Rybelsus Review 2025: An Antidiabetic Drug for Weight Loss?

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What Is Rybelsus?

Rybelsus is an antidiabetic medication manufactured by Novo Nordisk, a global pharmaceutical company specializing in diabetes care.

One of the flagship products of the Rybelsus brand is Rybelsus (semaglutide), which is an oral medication used to improve blood sugar control in adults with type 2 diabetes. Another unique product under the Rybelsus brand is Ozempic (also semaglutide). Ozempic is an injectable GLP-1 RA used to improve glycemic control in adults with type 2 diabetes.

Novo Nordisk has been in diabetes care for decades and has a long history of innovation. But does this company deliver the results they promise? Let’s get to know!

Rybelsus is an oral medication developed by Novo Nordisk. It is the branded version of a generic medication called semaglutide and belongs to the class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs).

How Does Rybelsus Work?

We did some study to see if the Rybelsus by Novo Nordisk works. And here’s what we discovered.

Rybelsus (semaglutide) belongs to the class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Understanding how Rybelsus works requires an overview of the mechanism of action of GLP-1 RAs.

GLP-1 is a naturally occurring hormone produced in the gut, which regulates blood sugar levels. It promotes insulin release from the pancreas, inhibits glucagon secretion (a hormone that raises blood sugar levels), and slows stomach emptying.

Rybelsus emulates the actions of natural incretin hormones (gut peptides released by the stomach upon food consumption). This hormone plays crucial roles in regulating blood sugar levels, especially after a meal.

By stimulating insulin release from pancreatic beta cells in response to elevated blood sugar levels, Rybelsus aids in lowering blood glucose levels. And by inhibiting glucagon production, it further contributes to reducing blood sugar levels. Additionally, since Rybelsus for weight loss slows down gastric emptying, increases feelings of fullness, and decreases appetite, it can help overweight and obese people lose weight^[1].

Unlike the traditional injectable GLP-1 RAs, Rybelsus is an oral tablet. To overcome the degradation of semaglutide by dipeptidyl peptidase-4 (DPP-4), Rybelsus incorporates the SNAC (sodium N-[8-(2-hydroxybenzoyl]) caprylate) technology. This makes it more convenient to use.

But how do we know Rybelsus is effective? Research published in Drugs in R&D^[2] shows that Rybelsus showed significant reductions in HbA1c levels (a measure of average blood sugar levels over several months) and is associated with weight loss. It reduced A1C levels between 1-2% and reduced weight by 5–10 lbs.

Rybelsus Ingredient – Is It Safe & Effective?

Let’s discuss the key ingredient in Rybelsus.

Semaglutide (GLP-1 agonist):

Semaglutide stimulates the GLP-1 receptors in the body, leading to increased insulin secretion from pancreatic beta cells and decreased glucagon secretion from alpha cells. Based on research by InformedHealth.org^[3], this helps regulate blood sugar levels, particularly after meals, as highlighted in our another FuturHealth Reviews.

Dr. Richard Pratley, a Professor of Medicine at the University of Florida, states:

Semaglutide is a breakthrough medication for the treatment of type 2 diabetes. Its remarkable efficacy in reducing blood sugar levels and promoting weight loss.

Verdict: We approve of the key ingredient in Rybelsus for diabetes control. However, if your reason for taking Rybelsus is to lose weight, you should absolutely consider a more reliable weight-loss supplement.

How to Use Rybelsus?

Here’s a general guide on Rybelsus dosage:

• Before starting Rybelsus dose or making any changes to your diabetes treatment plan, it’s important to consult with your healthcare provider.
• Start with the prescribed dosage. Typically, the starting dose is Rybelsus 3mg once daily for the first 30 days. After that, the amount is increased to 7 mg once daily, the recommended maintenance dose.
• Rybelsus tablets should be taken whole with a glass of water, preferably at the same time each day. Do not crush, chew, or split the tablet.
• Take Rybelsus dose in the morning with or without food.
• Along with taking Rybelsus dosing , following a healthy lifestyle, including a balanced diet and regular physical activity, is crucial.
• Keep monitoring your blood sugar levels regularly while using Rybelsus.
• To derive the maximum benefit from Rybelsus, it’s essential to adhere to your prescribed treatment plan. Take the medication as directed, follow up with your healthcare provider regularly, and discuss any concerns or side effects that you may experience.

Benefits of Rybelsus

Rybelsus has the following benefits:

• Blood sugar control in type 2 diabetes mellitus
• Moderate weight loss (5 to 10 lbs)
• Cardiovascular benefits (reduces heart-related deaths)
• Convenient to use, especially because it is in an oral dosage form.

Side Effects of Rybelsus

While Rybelsus can effectively manage blood sugar levels and help you lose some weight, it also has some side effects you should be concerned about. Here are some of the side effects associated with Rybelsus:

1. Gastrointestinal Issues:
According to a study published in the Frontiers in Endocrinology^[4], the most frequently observed side effects of semaglutide include nausea (reported by approximately 20% of patients), vomiting (4% to 11.5% of patients), and diarrhea (4.5% to 11.3%).

2. Thyroid C-Cell Tumors:
Rybelsus has a “black box” warning on its FDA label^[5], highlighting the potential for severe or life-threatening side effects. The label also mentions that animal studies have demonstrated an elevated risk of thyroid C-cell tumors associated with Rybelsus. While the impact on humans remains uncertain, it is crucial to consult a doctor, particularly if there is a family history of thyroid tumors or related conditions.

3. Hypoglycemia:
Semaglutide, like other diabetes medications, can lower blood sugar levels. In some cases, it may cause hypoglycemia (low blood sugar). Symptoms of hypoglycemia can include sweating, dizziness, confusion, tremors, and hunger. Monitoring blood sugar levels regularly is important, especially if taking other diabetes medications alongside Rybelsus.

4. Loss of Appetite and Weight Loss:
Some individuals may experience decreased appetite and subsequent weight loss while taking Rybelsus. This can benefit people with type 2 diabetes who are overweight or obese. However, it is essential to maintain a healthy and balanced diet to avoid excessive weight loss.

5. Pancreatitis:
Although rare, reports of pancreatitis (inflammation of the pancreas) have been associated with using GLP-1 RAs^[6]. Symptoms can include severe abdominal pain that may radiate to the back, nausea, vomiting, and fever. If these symptoms occur, immediate medical attention is necessary.

Rybelsus Review – FAQs

Q: What is Rybelsus?

A: Rybelsus is the brand name for semaglutide, an oral prescription drug used to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Unlike other GLP-1 RAs, Rybelsus is taken in tablet form rather than injected.

Q: How Does Rybelsus Work?

A: Rybelsus works by mimicking the effects of a hormone called GLP-1, which is naturally produced in the body. It helps lower blood sugar levels by stimulating insulin release and reducing glucagon production, a hormone that raises blood sugar. Rybelsus also slows down the emptying of the stomach, leading to increased feelings of fullness and reduced appetite.

Q: Is Rybelsus Effective in Managing Type 2 Diabetes?

A: Yes, Rybelsus is effective in managing type 2 diabetes. Clinical studies have demonstrated that it can lower blood sugar levels, reduce HbA1c (a measure of long-term blood sugar control), and promote weight loss. It is often prescribed alongside a healthy diet and exercise to help improve overall glycemic control.

Q: Should You Use Rybelsus For Weight Loss?

A: People looking to lose weight often wonder if they should use Rybelsus since it helps users drop a few pounds. As stated earlier, Rybelsus can help overweight and obese patients lose weight.

However, when you consider how much weight you get to lose (just 5 to 10 lbs) and the cost and side effects of this drug, you’ll see that you’re better off with something tailored for weight loss that can help you lose more weight without the side effects of Rybelsus.

If you need Rybelsus for its weight-loss properties only, you should remember that it is an antidiabetic medication and can cause a dangerous drop in your blood glucose level if you’re not diabetic. Even diabetic patients should be concerned with the possible hypoglycemic effects of Rybelsus.

You’ll also need to consider the cost of Rybelsus to other weight loss supplements. The monthly cost of Rybelsus is comparable to the yearly cost of other more effective weight loss supplements. Lastly, the FDA does not approve Rybelsus for weight loss, so we do not recommend it for that purpose.

So, if your reason for taking Rybelsus is to lose weight, you should absolutely consider a more reliable weight-loss supplement such as PhenQ or BellySlim-XT.

Q: What Are the Common Side Effects of Rybelsus?

A: The most common side effects of Rybelsus include nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually mild and improve over time as the body adjusts to the medication. It is recommended to start with a low dose and gradually increase it to minimize these effects.

Q: Who Can Take Rybelsus?

A: Rybelsus is for use in adults with type 2 diabetes. It may be prescribed as an initial treatment for diabetes or as an addition to other diabetes medications, such as metformin. However, it is important to consult a healthcare professional to determine if Rybelsus suits you, as individual factors and medical history may affect its use.

Q: Can Rybelsus Help You Lose Weight?

A: While Rybelsus has weight loss effects, there are several downsides and drawbacks to using this medication for this purpose. The FDA does not approve Rybelsus for weight loss, and the side effects and costs of Rybelsus make it a poor choice for weight loss.

Q: How Much Does Rybelsus Cost?

A: $1,000 for a 30-day supply.

However, Rybelsus price can vary over time due to changes in market conditions, insurance coverage, discounts, and other factors.

Q: What are the buying options for this product?

A: You can buy it from Amazon and Walmart. Prices might differ, so make sure to check both.

Q: Is Rybelsus Legit or Scam?

A: Rybelsus is a legitimate antidiabetic medication from Novo Nordisk. While it is approved and helps manage blood sugar levels, potential side effects, high cost, and limited weight loss effectiveness should be considered before use. Consulting with a healthcare professional and exploring alternatives is advised.

Rybelsus Reviews by Customer

Drugs.com, the only website we know that allows users to post Rybelsus weight loss reviews of their prescription medications, has published numerous studies of Rybelsus medication.

Rybelsus has received an average user rating of 5.8/10 on Drugs.com’s reviews page, which is a poor score.

The top positive review is from a user named “sue”, who claimed that the product had helped with his appetite:

I started this 7mg along with 1000mg of Metformin in August of 2020 and I have lost over 65 pounds. I was insulin resistant and could not lose weight regardless of my diet. I’m 56 years old and this has been the easiest weight loss I have ever had and I have done it all. I did begin with a low-carb diet but now I eat what I want in moderation. It definitely helped with my appetite and I feel full quickly. I am under a doctors supervision and go monthly and all of my numbers are great. It may not work for everyone but for me it’s been a lifesaver.

Another user named Gumbo says,

I’ve been on rybelsus since 1 December at a dose of 3 mg. January 1 started 7mg. I don’t like taking medication and was scared of this medication due to other reviews I have read. I am very pleased with the outcome. I lost 5 lbs with very little exercise. My side effects were nausea and loss of appetite. Nausea only occurred when I ate junk food and sweets. A1c down from 7 > 6.2. Plus I do not take any other meds for diabetes. Hope my review will help others.

Verdict: We approve of this medication because it works for managing type 2 diabetes and can help users lose some weight.

Rybelsus Review – Conclusion

When evaluating Rybelsus as a treatment option for type 2 diabetes, it is essential to consider its potential benefits and drawbacks. The medication has shown promise in improving blood sugar control and aiding in weight loss, which can benefit individuals managing diabetes.

However, it is important to be aware of the reported gastrointestinal side effects and the risk of experiencing hypoglycemia associated with Rybelsus. These factors should be considered, as they can significantly impact an individual’s overall well-being and quality of life.

Another aspect to consider is the cost of Rybelsus, as it may pose a financial burden for some individuals, particularly when compared to alternative treatment options. So, if you’re only looking to lose weight with Rybelsus, there are other supplements you should consider.