In This Review
Overview
We all want to live a long, vibrant life, and following a healthy lifestyle can significantly support our overall well-being and longevity. However, aging is a natural process that can negatively impact organ health, immune function, and vitality. Is there a natural way to enhance your lifespan and promote healthier aging?
ActiveSpan is a natural supplement formulated with potent ingredients backed by research, designed to help reverse aging and support the health of multiple organs and systems. Whether you’re looking to boost heart health, digestive function, brain power, metabolism, or vitality, ActiveSpan is here to help. With ingredients known for their anti-aging benefits, it supports telomere lengthening, energy levels, and stress management—making it one of the best longevity supplements available today.
If you’re wondering, Is ActiveSpan worth it? or Does ActiveSpan really work?, read on as we dive into the details of this anti-aging supplement with adaptogens, backed by a money-back guarantee and positive results from users worldwide.
What is Nation Health MD ActiveSpan?
ActiveSpan by Nation Health MD is an all-natural, plant-based supplement packed with eight potent, antioxidant-rich ingredients designed to support healthy aging. Backed by research, this formula is known for its ability to repair DNA and increase telomere length, contributing to improved longevity.
The bioactive agents and antioxidants in ActiveSpan lower oxidative stress, helping to repair damage across the body. This supports the health of the heart, gut, brain, and immune system, promoting balanced blood sugar levels and lower blood pressure.
Additionally, ActiveSpan stimulates neurotransmitter synthesis to boost cognitive function, enhance mood, reduce stress, and improve sleep quality. It also helps reduce signs of aging on the skin, including wrinkles and fine lines.
With its anti-inflammatory agents, ActiveSpan eases joint and muscle pain. Many users report powerful benefits to their overall vitality, energy levels, and quality of life with consistent, long-term use.
How Does Nation Health MD ActiveSpan Rate?
Brand Highlights
- All-natural, results-driven supplements.
- One-year money-back guarantee.
- Backed by medical experts.
- Manufactured in USA facilities.
- Discounts on bulk and subscriptions.
Key Ingredients
- ashwagandha
- L-Glutamine
- Cat’s Claw Bark Extract
- Astralagus Root
- L-Citrulline
Pros and Cons of Nation Health MD ActiveSpan
Pros
- ActiveSpan contains all-natural, premium extracts and nutrients.
- Free from GMOs, gluten, dairy, and soy.
- Suitable for vegetarian and vegan diets.
- Ingredients backed by research for longevity and health benefits.
- Well-tolerated by users with no serious side effects.
Cons
- ActiveSpan by Nation Health MD is available online only.
- The results may vary for different individuals
About the Manufacturer
The manufacturer of ActiveSpan is a U.S. health and wellness company called Nation Health MD, headquartered in Manassas, Virginia. The organization’s mission is to offer all-natural, science-backed supplements to support multiple aspects of health and longevity.
The team includes a group of medical experts led by pharmacist Lisa King, RPh, and the ingredients are supported by science. All of the company’s products are manufactured safely in a facility in the USA.
How Does Nation Health MD ActiveSpan Work?
ActiveSpan contains 8 potent extracts and amino acids, supported by research from experts like Dr. David A. Sinclair, Ph.D. at Harvard. These ingredients help repair DNA damage, boost enzyme activity, and promote telomere length, supporting healthy aging and longevity. As explained in our review of Zenith Labs Longevity Activator, these effects help support overall longevity.
The supplement’s antioxidants lower oxidative stress, reducing inflammation and supporting the health of the heart, brain, joints, digestive tract, and metabolism. A research review in BioMed Research International discusses the impact of antioxidants on aging, explaining [1]:
If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, the lifespan of organisms should be extended by administration of exogenous antioxidants.
ActiveSpan also boosts nitric oxide levels to improve circulation, lower blood pressure, and support cardiovascular health [2]. It enhances cerebral blood flow, supports brain health, and boosts neurotransmitters like GABA, dopamine, and serotonin to improve mood, lower stress, enhance sleep, and sharpen cognitive function.
Finally, the antioxidants and bioactive agents in ActiveSpan help reduce wrinkles and fine lines, supporting overall skin health.
Nation Health MD ActiveSpan Ingredients: Are They Safe & Effective?
These are some of the primary ActiveSpan ingredients:

Ashwagandha
This ancient Ayurvedic plant is rich in antioxidants and bioactive agents like withanolides, as we said in our review of Youth Switch. It supports immune function and hormonal health, and it is also an adaptogen that helps boost cognitive function, improve mood, and lower stress levels.
In addition, ashwagandha supports athletic performance and heightened energy levels, and some evidence indicates its potential longevity benefits. A study published in the Annals of Neurosciences concluded that ashwagandha helps extend the lifespan of roundworms called C. elegans (3).

L-Glutamine
This amino acid supports a healthy gut barrier lining to improve digestive health, and it also helps boost nutrient absorption. Research supports the immune-strengthening properties of L-glutamine, and it also supports brain function and helps lower stress.
A study of mice published in Frontiers in Pharmacology concluded that L-glutamine supplementation helps protect against oxidative stress-induced aging (4).

Cat’s Claw Bark Extract
Derived from the Uncaria tomentosa vine in the Amazon rainforest, cat’s claw has antioxidants like flavonoids and polyphenols that support immune and organ health, and anti-inflammatory agents that help ease muscle and joint pain.
In addition, evidence indicates it helps repair damage to DNA for potential longevity benefits. A comparative study published in Phytotherapy Research concluded that Cat’s Claw helps significantly enhance DNA repair in human skin (5).

Astralagus Root
The root of this plant has powerful antioxidants and bioactive compounds that help boost the immune system, support heart and liver health, and ease fatigue. It is an adaptogen that helps ease stress, and there is significant support for its potential to impact telomere length and support healthy aging.
A study of a middle-aged population published in Nutrients concluded that a natural astragalus supplement helps lengthen telomeres and support longevity (6).

L-Citrulline
his amino acid is a powerful antioxidant that lowers oxidative stress to promote body-wide repair, supporting the health of the heart, brain, liver, and immune system. It also boosts nitric oxide to help improve circulation and lower blood pressure.
In addition, L-citrulline has potential longevity benefits, according to the research. A study published in Molecules concluded that l-citrulline supplementation helps attenuate age-related impairments in mice and may extend the lifespan of C. elegans (8).
How to Take Nation Health MD ActiveSpan?
- Recommended Dosage: Take 2 capsules daily with an 8-ounce glass of water.
- Maximum Dosage: Do not exceed the recommended amount unless directed by a healthcare practitioner.
- For Best Results: Take consistently over the long term for optimal health, well-being, and longevity.
- Healthy Lifestyle: Combine with adequate hydration, a nutrient-rich diet, regular exercise, and stress management for enhanced benefits.
Benefits of Nation Health MD ActiveSpan
These are the primary ActiveSpan benefits:
- Supports Longevity and Healthy Aging – The ingredients in ActiveSpan help stimulate DNA repair, boost cellular energy, and increase telomere length to support longevity and healthy aging.
- Helps Strengthen the Immune System – The formula is packed with antioxidants that kill free radicals to lower oxidative stress and inflammation, helping to strengthen the immune system.
- Supports Brain and Cognitive Health – ActiveSpan has antioxidants that repair damaged neurons and increase neurotransmitter synthesis, and it supports increased cerebral blood flow to help boost brain health and cognitive function.
- Helps Lower Stress, Improve Sleep and Boost Mood – ActiveSpan contains several adaptogens that increase levels of neurotransmitters like GABA and serotonin, supporting enhanced mood, lower stress levels, and improved sleep quality.
- Supports Heart Health – This supplement enhances body-wide circulation and improves nutrient and oxygen uptake. It helps balance blood pressure and vessel health, supporting the cardiovascular system.
- Supports Gut Health and Digestion – The ingredients in ActiveSpan help balance the gut microbiome and boost nutrient uptake, supporting digestive health.
Side Effects of Nation Health MD ActiveSpan
The supplement contains natural ingredients that are safe for most individuals, with no reported ActiveSpan side effects. Some users may experience mild issues like digestive upset and nausea, which should resolve in a few days in most cases.
If you have persistent symptoms, consult with a healthcare practitioner for advice on usage and dosage. Before taking ActiveSpan, check the label carefully to ensure that you do not have an ingredient allergy.
Safety of Nation Health MD ActiveSpan
ActiveSpan contains all-natural, plant-based ingredients and is free of GMOs, gluten, dairy, and soy, making it well-tolerated by most users and suitable for vegetarian and vegan diets.
However, individuals with low blood pressure, autoimmune diseases, or stomach ulcers should avoid the product. Diabetics should consult with a physician before use and monitor their blood glucose levels carefully.
ActiveSpan is also not recommended for those taking lithium, blood pressure medications, liver medications, blood thinners, or immunosuppressants, and it should not be combined with sedatives.
For best safety, it’s important to consult with a healthcare provider before taking ActiveSpan. All Nation Health MD supplements are manufactured safely in the USA.
How Effective is Nation Health MD ActiveSpan?
ActiveSpan was developed by a team of medical experts, led by Lisa King, RPh, using ingredients backed by research from prestigious institutions like Harvard University.
Scientifically supported, ActiveSpan helps support telomere length, repair DNA, and enhance the health of multiple organs and systems, contributing to longevity and overall well-being. Its powerful formula aids in promoting healthy aging, improving cognitive function, and boosting metabolic health.
User feedback is overwhelmingly positive, with many praising ActiveSpan for its ability to improve vitality, support healthy aging, and enhance overall wellness. This supplement has proven to be an effective anti-aging solution, making it a top choice for those seeking a natural supplement to improve energy levels and longevity.
How Much Does Nation Health MD ActiveSpan Cost?
ActiveSpan is available exclusively on the official Nation Health MD website. Enjoy free U.S. shipping and significant discounts on bulk and subscription purchases. Here’s the pricing:
One Time Purchase
- 1 Bottle – $49
- 3 Bottles – $45 per bottle
- 6 Bottles – $42 per bottle
Subscription
- 1 Bottle – $44.10
- 3 Bottles – $40.50 per bottle
- 6 Bottles – $37.80 per bottle
Save 10% with a subscription for continuous delivery and better long-term value.
Nation Health MD ActiveSpan Review: FAQs
Q: What if ActiveSpan Doesn’t Work For Me?
A: The company offers an outstanding 365-day 100% money-back guarantee on all orders. If you are dissatisfied with ActiveSpan, contact customer service and return the unused bottles within a year of the order according to their instructions. The company promises a full refund of the product price or an exchange.
Q: What is Unique About ActiveSpan?
A: ActiveSpan is designed by medical and pharmaceutical experts, and includes eight potent extracts and amino acids backed by research from leading institutions like Harvard for their health and longevity benefits. The formula is superior to many competing blends on the market.
Q: Who is ActiveSpan For?
A: ActiveSpan is designed for adults who want to combine a healthy lifestyle with a natural supplement that helps support healthy aging, extend their lifespan, and enhance multiple aspects of well-being, including heart, gut, metabolic health, and more. Before taking it, consult with a healthcare practitioner for approval.
Q: Can I Take ActiveSpan Long-Term?
A: Yes, ActiveSpan is safe for long-term use, and the company recommends taking it consistently over time to experience optimal health, anti-aging, and longevity benefits.
Q: What’s the best way to take ActiveSpan for optimal results?
A: For best results, take 2 capsules of ActiveSpan daily with an 8-ounce glass of water. It’s most effective when combined with a healthy lifestyle that includes a nutrient-rich diet, regular exercise, and stress management. Consistency is key to experiencing its full benefits.
Q: Is there a money-back guarantee with ActiveSpan?
A: Yes, Nation Health MD offers a one-year money-back guarantee on all ActiveSpan purchases. If you’re not satisfied with the product, you can request a full refund within 365 days of purchase, giving you peace of mind while trying the supplement.
What Do the Nation Health MD ActiveSpan Customer Reviews Say?
The ActiveSpan reviews on the official website and independent sites are overwhelmingly positive overall, with many individuals citing potent health benefits like added energy, enhanced mood, improved gut health, and much more.
Overall, users are thrilled with the benefits, find the cost of ActiveSpan to be very reasonable, and report no unpleasant side effects. On the official website, 27 customers give the supplement a total rating of 5 stars.
One of the top 5-star Nation Health MD ActiveSpan reviews comes from Michael M. Smith, who is thrilled with the health and longevity benefits:
I’ve enjoyed more energy and better health since starting ActiveSpan. If you find that your body and mind are healing more slowly and you’d like to feel younger, I strongly recommend that you try this product and decide for yourself if it isn’t the answer you’ve been looking for.
Another top ActiveSpan review is from Tony O., who raves about the benefits to his sleep quality, energy, and overall health:
Since I started ActiveSpan, my sleep is relaxed; I easily fall asleep on demand in a good mood and wake up as having had enough sleep without tiredness; always with full completeness. No more sleep interruptions. No more weakness and chronic fatigue. I also note a boost in my cellular energy. I strongly recommend it for longevity purposes if you care about living longer.
Nation Health MD ActiveSpan Review: Conclusion
Backed by high-level research, Nation Health MD ActiveSpan is a leading natural supplement that supports healthy aging and longevity. The antioxidant-rich blend helps lengthen the lifespan, support heart, brain, gut, and metabolic health, boost mood and sleep quality, lower stress, and much more.
The ActiveSpan supplement has gained attention and popularity in the market, with glowing reviews from users who note added energy and well-being, improved organ function, better mood, and enhanced quality of life. Most highly recommend it to other users looking for a boost in health and longevity.
ActiveSpan is an all-natural, plant-based supplement free of GMOs, gluten, dairy, and soy. The formula is safe, well-tolerated by users, and safely manufactured in the USA. Before taking it, consult with a healthcare practitioner for approval. For more information or to purchase ActiveSpan, visit the official website.
Where To Find It?
You can BUY it directly from the Official Website
As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.
Below you'll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.
Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned anti-aging products and anti-wrinkle creams based on the available research:








Rachel K.
Sharen Leo
I love how it’s a natural supplement that targets aging from the inside out, and the best part is that it doesn’t give me jitters like some other supplements I’ve tried. I’m excited to continue this journey with ActiveSpan and would highly recommend it to anyone looking to boost their vitality and overall well-being!
Marko Rib
It’s easy to integrate into my daily routine, and I love that it’s all-natural. For anyone wanting to feel younger and improve their skin health, I definitely recommend giving it a try!