Mushroom Defense Review: Mushroom Blend For Enhanced Immune Health

Mushroom Defense is a 100% organic mushroom-based supplement that offers health benefits like enhanced immunity, energy, and cognitive benefits. Read more.

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In This Review

What is Mushroom Defense?

Mushroom Defense is an organic formula that blends a number of immune-enhancing ingredients for better general health and less chance of contracting a bacterial or viral infection. It can provide added energy, decrease fatigue, and offer brain health benefits like improved memory, sharpened mental focus, and a decrease in brain fog. It may also slow the progress of mental decline, lowering the risk of developing a degenerative condition.

How Does It Rate?

Overall Rating: 4.8

Value for Cost

4.8/5Value for Cost
Return Policy

4.9/5Return Policy


Brand Highlights

  • The brand is cruelty-free.
  • The ingredients are 100% organically sourced.
  • The manufacturer is BBB accredited.
  • The production takes place in the USA in a GMP certified facility.

Key Ingredients

  • Turkey Tail
  • Lion’s Mane
  • Chaga
  • Reishi
  • Black Fungus
  • White Button
  • Maitake
  • Cordyceps Sinensis
  • Agaricus Blazei
  • Shiitake


  • This supplement can strengthen the immune system.
  • It can enhance your mental focus and memory.
  • It prevents the contraction of bacteria and viruses.
  • It provides you with added energy.
  • This supplement can slow the progress of cognitive decline.


  • The results will vary for different individuals.
  • Some users may be intolerant to mushrooms.
  • High demand may lead to low stock at times.

How Does It Work?

This is one of the top immunity supplements on the market, with a rich blend of Organic mushrooms high in antioxidants. They destroy potentially damaging free radicals in your system, decreasing oxidative stress.

A review in the Journal of Dairy Sciences discussed the physiology and action of antioxidants in the immune system [1].

This promotes repair and healing, improves general health, and strengthens immunity. Mushrooms also have protein and fiber, which support digestive health and promote more regular bowel movements.

A review in the British Journal of Nutrition examined the immune-boosting properties of prebiotics and dietary fiber [2].

They may also decrease appetite for possible weight loss, and decrease issues like bloating and gas. Some mushrooms improve energy by enhancing circulation and promoting the more efficient use of oxygen in the body. Others may enhance exercise endurance for a stronger workout.

In addition, anti-inflammatory agents decrease bodily swelling. Certain mushroom strains stimulate the release of key brain neurotransmitters like dopamine, which could enhance aspects of brain health like memory and mental focus.

Mushroom Defense Ingredients – Are they Safe & Effective?

These are some of the primary active ingredients:

Turkey Tail

This is a potent, immune-boosting mushroom that is full of antioxidants that kill harmful free radicals. It also has prebiotics, which feeds healthy gut bacteria to promote an optimal microbiome and ease symptoms like bloating and diarrhea, as we described in our Trivexa Review.

In addition, turkey tail has anti-bacterial and anti-inflammatory properties, and it could also boost athletic performance. A case report in Global Advances in Health Medicine discussed the possible use of turkey tail in the treatment of breast cancer [3].


This is a medicinal, edible mushroom that is very high in antioxidants, and offers immune and general health benefits like decreasing cholesterol levels and possibly enhancing strength and workout performance, as we discussed in our Nuzena Mushroom Immunity Defense+ article.

There’s some evidence that it may help treat lower urinary tract issues. A study in Scientific Reports demonstrated the immune suppressant benefits of reishi mushrooms in mice [4].

Lion’s Mane

This medicinal mushroom contains compounds that promote brain health and help slow the development of brain conditions like Alzheimer’s disease. It supports the health of the nervous system and could decrease anxiety and depression, as we described in our article of NervoLink Review.

It may improve digestion, and heart health, and decrease inflammation. Lion’s mane has potent antioxidants and strengthens the immune system. A study in the International Journal of Medicinal Mushrooms showed the neurotrophic properties of lion’s mane mushrooms [5].


This is an edible mushroom that is high in antioxidants. It can strengthen the immune system, protect the cells, increase white blood cell count, and according to some studies could help to prevent cancer.

It has anti-microbial and anti-inflammatory agents and may support heart health. A study in the Journal of the American College of Nutrition concluded that consuming shiitake daily increased immunity in healthy young adults [6].

Note: Eating old mushrooms can be harmful and can cause side effects such as nausea, vomiting, diarrhea, and even death. Mushrooms contain toxins that can break down over time, making them more dangerous to eat. It is important to check the freshness of mushrooms before eating them

Frequently Asked Questions

Q: What is the Return Policy By Mushroom Defense?

A: The manufacturer has a very generous 67-day return policy, which is 60 days plus an extra week to send the order back. If you’re not happy with your purchase, contact customer service for instructions and then return the items within 67 days of the purchase. You’ll get a full, hassle-free refund.

Q: Is Mushroom Defense Cruelty-Free?

A: Leading Edge Health Inc. is a cruelty-free company, meaning they will never test any of their products on animals, or work with suppliers or associates who do or purchase information from companies that conduct animal testing.

Q: How Do You Take Mushroom Defense?

A: The recommended dosage is 2 capsules daily, at any time you wish. Do not take more than this amount under any circumstances.

Q: Where to Buy Mushroom Defense?

A: This supplement is for sale on the manufacturer’s website, the official website, and from a number of other retailers online and in stores. There is a summer sale right now, and if you use the code SAVE15 at checkout you get a 15% discount.

American residents who order 6 bottles or more get free shipping. The price list is as follows:

  • 1 Month – $59.99
  • 2 Months – $109.99
  • 3 Months – $154.99
  • 6 Months – $289.99

Q: What Sets Mushroom Defense Apart From the Competition?

A: This manufacturer has 25 years of experience in the health and wellness industry, and they make safe, effective supplements that are 100% organic and free of any harmful additives or fillers. The formula is richer than many competing brands, and the ingredients have scientific support.

What Do the Reviews Say?

The vast majority of the Mushroom Defense reviews were from happy customers. Users raved about how healthy they felt and how few illnesses they had experienced recently, plus they loved the added energy and brain boost. Here are some of the top comments:

Great Supplement

I found this online, and I wanted to see if it would improve my energy levels. So far it’s working really well, as I do feel much more activated during the day and I feel like I also sleep better because of that. I will definitely keep taking it. – Dessie

I Love This

This is a great mushroom complex, with all of the ingredients you would want. I know a lot about medicinal mushrooms, and I can tell you for sure that this is a strong product with amazing immunity benefits. I feel great and have ordered more already! – Carol P.

Good Product

I really like this supplement. I started feeling a lot better and more energetic within a few days. Now after a few weeks, I have seen other benefits like better digestion and a better attention span. I highly recommend this defense formula. – Lynn D.


This product is a blend of healthy mushrooms that offer a range of benefits, and in particular, strengthen the immune system and decrease the risk of contracting viral and bacterial illnesses. Other Mushroom Defense benefits include added energy and brain benefits like mental focus and clarity.

The reviews for Mushroom Defense on the whole were quite glowing. The vast majority of the customers loved the benefits of this supplement, from added energy to reduced illness and lower brain fog. Many said they planned to keep taking it long-term, and found it more than worth the cost.

This supplement contains 100% organic, safe ingredients with no added fillers or additives. There are few if any side effects from Mushroom Defense formula, and the manufacturer follows GMP safety standards. This is a doctor and RDN-recommended product that offers great health and immunity properties.

Below are some of the best Immune System Supplements on the market today, in our opinion.

Our Top Immune System Supplements

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned Immune System Supplements based on the available research:

VitaPost Immune Support | Healthy Immune System
Nutrient-Rich Formula*Gold Star Evidence
Reduces Risk of Illness*Gold Star Evidence
Enhances Immune Function*Gold Star Evidence
Supports Overall Wellness*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
VitaPost Immune Complex | Balance Gut Microbiome
Provides Nutritional Support*Gold Star Evidence
Boosts Energy and Vitality*Strong Evidence
Reduces Inflammation*Gold Star Evidence
Antioxidant Protection*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Biotics 8 | Men’s High-Performance Probiotic Formula
Helps Balance Testosterone Levels*Gold Star Evidence
Boost Immune System Resilience*Strong Evidence
Strengthens Digestive Integrity*Gold Star Evidence
Improves Gut-Brain Connection*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Mushroom Defense

Mushroom Defense Review: Mushroom Blend For Enhanced Immune Health

Customer Reviews & Ratings

4.0 out of 5

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  1. Jason G.

    Excellent product Mushroom Defense
    Super impressed with this Mushroom Defense. I originally bought Mushroom Defense for the immune system boost but I’ll keep buying it for the mental clarity I get while taking these. They are a bit pricey, but the quality is excellent so to me it’s an excellent value.

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Mushroom Defense
Leading Edge Health
60 Capsules
Turkey Tail, Reishi, Lion’s Mane, and Shiitake

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    6 Sources

    We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

    [1] Bendich A. Physiological role of antioxidants in the immune system. J Dairy Sci. 1993 Sep;76(9):2789-94. doi: 10.3168/jds.S0022-0302(93)77617-1. PMID: 8227682.
    [2] Schley PD, Field CJ. The immune-enhancing effects of dietary fibers and prebiotics. Br J Nutr. 2002 May;87 Suppl 2:S221-30. doi: 10.1079/BJNBJN/2002541. PMID: 12088522.
    [3] Trametes Versicolor (Turkey Tail Mushrooms) and the Treatment of Breast Cancer
    [4] Zhao, R., Chen, Q., & He, Y. (2018). The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network. Scientific Reports, 8(1). DOI: 10.1038/s41598-018-30881-0
    [5] Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of Lion's mane medicinal mushroom, Hericium Erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. DOI: 10.1615/intjmedmushr.v15.i6.30. PMID: 24266378.
    [6] Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults

    **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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