FLEXISEQ Gel Review: How Safe and Effective Is This Product?

By on
Page Score: 2.9 / 5.0
Advertising Disclosure ?

Advertising Disclosure

The content that appears on this page are from companies from which this website receives compensation, which may impact how, where and in what order products appear. This table does not include all companies or all available products. may be used in posts without being labeled as such, however every attempt will be made to maintain transparency. All editorial content is written without prejudice or bias, regardless of sponsor or affiliate associations.

FLEXISEQ Gel Overview

Topical treatments for joint pain is now widely available in the market. However, there are very few products that is equipped with various clinical trials to prove its effect in improving* joint function and joint health. FLEXISEQ is one of those products that have been tested to equate with the effects of NSAIDs (non-steroidal anti-inflammatory drugs) without the harmful side effects.

What is FLEXISEQ Gel & What Does It Do?


FLEXISEQ is a topical joint product that consists of a patent formula called Sequessome. They are tiny lipid spheres that are able to can penetrate the skin to deliver the phospholipids deep into the joints where they are indeed needed. Sequessome helps increase* lubrication around the joints thus reducing* friction and making movement easier. In a general perspective, FLEXISEQ does offer the following benefits:

  • It increases* lubrication around the joints
  • It reduces* friction
  • It helps reduce* joint pain and soreness
  • It improves* joint and cartilage health
  • It helps prevent wear and tear due to constant friction
  • It helps improve* flexibility and mobility

Who Manufactured FLEXISEQ Gel?

FLEXISEQ is conceptualized and manufactured by a company named Pro Bono Bio. This joint product is manufactured in Germany.

What Does It Contain?

It contains nanostructures called Sequessome technology. This patent ingredient is minute phospholipid spheres that help lubricate the joints once it reaches the affected area. It is for this technology that FLEXISEQ received various recognitions and awards for its contribution to in helping people with joint pain especially those suffering from osteoarthritis.

How Does it Works?

This product works through the technology of nanostructures called Sequessome which is made from spheres of phospholipids. As gel is applied to the skin and allowed to dry, the tiny spheres of lipids penetrate deep down the skin and travels to the joints. It increases* the lubrication around the joints to prevent friction during each movement and less friction means reduced* pain. With this improved* lubrication, the joints are also protected from the damaging pain due to constant wear and tear. It also enables the joints to repair themselves as lipid structures are supplied.

How To Use FLEXISEQ Gel?

Apply a luscious amount of gel enough to cover the target area. Massage it into the affected joint and allow it to dry for around 10 minutes. The drying of the gel will allow penetration of the topical treatment deep down into the joints. It can be applied twice daily or as directed by your physician.


  • Follow the instructions for use as per manufacturer’s directions
  • Wash your hands after use to avoid transfer of gel to other parts of the body
  • Clean your skin prior to applying FLEXISEQ to ensure optimum penetration of the lipids


  • Do not use this product if you are pregnant or nursing babies as its safety has not been established on growing fetus/ breastmilk
  • Do not apply in areas near the eyes, nose, mouth, or areas with broken skin
  • Avoid using lotion or powder prior to application of the gel however you may use non-alcohol based, non-fragrant lotion after the gel has dried thoroughly (minimum of 10 minutes)

FLEXISEQ Side Effects

Since FLEXISEQ is not made from any drug formulation or herbal combination; it does not produce systemic effects like other joint medications/ topical treatments. However, it can cause minor skin itching or redness especially to people with sensitive skin. This effect can be reduced* over time by manipulating the amount of gel applied on the skin. If irritation is noticed, reduce* the amount of gel and increase* it gradually until the desired effect is reached. FLEXISEQ contains lipid components that are naturally occurring in the body thus no other side effects is reported.

Does It Smell Bad?

The consumers who purchased this product did not complain of any bad smell. Also, because it is not made from herbs and does not contain menthol, it does not give off any pungent odor.

Will It Work For Long Term Care?

Flexiseq is not a treatment for joint conditions however it helps relieve signs and symptoms associated with these conditions. It helps improve* lubrication within the joints thus enhancing* flexibility and mobility.

Has Any Research Been Done On FLEXISEQ Gel?

There have been numerous clinical trials and studies that have been published in lieu with the effectiveness of Flexiseq in relieving joint pain, improving* flexibility, and enhancing* mobility. It has been recently awarded by The Federal Association of German Pharmacists (BVDA) with “Innovation Award 2013” for being able to help people with osteoarthritis through the use of its Sequessome technology. Also, there is a clinical trial saying that FLEXISEQ is as effective as Celecoxib (NSAID mostly prescribed for joint pain) minus all the side effects.

Final Verdict

Flexiseq gel is quite a good topical joint product as its efficacy is proven and duly recognized by various associations and writing bodies. If you have been long suffering from the limited flexibility and joint pain with every movement, then FLEXISEQ might just be the answer you have been searching for.

Bones are connected by joints, which allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. Topical joint relief supplements tend to work more quickly, helping to relieve pain directly in the affected area compared to supplements taken orally. A topical joint pain relief supplement should be evaluated on its: potential to block the transportation of pain signals, potential to act as a counterirritant to reduce soreness, potential to act as a counterirritant to reduce soreness and quality of Ingredients backed by clinical research.

Below you’ll find some of the most effective topical joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices
Fight Joint Pain and Inflammation
Enhance Joint Mobility
Prevent Recurring Damage
Long Lasting Results
Quality of Ingredients
Blue Goo
Blue Goo
Fight Joint Pain and Inflammation
Enhance Joint Mobility
Prevent Recurring Damage
Long Lasting Results
Quality of Ingredients
Australian Dream Cream
Australian Dream
Fight Joint Pain and Inflammation
Enhance Joint Mobility
Prevent Recurring Damage
Long Lasting Results
Quality of Ingredients
Topricin Cream
Fight Joint Pain and Inflammation
Enhance Joint Mobility
Prevent Recurring Damage
Long Lasting Results
Quality of Ingredients
disclosure disclosure disclosure disclosure disclosure