Differin Adapalene Gel Reviews – Does it really clear acne?

Differin Adapalene Gel Prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, reducing inflammation deep in the skin and texture by clearing acne.

We independently research, review, and recommend the best products. Healthcare professionals review articles for medical accuracy. When you buy through our links, we may earn a commission. Read more about our process for evaluating brands and products.

In This Review

Differin Adapalene Gel Overview

Differin Adapalene Gel is a dermatologist-prescribed anti-acne product whose key ingredient is an active form of vitamin A.

It is recommended for cases of severe acne and works by allowing the skin to renew itself and preventing the formation of new breakouts.

Differin Gel consists of Adapalene as the key ingredient. This chemical has been used in treating acne for many years now.

Due to the many side effects of the drug, it is available only through prescription. But with regards to effect against acne, it really works well and is thus recommended by most dermatologists.

How Does It Rate?

Overall Rating: 3.5
differin adapalene gelDifferin Adapalene Gel Acne Treatment


Value for Cost

3.2/5Value for Cost
Return Policy

3.4/5Return Policy


Brand Highlights

  • Differin Adapalene Gel is manufactured by the company known as Galderma Laboratories, L.P. Adapalene is a form of topical retinoid that has been proven to combat acne right at its root cause.
  • Aside from preventing breakouts, it also helps restore skin texture and even out skin tone.
  • The product is so effective at its job that it is recommended by most dermatologists to their acne patients.


drmtlgy gentle acne cleanser

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Adapalene


  • It is said to fight acne at its root cause, targeting acne-causing bacteria.
  • It may regulate the oil production.
  • It may clear the skin and prevents formation of breakouts.
  • It claims to effectively eliminate acne after 12 weeks of regular use.


  • It is available only through prescription by dermatologists.
  • The product will make the skin more sensitive to UV rays.
  • The acne may get worse on the first week of using the product.

How Does it Works?

A prescription-strength retinoid can clear and prevent acne.
To clear and prevent pimples, blackheads, and clogged pores, it regulates skin cell turnover and reduces inflammation deep in the skin.
Effectively treats acne and restores the natural tone and texture of your skin.

Differin Adapalene Gel Ingredients – Are they Safe & Effective?

As its name suggests, Differin Adapalene Gel has this key ingredient:


(in 0.1% concentration) This ingredient is a form of vitamin A that has been in use for years as a first-line defense against acne; it works by targeting the two main causes of acne – excess oil and acne-causing bacteria.[1]

You May Also LikeHiruscar Reviews and Skinception Dermefface FX7


Revamin Acne

*All individuals are unique. Your results can and will vary.

Differin Adapalene Gel FAQ’s

Q : How Do I Use This Product?

A: Differin Adapalene Gel is applied to the affected areas once daily, at bedtime. Before applying, you should wash your face first, preferably with a gentle, non-medicated cleanser. After patting your skin dry, dispense a small amount of the product and gently spread it into a thin layer over the affected area. Follow it with a moisturizer to prevent the skin from getting too dry.

Q : Is It Suitable For Pregnant or Lactating Women?

A: Differin Adapalene Gel is contraindicated for pregnant or lactating women, as it may cause harm to the baby.

Q : Is It Recommended For All Ages?

A: Differin Adapalene Gel must not be used by children under 12 years of age.

Q : What Are The Precautions For Using This Product?

A: Differin Adapalene Gel must not be applied on broken, sunburned, or irritated skin. These areas must be allowed to heal first before using the product.

It is also advised to avoid using other products that contain glycolic or alpha hydroxy acids, as they can further contribute to the drying effect of the gel.

Q : How Long Before I See Some Improvements?

A: It would take about 8-10 weeks before there could be any noticeable changes. The first week of use may result in worsening of acne, but only because the product is purging all the impurities from the pores.

This indicates that the product is working. Continue using the product as directed even if you think that it is not working.

Q: What are the possible side effects of Differin Adapalene Gel?

A: Differin Adapalene Gel will make the skin more sensitive to sunlight, or even artificial UV rays.

Exposure to sunlight may cause sunburn, so it is advised that you use a sunscreen with at least SPF 30 when going out. Other side effects include redness, itching, stinging, and peeling.

These side effects occur during the first four weeks of use and should lessen or eventually disappear with continued use.


drmtlgy gentle acne cleanser

*All individuals are unique. Your results can and will vary.

Differin Adapalene Gel Review – Final Verdict

Differin Adapalene Gel is one of the best solutions for acne. It offers lots of benefits, but it also has some fair share of side effects.

To determine if this topical treatment is suitable for you, ask for your dermatologist’s advice first.

If you suffer from acne and breakouts and you haven't been using an acne product, this could be an excellent time to begin. A product like this can unblock and clear your pores and get rid of any excess oils on the skin's surface. These products dry out existing acne on the skin and prevent future blemishes from forming.

Below are some of the best acne products on the market today, in our opinion.

Our Top Acne Products Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned acne creams, dietary supplements, and scar removal creams based on the available research:

Drmtlgy Gentle Acne Cleanser | Gentle Skin Cleanser Formula
Reduce Blemishes*Gold Star Evidence
Remove Excess Oil*Gold Star Evidence
Reduce Acne Breakouts*Gold Star Evidence
Promote Clear Skin*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Revamin Acne Cream | Innovative Formula for Acne Free Skin
Regulates Sebum Production*Gold Star Evidence
Reduces Acne & Blemishes*Gold Star Evidence
Prevent Future Breakouts*Gold Star Evidence
Lightweight & Non-Greasy*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Zinamax | Advanced Formula for Clear Skin
Reduce Acne Blemishes*Gold Star Evidence
Improves Skin Texture*Strong Evidence
Balances Oil Production*Gold Star Evidence
Minimizes Hyperpigmentation*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Differin Adapalene Gel

Differin Adapalene Gel Reviews – Does it really clear acne?

Customer Reviews & Ratings

5.0 out of 5

Review this Product

Leave a review and share your experience with others.

Write a Review

  1. Breann Elizabeth Lowe

    I absolutely love Differin
    I absolutely love Differin! I’ve tried many prescription and over-the-counter products to combat my acne and nothing worked, including Proactiv! I’ve tried Clearasil, Clindamycin, Retin A Cream, Benzoyl Peroxide, Salicylic Acid, etc. Nothing worked until I came across Differin! I’ve seen so much change in my skin and my aging process is pretty good with it and it seems to slow down compared to most and I’m currently 21 years old. Thank you for making Differin and please don’t change any ingredients.
  2. Crissi

    I decided to try this since it can now be bought over the counter and it’s absolutely amazing! It’s the first and only thing that has ever worked on my acne. If you just have the occasional pimple this isn’t for you because it’s not a spot treatment. But if you have full-blown acne you need to try it because it really works. I’ve been dealing with acne since I was a teenager, I’m 31 now and have tried most of the other over the counter products with no luck. This stuff is seriously amazing. I haven’t seen my fact this clear since I was a child. Give it time to work! I got lucky and started showing results after the first week but other says that it can get a bit worse before it gets better, because that’s how it works.

Write a Review

Your email address will not be published. Required fields are marked *

5000 characters remaining.

Explanation ?

Privacy Policy

Submitting this review means that you agree to our Review Guidelines, confirming that you are a verified customer who has purchased the product and may have used the merchandise or experienced the service, and providing only a real interaction and experience without ulterior motives or has an affiliate or business with the company in any way. By ticking this box and submitting this review, you also accept that submitting fake reviews is a violation of Consumer Health Digest’s Terms of Use and such conduct will not be tolerated.


How to Upload your Proof of Purchase:

Please follow the instructions listed below to upload your electronic proof of purchase.

  • To upload your physical paper receipt, simply take a picture of it with your camera or phone. You may also try taking a still picture of it with your computer’s webcam.
  • Once you have taken the picture, save the image as a JPG, TIF, or PDF file.
  • Please note that you cannot upload a file that is larger than 2MB.
  • Then all you have to do is click the Browse button and search for your receipt picture file. You can also drag and drop the file into the provided field.

If you are still not able to upload your proof of purchase, please contact us for further assistance (take a moment to look over the sample bill below).


Have a Question? Please Tell Us What We Are Missing Here!

Note: Consumer Health Digest isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
Differin Adapalene Gel
1.6 oz

1 Source

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Piskin S, Uzunali E. A review of the use of adapalene for the treatment of acne vulgaris. Ther Clin Risk Manag. 2007 Aug;3(4):621-4. PMID: 18472984; PMCID: PMC2374937.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

*Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

email img
  1. About Us
  2. Editorial Policy
  3. DMCA Policy

Note: Results may vary about any product effectiveness. The information contained in this website is provided for general informational purposes only. No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition.

3 E Evergreen Road #1193, New City, NY 10956
Phone: +91-712-2543006

Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Your use of this website indicates your agreement to this websites published terms of use and all site policies. Please see our Medical Disclaimer for more information.

Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here.

Do Not Sell My Personal Information

Helping the Cause

Make a Donation

Follow Us


Advertising Disclosure

The content that appears on this page is presented as an overview vs. comparative marketing. The provided information includes product information, overviews, buying guides, and product specifications. All trademarks, registered trademarks and service-marks mentioned on this site are the property of their respective owners. If something is factually inaccurate please contact us and let us know. By contributing your product facts helps to better serve our readers and the accuracy of the content.

The table below does not include all companies or all available products in the market but those that we promote as their affiliates. In full compliance with the FTC guidelines, please assume that any and all links on the table are affiliate links, and we may receive compensation if you click one of these and make a purchase. We are independently owned and the opinions expressed here are our own. All editorial content is written without prejudice or bias, regardless of sponsor or affiliate associations. Read more about our process.