FLEXISEQ Gel Reviews – Is It Effective In Reducing Arthritis Pain?

Flexiseq is an excellent pain reliever for joints. It aids in the improvement of joint lubrication, resulting in increased flexibility and mobility.

We independently research, review, and recommend the best products. Healthcare professionals review articles for medical accuracy. When you buy through our links, we may earn a commission. Read more about our process for evaluating brands and products.
By on

In This Review

What is FLEXISEQ Gel?

Topical treatments for joint pain is now widely available in the market. However, there are very few products that is equipped with various clinical trials to prove its effect in improving joint function and joint health.

FLEXISEQ is one of those products that have been tested to equate with the effects of NSAIDs (non-steroidal anti-inflammatory drugs) without the harmful side effects.

FLEXISEQ is a topical joint product that consists of a patent formula called Sequessome.

They are tiny lipid spheres that are able to penetrate the skin to deliver the phospholipids deep into the joints where they are indeed needed.

Sequessome helps increase lubrication around the joints thus reducing friction and making movement easier. In a general perspective,

FLEXISEQ does offer the following benefits:

  • It increases lubrication around the joints
  • It reduces friction
  • It helps reduce joint pain and soreness
  • It improves joint and cartilage health
  • It helps prevent wear and tear due to constant friction
  • It helps improve flexibility and mobility

How Does It Rate?

Overall Rating: 3.6

Value For Cost

3.7/5Value For Cost
Return Policy

3.6/5Return Policy


Brand Highlights

  • Flexiseq Gel has been manufactured by a company known as Pro Bono Bio. This is the company on the forefront when it comes to manufacturing nano-physical healthcare products.
  • The company has already sold this supplement in Ireland, Austria, Germany, Singapore, and Malaysia.
  • Pro Bono Bio is based in the UK and its Chief Executive and Chairman, John Mayo, is glad to launch the world’s first nano-physical product to be clinically proven.

Key Ingredients

  • Plant-based Phospholipids


  • Lubricates the joints to prevent friction preventing damage that could be caused by wear and tear of the joints.
  • It might improve joint flexibility.
  • Supports joint pain and soreness reduction.
  • It may improve cartilage health.


  • It only provides short-term relief for joint conditions.
  • It might not be safe for pregnant or nursing mothers.
  • It has to be used on the bare skin as it may cause negative reactions if used on skin that has lotion or powder.

How Does FLEXISEQ Gel Work?

This product works through the technology of nanostructures called Sequessome which is made from spheres of phospholipids.

As gel is applied to the skin and allowed to dry, the tiny spheres of lipids penetrate deep down the skin and travels to the joints.

It increases the lubrication around the joints to prevent friction during each movement and less friction means reduced pain.

With this improved lubrication, the joints are also protected from the damaging pain due to constant wear and tear.

It also enables the joints to repair themselves as lipid structures are supplied.


FLEXISEQ Gel Ingredients – Are they Safe & Effective?

It contains nanostructures called Sequessome technology. This patent ingredient is Plant-based Phospholipids that help lubricate the joints once it reaches the affected area[1].

It is for this technology that FLEXISEQ received various recognitions and awards for its contribution to in helping people with joint pain especially those suffering from osteoarthritis.


FLEXISEQ Gel Questions and Answers

Q: How To Use FLEXISEQ Gel?

A: Apply a luscious amount of gel enough to cover the target area. Massage it into the affected joint and allow it to dry for around 10 minutes.

The drying of the gel will allow penetration of the topical treatment deep down into the joints.

It can be applied twice daily or as directed by your physician.

Q: Does It Smell Bad?

A: The consumers who purchased this product did not complain of any bad smell. Also, because it is not made from herbs and does not contain menthol, it does not give off any pungent odor.

Q: Will It Work For Long Term Care?

A: Flexiseq is not a treatment for joint conditions however it helps relieve signs and symptoms associated with these conditions.

It helps improve lubrication within the joints thus enhancing flexibility and mobility.

Q: What are similar products to FLEXISEQ Gel?

A: Aspercreme, APEAZ Cream are some products available in the market with similar benefits.

Q: Has Any Research Been Done On FLEXISEQ Gel?

A: There have been numerous clinical trials and studies that have been published in lieu with the effectiveness of Flexiseq in relieving joint pain, improving flexibility, and enhancing mobility.

It has been recently awarded by The Federal Association of German Pharmacists (BVDA) with “Innovation Award 2013” for being able to help people with osteoarthritis through the use of its Sequessome technology.

Also, there is a clinical trial saying that FLEXISEQ is as effective as Celecoxib (NSAID mostly prescribed for joint pain) minus all the side effects.

FLEXISEQ Gel Review – Final Verdict

Flexiseq gel is quite a good topical joint product as its efficacy is proven and duly recognized by various associations and writhing bodies.

If you have been long suffering from the limited flexibility and joint pain with every movement, then FLEXISEQ might just be the answer you have been searching for.

Still, it is highly recommended that research more about the joint related products to get the satisfactory result.

Bones are connected by joints, which allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. Topical joint relief products tend to work more quickly, helping to relieve pain directly in the affected area compared to products taken orally. A topical joint pain relief product should be evaluated on its: potential to block the transportation of pain signals, potential to act as a counterirritant to reduce soreness and Quality of Ingredients* backed by clinical research.

Below you’ll find some of the most effective topical joint pain products on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain relief gels, gummies, and creams based on the available research:

Well Care Botanicals | Hemp Extract Pain Relief Cream
Remove Inflammation & Soreness*Gold Star Evidence
Pain-Relieving Benefits*Gold Star Evidence
Supports Cartilage and Tissue*Gold Star Evidence
Rapid Pain Relief*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Barker Wellness | Cannabinoid-Infused Products
Nurtures Body & Mind*Gold Star Evidence
Targets Sleep & Focus*Strong Evidence
Wide Range of Products*Gold Star Evidence
Natural and Organic*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Aspercreme | Best Pain Relief Cream
Non-Greasy Cream*Gold Star Evidence
Relieves Arthritis Pain*Strong Evidence
Supports Joint & Muscles*Strong Evidence
Fast-Acting Formula*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for FLEXISEQ Gel

FLEXISEQ Gel Reviews – Is It Effective In Reducing Arthritis Pain?

Customer Reviews & Ratings

5.0 out of 5

Review this Product

Leave a review and share your experience with others.

Write a Review

  1. J Bovey

    Unbelievable results from FLEXISEQ Gel!
    I never thought it would work on my extensive and complex back problems. Believing it was just for osteoarthritis I bought my first tube with a mixture of cynicism and a ‘might as well give it a go. I have tried everything else’ attitude. With the cripling pain of extreme lordosis, extreme kyphosis, SI joint pain, and a twisted pelvis to name but a few of my problems I had tried everything from expensive massages, osteopathy, aids such as heat pads, etc, etc. and I was still unable to walk and in agony. From the very first application, it worked! The pain seemed to just melt away. I could not believe it! I was amazed. It is drug-free and safe. I am getting the best results EVER! For goodness sake TRY IT! You will know very quickly if this is for you. To be pain-free and out of a wheelchair, words cannot describe the feeling. All I can now hope is that one day this INCREDIBLE product will be available on prescription in place of damaging NSAIDS! And even better it is a UK company which has developed this technology. I can’t thank them enough! THIS IS A TRUE STORY. I AM NOT CONNECTED WITH THE MANUFACTURERS IN ANY WAY. I SIMPLY WANT OTHER SUFFERERS TO KNOW YOU DO NOT NEED TO GO THROUGH THAT EXCRUCIATING PAIN. FOR YOUR OWN SAKE TRY THIS!
  2. Carol R.

    Flexiseq working for me
    Following a hip replacement, I found my knees were causing more problems than the hip. I used Voltrol which worked but you can only use that for a limited time. I then tried Flexiseq and that has worked well. Waiting 10 minutes for it to dry can be a nuisance. I have been using it for about 3-4 weeks. I may stop after the current tube and see what happens. It is expensive but it works. I am not sure about using it long term.

Write a Review

Your email address will not be published. Required fields are marked *

5000 characters remaining.

Explanation ?

Privacy Policy

Submitting this review means that you agree to our Review Guidelines, confirming that you are a verified customer who has purchased the product and may have used the merchandise or experienced the service, and providing only a real interaction and experience without ulterior motives or has an affiliate or business with the company in any way. By ticking this box and submitting this review, you also accept that submitting fake reviews is a violation of Consumer Health Digest’s Terms of Use and such conduct will not be tolerated.


How to Upload your Proof of Purchase:

Please follow the instructions listed below to upload your electronic proof of purchase.

  • To upload your physical paper receipt, simply take a picture of it with your camera or phone. You may also try taking a still picture of it with your computer’s webcam.
  • Once you have taken the picture, save the image as a JPG, TIF, or PDF file.
  • Please note that you cannot upload a file that is larger than 2MB.
  • Then all you have to do is click the Browse button and search for your receipt picture file. You can also drag and drop the file into the provided field.

If you are still not able to upload your proof of purchase, please contact us for further assistance (take a moment to look over the sample bill below).


Have a Question? Please Tell Us What We Are Missing Here!

Note: Consumer Health Digest isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
Plant-based Phospholipids

1 sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1]van Hoogevest P, Wendel A. The use of natural and synthetic phospholipids as pharmaceutical excipients. Eur J Lipid Sci Technol. 2014 Sep;116(9):1088-1107. doi: 10.1002/ejlt.201400219. Epub 2014 Aug 25. PMID: 25400504; PMCID: PMC4207189.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

Free E-Newsletter

Your subscription could not be saved. Please try again.
Your subscription has been successful.
  1. About Us
  2. Editorial Policy
  3. DMCA Policy

Note: Results may vary about any product effectiveness. The information contained in this website is provided for general informational purposes only. No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition.

3 E Evergreen Road #1193, New City, NY 10956
[email protected]
Phone: +91-712-2543006

Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Your use of this website indicates your agreement to this websites published terms of use and all site policies. Please see our Medical Disclaimer for more information.

Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here.

Do Not Sell My Personal Information

Helping the Cause

Make a Donation

Follow Us


Advertising Disclosure

The content that appears on this page is presented as an overview vs. comparative marketing. The provided information includes product information, overviews, buying guides, and product specifications. All trademarks, registered trademarks and service-marks mentioned on this site are the property of their respective owners. If something is factually inaccurate please contact us and let us know. By contributing your product facts helps to better serve our readers and the accuracy of the content.

The table below does not include all companies or all available products in the market but those that we promote as their affiliates. In full compliance with the FTC guidelines, please assume that any and all links on the table are affiliate links, and we may receive compensation if you click one of these and make a purchase. We are independently owned and the opinions expressed here are our own. All editorial content is written without prejudice or bias, regardless of sponsor or affiliate associations. Read more about our process.