professional to be sure that it is the right supplement for your health needs.

Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

JointXL Plus - Joint Health Formula
Reduces Joint Pain & Soreness*Gold Star Evidence
Enhances Comfort & Mobility*Gold Star Evidence
Prevents Joint Degeneration*Gold Star Evidence
Supports Tissue Repair *Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
BioDynamix Joint Genesis | Doctor Formulated
Reduces Pain and Stiffness*Gold Star Evidence
Improves Joint Lubrication*Gold Star Evidence
Supports Joint Function*Gold Star Evidence
Relieves Inflammation & Discomfort*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
ProJoint Plus - VitaPost | Premium Joint Support
Supports Cartilage Health*Gold Star Evidence
Supports Joint Health*Gold Star Evidence
Lubricates Stiff Joints*Strong Evidence
Supports Joint Mobility*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Relief Factor | Best Pain Relief Supplement
Relief Aches and Pains*Gold Star Evidence
Reduces Inflammation*Strong Evidence
Protect Joints Damage*Strong Evidence
Support Immune System*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Conolidine

Conolidine Review – Is Conolidine The Best Joint Supplement?

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Piperine, Tabernaemontana Divaricate (Pinwheel Flower Extract)

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    5 Sources

    [1] The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7
    [2] Bioavailability enhancers of herbal origin: An overview
    [3] Anti-Inflammatory and Antioxidant Properties of Piper Species: A Perspective from Screening to Molecular Mechanisms
    [4] Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials
    [5] Conolidine: A Novel Plant Extract for Chronic Pain

    **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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