Nucific Bio X4 Review – Does Bio X4 Work and Is It Safe To Use?

Bio X4 contains 12 billion CFUs, from 5 powerful Lactobacillus and Bifidobacterium probiotic strains, to help ensure smoother, more comfortable digestion.

In This Review

What is Nucific Bio-X4?

Bio X4 is a nutritional supplement that is designed to help one in weight loss management. Thus, it may assist you in achieving your desired goals and help you live a healthier life.

It’s a product that can help reduce appetite to theoretically consume fewer calories and thus minimize weight gain.

In this honest review, we’ll dive deep into the realities of this probiotic supplement. Does Bio X4 really work? Let’s find out here!

Features 4-In-1 Weight Management Probiotic
Form Capsules
Benefits Digestive Support, Energy, Immune Support, Weight Support
Ingredients Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus plantarum, Bifidobacterium lactis, Bifidobacterium animalis, Amylase, Bromelain, Lipase, Green tea extract (50% EGCG), Slimaluma
Type Supplement
  • Nucific Bio X4

    Nucific Bio X4

  • Dr. Amy Lee Nucific Bio X4

    Dr. Amy Lee Nucific Bio X4

  • Dr. Amy Lee Bio X4

    Dr. Amy Lee Bio X4

  • Nucific Probiotic

    Nucific Probiotic

Who is the Manufacturer Nucific Bio X4?

Bio X4 is manufactured by Nucific, a California-based company led by Dr. Amy Lee, Nucific’s head of nutrition [1].

Dr. Amy Lee is board-certified by the American Board of Internal Medicine, and a member of the National Board of Physician Nutrition Specialists and the American Board of Obesity Medicine. “We’ve simply accepted as true so much misinformation about weight loss,” said Dr. Amy Lee, Nucific’s Head of Nutrition.

It is a relatively new product, but the manufacturer’s website is professional and comprehensive and positions itself as having the overall mission of improving health and helping people always feel their best through products with ingredients to support nutritional deficiencies.

Consistent with that intent for good health is concern over the health of the environment and so the product packaging is also earth-friendly.

You can BUY it directly from the Official Website

How Does Nucific Bio X4 Work?

BIO-X4 ensures that you stay in great shape, while the weight loss supplement works on reducing your waistline. The product contains a wide array of fat-loss and digestive enhancing Bio X4 ingredients.

The caffeine in green tea speeds up the metabolism, which puts the body into the fat-burning state of thermogenesis. Naturally, this can lead to rapid weight loss. It can also provide extra energy, which helps you to extend your workout.

In addition, there’s an ingredient that can suppress appetite and cravings. According to an article in Medical Clinics in North America, appetite suppression may play more of a role than metabolism in weight loss.

The formula is rich in probiotics and digestive enzymes for weight loss which promote good bacteria in the gut, helping to ease digestion and prevent symptoms like gas and bloating. According to the study in the Journal Nutrients, probiotics may help rebuild “good” bacteria in your body and support bacteria levels.

Feature Product & Coupon

Bio X4

#1 Weight Managing Probiotic

Health Benefits of Bio X4

  • Manages Cravings*
  • Promotes Weight Management*
  • Supports Smoother Digestion*
  • Boosts Metabolism*
  • Reduce Appetite*

*Individual results can and will vary.

What else does Bio X4 do for you?

Some users of BIO-X4 have already reported seeing:

  • Reduced cravings for unhealthy junk food
  • Increased energy levels throughout the day
  • Improved levels of weight loss
  • An absence of gas, irregular visits to the bathroom and bloating

In addition, this product does not contain gluten, lactose, or fillers so those who are allergic to these ingredients will not have a reaction. The nutrients can accomplish this and suppress cravings for food.

The underlying rationale for the development was the recognition that people seldom get the absolute best nutrients on a daily basis from food and yet the body needs to operate at peak performance.

Nucific Bio X4 Ingredients – Are they Safe & Effective?

There are a host of Bio X4 ingredients considered beneficial for ultimate digestive support and management. It contains a collection of vitamins, minerals, amino acids, and herbs that help to promote bowel regularity and support immune health [4].

Nucific Bio X4 Supplement Facts

Nucific Bio X4 Supplement Facts

Bio X4 can generally help you in losing weight and includes the following ingredients:

Green Tea – This has Epigallocatechin gallate (EGCG) as its main component. It can increase metabolism and improve the rate of fat loss, [3] leading to rapid weight reduction. A meta-analysis in the International Journal of Obesity found that the catechins in green tea significantly reduced weight loss.

Probiotic Blend – It’s made up of Lactobacillus blend Lacidophius, Larhamnosus, Lplantarum Bifidobacterium lactis, and B animals. Nucific Bio X4 has 4 billion CFU per capsule. The probiotics grow good gut bacteria and support digestion, decreasing symptoms like bloating. They also boost the immunity system. A review in ISNR Nutrition explored the health benefits of probiotics.

Caralluma Fimbriata – Caralluma Fimbriata Extract is an appetite suppressant [6]. It can reduce body weight by fooling the brain into believing that the stomach is full. It may work to control hunger and cravings [2]. A study published in the Journal Perspectives in Clinical Research explored the link among Caralluma fimbriata and weight loss.

Digestive Enzyme Blend – It includes Amylase from Aspergillus Oryzae, Bromelain, and Lipase from Rhizopusorzae. Amylase is an enzyme that can catalyze the transformation of starch to sugars whereas Bromelain is found in the pineapple stems.

It’s an enzyme that minimizes inflammation either from injury or surgery. Lipase may help in the hydrolysis of lipids [7]. An article in Natural Medicine Journal explored the use of digestive enzymes in certain digestive disorders.

SEE ALSOMulti-GI 5 and Bio Complete 3

Pros and Cons of Nucific Bio X4

As claimed by the manufacturer, the benefits and drawbacks include:


  • It does not contain lactose, fillers or gluten. The ingredients are 100 percent pure.
  • There’s a 90-day money back guarantee. If the product does not give you the desired results you can return it to the manufacturer and get a refund.
  • The packaging of this appetite suppressant supplement is environmentally friendly.
  • Nucific Bio X4 is clinically tested by third-party labs.
  • There is transparency about the company’s board members and their credentials.
  • The manufacturer offers free shipping.


  • For better results you have to maintain a proper diet and exercise.
  • Results will vary for different customers.
You can BUY it directly from the Official Website

Is Nucific Bio X4 Safe?

Nucific Bio X4 is a probiotic-based nutritional weight loss product. It seems to be safe and effective to use, based on the quality collection of organic ingredients included. There are no synthetic or chemical substances included, and the product should not lead to any side effects.

How Does Nucific Bio X4 Rate?

Feature Rating Comments
Ingredients 10 Scientifically proven ingredients aid in the optimization of your digestive system and the control of unhealthy cravings, improved all-day energy, and slimming support.
Price 9.5 Average cost for the market for a high level supplement.
Safety 9.5 Nucific is a well-known company that uses professionally sourced ingredients, gluten-free and allergen-free capsules, and offers a 90-day money-back guarantee.

Nucific Bio X4 Customer Service Info

What Consumers Are Saying About Nucific Bio X4?

Will help with severe constipation!

I was diagnosed with celiac disease about 2 months ago….eliminated gluten, dairy, and added sugar from my diet. I went from having a BM every 7-10 days to having a BM every 3-5 days. A few weeks ago, I started using this Nucific Bio X4 probiotic in hopes that it would help me increase my BMs. SUCCESS!!! Over the last 4 days, I’ve had a healthy BM each day!!!! For me, truly a miracle! This has not happened in over 10 years! I highly recommend using this Nucific Bio X4! ~ Terri La Rue

Nucific BioX4 is a Great product

Great product! Was having stomach trouble. Everything I ate would cause me to have stomach pain and diarrhea. After 2 weeks of taking this, my system was back to normal and has been since.~ Karen Drasheff

*Individual results may vary

Nucific BioX4 | 4 Weight Loss Secrets Combined to Work Like MAGIC (Video Credit: YouTube)

Nucific Bio X4 FAQ

Q: Who should take Bio-X4?

A: Bio-X4 is designed to optimize your overall digestive health — from the inside out. It’s a fantastic choice for anyone who wants to enjoy smoother digestion, a slimmer waistline, smooth bowel movements, and higher energy levels.

Q: How to Take Bio X4?

A: Take 1 capsule of Bio X4 dietary supplement with every 3-time meal. Supplementing each meal with the digestive helps to process your food, obtaining the maximum amount of nutrients.

Q: How many pills are in one bottle of Bio X4?

A: A bottle of Bio X4 contains 90 capsules, and you can buy it from Bio X4’s official website. The website offers you different offers that will also help you save money on a purchase.

Q: Are there any Bio X4 side effects?

A: According to the manufacturer’s claim, Bio X4 is free of any side effects. It is formed of pure elements. You can take them with your diet restrictions as it is gluten and allergy-free. None of the Bio X4 reviews mentioned having symptoms.

Q: Does Bio X4 Really Work?

A: Bio X4 certainly does work, and it works well. It contains a potent blend of ingredients that support digestive health, as well as substances that help with weight management and suppress cravings. According to the Nucific Bio X4 Amazon reviews, this product is highly effective.

Nucific – BIO X4 (Video Credit: YouTube)

Q: How long should expect to wait before I see results?

A: Everyone has a different digestive system and will experience the results somewhat differently. But some of the Nucific Bio X4 reviews state that it takes a minimum of 60 days to work fully.

Q: Can You Buy Bio X4 in stores?

A: No, you won’t find it in the stores. You can purchase it from its official website. Bio X4 is available to purchase from Nucific’s website, with a 30-day supply of 90 capsules costing $99 (equating to $1.10 per capsule).

Q: Where to Buy Bio X4?

A: A bottle of Bio X4 contains 90 capsules, and you can buy it from the Official Website. The site has different offers that will also help you save money on your purchase.

Q: How much is a bottle of Bio X4?

A bottle of Bio X4 costs $99. If you make your purchase today, the company offers Bio X4 for sale at a significant discount. Better still, you will save money when you buy three bottles and not a single bottle.

Q: Is Bio X4 worth the money?

A: Yes. This probiotic weight reduction pill may aid to help ensure smoother, more comfortable digestion. Digestive enzymes aid digestion and increase nutrition absorption, allowing your body to stay fit!

Q: Is Bio X4 Legit or a Scam?

A: There’s no doubt at all that this is a legitimate product. The Bio X4 reviews Amazon speak very highly of this brand, making it clear that this is a real item. According to the Nucific Bio X4 consumer reports, and Nucific Bio X4 review states that it is a reputable and well-known company and has a good money-back guarantee, so there are no indications of a Bio X4 scam.

Q: Is Nucific a Good Company?

A: Yes. Nucific is a well-known health supplement Brand. It’s a reliable brand with a solid reputation on the market because of its high-quality, well-researched products. Nucific Bio X4 is one of the top weight loss supplements.

Bio X4 Alternatives

There are a few products online with similar gut health and weight management claims as BIO-X4, but not many with the same combination of ingredients to produce this intended benefit.

The two most similar products in their health claims and ingredients are Morning Complete and Active-PK.

Bio X4 Review – Final Verdict

Nucific BIOX4 contains rich organic ingredients that can help provide digestive support, suppress appetite, and strengthen immune health. The supplement helps with weight loss by suppressing cravings and appetite and boosting metabolism. It’s a new product which is already very popular in the market, and the price is reasonable.

 Nucific Bio X4 Before and After Pictures

Nucific Bio X4 Before and After Pictures

Most of the Bio X4 reviews had very good things to say about the product. Many said they lost a lot of weight, and some people sent in the Bio X4 before and after pictures to prove it. Customers were also happy with the benefits to their digestive health. There were very few Bio X4 complaints but no negative reviews.

This is a high-quality product that contains safe ingredients and has no side effects associated with taking it. Bio X4 results in improved digestion and a slimmer you in record time, plus it supports your general health and immunity.

Where To Find It?

You can BUY it directly from the Official Website

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Nucific Bio X4

Nucific Bio X4 Review – Does Bio X4 Work and Is It Safe To Use?

Average Customer Rating

out of 5

Review this Product

Leave a review and share your experience with others.

Write a Review

  1. Ardele Steele

    Excellent Product
    I have been on the Bio X4 product for three months now with positive results…I have lost some pounds. Boost in energy and my cravings have changed.
  2. Ted Fox

    Couldn't be happier!
    After watching Dr. Amy’s video about her research, I decided to take the chance, as food (and especially sugary foods) had become my default source of comfort over the last 16 months of pandemic lockdown. Not to mention I simply couldn’t afford to keep buying new, larger pants.

    I started taking Bio-X4 exactly 4 weeks ago. I switched to a 70-80% plant-based diet, only eating chicken or beef once a week, and I was very persistent using the daily Diet Journals that came with my order. (They have made it so much easier to recognize patterns and bad choices.) Now, I am a 39-year survivor of HIV/AIDS and am eternally grateful for the medications that have kept me alive. However, those same meds have been wreaking havoc with my digestive system for more than a decade, leaving me seriously dependent on a daily intake of some type of Imodium.

    Within the first week, my ‘bathroom habits’ had made a complete 180, and I haven’t needed an anti-diarrheal since. That alone is reason to celebrate and stick with it. Even better, my sugar cravings and consumption have diminished by 80-90%. Of course, I have them still and occasionally give in, but for a life-long sugar junkie like me, that’s almost miraculous. I stepped on a scale two days ago for the first time since starting this program, and I was ecstatic to see I have lost 12 pounds over the past 28 days.

    I hardly know how to say thank you enough.
    Ted Fox

  3. Susanna Shipmon

    Bio X4 Reviews and Testimony
    Bio X4 had allowed me to lose weight in a safe and steady way that I haven’t been able to do any other way. It manages my cravings so I don’t overeat. I have regular bathroom habits which I didn’t always have. I feel light and I’m never bloated so my stomach looks thinner. I have plenty of energy and I haven’t felt sluggish since I started taking it.
  4. Michael Nixon

    Bio X4 and a healthier system
    Great product by Dr. Amy Lee and results! Having a healthy digestive tract makes every day go better! Sorry about the pun! Managing weight, having more energy, and eating what I want have been great improvements to my quality of life!
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Bio X4 Ques and Ans

  • Q: Does Bio X4 work if you have an ileostomy?

    A: Bio X4 pills are generally safe to consume. There have been many studies done on the effects of probiotics and the results vary.

    Some believe that more research is necessary. There is evidence that using probiotics at the same time as antibiotics, reduces the chance of diarrhea and infections. Further, it is shown the probiotics can be beneficial for diarrhea.

  • Q: Can people with Type 2 diabetes take BIO-X4?

    A: Not surprisingly, there are many types of probiotic supplements available, one of them is BIOX4. Supplements may contain just one strain of probiotics, or they may have multiple strains.

    Common strains of probiotics include the Lactobacillus, Bifidobacteria, Saccharomyces boulardii, and Bacillus coagulans. It's a good idea to check with your doctor before taking a probiotic supplement. Some people should not take them, including people who have an overgrowth of yeast, small intestine bacterial overgrowth, or a compromised immune system.

  • Q: Can you or should you take these on an empty stomach? What if you only eat one meal a day and you only take it once a day in what extent will that help?

    A: Bio X4 is best taken with your meals to increase digestion and enhance nutrient absorption. Taking more than three capsules a day may be possible. However, it must not exceed six.

  • Q: What if you forgot to take Bio X4 a day?

    A: If you miss a Bio X4 dosage for a whole day, just proceed as normal on the following day. It can allow the body to build up the best level of enzymes, nutrients, and beneficial bacteria.

  • Q: What quantity should I order?

    A: You can order 1, 3, or 6 bottles. If you really want to save money, order six bottles at once for a big discount.

  • Q: What is the telephone number for me to order and speak to someone. The number I have is wrong.

    A: You may contact them by calling on the number available on the official website. (888) 679-5520

  • Q: What does the date on the bottom of the container signify? I take 1 capsule per day and my original supply has lasted years…do these capsules lose potency over time?

    A: It's the date up until which the drug manufacturer can guarantee that the medicine is fully potent and safe to take based on scientifically sound product testing. It is usually expressed by month and year. The product can legally be used or dispensed until the last day of the stated month and year.

  • Q: Can You Take Bio X4 While Pregnant?

    A: Although these are naturals ingredients and safe, according to the manufacturer, it is essential for pregnant women and nursing mothers to contact a doctor before using the product.

    Note: Always consult a doctor before starting any new supplements due to potential drug-nutrient interactions.

  • Q: Is this something one would need to take for the rest of his life?

    A: As observed above, a bottle has 90 capsules. Preferably, you should take one pill thrice daily, before meals, and with a glass of plain water. How long does Bio X4 last? --- Bio X4 does not last very long, especially when you consider the price. For almost $50 this product only lasts for 15 – 30 days.

  • Q: How Much Caffeine is in Bio X4?

    A: Not a huge amount. There's some caffeine in green tea, and it's just enough to get your metabolism revved up and burning fat but not enough to leave you jittery.

  • Q: Is Bio X4 effective for weight loss and safe for 12 to 13 years old kids

    A: Ages under 18 years old. Bio X4 is made for adults who want to lose weight and have a compromised digestive system. Weight loss or probiotic supplements are not recommended for children.

  • Q: I ordered bio x and a small recipe book came with it but it was in another language. Can I get the book in English?

    A: That could have happened by chance. You must contact them, and they will assist you. here is the contact info: Mon – Fri 6 AM-5 PM PST Sat-Sun 6 AM-4 PM PST 888-679-5520 [email protected]

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Nucific Bio X4
90 Capsules
Green Tea, Probiotic Blend, Caralluma Fimbriata, Digestive Enzyme Blend

12 sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] A personal note from Dr. Amy
[2] Griggs, Joanne L et al. “Caralluma Fimbriata Supplementation Improves the Appetite Behavior of Children and Adolescents with Prader-Willi Syndrome.” North American journal of medical sciences vol. 7,11 (2015): 509-16. doi:10.4103/1947-2714.170611
[3] Wolfram S. Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr. 2007 Aug;26(4):373S-388S. doi: 10.1080/07315724.2007.10719626. PMID: 17906191.
[4] Aslam, Muhammad et al. “Vitamins: Key Role Players in Boosting Up Immune Response-A Mini Review.” (2017).
[5] Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). 2009 Sep;33(9):956-61. doi: 10.1038/ijo.2009.135. Epub 2009 Jul 14. PMID: 19597519.
[6]Arora, Ekta et al. “To evaluate efficacy and safety of Caralluma fimbriata in overweight and obese patients: A randomized, single blinded, placebo control trial.” Perspectives in clinical research vol. 6,1 (2015): 39-44. doi:10.4103/2229-3485.148812
[7] Lipid Hydrolysis
[8] Rao, Satish S C et al. “Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.” Clinical and translational gastroenterology vol. 9,6 162. 19 Jun. 2018, doi:10.1038/s41424-018-0030-7
[9] Jungersen, M., Wind, A., Johansen, E., Christensen, J., Stuer-Lauridsen, B. and Eskesen, D. (2014). The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®. Microorganisms, [online] 2(2), pp.92–110. Available at: [Accessed 29 Oct. 2021].
[10] Probiotic research priorities for the healthy adult population: A review on the health benefits of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12:
[11] The safety of green tea and green tea extract consumption in adults – Results of a systematic review:
[12] Properties and Therapeutic Application of Bromelain: A Review:

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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