The Best Diet Pills (2022) – Learn The Science

Here are the best and highly rated diet pills and supplements of 2022.

Which Diet Pills Really Work?

With as much as 45% of overweight and 67% of obese Americans trying to lose weight[1], we should suspect that the demand for diet pills is huge.

The Best Diet Pills (2022) – Learn The Science
Popular fast weight loss pills and supplements reviewed. Shutterstock Images

In fact, “The U.S. Weight Loss & Diet Control Market” study found that the demand for dietary aids of all kinds reached $55 billion in 2007 alone[2].

Such high numbers mean that the market is flooded with all kinds of products making your search for safe diet pills easy and challenging at the same time.

We can use a little help from ‘SCIENCE’ – aka a good, trustworthy diet supplement that can help suppress your appetite, kick start your metabolism, and give a little hand to your weight loss journey!

To help you find top-rated diet pills that are both safe and effective, we explain the most effective weight loss pills that actually work and review some of the best diet pills for women and men in 2022.

The Need for Diet Pills

Experts agree that the best and most effective way to lose weight is through calorie restriction, healthy eating, and exercising. Because such lifestyle and dietary modifications can be difficult to maintain, many people turn to dietary supplements in the hopes of losing weight.

While the need for weight loss treatments is definitely high in countries such as the United States, scientists believe that these pills won’t help anyone lose weight when not used in conjunction with a healthy eating and exercising plan.

What to Look for in the Best Diet Pills?

As explained by the National Institute of Health (NIH[1]), many weight-loss supplements tend to be rather costly and their efficiency is highly debatable.

According to the U.S. Government Accountability Office, some supplements were found to be potentially harmful[3] so consider product safety before buying these pills. And because some of the ingredients in these pills were found to interact with certain medications, it is important to talk to your doctor before taking them.

In short, the NIH suggests researching what is known and what is not known about the ingredients in these dietary supplements before taking them.

15 Best Diet Pills for 2022

We’ve researched the most popular diet pills available on the market and picked out the 15 best weight loss pills for women and men (reviewed by science) in terms of safety and efficiency.

Here is our top 15 best weight loss products to help you achieve your weight loss goals.

#1 PhenQ

This is a dietary supplement that promises to help you shed weight and maintain overall good health.
How it works:The nutritional supplement contains active ingredients that help one lose weight in five different ways.
The first is thermogenesis, where the body gets a boost to accelerate the trimming of stored fat.

Second, it helps prevent fat storage by preventing the formation of new fat cells. Also, PhenQ claims to act as an appetite suppressant by making hunger cravings more manageable.

Ingredients:The prominent ingredients in this product are Capsimax powder, which is a blend of capsicum, caffeine, piperine, and niacin (vitamin B3), Calcium Carbonate, Chromium Picolinate, caffeine, nopal, and L-Carnitine Furmarate.

Effectiveness:The final way PhenQ helps with weight loss is by boosting one’s mood to prevent crankiness which may come up during dieting.
Additionally, the supplement contains caffeine, which will boost one’s energy levels so they can be more active and shed stubborn weight naturally.

Click here to learn more about this product.

#2 Slendarol

If you are looking for a natural way to lose weight, Slendarol may be the ideal choice for you. This vegan-friendly and scientifically best proven weight loss pills, made by Vita Balance, promises to help you lose weight through your diet and maintain overall health.

How it works: The product is said to help you lose extra pounds by burning fat, preventing further accumulation of fat, suppressing appetite, and reducing calorie intake. It is also said to boost metabolism for long-term benefits.

Ingredients: The ingredients include raspberry ketone, green coffee, green tea, and Cambogia garcinia which are the best fat-burning supplement. The excellent ingredients available in the product are said to help you lose weight through diet and exercise.

Effectiveness: The product works by giving the body the energy it needs as the manufacturer claims to use a natural formula that has been studied to ensure it works without the nervousness for which conventional diet pills and fat burning pills to help lose weight are known.
It is recommended to take 2 Slendarol capsules daily while having your meal.

Click here to learn more about this product.

#3 Phen24

These weight loss supplements is manufactured by Wolfson Berg Limited, a company known for sports and fitness products.

How it works: Phen24 is the best weight loss supplement for men and women designed to target fat cells in the body, prevent the building of extra fat, reduce weight during the day, and trigger your body’s metabolism.  

Phen24 supplement is also said to come in two types of pills; day and night. The daily pill is said to work on quickening the process of thermogenesis, while the night pill is said to work on killing midnight cravings, reducing stress hormones, and regulating sleep.

Ingredients: It is made using all-natural ingredients in the proper proportion. A lot of health supplement products are said to have used mainly all the ingredients used in this product because of the properties they contain.
It claims that only ingredients that have been shown to be effective in clinical studies have been added to the Phen24 formula.
It also claims that all the ingredients contained in the supplement have been refined to ensure a maximum concentration, leading to a more effective product for people who have a hard time losing weight.

This fat loss supplement is likely to be safe, and it is recommended to take one day pill in the morning with breakfast, and at night, you take two-night pills. It is advised to take it 15 minutes before meals and drink it with a glass or two of water.

Click here to learn more about this product.

#4 Forskolin 250

Another great supplement by Wolfson Berg Limited, Forskolin 250, is said to reduce weight loss by strengthening your metabolism and generating suitable enzymes.

How it works: Forskolin 250 is a natural dietary supplement and is an advanced product known to increase metabolism.
Along with being a solution to many other health problems, there are claims that the product has proven to be a supplement for weight loss. Each 250 mg dose helps get rid of excess fat and brings you a step closer to your body’s goals.

Ingredients: Forskolin 250 is obtained from the root of the plant Coleus forskohlii. Unlike other dietary supplements, this product has only two other ingredients in addition to Forskolin. The ingredients are Brown Rice Flour and Magnesium Stearate.

The active ingredient found in this supplement is also said to be used to treat other health ailments. Therefore, it is recommended to take two tablets a day. Take one while having breakfast and the other for lunch or whatever suits you better. It is also advised to drink plenty of water after taking the tablet.

Effectiveness: It is said to be a healthier alternative to conventional but aggressive supplements.
Click here to learn more about this product.

#5 Garcinia Extra

Garcinia Extra is a dietary supplement that can be used alongside a weight loss program to speed up a person’s results.

How it works: The manufacturers of this supplement claim that garcinia extra aids in the loss of weight by “reducing the ability of the body to absorb fat,” “toned muscles replaced by fat,” “improving mood,” and subduing “the drive to respond to stressful situations with food.”
It is advised to take two Garcinia Extra capsules daily, ideally, 20-30 minutes before a meal, along with a sensible diet and exercise program.

Ingredients: The product is said to be made from only natural weight loss supplements to help lose weight and will not expose the user’s body to any type of potentially harmful chemicals.

Effectiveness: The likely downside to the product can be that; though it is said to be safe, the user may still experience some side effects such as dizziness, headache, dry mouth, or an upset stomach. Because of the ingredients present in the product, it is advised that you should stay away from this weight loss medication or consult your doctor before use if you have any health problems.

The product is available on the manufacturer’s website and other retailers online.

Click here to learn more about this product.

#6 Phen375

PHEN 375 It is a weight loss supplement that is formulated to target the fat cells in the body and prevent the formation of extra fats.

How it works: It works by increasing body metabolism, suppressing appetite, and enhancing the body’s ability to burn excessive amounts of fat accumulated within the user’s body. The entire Phen375 formula has been developed by a team of scientists and weight loss experts, and the components are based on scientific research.

Ingredients: Only ingredients that have been proven effective through clinical studies have been added to the Phen375 formula. It should be noted that all ingredients in the product have been highly refined to ensure a sufficient concentration; thus leading to a more potent product for individuals who are having a hard time losing weight effectively.

Effectiveness: Phen375 has not been developed to be used alone. The supplement should ideally be combined with an exercise program and, of course, a diet that contains a lot of healthy foods and excludes the consumption of unhealthy foods that are high in sugars and fats.

The product can be purchased directly from its official website and will be shipped directly to the customer after they have completed the payment for their order.

Click here to learn more about this product.

#7 Green Coffee Plus

Green Coffee Plus is a safe weight loss pill that contains green coffee bean extract as the main ingredient to promote the natural shedding of weight.

How it works: It is the best metabolism booster pills for weight loss. The product claims to boost metabolism enabling the body to use up all the stored fat and calories for energy. It also claims to increase the melting of fats through an increase in energy so you can burn up more fat during your daily activities.

Ingredients: Green coffee bean extract contains an active compound known as called chlorogenic acid that helps one lose weight fast.
This supplement comes in a bottle that contains 60 capsules, two for each day. Made with natural ingredients, this supplement contains a High Potency Green Coffee Bean Extract in its pure form for its full effects and 50% chlorogenic acid, which is the potent ingredient responsible for weight loss.

Effectiveness: Besides weight loss, Green Coffee Plus may help eliminate free radicals that may be harmful to one’s health. It is the best pill to lose belly fat also the best natural weight loss pill.

Click here to learn more about this product.

#8 Keto Fuel

Keto Fuel is a weight loss supplement that is available in powder form.

How it works: To understand how Keto Fuel works, we’d have to learn more about ketosis. The supplement relies on the body’s metabolic state known as ketosis, which means that the body will use fats for energy instead of carbs.

When taken in between meals, before a workout, or in the morning, this supplement is supposed to provide all the electrolytes and energy needed for the day. The product contains BHB as the primary ingredient, and its role is to kick-start the body’s metabolic state.

Ingredients: The nutritional drink provides all the necessary nutrients to maintain a low-carb state leading to weight loss.
Keto Fuel powder should be mixed with oil and water to make a complete meal. It claims to provide all the calories you need, from 1200-2500, depending on how much oil you add to the mixture.

This product is gluten-free, soy-free, dairy-free, nut-free, and vegan.

Click here to learn more about this product.

#9 Vysera CLS

Vera CLS is a dietary supplement that can be used alongside a weight loss program to speed up the results a person can achieve.

How it works: The combination of components may not only be used for cutting down on the accumulated fat in the body but may also be beneficial for individuals who would like to build some muscle mass while they are losing weight.

While not a lot of information can be found regarding the manufacturer of Vysera CLS, and there is also a lack of details regarding the particular product, we did notice contact details are provided on the product’s official website.

Thus, individuals who require more details or have questions can utilize these details to get in touch with the manufacturer of the supplement.

Ingredients: The product is made from only natural ingredients and will not expose the user’s body to any type of potentially harmful chemicals.
The key ingredients found in this supplement include L-Lysine, L-Arginine, and Oxo-Proline. The combination of components may not only be used for cutting down on the accumulated fat in the body but may also be beneficial for individuals who would like to build some muscle mass while they are losing weight.

Effectiveness: The downside to the product is the fact that it is quite pricey, especially when you look at the ingredients and compare the product to some of the competitors currently available on the market.

A single bottle of the product will cost the customer $99, and will only last for 30 days. A subscription plan is available, which will reduce the cost of the product to $79.20 per 30-day supply.

Click here to learn more about this product.

#10 GC 180 XT

Another all-natural supplement, GC 180 XT claims to offer weight loss benefits with the help of the extract from the Garcinia Cambogia fruit which several studies found helped aid in weight loss.

How it works: The product allegedly helps you lose weight by suppressing your appetite and simultaneously inhibiting the accumulation of fat cells in your body.

Both of these functions are beneficial for any individual looking to lose weight. By suppressing the user’s appetite, cravings will not cause the user to continually opt for potato chips, burgers, pizza, and other unhealthy choices when they are in-between meals.

Ingredients: The fact that the accumulation of fat cells is inhibited by the active ingredient found in GC 180 XT also means that the individual will be at a significantly lower risk of gaining more weight.

The product contains three additional ingredients such as chromium which helps regulate blood glucose levels, and calcium, and potassium, which helps in the absorption of Garcinia Cambogia.

Effectiveness: All of the ingredients found in GC 180 XT is considered safe and should not cause any unpleasant side effects to occur.

This particular supplement utilizes one of the most popular ingredients in the weight loss industry at the moment, but for some individuals, it may be too expensive. Some cheaper alternatives may exist on the market.

Click here to learn more about this product.

#11 Meratrim Platinum+

One factor that sets Meratrim Platinum+ above many competing products that are available on the market at the moment is the fact that this product has many positive reviews on the internet.

How it works: By utilizing this specific combination of the two ingredients, users are expected to experience visible results in their weight loss efforts within one to two weeks after a user has started taking the supplement daily.

It should be noted, however, that the product should be combined with exercise and healthy eating options to experience positive results.

Ingredients: Meratrim Platinum+ contains two main ingredients – the extracts from Sphaeranthus indicus and Garcinia mangostana. The two herbal extracts were chosen because one study published in The Journal of Medicinal Food found the combination of these two herbs was a well-tolerated and effective aid in weight management.

The combination will also provide more impressive results as compared to using either one of these particular ingredients individually.

Effectiveness: It is quite difficult to find weight loss products with a lot of positive reviews lately since there are simply too many products on the market today – all claiming to provide fast and effective weight loss results. This supplement costs $40 per bottle, and each bottle contains 60 capsules. Two capsules should be taken every day.

Click here to learn more about this product.

#12 PGX Daily Ultra Matrix

PGX Daily Ultra Matrix is another effective weight loss supplement that is also backed by a large number of positive reviews and testimonies, which can be found on the product’s official website, as well as third-party store listings, such as at

How it works: The supplement utilizes a unique proprietary blend, known as PGX or PolyGlycopleX. This exclusive blend has been developed to assist with offering the user a significant reduction in appetite and cravings; thus providing the perfect solution for individuals who find themselves craving food between the main meals in their day.

The proprietary blend is made from plant-based fibers that absorb water inside the stomach, and then slowly expand. This causes an increase in fullness and also helps to slow down the rate at which glucose is released into the user’s bloodstream.

Ingredients: PGX Daily Ultra Matrix is an all-natural supplement and only includes plant-based ingredients. The supplement does not contain any gluten. It is also a stimulant-free product, which makes it perfect for individuals who are sensitive to products that do include stimulants.

Effectiveness: The product also contains a unique delivery system that increases the efficiency of the product – the soft gel capsules are also easy to swallow, making the product more convenient than many of its competitors.

Click here to learn more about this product.

#13 Skinny Fiber Pills

Skinny Fiber is a product manufactured by Skinny Body Care that uses only 100% natural ingredients.

How it works: As the name of the supplement suggests, Skinny Fiber primarily relies on a variety of fibers to assist a user in reaching their weight loss goals.

The main goal of the product is to assist with improving digestive health by including individual fibers, but also to slow down metabolism at the same time – this, in turn, will help to provide a noticeable reduction in the user’s hunger, especially at times when they are most likely to experience cravings.

The product should be taken before a meal with lots of water so that the fibers could absorb the water and create bulk which, of course, creates a feeling of fullness. This is something you get from food sources of fiber and is completely safe and natural.

Ingredients: The Skinny Fiber dietary supplement contains herbal extracts from Glucomannan, Cha De Burge, and Caralluma Fimbriata. The product also contains digestive enzymes to help in digestion and to speed up the burning of fat.

Effectiveness: All of the ingredients found in the Skinny pill have been deemed safe and will not cause the user to experience any adverse reaction that could be harmful to their wellbeing. It should be noted that, in addition to controlling appetite through the inclusion of fiber, this supplement is also beneficial for blood glucose and cholesterol levels.

Click here to learn more about this product.

#14 ProBioslim

probiotic is a probiotic weight loss supplement whose popularity is quite evident by its high presence on the market. You can find the product on many lifestyle company websites, at many retail stores like Wal-Mart, and you can also buy the product on Amazon.

How it works: The fact that ProBioslim focuses on introducing a particular strain of probiotics to the user’s body is unique to this product, and also beneficial. It is known that a healthy microbiome leads to more natural weight loss – and probiotics are harmless to the body; thus meaning the product is also safe.

The fact that ProBioslim focuses on introducing a particular strain of probiotics to the user’s body is unique to this product, and also beneficial. It is known that a healthy microbiome leads to more natural weight loss – and probiotics are harmless to the body; thus meaning the product is also safe.

Ingredients: The primary ingredient of ProBioslim is a probiotic named LactoSpore Bacillus Coagulans, but this is most certainly not the only ingredient that can be found in this supplement.

In addition to this probiotic, the supplement also contains Green Tea Extracts, Ficus Carica Fruit Extracts, Actinidia Deliciosa Fruit Extracts, Camellia Sinensis Leaf Extract, Caffeine, Carica Papaya Fruit Extract, and a proprietary blend called the LS3664 Whole Health Superblend.

Effectiveness: Numerous testimonies and reviews can be found on the internet about this product, with most of these reviews stating the user was able to experience a variety of benefits when they used ProBioslim to help them lose weight.

Click here to learn more about this product.

#15 Leptigen

Leptigen is a relatively popular weight loss supplement that primarily acts upon the user’s metabolism and blood sugar levels.

How it works: The product helps to slow down metabolism, which helps to make the user feel fuller for a longer period after they have had a meal.

The benefits provided to blood sugar levels help to diminish cravings during the day; thus making the user less likely to opt for foods that are not good for their health – or their weight – during the day.

The product includes a variety of natural ingredients and avoids the use of any chemicals that could do more harm than good to the user’s body.

Ingredients: The main ingredients of Leptigen include Chromemate, Green Tea Extracts, Caffeine, and a proprietary blend known as Meratrim, which contains Garcinia Mangostana and Sphaeranthus extracts.

One particular advantage that Leptigen has over competitors is the fact that their formula has been tested in two different clinical trials. Both of these clinical trials provided positive results, and the participants were satisfied with the weight loss they were able to achieve while utilizing the product.

Effectiveness: Leptigen is backed by many testimonies where customers claim to lose weight effectively while using this supplement. The product has not been associated with any side effects, and many individuals who take the supplement also experience a significant boost in their energy levels.

Click here to learn more about this product.

Do Diet Pills have any Side Effects?

According to the U.S. Government Accountability Office, side effects[3] from these pills tend to be mild in most cases and include unpleasant digestive symptoms, sleeping problems, and rashes.

However, some ingredients, such as dehydroepiandrosterone (DHEA) were associated with an increased risk of certain cancers. So reading the product label and researching product safety is a must when choosing your diet pills.

Are Weight Loss Pills Effective?

The answer to this question is very complicated – yes and no. Diet and weight loss tablets can work, but they are most certainly not magic pills that will cause fat to be burnt excessively without any effort from the user’s side. There are no guaranteed weight loss pills.

For diet pills to effectively work, a user needs to implement a healthy eating plan that includes fewer calories than the number of calories they will use during the day, and the user also needs to implement a practical workout routine into their schedule.

Diet pills usually help to speed up the rate at which fat is burnt during exercise or help the user better control their cravings by making them feel fuller for longer.

When a weight loss pill is used without implementing these additional efforts, then it is most likely only going to end up being a waste of money from the user’s side.

How Long will it take to Show Results?

Results largely depend on your overall health status, your current diet and exercising program, and the type of pills used.

Because these supplements do not weight loss drugs meant to treat medical conditions but rather natural additions to your regular diet, there is no absolute time limit for them to kick in like in cases of pharmaceutical drugs.

WARNING: It is important to research carefully before choosing any extreme weight loss pill, as some may have side effects, or interact with existing conditions. Always consult with your physician before taking these or any other kind of pill or dietary supplement!

What are the Popular Ingredients in Diet Pills?

Today’s diet pills contain ingredients that aid in weight loss either by increasing feelings of satiety, reducing appetite, or affecting the metabolic rate. These ingredients are usually extracted from plant sources, but some are also laboratory-made.

The most popular ingredients in diet pills include bitter orange (synephrine) to speed up the metabolism and suppress appetite[4]; caffeine to increase fat oxidation; chitosan to bind dietary fat in the digestive tract, and green coffee bean extract for better fat burning.

Recommended Dosage

One of the particular appeals of a diet pill is that you, the consumer, don’t have to worry about the exact dosage of each ingredient–the nutritionists and food scientists are supposed to take care of that for you.

Some of the low-end weight loss pills may not have the appropriate dosage of their ingredients, but with a top-rated weight loss pill, you can just follow the recommended dosage on the bottle.


If you desperately want to lose weight, diet pills alone won’t make you achieve your goals. The best dietary supplements listed here are only an addition to a diet and exercise plan.

Their main mode of action is suppressing your appetite, increasing metabolic rate, aiding in fat burning, and some even aid in better digestion.

Whatever your diet pill of choice may be, make sure that it contains safe ingredients and that you follow a proper weight-loss regime.

Go Ahead & Choose The Diet Pills That You Found Best!

[1] Approximately 15% of U.S. adults have used a weight-loss dietary supplement
[2] The U.S. weight loss market reached
[3] Data on FDA’s Consumer Protection Actions Related to Dietary Supplements
[4] Common Ingredients in Weight-Loss Dietary Supplements
[5]Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans.
[6] Efficacy and Tolerability of an Herbal Formulation for Weight Management.
[7] Dietary supplements for weight loss. National Institutes of Health Office of Dietary Supplements. Accessed Dec. 18, 2017.
[8] Khera R, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: A systematic review and meta-analysis. JAMA. 2016;315:2424.
[9] Beware of products promising miracle weight loss.
[10] Zheng EX, et al. Liver injury from herbal, dietary, and weight loss supplements: A review. Journal of Clinical and Translational Hepatology. 2015;3:93.
[11] Lopez HL, et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition. 2013;10:22.

Felicia Newell, RD, CPT

Felicia Newell, RD, is a Registered Dietitian, Nutritionist, Food and Nutrition Expert, Writer, and Health Coach.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links."This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."