In This Review

What are Stem Cell Serums?

Stem cell serums are skin care products developed using a broad category of cells responsible for tissue regeneration and renewal. Stem cell serums contain cells that help your skin to heal, says Dr. Hal Simeroth, the founder of Stemology Skincare and a professor of a Ph.D. in Biotechs.

Stem cells are special because they are undifferentiated and possess the invaluable properties of differentiation and self-renewal. They have the ability to divide to make more cells to an extent of becoming capable of repairing and replacing damaged tissues in some organs. Stem cells give rise to more stem cells with more specialized functions, adds Dr. Hal.

How We Research?

Mary Beth Parisi is a full-time skincare consultant and researcher; we pick products based on user experience, internet reviews, and product effectiveness. We also consult with our dermatology specialists, who work as full-time dermatologists in Dallas, Texas, and also engage in skin care product research and methodology. Board Certified Dermatologists Dr. John Kelly and Dr. Dario Kivelevitch of U.S. Dermatology Partners assess each product and rate it based on their understanding of the ingredients, skin type, pricing, user experience, and other aspects. They scored each product in each category on a scale of 1 to 5. We finalized the 6 Best Stem Cell Serums 2024 after collecting all of the data.

Our Top Picks

6 Best Stem Cell Skin Care Products According to Skin Type

If you want to find a stem cell serum that will work for you, here is a rundown on the best stem cell serums 2024, reviewed by our expert.


Age Delay Stem Cell Serum | Best Stem Cell Skin Care

Beverly Hills MD Age Delay Stem Cell Serum

Beverly Hills MD Age Delay Stem Cell Serum

(4.9/5) 10 REVIEWS
  • High-Quality Ingredients
  • Risk-free Trial
  • Affordable Price
  • Powerful Testimonials
  • Reputable History
  • Form: Serum
  • Quantity: 30 ml
  • Skin Type: All Skin Types.
  • Age: Adult.
  • Dosage: Twice Daily.
  • Ingredients: Glycerin, Capric Triglyceride, Palmitoyl Tripeptide-3.
  • Usage: Best for Repairing, Smoothing, Glowing.
  • Safety: Dermatologists Tested.
  • Refund Policy: 90-Days
  • Company Info: +1 855-865-9526

Best Stem Cell Beauty Product!!

“I’ve used Age Delay Stem Cell Serum product for more than two years. At age 55, I frequently receive comments on my skin. This serum is wonderful. It moisturizes my dry skin, makes me feel smoother, and removes any lines from my skin. I felt like the day I started taking it, I stopped aging.” – Cassie Sampson.


John Kelly, Board Certified Dermatologist claims Beverly Hills MD Age Delay Stem Cell Serum is the extraordinary skin-revitalizing potential of stem cells harnessed by the technologically enhanced formula. Its strong ingredients work to revitalize your skin and give you a considerably younger appearance.

colanAccording to clinical study[1], It has found that after 8 weeks of use, Beverly Hills MD Age Delay Stem Cell Serum significantly improved wrinkles and fine lines, as well as overall skin tone, texture, and hydration. Additionally, the study found that the product was well tolerated and did not produce any adverse side effects.colan-1

Beverly Hills MD Age Delay Stem Cell Serum is an anti-aging skincare product intended to assist. The serum acts to increase collagen formation in the skin, which helps to lessen wrinkles, crow’s feet, and other aging symptoms. Along with moisturizing and nourishing the skin, the serum also aids in balancing skin texture and tone, says a dermatologist. Advanced natural compounds including peptides, growth factors, and antioxidants are included in the serum’s formulation to support the maintenance of a youthful, healthy complexion. All skin types can use this product, and everyday usage will yield the greatest results.

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Juice Beauty Stem Cellular | Best Stem Cell Serum

Juice Beauty Stem Cellular

Juice Beauty Stem Cellular Anti-Wrinkle Overnight Cream

(3.7/5) 127 REVIEWS
  • Form: Cream
  • Quantity: 50 ml
  • Skin Type: All Skin Types.
  • Age: Adult
  • Dosage: Night time.
  • Ingredients: Resveratrol, Grape Juice, Jojoba Oil, Shea Butter.
  • Usage: Replenish, Restore & Renew Skin.
  • Safety: Free from Parabens, Sulfates, GMO.
  • Return Policy: 30-Days
  • Company Info: +1-800-588-0266

Best stem cell face serum!!

“While I appreciate the fragrance and have high expectations for its effects on my skin, I do harbor some doubts. The cream tends to ball up on the skin due to its thickness. Additionally, after an extended period without any, I experienced a deep, under-the-skin acne cyst, leading me to question if the heavy cream played a role. Ideally, I would prefer it to be slightly thinner, perhaps just a bit thicker than the day cream, as I genuinely enjoy this stem cell beauty treatment.” – Jewls G.

The Juice Beauty Stem Cellular Anti-Wrinkle Overnight Cream is a very moisturizing product that works as you sleep to minimize the appearance of deep lines and wrinkles. A combination of potent antioxidants, including vitamin C and grape juice, are included in its formulation to help nourish and protect the skin, claims Dr. John Kelly.

colanAccording to Journal of Cosmetic Dermatology in 2019, which demonstrated Juice Beauty Stem Cellular is a skincare line developed by dermatologists and scientists in order to provide clinically-proven results. How using this product significantly improves the firmness, moisture, and texture of the skin. Additionally, the study demonstrated that the product’s active ingredients, including Vitamin C[2], peptides, and plant stem cells, aid in minimizing the appearance of wrinkles and fine lines.colan-1

Additionally, the cream has a mixture of organic oils that moisturize and nourish the skin, including jojoba and avocado, making it the best face firming cream, as per the study. A little bit of it goes a long way, and it is meant to be used as part of your nighttime skincare regimen. This product doesn’t include parabens, phthalates, or synthetic perfumes and is vegan and cruelty-free.

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Bioeffect EGF Serum | Best Stem Cells Product

Bioeffect EGF Serum

Bioeffect EGF Serum

(3.5/5) 58 REVIEWS
  • Form: Serum
  • Quantity: 15 ml
  • Skin Type: All Skin Types.
  • Age: Adult
  • Dosage: Twice a Day.
  • Ingredients: Barley EGF, Hyaluronic Acid, Glycerin, Icelandic Water.
  • Usage: Visibly Smoother, Plumper, and Firmer Skin.
  • Safety: Oil-free, Fragrance-free, Alcohol-Free, Paraben-Free, and Gluten-Free.
  • Return Policy: 14-Days
  • Company Info: +1-888-721-0372

Stem cell skincare that actually works!

“This product is fantastic. Since I started using Bioeffect EGF Serum a little more than two weeks ago, I can definitely tell a difference in my skin. My skin feels firm and healthy, and my wrinkles are beginning to fade. I heartily endorse this item. I’ve tried a lot of different creams, but none have given me results like these. My skin feels and looks more youthful.” – Michelle D.

The Bioeffect EGF Serum is a powerful anti-aging serum that contains hyaluronic acid serums, which minimizes wrinkles, enhances moisture retention, and rejuvenates youthful skin. It includes a plant-based version of epidermal growth factor (EGF), a peptide that aids in cell renewal and repair, claims dermatologist Dario Kivelevitch. Hyaluronic acid and barley growth factor, which assist to retain moisture and offer long-lasting hydration, are also included in the serum’s formulation. With consistent usage, this serum can help to balance out skin tone, minimize the appearance of wrinkles, and bring back a healthy, young shine.

A clinical study conducted by Dr. Ronald Moy, professor of dermatology at UCLA, Beverly Hills in the United States, discover that BIOEFFECT EGF SERUM significantly improved skin texture, decreased pore size, and diminished the appearance of brown spots and fine lines. 30 individuals used the serum twice daily for three months to one side of their faces. After the trial period, there was a noticeable improvement in skin thickness and a decrease in fine lines and wrinkles. Brown spots, the texture of the skin, and pore size were all significantly improved by the serum.

Dr. Dario also added, with only 2-4 drops, this coveted growth factor serum has been proven to drastically lessen the visibility of wrinkles and fine lines, improve skin hydration, and revitalize the complexion. Discover a clean skincare mix with just 7 ingredients for purity and maximum effectiveness.

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Introstem Stem Cell | Top Stem Cell Skincare

Introstem Stem Cell

Introstem Stem Cell Vitamin C Serum

(3.3/5) 13 REVIEWS
  • Form: Serum
  • Quantity: 50 ml
  • Skin Type: All Skin Types.
  • Age: Adult
  • Dosage: Once a Day.
  • Ingredients: Vitamin C, Grape Stem Cells, Hyaluronic Acid, Vitamin E.
  • Usage: Promote Healthy Skin, Brighten and Even Out the Complexion.
  • Safety: Not Tested on Animals, Free of Parabens, Phthalates.
  • Return Policy: 30-Days
  • Company Info: +1-800-919-9955

Perfect stem cell for skin care!!

“Even though I’ve just been using this product since May, people have already complimented me. What have you changed, you look so moisturized and plump. As an aging esthetician for more than 20 years, “Fresh” and “Younger”. I’m very delighted about this product. It accomplishes all of its goals and more!” – Lesley Hill.

Dermatologist John Kelly asserts that the Introstem Stem Cell Skincare product, specifically the Vitamin C Serum, is an anti-aging solution that combines vitamin C, human growth factors, and plant stem cells. This unique blend aims to improve skin tone and texture while diminishing wrinkles. Notably, the serum is devoid of parabens, sulfates, or phthalates, highlighting its formulation with natural, plant-based components.

According to the Journal of Clinical Aesthetics and Dermatology, after eight weeks of usage, the Introstem Stem Cell Vitamin C Serum showed noticeable anti-aging effects, such as increased skin firmness, moisture, and wrinkles. The study also discovered that the serum boosted the formation of elastin and collagen. Additionally, the participants reported that the serum was secure and well-tolerated.

He exclaims that the serum is made to be used often in order to promote collagen formation, lessen the appearance of wrinkles, and improve the health and vitality of the skin. It lessens inflammation, minimizes the appearance of dark spots and discoloration, and protects the skin from environmental harm. The serum also contributes to reduced pore size, increased skin suppleness, and sustained hydration.

Official Website


Ronas Stem Cell Solution | Best Stem Cell Serum for Face

Ronas Stem Cell Solution

Ronas Stem Cell Solution

(3.2/5) 417 REVIEWS
  • Form: Serum
  • Quantity: 5ml x 10vial
  • Skin Type: All Skin Types.
  • Age: Adult
  • Dosage: Twice Daily.
  • Ingredients: Hydrolyzed Pea Protein, Sodium Hyaluronate, Green Tea Callus Culture Extract.
  • Usage: Best for Revitalizing, Moisturizing, Soothing Skin.
  • Safety: Cruelty-Free, Vegan, Non-Comedogenic.
  • Return Policy: 14-Days
  • Company Info: +1-800-814-1766

Best stemcell product.


“My skin is now more radiant and less dry after using only half of the box. I just use about the size of my pinky fingernail at a time, and it stretches wonderfully. I used half of it in a month and use it both morning and night. One package is two months for me. I’ll give a different box a try before deciding whether to continue.” – Kiteru.

A cutting-edge world’s best anti-aging products from Ronas, created to revitalize the skin is called Ronas Stem Cell Solution. It includes plant stem cells, which have been shown in studies to increase skin elasticity, reduce wrinkles, and even out skin tone, says Dr. Dario Kivelevitch.

colanAccording to study[3] published in the journal skin pharmacology and physiology looked at the use of hydrolyzed pea protein in anti-aging skincare products and found that it had a significant positive effect on wrinkles, firmness, and skin tone.colan-1

The skin feels soft and silky once the substance is quickly absorbed into it. Hyaluronic acid, which is also present, aids in providing the skin with intense hydration and nourishment, he added. It also has antioxidants, which aid in protecting the skin from environmental harm. Dermatologists advise Ronas Stem Cell Solution, which is good for all skin types.

Official Website


Swiss Apple Stem Cell | Best Stem Cells Skin Care Products

Swiss Apple Stem Cell

Swiss Apple Stem Cell

(3.1/5) 78 REVIEWS
  • Form: Serum
  • Quantity: 30 ml
  • Skin Type: All Skin Types.
  • Age: Adult
  • Dosage: Twice Daily.
  • Ingredients: Hyaluronic Acid, Matrixyl 3000, Copper Peptide (GHK-Cu), and Dermaxyl.
  • Usage: Best for Anti Aging, Elasticity, Discoloration.
  • Safety: Cruelty Free and Vegan Friendly.
  • Return Policy: 30-Days
  • Company Info:

Best stemcell product.

“My newest favored skincare item. It truly does work. My pour size has decreased, and it smells fantastic. Quickly absorbs and has reduced small lines around the lips and eyes. Also, the skin tone is more even. I apply it underneath my moisturizer, and the skin somewhat tightens, improving the appearance of my turkey neck. This serum has made me appear better, thus I wholeheartedly endorse it.” – Jennifer.

Swiss Botany’s revolutionary anti-aging product is called Swiss Apple Stem Cell 3000. It uses a rare Swiss apple called the Uttwiler Spatlauber to produce a serum with potent anti-aging properties, claims Dr. John Kelly. Plant stem cells are isolated and concentrated for optimal efficacy before being used to create the serum.

colanAccording to study, stem cells from the Uttwiler Sptlauber apple can promote skin renewal, help preserve skin longevity, and lessen the appearance of wrinkles and fine lines.colan-1

Dermatologists claim further that the serum promotes healthy-looking skin, lessens wrinkles and discoloration, and restores elasticity and firmness. It also aids in preventing early aging indications and environmental stresses. A secure and efficient method to delay the onset of aging, Swiss Apple Stem Cell 3000 can make skin feel and look younger and healthier.

Official Website

How We Select the Best Stem Cell Products For Face?

In order to find the best stem cell products for each skin type, we spoke with dermatologists about the ingredients, textures, and formulae to look for and avoid when choosing a stem cell serum. They highlighted the need of using mild, non-irritating chemicals, take your climate into account, and determine whether stem cell serum formulation (cream, gel, foamy, or bar) is best for each kind of skin.

We chose stem cell serums that were created to fit a wide range of skin types for treating anti-aging issues, repairing and replacing damaged tissues, and addressing common skin issues including skin tightening. We picked both affordable and luxurious stem cell serums to provide everyone with a variety of price options.

How Do Stem Cells Serum Work?

stem cells for skin care

Stem cells naturally contain antioxidant properties responsible for nourishing the skin. When you apply stem cell serums, they penetrate deep into the skin to promote skin cell turnover and increase collagen synthesis in the body. Our article on Isagenix Collagen Elixir Reviews shares deeper insight into the importance of collagen.

When there is enough collagen in the body, it will restructure the skin resulting in fewer wrinkles and fine lines. The skin texture and tone will also improve, leading to radiant and younger-looking skin.

Both plant and human stem cells are packed with amino acids and proteins responsible for signaling the body cells to rejuvenate, making your skin appear smooth and younger, says Dr. Michele Green, a board-certified dermatologist and RealSelf contributor in New York City.

How to Choose the Best Stem Cell in Skin Care?

1. Ingredients

Taking note of the ingredients in a stem cell serum is crucial because you are able to tell whether or not the product is going to address your skin concerns. Every ingredient in a product has a function or a role it plays. Some are usually included in a product to address a specific skin concern. So, the ingredients will help you to know whether or not a given stem cell serum will address your skin issue.

2. Brand

Brand is another thing you should consider when buying a stem cell serum. This is because we have brands that produce quality products while others produce less effective products. Products from a brand with a good reputation are likely to be authentic and the chances that they will work to address your skin concerns are high.

3. Price

Stem cell serums vary in price depending on the brand. Some products may be expensive while others are averagely priced for the market. However, it does not mean that expensive stem cell serums are more effective than those sold at a lower price. You can always do your personal research to help you make a more informed purchase decision.

What Key Ingredients Are in Best Stem Cell Serums?

  • Organic Aloe Leaf Extract

    Aloe Vera is a medicinal plant packed with potent skin-enhancing properties such as enzymes, antioxidants, Vitamin C, and Vitamin A[4]. Various clinical studies have shown that extracts from this herb have a soothing effect on irritated and dry skin. It can also help fight skin inflammation and combat acne and eczema.

    A research study published in the Iranian Journal of Medical Sciences shows that Aloe Vera extracts contain wound healing, anti-inflammatory, and skin protection properties and, therefore, their application to the skin can help improve the overall health of the skin.

  • Glycerin

    Glycerin is a humectant and moisturizer, a substance rich in molecular structure. Glycerin is commonly used in the formulation of skin care products because of its ability to retain moisture and water in the skin.

    An article published in Clinical Cosmetic, and Investigation Dermatology shows that glycerin can help increase skin hydration and also play the role of skin barrier function.

  • Hyaluronic Acid

    Hyaluronic acid is one of the most common moisturizers and humectants in the formulation of skin care products with stem cells, delivering a combination of skin-enhancing properties that effectively maintain skin hydration and contribute to the reduction of wrinkles and fine lines.

    A research study in the Molecule Journal has shown that Hyaluronic Acid has the ability to improve the skin’s firmness and radiance. It has also been shown to support moisture retention and skin regeneration.

  • Sea Weed Extract (Chondrus Crispus)

    Chondrus crispus is a seaweed extract packed with potent skin-enhancing properties, making it the best humectant, moisturizer, and viscosity-controlling ingredient.

    According to a research study in NCBI, bioactive compounds from the seaweed extract have been confirmed to be useful in the cosmetic and skin care industry. They contain photo-aging properties that can protect the skin from UV rays-related damages.

  • Vitamin C

    Vitamin C is a multi-tasking super ingredient that works to fade away wrinkles and fine lines, boost collagen production, rejuvenate the skin, and protect it against photo-aging and environmental damage.

    An article published in Nutrient Journal shows that when you apply products containing vitamins C on the skin, they provide it with antioxidant protection against UV rays-related damage. The research further reveals that Vitamin C if applied to the skin can help boost the production of collagen responsible for maintaining the skin’s firmness.

What Do Dermatologists Think About Stem Cell Products?

While the efficacy of stem cells in skin care products depends on who you reach out to for advice, some dermatologists think that stem cells possess the ability to repair and protect the skin from environmental aggressors. They penetrate deep into the skin cells to deliver reparative agents and moisture to create more youthful skin.

For instance, skin care products containing plant-based stem cells repair the cell at the cellular level (penetrates much deeper) compared to other regular skin care products, says Dr. Eve Lupenko, a board-certified dermatologist at Greenberg Cosmetic Surgery in New York City.

Dr. Lupenko also thinks that the most preferred is plant-based stem cells because more research studies are backing the efficacy and safety of plant-based stem cell serums. She says that with plant-based stem cells, you don’t have to worry about transmitting human or animal diseases, another reason why she advises people to stick to plant-based stem cell serums.

However, their others who still don’t understand or are yet to be convinced why stem cells are all of a sudden buzzing in the skin care industry. Dr. Sejal Shah, board-certified dermatologist and RealSelf contributor in New York City believes that though stem cells may be packed with potent antioxidants and also possess moisturizers and hydrates which are good for the skin, it does not mean that their efficiency is superior to non-stem cell products.

Dr. Michele Green, on the other hand, sees the potential in combining stem cells with other treatments. Though the products containing stem cells do work, there is a possibility of improving the benefits dramatically when you incorporate other skin treatment procedures like Fraxel lasers, injectable fillers, and botox among others, she says.

Product Comparison

Here’s a short comparison of our top recommendations to make your decision easier:

Beverly Hills MD Age Delay Stem Cell Serum Juice Beauty Stem Cellular Bioeffect EGF Serum Introstem Stem Cell Ronas Stem Cell Solution
Rating colan colan colan colan colan
Cost $110.00 $67.50 $164.99 $61.51 $65.00
Dosage Twice Daily Night time Twice a Day Once a Day Twice Daily
Usage Best for Repairing, Smoothing, Glowing. Replenish, Restore & Renew Skin. Visibly Smoother, Plumper, and Firmer Skin. Promote Healthy Skin, Brighten and Even Out the Complexion. Best for Revitalizing, Moisturizing, Soothing Skin
Return Policy 30 Days 30 Days 30 Days 30 Days 14 Days
Pros Dermatologists Tested. Free from Parabens & Sulfates. Oil-free, Fragrance-free Not Tested on Animals, Free of Parabens. Cruelty-Free, Vegan.
Review Highly Effective. Affordable Deal Results May Vary Highly Expensive. Results into Side Effects.
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Q: Do stem cell serums really work?

A: According to dermatologists or skin experts, stem cell serums do work. The serums are formulated using both plant and human cell stems meaning that they are packed with proteins and amino acids that signal the body cells to self-repair and rejuvenate. The overwhelmingly positive reviews from customers are also proof that stem cell serums are efficient.

Q: Are stem cell serums safe?

A: Stem cell serums are formulated using ingredients sourced from natural sources, meaning that they do not contain harsh chemicals that can cause harm to your body. Also, there are no reported cases of severe side effects from users, meaning that they are safe for the skin. However, the best practice would be to work with your dermatologist to help you determine which stem cell serum will work effectively on your skin, says Dr. Eve Lupenko.

Q: How often should I use a stem cell serum?

A: A review on stem cell serum published in Miracle 10 blog explains that since serums are usually formulated using powerful ingredients, it is good to give them time to absorb all the ingredients. It is, therefore, advisable that you apply stem cell serum 2-3 times per week, preferably in the evening on freshly cleansed skin. For optimal results, you should always follow up with a moisturizer to help lock in the serum as you sleep.


Stem cells are packed with peptides and amino acids, ingredients considered to be skincare powerhouse because of their ability to rejuvenate and repair the skin. Also, stem cells naturally, are packed with antioxidant properties that the body requires to nourish the skin cells, and promote collagen synthesis and cell turnover.

Stem cell serums claim to work to reduce the appearance of wrinkles and fine lines as well as improve the skin tone and texture to give you a much younger skin appearance. So, if you are out in search of the best stem cell serum that can totally improve the overall health of your skin, check out our pick in this review. We believe that after reviewing the products on our list, you will definitely find one that matches your skin care needs.

Why Trust Us?

The Consumer Health Digest is a group of dermatologists and medical professionals who work together to provide consumers with the best information possible. We also strive to provide the best information to our customers by considering their skin type, age group, and safety into mind.

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MaryBeth Parisi, MD

Dr. MaryBeth Parisi is a board-certified Harvard trained Dermatologist. She has over 18 years of experience in the field of skin care.

4 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] "Stem Cell Basics | STEM Cell Information". Stemcells.Nih.Gov, 2023, Accessed 16 Feb 2023.
[2] Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211. doi: 10.3390/nu9111211. PMID: 29099763; PMCID: PMC5707683.
[3] EWG Skin Deep® | What is HYDROLYZED PEA PROTEIN (2023). Available at: (Accessed: 16 February 2023).
[4] Villamor E, Fawzi WW. Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev. 2005 Jul;18(3):446-64. doi: 10.1128/CMR.18.3.446-464.2005. PMID: 16020684; PMCID: PMC1195969.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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