In This Review
Overview
Keeping your blood sugar and cholesterol levels balanced is essential for staying healthy. This is because imbalances can lead to serious issues like diabetes, heart disease, or stroke.
One natural compound that’s popular for supporting metabolism is Berberine. That’s why today, many supplements add Berberine to their ingredients for improving blood sugar, heart health, and gut health as well.
Berberine Synergy is one of these supplements. Berberine Synergy by Designs for Health claims to promote metabolic health and enhance cardiovascular and liver function.
But does Berberine Synergy really work as it claims? Well, let’s find out.
In this review, we’ll take a closer look at Berberine Synergy’s formulation, effectiveness, benefits, customer feedback, and potential drawbacks.
So, keep reading to see if Berberine Synergy is the right supplement for your metabolism.
What is Berberine Synergy?
Berberine Synergy is a dietary supplement designed to support metabolic health and maintain normal insulin function. This supplement claims to combine two major compounds (Berberine and Alpha Lipoic Acid) to regulate blood sugar levels, lipid metabolism, and cardiovascular function.
Berberine Synergy is said to contain 400 mg of berberine and 100 mg of ALA per capsule. Designs for Health claims that this combination takes advantage of the benefits of both compounds.
This product is said to be gluten-free, dairy-free, soy-free, non-GMO, and vegan-friendly. It is targeted at adults looking to support their overall metabolic health.
But are all these claims true? The remaining sections of this review will shed more light on this.
How Does Berberine Synergy Rate According to Our Experts?

Brand Highlights
- Founded in 1989
- Family-owned company
- Claims to be recommended by USA Functional Medicine Professionals
- Claims to comply with FDA Good Manufacturing Practices (GMPs).
- Claims to be known for practitioner-recommended supplements.
- Claims to focus on creating high-quality and clinically formulated products.
Key Ingredients
- Berberine HCl
- Alpha Lipoic Acid (ALA)
Pros
- Combines berberine and ALA.
- Vegan, non-GMO, gluten-, soy-, and dairy-free.
- 30-day money-back guarantee.
Cons
- Price may not suit all budgets (relatively more expensive than similar products).
- Effectiveness may vary from person to person.
- The return policy is strict, stressful, and complicated.
- It could cause side effects such as stomach upset.
- Capsules must be taken with meals, which may not suit everyone’s routine.
- Mixed reviews about its impact on blood sugar and cholesterol levels.
About the Brand
Berberine Synergy is produced by Designs for Health, a company that claims to specialize in creating products backed by clinical research and designed to support various aspects of health.
Based in the USA, Designs for Health claims that its supplements are made in facilities adhering to quality control standards. The brand emphasizes using vegan, gluten-free, and non-GMO ingredients, which they claim aligns with their commitment to clean and effective formulations.
Designs for Health primarily distributes its products online and through practitioners, which could limit direct accessibility. Additionally, its complex return policy raises concerns about the brand’s approach to customer satisfaction.
How Does Berberine Synergy Work?
Berberine Synergy works by combining berberine hydrochloride and alpha lipoic acid (ALA), which they claim supports metabolic health, blood sugar regulation, and cardiovascular function.
Berberine is believed to activate an enzyme called AMP-activated protein kinase (AMPK), which regulates cellular metabolism. ALA, on the other hand, is a potent antioxidant that aids in reducing oxidative stress and supporting mitochondrial function.
Together, these ingredients aim to promote healthier glucose metabolism and protect cells from damage caused by free radicals. However, individual results vary based on factors like diet, lifestyle, and existing health conditions.
Berberine Synergy Ingredients – Are they Safe and Effective?
Here are the key ingredients in Berberine Synergy:
Berberine HCl
Berberine HCl is a plant-derived alkaloid that plays a role in regulating blood sugar levels and improving metabolic health. It helps to activate AMPK, which may enhance glucose uptake and stimulate lipid oxidation to produce energy. It may also reduce glucose production in the liver and improve insulin sensitivity.
Our Berbamax Reviews (another supplement with this ingredient) highlight that berberine supports balanced blood sugar levels and healthy lipid metabolism.
Jun Yin (a researcher at Pennington Biomedical Research Center, Baton Rouge, Louisiana, U.S.A.) and his fellow researchers say in their report, In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.
Alpha Lipoic Acid (ALA)
Alpha lipoic acid is an antioxidant included to complement the effects of berberine. According to research in Free Radical Biology and Medicine, ALA helps reduce oxidative stress and support mitochondrial function.
As discussed in our ExoBurn Review (another supplement containing this ingredient), it plays a role in glucose metabolism. This facilitates the conversion of glucose into energy and also enhances the body’s sensitivity to insulin.
This ingredient is intended to enhance the antioxidative properties of the product and may contribute to its cardiovascular and metabolic benefits.
How to Use Berberine Synergy?
Here’s how to use Berberine Synergy:
- Take one capsule per day with a meal, as food may enhance absorption and minimize potential stomach discomfort.
- For additional support or as directed by a healthcare practitioner, the dosage may be increased to two capsules daily.
Avoid exceeding the recommended dose unless advised by a medical professional. Store the capsules in a cool, dry place to preserve potency and prevent spoilage.
Benefits of Berberine Synergy
Here are some of the potential benefits of Berberine Synergy as claimed by the manufacturer:
- Supports Blood Sugar Regulation
- Promotes Lipid Metabolism
- Antioxidant Support
- Supports Cardiovascular Health
The supplement is said to help maintain healthy blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver.
They claim it can support normal cholesterol and triglyceride levels, which contributes to better cardiovascular health.
The inclusion of alpha lipoic acid is said to provide antioxidant properties that may protect cells from damage caused by free radicals.
Designs for Health claims that the product may help improve overall heart health by supporting healthy lipid levels and reducing oxidative stress.
Side Effects of Berberine Synergy
Berberine Synergy is claimed to be safe for most individuals due to its natural and allergen-free formulation. However, some users might experience minor side effects, including:
- Digestive discomfort such as bloating, diarrhea, or nausea, particularly if taken on an empty stomach.
- A slight drop in blood sugar levels, which could cause lightheadedness in sensitive individuals.
- Mild headaches or fatigue reported by some users, possibly related to changes in blood sugar levels.
If these symptoms persist or worsen, it is advised to stop using the product and consult a healthcare provider.
Is Berberine Synergy Safe to Use?
Berberine Synergy is considered safe for most adults when taken as directed. The product is vegan, gluten-free, non-GMO, and free from common allergens like soy and dairy. This may reduce the risk of adverse reactions for most users.
However, individuals with medical conditions such as diabetes or those taking medications that affect blood sugar should consult a healthcare provider before use. Pregnant or nursing individuals are also advised to seek medical advice.
Additionally, it is associated with side effects like stomach discomfort or low blood sugar, though it’s claimed to be mild.
Berberine Synergy Price
Berberine Synergy is priced to cater to various budgets, with options for single purchases or bulk deals:
- Single Bottle: A 60-capsule bottle is priced at $47.25, which provides a one-month supply if taken as directed.
- If you subscribe to their auto-ship package, you’ll save 5% on your order. This brings a single bottle to $44.89.
Looking to purchase? You may find Berberine Synergy available on platforms like Amazon or Walmart, giving you even more options to shop conveniently.
Berberine Synergy Review – FAQs
Q: Who can use Berberine Synergy?
A: Berberine Synergy is intended for adults looking to support their metabolic and cardiovascular health. Individuals with specific medical conditions should consult their healthcare provider before use.
Q: How should I take Berberine Synergy?
A: The recommended dosage is one capsule per day with a meal. Your healthcare practitioner may suggest adjustments based on your needs.
Q: Can I take Berberine Synergy if I am on medication?
A: Individuals taking medications, especially those for diabetes or high blood pressure, should consult a healthcare provider before using this product to avoid potential interactions.
Q: Is Berberine Synergy safe during pregnancy?
A: The manufacturer advises pregnant or nursing individuals to consult their healthcare provider before using this supplement.
Q: Does it have a return policy?
A: Yes, Berberine Synergy comes with a return policy with a 30-day money-back guarantee. However, their return policy is strict, and you may want to read it in detail before purchasing.
Berberine Synergy Customer Review
based on 615 user feedback.
Some customers appreciated its claimed benefits.
For example, Clara said, After a few weeks, my blood sugar levels seemed more stable, and I felt less fatigued.
Similarly, John noted, It helped me manage my cholesterol levels better than expected.
However, others expressed dissatisfaction. Lisa shared, I didn’t notice any significant changes even after a month.”
Another user, Mark, commented, It upset my stomach, and I had to stop taking it.
These mixed reviews suggest that while some users see results, others report no benefits or mild side effects, which highlights the variability in individual responses.
Berberine Synergy Review – Conclusion
Berberine Synergy claims to support metabolic health, regulate blood sugar, and promote cardiovascular function with its combination of berberine and ALA. Its vegan and allergen-free formula is a feature that looks appealing to those with dietary restrictions.
However, customer reviews are mixed, with some users reporting noticeable improvements and others experiencing little to no benefit. Also, its high price and strict return policy also create significant concerns for potential buyers.
While Berberine Synergy may work well for some individuals, its inconsistent results suggest it might not be the best option for everyone. So, you may have to check out other alternative supplements that are more affordable and more customer-friendly with their policies.
Below you'll find some of the most effective blood sugar products on the market today, in our opinion.
Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned Blood Sugar Supplements based on the available research:

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