Syn-Ake Venom Cream Reviews: Is It Safe To Implement?

Syn-Ake is a whitening and anti-wrinkle eye cream that moisturises and adds elasticity to the sensitive eye area.

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In This Review

What is Syn-Ake Venom Cream?

Syn-Ake Venom Cream (also called Prolou) is a skin cream that claims to contain the same ingredient in venom from the Tiger Viper snake. However, instead of paralyzing like a real snakebite, the synthetic imitation of the venom relaxes the face muscle resulting in smooth skin. The product claims to reduce wrinkles in just a few days. It is sold by

Syn-Ake Venom Cream has a 30-day money back guarantee policy. There is a detailed customer care section on the website that explains the return and exchange policies in detail. A contact phone number is available for customers with questions or concerns, however it is an international number. An email form is also available for questions.

How Does It Rate?

Overall Rating: 3.6
Syn-Ake Venom CreamSyn-ake Venom Cream



Value for Cost

3.5/5Value for Cost

Return Policy

3.4/5Return Policy



Brand Highlights

  • Syn-Ake Venom Cream has performed some clinical studies.
  • 45 volunteers tested Syn-Ake twice daily and reported reduced forehead wrinkles by 52% in just 28 days.
  • Prolou is one of the only products on the market to use Syn-Ake. It costs $69.20 for a 50ml jar.


beverly hills

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Syn-Ake
  • Caviar extract
  • Arbutin
  • Shea butter
  • Adenosine
  • Vitamin E


  • It may help to reduce wrinkles
  • It may provide more flexible skin
  • Syn-Ake is ecology-friendly and contains no preservatives.
  • Ingredients are listed on the website.


  • Syn-Ake is relatively new technology that hasn’t been around that long.
  • It is available online only

How Does it Work?

Syn-Ake Venom Cream brags it will reduce wrinkles in just a few days. The website recommends that the product be used for 30 days, twice daily, to see the best results. Syn-Ake Venom Creamcan be used by adult men or women of any age. It can be worn under make-up and is safe to use under the eyes. It can be used during pregnancy.

Syn-Ake Venom Cream Ingredients – Are they Safe & Effective?


– Syn-Ake is a small peptide that works in tandem with the skin’s natural processes to help reduce the appearance of wrinkles & laughter lines quickly.

Caviar extract

– Caviar contains antioxidants that protect and nourish the skin, as well as omega-3 and 6 fatty acids that moisturise and improve skin texture. Caviar, in fact, is a highly effective moisturising agent that is primarily used to hydrate and soften the skin.[1]


– Arbutin inhibits melanin activity in the skin, which aids in the reduction of unwanted pigmentation caused by sun exposure. It is also useful for fading scars due to its anti-inflammatory properties.[2]

Shea butter

– It acts as an emollient, softening and hydrating the skin. Shea butter protects skin from environmental damage, such as pollutants, because it contains several types of fatty acids, including lineoleic, oleic, palmitic, and stearic acids, which improve the skin’s natural barrier.


– Adenosine reduces the appearance of wrinkles by energizing the skin’s surface. Adenosine-containing skincare has been shown in studies to significantly improve skin smoothness, reduce the appearance of crow’s feet, and reduce the depth of brow wrinkles. The result is a smoother, more youthful complexion.[3]

Vitamin E

– Vitamin E is best known for its skin health and appearance benefits. It can be applied topically to the face to reduce inflammation and rejuvenate the skin. Many people swear by the effects of applying topical vitamin E to the face overnight.


Serious Skincare Insta-Tox

*All individuals are unique. Your results can and will vary.

Syn-Ake Venom Cream FAQs

Q: What Exactly Is Syn-Ake?

A: Syn-Ake is a patented anti-aging ingredient created by the Swedish firm Pentapharm Ltd that mimics the action of snake venom. It is designed to relax the muscles in the face, thereby reducing the appearance of wrinkles and fine lines.

Q: Is Syn-Ake safe?

A: Syn-Ake is a synthetic peptide that is a safe and effective alternative to “Botox” in treating facial expression lines.

Q: How can Syn-Ake benefit your skin?

A: Syn-Ake reduces the appearance of deep wrinkles by relaxing the face and, when used earlier, can delay their progression, creating an age-freezing effect. Syn-Ake (4%) effect was measured and compared to a placebo. A cream was applied twice daily for 4 weeks.

Syn-Ake Venom Cream Review – Final Verdict

Syn-Ake Venom Cream claims it can replace a customer’s existing skin cream completely. The studies show it has been proven to reduce wrinkles by up to 52% and has a smoothing effect of 82%.

Syn-Ake describes itself as a “cutting edge” beauty product made with the best ingredients money can buy. However, it would be recommended to research more about the product before taking any decision.

As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.

Below you’ll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.

Our Top Wrinkle Cream Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned anti-aging products and anti-wrinkle creams based on the available research:

Beverly Hills MD - Best #1 Rated Skincare Brand
Brand SealBeverly Hills MD
Innovative Science-Backed Skincare Products*Gold Star Evidence
Range of Products for Specific Skin Concerns*Gold Star Evidence
Cruelty-Free, Premium Quality Ingredients*Gold Star Evidence
Visibly Lifts Skin From The Inside, Out*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Read Review
Serious Skincare Insta-Tox - Instant Wrinkle Eradicator
Instantly Smoothes Out Deep Wrinkles*Gold Star Evidence
Removes Under-eye Bags And Crow'S Feet*Gold Star Evidence
Minimizes The Appearance Of Sagging*Gold Star Evidence
Helps Provide Smoother, Tighter Skin*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
XYZ Smart Collagen | The Best Collagen Cream
Wrinkles Reduction*Gold Star Evidence
Improves Skin Firmness*Gold Star Evidence
Improves Skin Texture*Strong Evidence
Smart Collagen Management*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Deep Wrinkle Filler | Anti-aging Skin Care Formula
Erase The Appearance Of Fine Lines*Gold Star Evidence
Fill in Deep Wrinkles*Gold Star Evidence
Give Skin a Smoother, More Flawless Appearance*Strong Evidence
Nourishes Skin For Lasting Results*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Syn-Ake Venom

Syn-Ake Venom Cream Reviews: Is It Safe To Implement?

Customer Reviews & Ratings

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  1. Naimah

    I want confirmation of this product
    Hi, I have been using SYN-AKE cream (inc eye cream) along with the serum (formula 10) prior to becoming pregnant. I purchased this from the website YesStyle. I am now 10 weeks pregnant and came across your article for confirmation that the above products are safe to use during pregnancy which your article did confirm. I also contacted through YesStyle website to get confirmation of the same. They, however, gave an opposite response stating. In reference to your query, per checking we do not recommend the item Syn-Ake cream to a pregnant woman it is not safe especially during the lactic period and if you’re are prone to edemas. Now I’m really confused and I want confirmation if this product is or isn’t safe to use during pregnancy. I shall be grateful for your response. Thank you!

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Syn-Ake Venom
Syn-Ake, Caviar extract, Arbutin, Shea butter, Adenosine and Vitamin E

3 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Kaur N, Chugh V, Gupta AK. Essential fatty acids as functional components of foods- a review. J Food Sci Technol. 2014 Oct;51(10):2289-303. doi: 10.1007/s13197-012-0677-0. Epub 2012 Mar 21. PMID: 25328170; PMCID: PMC4190204.
[2] Diet Review: Anti-Inflammatory Diet:
[3] Sator PG. Skin treatments and dermatological procedures to promote youthful skin. Clin Interv Aging. 2006;1(1):51-6. doi: 10.2147/ciia.2006.1.1.51. PMID: 18047257; PMCID: PMC2682446.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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