In This Review
Overview
Many people start to notice visible signs of aging, such as fine lines and wrinkles, as they grow older. These changes are often caused by environmental stress, genetics, and the natural decline of collagen in the skin.
Unfortunately, these factors can make people feel less comfortable in their skin. Since there is only so much makeup can do to conceal these signs of aging, most people try to get more permanent solutions from skincare products.
However, not all products live up to their claims. And that is why this Peter Thomas Roth Peptide 21 Wrinkle Resist Serum review exists: to help you find out if this is a product you can trust.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum claims to be able to reduce the appearance of wrinkles, improve hydration, and enhance skin texture.
But is this serum truly the solution for addressing fine lines and wrinkles, or is it just another product with clever marketing?
In this review, we’ll take a closer look at its features, ingredients, pricing, and more. By the end, you’ll know if it’s worth adding to your skincare routine.
Let’s get started.
What is Peter Thomas Roth Peptide 21 Wrinkle Resist Serum?
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum is an advanced skincare product designed to target visible signs of aging. It claims to reduce the appearance of fine lines, wrinkles, and uneven skin texture while improving skin hydration and elasticity.
This serum is formulated with a 73% complex of 21 peptides and neuropeptides, along with two gamma proteins. These ingredients aim to boost collagen production, support skin firmness, and improve radiance. It also includes skin-nourishing elements like squalane and hyaluronic acid to provide hydration and vitamins A, C, and E for added antioxidant protection.
The serum is marketed for individuals looking for an effective way to combat aging skin on both the face and neck. Its lightweight texture makes it easy to apply and integrate into a daily skincare routine.
But is it the right choice for achieving smoother and younger-looking skin? Let’s consider its features further.
How Does Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Rate?
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum earns a 3.5 out of 5 rating. Its blend of ingredients like peptides shows the potential to reduce fine lines and wrinkles. However, the product’s relatively high price and limited return policy are notable drawbacks.
The brand offers a 30-day return policy for purchases made through its official website, but this policy is only valid for U.S. customers. This lack of a flexible return policy that also restricts international buyers may discourage some users.

Brand Highlights
- Manufactured in the USA with globally sourced ingredients.
- Claims to create advanced and clinically tested skincare formulas.
- Available in over 30 countries worldwide.
- Free standard shipping on U.S. orders over $50.
Key Ingredients
- Peptides
- Neuropeptides
- Hyaluronic Acid Complex
- Squalane
- Vitamin A
Pros
- Includes hydrating and nourishing ingredients.
- Lightweight formula that is suitable for daily use on both the face and neck.
- 30-day money-back guarantee.
Cons
- Relatively expensive compared to similar products in the market.
- Limited return policy, which excludes international buyers and loyalty rewards customers.
- Some users report dispenser issues, such as defective pumps or leaks.
- Results may vary and require consistent use to see noticeable changes.
- Contains fragrance, which might not suit individuals with sensitive skin.
- No clinical trials or studies provided directly by the brand to substantiate claims.
About the Brand
Peter Thomas Roth was established over 30 years ago in the USA and is now available in 30 countries. The brand claims to focus on clinically advanced skincare solutions with the goal of addressing a variety of skin concerns, such as aging, hydration, and uneven texture, using science-backed formulations.
The company claims to manufacture its products in state-of-the-art facilities to meet strict safety and quality standards. Peter Thomas Roth states that it does not test its products on animals but acknowledges that some raw materials may have been tested by suppliers in the past.
Despite its prestige and popularity, the brand has faced some concerns from customers regarding limited return policies and occasional packaging issues.
How Does Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Work?
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum works by targeting signs of aging through a high concentration of peptides, neuropeptides, and gamma proteins. These ingredients aim to support collagen production, enhance elasticity, and reduce the appearance of fine lines and wrinkles.
Peptides are short chains of amino acids that signal the skin to produce more collagen, which helps maintain its firmness and smooth texture. According to a study in The International Journal of Cosmetic Science, peptides have demonstrated effectiveness and high subject satisfaction for wrinkle reduction and skin rejuvenation.
The serum’s inclusion of hydrating ingredients like hyaluronic acid ensures the skin remains moisturized and prevents dryness that can make wrinkles more obvious.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Ingredients – Are They Safe & Effective
Peptides
This serum contains 21 peptides (short chains of amino acids) that support collagen production and improve skin firmness. As highlighted in our RenewRitual Review (another product containing this ingredient), some peptides slow the movement of facial muscles, so wrinkles and lines appear less prominent.
According to a study published in the International Journal of Molecular Sciences, peptides can improve skin elasticity and reduce wrinkles.
Neuropeptides
Neuropeptides relax facial muscles, reducing the appearance of expression lines and wrinkles. By promoting a smoother surface, they mimic the effects of injectables without invasive procedures. An article in Frontiers suggests that Neuropeptides also play a pivotal role in the process of wound healing.
Hyaluronic Acid Complex
Hyaluronic acid draws moisture into the skin to aid hydration and plumpness. This reduces the appearance of fine lines caused by dryness. Research published in Dermato Endocrinology shows that hyaluronic acid reduces skin dryness and plumps the skin, reducing the appearance of wrinkles and fine lines
Squalane
Squalane is a lightweight moisturizer that prevents water loss and improves skin texture. As documented in our Ageless Glow Review (another product containing this ingredient), Squalane is a great moisturizer that helps to hydrate the skin and fight aging symptoms like wrinkles and dark spots
According to a study in Molecules, Squalane is a lightweight yet deeply hydrating emollient that effectively prevents water loss and improves elasticity. This leaves the skin soft and supple.
Vitamin A
Vitamin A (retinyl palmitate) supports skin cell turnover and helps to reduce fine lines and wrinkles. According to a publication in Frontiers in Pharmacology, retinyl palmitate demonstrated anti-photoaging ability by inhibiting the inflammatory response and apoptosis and promoting collagen production.
How to Use Peter Thomas Roth Peptide 21 Wrinkle Resist Serum?
Here’s how to use the serum for the best results:
- Apply the serum to clean dry skin. Use it after cleansing and before applying moisturizer or sunscreen.
- Dispense a small amount onto your fingertips and gently smooth it over your face and neck.
- Use the serum twice daily, once in the morning and once at night, as part of your regular skincare routine.
For optimal absorption, allow the serum to fully dry before layering other products. Avoid contact with eyes. If irritation occurs, discontinue use and consult a dermatologist.
Benefits of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum offers several benefits. They include:
- Reduces the Appearance of Fine Lines and Wrinkles
- Improves Skin Elasticity and Firmness
- Hydrates and Moisturizes Skin
- Enhances Radiance and Skin Tone
- Nourishes with Antioxidants
- Addresses Texture and Smoothness
The serum claims to visibly reduce fine lines and wrinkles with its blend of 21 peptides and neuropeptides, which target the skin’s natural structure.
With gamma proteins derived from Asian natto gum, the product is said to enhance skin elasticity and improve firmness over time.
Infused with a hyaluronic acid complex and squalane, the serum claims to deeply hydrate the skin, preventing dryness and flakiness.
The brand states that the serum helps brighten uneven skin tone and promotes a more radiant and even complexion.
Vitamins A, C, and E in the serum are included to provide antioxidant protection, which the brand claims helps shield the skin from environmental damage.
According to Peter Thomas Roth, the serum is designed to improve overall skin texture and leave it smoother and softer with regular use.
Side Effects of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum is generally considered safe for most users. However, some individuals may experience side effects, such as:
- Skin Irritation.
- Redness or itching.
- Breakouts or clogged pores.
- Sensitivity to fragrance.
- Allergic reactions, such as rash or swelling.
To avoid unwanted reactions, perform a patch test before applying the serum to your face and neck. If irritation persists, discontinue use and consult a dermatologist.
Safety of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum is formulated with ingredients generally recognized as safe for topical use. However, there are precautions to consider.
Users with sensitive skin or known allergies to any listed ingredients should perform a patch test before applying it to their face or neck. Those prone to irritation from products containing fragrance may experience minor discomfort.
The serum is intended for external use only and should not come into contact with the eyes. Pregnant or nursing individuals, as well as those managing skin conditions, are advised to consult a dermatologist before use.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Price
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum is available at the following price:
- 1 Bottle (30ml): $48.00
Orders over $50 qualify for free standard shipping within the United States. However, there are no bundle deals or discounts available, which makes the product less cost-effective for regular users.
International customers should note that free shipping is not available, and delivery times may be longer with higher shipping fees. For more convenient options, it may be worth checking availability on platforms like Amazon or Walmart, where competitive pricing or faster shipping could offer additional flexibility.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Review – FAQs
Q: What does Peter Thomas Roth Peptide 21 Wrinkle Resist Serum do?
A: This serum claims to target fine lines and wrinkles and also hydrate the skin to improve elasticity and firmness while providing a smoother and more radiant appearance.
Q: How long does it take to see results?
A: The brand states that users may notice visible changes in as little as two weeks with consistent use. However, results may vary depending on individual skin types and concerns.
Q: Is it suitable for sensitive skin?
A: While the product is designed for most skin types, it contains fragrance and active ingredients that may irritate sensitive skin. A patch test is recommended before use to ensure compatibility.
Q: How often should I use the serum?
A: The serum should be applied twice daily, once in the morning and once at night, after cleansing the skin. It can be used on the face and neck for optimal results.
Q: Can it be used with other skincare products?
A: Yes, the serum can be layered with moisturizers, sunscreens, or other skincare products. However, it’s essential to let the serum absorb fully before applying additional layers.
Q: Does the product have a money-back guarantee?
A: The product is covered by a 30-day return policy for orders made through the official website within the contiguous U.S. However, international orders, loyalty program redemptions, and items without a return authorization number (RA#) are not eligible for returns or refunds.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Customer Review
Customer feedback for Peter Thomas Roth Peptide 21 Wrinkle Resist Serum is mixed, with some users praising its effectiveness and others expressing disappointment.
KayNYC shared a positive experience:
Best serum for my face. Recently bought another one. Realized after purchase that something was different. The texture, the feel… Then, the bottle was named differently. But still is a Peptide line. It didn’t work as well as my Wrinkle Resist. So I gave it to my mom. But darn, I wish I got this again, I would use all my points on it.
On the other hand, some users were not as satisfied. For example, Amys commented:
I bought this, but when I went to use it, it has a floral smell to it. I can’t do any type of smells when it comes to makeup.
Similarly, Tatjana shared:
The item dispenser is defective and stuck in the lid. The dispenser had apparently also been opened before! Unfortunately, no return was possible. Stay away from this offer.
These reviews indicate that while some users find the serum effective, others face issues with its performance, packaging, and fragrance.
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Review – Final Verdict
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum claims to target fine lines, wrinkles, and uneven texture. It also promises hydration and nourishment with ingredients like hyaluronic acid, squalane, and vitamins A, C, and E.
While some users report smoother and more radiant skin, others have noted minimal changes even with consistent use. The serum is priced at the higher end, and the lack of bundle deals or free international shipping may discourage some buyers. Additionally, the mixed reviews on effectiveness and dispenser issues could raise concerns.
While Peter Thomas Roth Peptide 21 Wrinkle Resist Serum may be worth trying for those seeking an anti-aging product, its results are not guaranteed, and better options might be available for those on a budget or seeking faster results.
As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.
Below you’ll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.
Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned anti-wrinkle serums based on the available research:

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