Nuzena D-Mannose Natural Defense + Review: Is It Worth Buying?

Nuzena D-Mannose Natural Defense + guards against UTIs, promotes healthy bladder and liver function. Learn more in our comprehensive review.

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In This Review

Overview Of Nuzena D-Mannose Natural Defense +

Urinary issues can, unfortunately, take a lot of forms. But perhaps the most common issue regarding urinary health is urinary tract infection. The Mayo Clinic[1] defines urinary tract infection as:

A urinary tract infection (UTI) is an infection in any part of the urinary system. The urinary system includes the kidneys, ureters, bladder, and urethra. Most infections involve the lower urinary tract — the bladder and the urethra.

The worst part is that severe urinary tract infections can cause bodily pain in the lower back and on the side. UTIs can even cause fever and other serious symptoms if left unchecked.

And while urinary tract infections affect both men and women, it is a much more common condition for women[2]. So today, we will be taking a look at D-Mannose Natural Defense + which is a supplement that aims to help the user avoid UTIs altogether. Is this supplement worth it? Find out in the following D-Mannose Natural Defense + review.

What is D-Mannose Natural Defense +?

D-Mannose Natural Defense + is a natural supplement that can reduce the occurrence of urinary tract infections. It can also reduce the severity of urinary tract infections when you get them.

The formula for D-Mannose Natural Defense + includes pure ingredients that have been responsibly sourced. It has also been developed by dietitians, food scientists, and healthcare professionals.

Aside from UTIs, D-Mannose Natural Defense + can help improve the health of your bladder in general. This supplement also has a formula that is beneficial for liver detoxification.

As a result, it can help reduce the likelihood of non-alcoholic fatty liver conditions that could have broad-ranging disadvantages to your health.

D-Mannose Natural Defense + is a supplement that is free of harsh chemical additives so it should be perfectlysafe for most adult users. It takes a hollistic approach to bladder and urinary tract health.

How Does D-Mannose Natural Defense + Rate?

Overall Rating: 4.7
D-Mannose Natural Defense +D-Mannose Natural Defense +


Value for Cost

4.6/5Value for Cost



Brand Highlights

  • Nuzena sustainably sourced ingredients
  • The brand produces natural supplements
  • They offer free health consultations
  • Products are 3rd party tested

Key Ingredients

  • D-Mannose
  • Cranberry juice powder
  • Hibiscus flower extract
  • Dandelion root extract


  • It helps reduce UTIs
  • It supports good bladder health
  • Natural support for liver detoxification
  • Supports joint health
  • Promotes cellular rejuvenation
  • The formula is vegan-friendly


  • May not be eligible for free shipping
  • Individual results may vary

You can BUY it directly from the Official Website

Who is the Manufacturer of D-Mannose Natural Defense +?

D-Mannose Natural Defense + is produced by a company called Nuzena. Nuzena focuses on natural supplements that meet good manufacturing practices and their products are made in the United States.

The company is predicated on using integrative health solutions for their products. That’s why all of their supplements use natural ingredients that have been proven in modern clinical trials.

In order to provide an all-inclusive approach to health and well-being, Nuzena also provides free health reporting and personalized consultation for their customers. This allows them to suggest products that best match the individual’s health goals.

How Does D-Mannose Natural Defense + Work?

The main function of D-Mannose Natural Defense + is to help reduce the occurrence of urinary tract infections. According to the Cleveland Clinic[3] staff:

Microorganisms — usually bacteria — cause urinary tract infections. They typically enter through your urethra and may infect your bladder. The infection can also travel up from your bladder through your ureters and eventually infect your kidneys.

Urinary tract infections cause burning in the urethra, inflammation of the various tubes connected to your bladder and can make it feel like you aren’t completely evacuating your bladder when you urinate.

The ingredients in D-Mannose Natural Defense + are rich sources of antioxidants that have been shown to reduce the severity of urinary tract infection conditions[4]. These same antioxidants can also help reduce the inflammation that is characteristic of bladder infections and urethral agitation.

D-Mannose Natural Defense + Ingredients – Are They Safe & Effective?

Take a look at the following breakdown of D-Mannose Natural Defense + ingredients:

D-Mannose Natural Defense + supplement fact

D-Mannose Natural Defense + supplement fact


D-mannose is a form of natural sugar that is similar to glucose and occurs naturally in the human body. However, it has been especially effective in reducing the occurrence of UTI in test subjects[5].

The average recurrence of UTI without D-mannose supplementation was 50 days whereas D-mannose supplementation extended the length between urinary tract infection occurrences to 200 days, as we also explained in article of Gundry MD Lectin Shield Reviews.

Cranberry Extract

Cranberry extract is naturally rich in polyphenols and antioxidants. In a study review conducted by Cochrane[6], it was found that:

Taking cranberries as a juice, tablets or capsules reduced the number of UTIs in women with recurrent UTIs, in children with UTIs and in people susceptible to UTIs following an intervention such as bladder radiotherapy.

So we can see that cranberry supplementation, in almost any form, is beneficial for men, women, and children who frequently get UTIs or have just undergone a procedure that typically causes the infection.

Hibiscus Flower

Hibiscus flower has been observed in some studies to help reduce fatty liver conditions and improve liver health overall. In our Herbaly review, it is noted to lower blood pressure levels and support heart health. And in a Pubmed report[7], we see that:

Anatomic changes revealed that HSE (hibiscus sabdariffa extracts) improved the illness of liver steatosis. Ingestion of HSE was well tolerated and there was no adverse effect during the trial. No alteration was found for serum ?-amylase and lipase.

From this statement, we can see that hibiscus flower extract can help prevent serious illnesses such as non-alcoholic fatty liver disease and proliferate liver detoxification.


Dandelion root extract is actually a very nutrient-dense substance, even as it is considered a common and invasive weed. Dandelion extract is rich in vitamins A, B, C, and D as well as healthy minerals.

Dandelion root extract can also help remove excess fluids from the liver which helps to prevent liver issue. Studies have also suggested that dandelion root extract supplementation can improve gallbladder and liver function[8].

You can BUY it directly from the Official Website

Benefits of D-Mannose Natural Defense +

Some of the most important D-Mannose Natural Defense + benefits include:

Improved Liver Function: D-Mannose Natural Defense + can help prevent fluid buildup in the liver and excess fatty tissue.

Less frequent UTIs: It can also significantly reduce the occurrence of urinary tract infections.

Better Bladder Health: By eliminating the bacteria associated with UTI, D-Mannose Natural Defense + can keep the bladder functioning normally.

Antioxidant Support: Both cranberry and D-mannose are potent sources of antioxidants that can help reduce free radical damage.

Nuzena D-Mannose Natural Defense + Review – FAQs

Q: What are the side effects of D-Mannose Natural Defense +?

A: There have been no side effects reported by confirmed users but it is still a good idea to ask your doctor before taking any kind of supplement.

Q: Is D-Mannose Natural Defense + safe?

A: Yes. D-Mannose Natural Defense + is made with natural ingredients that are well-tolerated in the body.

Q: Who should use D-Mannose Natural Defense +?

A: Yes. D-Mannose Natural Defense + is made with natural ingredients that are well-tolerated in the body.

Q: Who should use D-Mannose Natural Defense +?

A: D-Mannose Natural Defense + is good for any adult user who often gets urinary tract or bladder infections.

Q: What is the return policy?

A: Consumers can return D-Mannose Natural Defense + for a refund within 30 days of the date of purchase.

Q: How to take D-Mannose Natural Defense +?

A: The instructions are to take 2 capsules of D-Mannose Natural Defense + a day with a meal.

Q: What sets D-Mannose Natural Defense + apart from the competition?

A: D-Mannose Natural Defense + included dandelion extract which is an uncommon but effective ingredient in supplements like this.

Q: Where to buy D-Mannose Natural Defense +?

A: You can get D-Mannose Natural Defense + on 3rd party retail sites and the Nuzena site. On the Nuzena site, a single bottle costs $40 but you can get it for $34 if you sign up for the subscription service.

What Do the D-Mannose Natural Defense + Reviews Say?

The D-Mannose Natural Defense + reviews have been very positive so far and mention things like:

D-mannose has really changed my life, sounds fake but it is true, I used to get UTIs all the time and the antibiotics were very strong and I was taking them often, I have not had a UTI since I’ve starting taking D-mannose, which is around 4 months. –Ann Gallagher

I often get UTIs, I have been reading up on this, the team at Nuzena gave me a lot of information, just received my order. –Faith Petty

My mother is wheelchair bound and gets UTIs often, I bought her these last month and she was very pleased with them so I am buying more. –Layla Carroll

My nurse mentioned dmannose because I am am always in for bladder infections, I am willing to try. Thank you –Tori Hammond

Nuzena D-Mannose Natural Defense + Review – Conclusion

D-Mannose Natural Defense + is a natural supplement that represents a safe solution if you get urinary tract infections often. The D-Mannose Natural Defense + reviews have been phenomenal which is a great sign for a supplement like this.

The health benefits of D-Mannose Natural Defense + are vast too. It can make it more comfortable to relieve your bladder, reduce your risk of serious bladder infections, and reduce the pains associated with UTI.

Plus, it’s made without the use of gluten or GMOs so it is safe for most adult users. For effective urinary tract infection relief we recommend D-Mannose Natural Defense +.

Where To Find It?

Pick it up on the Nizena Official Website

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for D-Mannose Natural Defense +

Nuzena D-Mannose Natural Defense + Review: Is It Worth Buying?

Customer Reviews & Ratings

5.0 out of 5

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  1. Katherine

    Effective and Reliable!
    I have struggled with urinary tract issues for quite some time, and Nuzena D Mannose Natural Defense + has been a game-changer for me. This supplement is not only effective but also reliable. I noticed a significant improvement in my symptoms within a short period. I highly recommend it to anyone dealing with similar issues.

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D-Mannose Natural Defense +
60 Capsules
D-Mannose, Cranberry juice powder, Hibiscus flower extract and Dandelion root extract

8 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Urinary Tract infection (UTI):
[2] Recurrent Urinary Tract Infections Management in Women:
[3] Urinary Tract Infections:
[4] Use of antioxidants in urinary tract infection:
[5] Why d-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections—Preliminary Considerations and Conclusions from a Non-Interventional Study:
[6] Cranberries for preventing urinary tract infections:
[7] Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans:
[8] Dandelion:

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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