In This Review


A good percentage of the world’s population experiences gut health-related problems. However, despite the prevalence, there are limited treatment options for treating these abdominal issues.

According to an International Research Group, about 40 percent of the world’s population experience chronic gastrointestinal issues.

Fortunately, there are quite a number of top-rated digestive enzymes in the market today that can help manage gut health issues. But to be able to manage gut health problems effectively, you need the best organic digestive enzymes.

So, which one is the best digestive enzyme brand? In this review, we look at some of the best digestive enzymes for bloating and gas and the existing research behind them.

Expert View

According to Alicia Romano, a specialized clinical dietician and nutritionist at Tufts Medical Center in Boston, a healthy gut is linked to balanced bacteria and other microbes in the digestive tract

Also, healthy immune function rides on gut health, meaning that any problem with gut health will also affect the body’s overall immunity.
Romano says that you can improve gut health by incorporating a number of things in your health regimen including digestive enzyme supplements and eating foods packed with probiotics and fiber.

She also recommends engaging in regular exercises, limiting alcohol intake, and reducing stress levels if you want to experience a healthy digestive system.

colanAccording to Consumer Health Digest Research & Analysis, Our best overall pick is Unbloat is an award-winning organic supplement that improves digestive health, reduces bloating, promotes weight loss, and boosts the immune system. For a more affordable pick, Enzymemd is a digestive support product that relieves bloating, gas, and indigestion discomfort.colan-1

Our Top Picks

Best Digestive Enzyme Supplements in 2024

We have compiled a list of the top 10 digestive enzyme supplements that are effective, safe, and affordable. Whether you’re looking for a vegan-friendly option or a supplement that contains multiple enzymes, we’ve got you covered.


Unbloat | Best Digestive Enzymes in a Nutshell



(4.9/5) 843 REVIEWS
  • Research Based Ingredients
  • keto Friendly
  • FDA Approved Facility
  • Gluten Free
  • Doctor Formulated Supplement
  • Form: Capsule
  • Quantity: 60 Capsules
  • Dosage: 2 Capsules Daily
  • Ingredients: Probiotics, Prebiotics, Folate, Magnesium, Milk Thistle Extract
  • Usage: Bloating Relief, Digestion, Healthy Gut
  • Safety: Vegetarian, Non-GMO, Gluten Free
  • Refund Policy: 30-Days
  • Company Info: 4240 Duncan Ave, St. Louis, MO 63110, USA, +1-877-880-0706,

Immediately! Day 1!

“I’ve been in stomach pain after I eat, digestive issues, and bloating so much that I was wearing a size bigger! Every time I would eat, I would have indigestion so bad and nothing would help take that gassy, bloat, discomfort away. It got to the point where I would be scared to eat! I notice I look slimmer (which is amazing ) But my favorite reason to keep taking these are being PAIN FREE! I was skeptical at first, but I’m so thrilled I took the chance and found something so easy to take but amazing results!” – Tammy S.


Unbloat is a natural supplement created by doctors. It has good stuff like probiotics, prebiotics, digestive enzymes, and plant ingredients. These things help your digestion and make your immune system stronger. Taking Unbloat can make you go to the bathroom regularly and stop problems like stomach cramps, diarrhea, gas, and feeling bloated. It might even help you lose weight and make you feel healthier overall. Unbloat has 25 billion CFU probiotic strains, which are like good soldiers in your intestines that fight bad bacteria, making things balanced. It also has prebiotics that feed the good bacteria, helping them grow.

A study[1] published by Kathleen Mikkelsen & Vasso Apostolopoulos in Springer found that adding folic acid and B12 to the diet can enhance the immune response in both animals and humans. Unbloat gives you quick relief and keeps supporting your digestion.

In 1-2 days, your worst bloating problems will get better, with smoother bathroom visits and less gas. Most people see bloating go away in 10-14 days. It is good for vegans, non-GMO, gluten-free, and friendly for paleo and keto diets. It’s made from natural things, and they check it in a place approved by the FDA in the United States.

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Nucific Digestive Enzyme | Best Digestive Enzymes for Gas and Bloating


Nucific Digestive Enzyme

(4.8/5) 20 REVIEWS
  • Natural Ingredients
  • Allergen Free
  • Affordable Price
  • Gluten Free
  • 100% Money Back Guarantee
  • Form: Capsule
  • Quantity: 90 Capsules
  • Dosage: 6 Capsules Daily
  • Ingredients: Sucrase, Amylase, Lipase, Lactase, Protease
  • Usage: Supports Smoother Digestion, Reduces Bloating and Gassiness
  • Safety: All Natural Ingredients, Allergen Free, Gluten Free
  • Refund Policy: 90-Days
  • Company Info: NA


“Alright, I was a bit unsure about popping these pills, but dang, they work! My stomach isn’t throwing tantrums after meals anymore. It’s like these enzymes whispered to my gut, “Chill, we got this.” Pleasantly surprised and feeling better. Good stuff!” – Linda


Nucific Digestive Enzyme is a special mix of more than 12 powerful digestive enzymes that help your body break down food, making it easier for you to get the most out of the nutrients and promoting smoother digestion.

A research study[2] published in PMC found that Proteases are versatile enzymes that assist in breaking down proteins, chopping them into smaller pieces, and aiding in protein digestion.

The ingredients in this product play a key role in breaking down carbs, cereals, and starches, converting them into usable energy. Enzymes like bacteria, fungi, and acid proteases work to break down proteins essential for a healthy body, including those found in the immune system, muscles, tissues, nails, skin, and hair. To keep the product cost-effective, we sell Digestive Enzyme directly to customers through the Nucific website, eliminating the need for intermediaries. This supplement is exclusively available for purchase online.

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Active Enzyme | Top Rated Digestive Enzymes


Activated You Active Enzyme

(4.8/5) 476 REVIEWS
  • High Quality Ingredients
  • Easy-Swallow Capsule
  • Natural Enzyme Production
  • Manufactured in the USA
  • 100% Money Back Guarantee
  • Form: Capsule
  • Quantity: 90 Capsules
  • Dosage: Take 1-2 Capsules With Each Meal
  • Ingredients: Amylase, Phytase, Lipase
  • Usage: Improved digestion, Reduced Inflammation
  • Safety: Easy-Swallow Capsule, 100% Money Back Guarantee
  • Refund Policy: 90-Days
  • Company Info: Santa Monica, California, 90404, +1-(800) 720-8403

Very Impressive Blend Of Enzymes!

“This is a very impressive enzyme combination that is made in a certified facility in the USA. The capsules are medium-sized – see my pictures – and are easy for me to swallow. I noticed no off tastes or aftertastes taking this. So far I am impressed – been taking 2 per meal as suggested.” – Sania


Active Enzyme is a supplement packed with 16 diverse enzymes sourced from plants and mushrooms. These enzymes play a crucial role in breaking down the food we consume, aiding our bodies in absorbing essential nutrients. By promoting efficient digestion, Active Enzyme facilitates smoother movement of food through the digestive system, potentially reducing feelings of gas and bloating.

The assortment of enzymes in Active Enzyme each has a specific function, targeting carbohydrates, proteins, fats, and even fiber. Together, they support the body in breaking down food into smaller components for energy and cell building. Beyond digestion, this supplement contributes to a healthy immune system by balancing gut bacteria, reducing inflammation, and thereby helping prevent infections, allergies, and diseases.

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1MD EnzymeMD | Best Enzyme Supplement for Digestion


1MD EnzymeMD

(4.7/5) 154 REVIEWS
  • High Quality Ingredients
  • Risk Free
  • Affordable Price
  • Manufactured in the USA
  • 100% Money Back Guarantee
  • Form: Capsule
  • Quantity: 60 Capsules
  • Dosage: Take 1-2 Capsules Daily
  • Ingredients: Saccharomyces Boulardii, Alpha-Amylase, Bromelain, Peptidase
  • Usage: Improved digestion, Reduces Bloating and Gassiness
  • Safety: High Quality Ingredients, Plant-based Enzymes
  • Refund Policy: 90-Days
  • Company Info: USA,, +1-(888) 393-4030

These work!

“This is such a breakthrough for me. I got my first bottle, and I noticed a great difference in the same week… My energy and stamina have increased. I feel so good. More of a feeling of being in balance. I have been looking for a product like this for a long time. Also, I am not as hungry, and it is helping me not overeat. So happy I found this!!!” – Kaira


EnzymeMD is a supplement designed to ease digestive discomfort associated with bloating, gas, and indigestion. It harnesses the power of 18 robust plant-based enzymes and a probiotic to address immediate issues and enhance long-term digestive health. This supplement aims to tackle unpleasant symptoms by neutralizing excessive gas, supporting the breakdown and absorption of nutrients, and reducing indigestion and bowel discomfort.

A article[3] published in MDPI found that bromelain has some significant qualities and healing properties. It can interfere with the growth of cancer cells, reduce inflammation, and help break down fibrin.

With a blend of potent enzymes and an essential probiotic, it works to enhance digestive function, helping the body efficiently process hard-to-digest foods. This, in turn, transforms these foods into usable energy, reducing the likelihood of indigestion. By promoting overall gut health, the essential probiotic in the formula contributes to sustained improvements in digestion. Simply take 1 or 2 capsules of this dietary supplement 20 minutes before a meal, or as directed by your physician, to experience its digestive support benefits.

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Biotics 8 | Best Digestive Enzyme Supplement


Biotics 8

(4.8/5) 241 REVIEWS
  • Natural Ingredients
  • Science Backed Formula
  • Affordable Price
  • GMP-certified
  • Zero preservatives
  • Form: Capsule
  • Quantity: 90 Capsules
  • Dosage: Take 3 Capsules Daily in the Morning
  • Ingredients: Resveratrol, Cat’s claw concentrate, Oat straw extract, Vitamin B and D3, L-Tyrosine
  • Usage: Improve Focus, Support Mental Wellbeing, Boost Testosterone Levels
  • Safety: Natural Ingredients, GMP-certified, Soy Free, Gluten Free
  • Refund Policy: 60-Day
  • Company Info: WOLFSON BRANDS (UK) LIMITED, 12 Payne Street, Glasgow, G4 0LF, United Kingdom, +44 203 476 4892

Excellent Recommendation!

“I mentioned my digestive issues to a friend, and she suggested Biotics 8. This ended up being the best advice I had heard in a very long time. This vitamin gives me greater energy and sharper attention, and my stomach feels much more comfortable. Give it a go!” – David


Biotics 8 is a daily dietary supplement created to support overall health. It contains a combination of fibers, digestive enzymes, probiotics, and prebiotics to improve the immune system, foster good gut bacteria, elevate mood, and increase energy levels. Specifically designed for men, it aids in maintaining a healthy digestive system by assisting in the breakdown of food and includes probiotics that are supportive of testosterone levels.

For optimal results, the manufacturer recommends a daily intake of two capsules with water. Starting with one capsule initially allows your gut to adjust, and eventually progressing to two capsules per day. Customer satisfaction is a priority, and if the product doesn’t meet expectations, the brand offers a 60-day 100% money-back guarantee for Biotics 8. If needed, you can contact customer care through the official website to facilitate the return process.

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Zenwise Digestive Enzymes | Best Natural Enzymes for Digestion


Zenwise Digestive Enzymes

(3.5/5) 1118 REVIEWS
  • Form: Capsules
  • Quantity: 180 Capsules
  • Brand: Zenwise Health
  • Dosage: 1 Capsule Daily
  • Ingredients: Advanced system of Enzymes, Green Papaya, Apple Pectin, Inulin Prebiotic
  • Usage: Supports Long Term Gut-Health, Supports Immune Health
  • Safety: AVA-Certified Vegetarian, Non-GMO Formulas
  • Refund Policy: NA
  • Company Info: 3452 Lake Lynda Dr., Building 100, Suite 361, Orlando, FL 32817, +1-800-940-1972,

Miracle Pill.

“This pill made a huge difference in my life in only a few days of taking it! Before having my gall bladder removed I had horrible tummy issues so you can only imagine how bad it got after! Amazingly they have all but stopped since starting taking one of these before each meal! I highly recommend it if you have a sensitive tummy, IBS, chronic diarrhea, constipation, or had your gall bladder removed. I can’t say enough about these wonder pills!” – MK

Zenwise Digestive Enzymes offer a plant-based 3-in-1 solution for gut health, combining Probiotics, Prebiotics, and Digestive Enzymes. This blend is designed to assist both women and men in maintaining long-term gut health and finding relief from issues like bloating gas, and digestive discomfort. As our bodies age, they naturally produce fewer digestive enzymes, making it tougher to handle certain foods we enjoy.

colanA study[4] published in PMC found that Eating a lot of fructans in the diet was easily tolerated and even helped with feeling satisfied in terms of appetite.colan-1

It is a non-GMO formula, that acts quickly to support the digestion of hard-to-digest foods, allowing you to enjoy your favorite meals without worry. It ensures the probiotics arrive alive and start working within hours, providing lasting support for thorough digestion and a robust immune system. The Botanical Blend, featuring ingredients like Turmeric, Ginger, Green Papaya, Inulin, Apple Pectin, Bladderwrack, Fennel, and Wakame, aims to give your gut the relief and support it needs for a comfortable digestive experience. These enzymes are Ava-certified vegetarian, and there’s no need for refrigeration.

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Pure Encapsulations Digestive Enzymes Ultra | Best Supplement for Digestion


Pure Encapsulations Digestive Enzymes Ultra

(3.3/5) 146 REVIEWS
  • Form: Capsules
  • Quantity: 90 Capsules
  • Brand: Pure Encapsulations
  • Dosage: 2 Capsule Daily
  • Ingredients: Proprietary Enzyme Blend, Amylase, Lactase, Beta-glucanase
  • Usage: Supports Digestion, Support Nutrient Bioavailability
  • Safety: Gluten Free, Non-GMO Formulas, Vegetarian
  • Refund Policy: NA
  • Company Info: Pure Encapsulations, LLC, 490 Boston Post Road, Sudbury, MA 01776, +1-(800) 753-2277

Not the right ones for me.

“I have only found a few digestive enzymes that work for me. One was Rainbow, which I can no longer find. I have used these ones for a couple weeks, and as of right now, I have no real relief when I am eating things that are not usually in my diet. I’ll change my rating if they start to work and I notice.” – Lizza

Digestive Enzymes Ultra is a supplement with a variety of vegetarian digestive enzymes to assist in breaking down proteins, carbohydrates, fats, fiber, and dairy. The included proteases work effectively across different pH levels to support digestion.

This comprehensive blend of digestive enzymes, part of the PureGI™ product line, aims to enhance nutrient bioavailability and absorption. Made with vegetarian ingredients, the supplement is gluten-free, GMO-free, and suitable for those following a vegetarian lifestyle. Simply take 2 capsules with each meal, or as directed by a health professional, to support your digestive well-being.

Official Website


Thorne Advanced Digestive Enzymes | Best Digestive Enzymes for Bloating


Thorne Advanced Digestive Enzymes

(3.5/5) 47 REVIEWS
  • Form: Capsules
  • Quantity: 180 Capsules
  • Brand: Thorne
  • Dosage: 2 Capsule Daily
  • Ingredients: Betaine Hydrochloride, L-Glutamic Acid Hydrochloride, Leucine, Silicon Dioxide
  • Usage: Helps Maintain Bowel Regularity, Minimizes Gas and Bloating
  • Safety: Gluten Free, Dairy Free, Soy Free
  • Refund Policy: NA
  • Company Info: USA, +1-(800) 228-1966

Exceeded expectations.

“The Advanced Digestive Enzymes supplement was recommended by a friend when discussing some issues I had lived with since my gallbladder was removed. Boy, I would have loved to have had Advanced Digestive Enzymes all along. Huge difference and much more comfort now after every meal.” – Shophia

Thorne’s Advanced Digestive Enzymes is a well-rounded mix of digestive enzymes designed to promote good digestion. This kind of supplement comes in handy when the body isn’t producing enough digestive enzymes, which can happen due to factors like aging or gallbladder removal.

This digestive enzyme blend supports occasional indigestion, reduces gas and bloating, and helps maintain regular bowel movements. Notably, it can be beneficial after the excessive use of antacids. The formula includes undiluted pepsin and pancreatin, without lactose commonly used as a diluent. Additionally, it contains oxbile to aid in the digestion process.

The supplement includes crucial proteolytic enzymes like hydrochloric acid (HCl) and pepsin from the stomach, pancreatin from the pancreas, and bile from the liver and gallbladder. These enzymes play essential roles in breaking down and absorbing nutrients from the food we eat. By combining all these elements, Advanced Digestive Enzymes provides a comprehensive solution for supporting the digestive process.

Official Website


Codeage | Best Probiotic and Digestive Enzymes


Codeage Digestive Enzymes Supplement

(3.6/5) 117 REVIEWS
  • Form: Capsules
  • Quantity: 90 Capsules
  • Brand: Codeage
  • Dosage: 1 Capsule Daily
  • Ingredients: Probiotics, Prebiotics, Apple cider vinegar, Black pepper, Turmeric
  • Usage: Help Promote a Healthy Gut Microbiome, Promote Healthy Digestion Support
  • Safety: Gluten Free, Dairy Free, Soy Free, cGMP-certified Facility
  • Refund Policy: 30-Days
  • Company Info: USA, +1-856-263-3243,

One a day Really works!

“I have used digestive enzymes for many years and know them to be very beneficial. But I wasn’t so fond of having to take a capsule with every meal, so when I found the Codeage digestive enzymes and saw the dose was once a day, I was immediately interested but skeptical because of always had to take one enzyme with each meal. Now after taking Codeage enzymes, I am no longer skeptical. They work just as well as taking 2 or 3 a day, and the price is so much more economical!! I just bought two more containers and will continue using these digestive enzymes – they are good quality and much less expensive than others I’ve used. Thank you, Codeage for a good product!” – TamaraJ

Codeage Fermented Digestive Enzymes is a comprehensive supplement for digestion, packing 14 different food enzymes, probiotics, prebiotics, and organic botanicals. Ingredients like apple cider vinegar, black pepper, ginger, kiwi, and turmeric are included to support digestive health, balance, and a healthy gut microbiome.

Besides digestive enzymes, the formula also incorporates an organic botanical blend to enhance the activity of digestive enzymes. The convenience of just one capsule a day makes it an easy addition to your routine. Plus, it’s a non-GMO, vegan, and gluten-free formula, suitable for those with dietary restrictions, and it’s produced in a GMP-certified facility in the USA with global ingredients to ensure quality and purity.

Official Website


Wholesome Wellness Digestive Enzymes | Best for Immune System


Wholesome Wellness Digestive Enzymes

(3.5/5) 164 REVIEWS
  • Form: Capsules
  • Quantity: 180 Capsules
  • Brand: Wholesome Wellness
  • Dosage: 2 Capsule Daily
  • Ingredients: Cellulase, Hemicellulase, Lactase, Alpha Galactosidase
  • Usage: Supports Smoother Digestion, Boost Immunity
  • Safety: GMP certified, Gluten Free, Non-GMO
  • Refund Policy: 30-Days
  • Company Info: 6804 NE 79th Court #320582, Portland, Oregon, 97218, USA,

Life Saver! The ONLY supplement that works!

“I have been using Wholesome Wellness Digestive Enzymes (1000 mg) for over 2 years. I can eat anything knowing these capsules (take before or within 30 minutes with food) help me digest my food. I do not get bloated, I am not in pain, and I have energy instead of the full and sluggish feeling I get otherwise. I am extremely happy with this product.” – Yasmin Steinke

Wholesome Wellness Digestive Enzymes features an Advanced Multi Enzyme System to aid digestion of various foods like fried, spicy, raw, processed, dairy, protein, salts, carbs, vitamins, and acidic fruits and veggies. The product also includes an immune-boosting probiotic with a potent 10 billion CFU dose, comprising 10 different probiotic strains. These strains are clinically proven to enhance prevention and support the immune system response.

colanA study[5] published in Food Science and Nutrition found that ginger has been used for a long time as a medicine and has been shown to have anti-inflammatory, antioxidant, antitumor, and antiulcer effects.colan-1

This supplement is vegan, non-GMO, gluten-free, and made with pure, natural, and organic ingredients. It is free from soy, peanuts, eggs, gelatin, ox, shellfish, artificial sweeteners, colors, and flavors. Proudly manufactured in the USA in a GMP-certified facility, 3rd Party Tested, and backed by a 100% satisfaction money-back guarantee, it provides a comprehensive approach to digestive health and immune support.

Official Website

How Does Digestive Enzyme Work?

The problem of indigestion is characterized by symptoms like bloating, gas, diarrhea, and overall gut health. Physicians usually recommend digestive enzyme supplements for individuals struggling with these kinds of symptoms.

Digestive enzymes are a replacement for enzymes the body is not able to produce in sufficient quantities for the body to be able to regulate the digestive system.

According to Dr. Rudolph Bedford[6], a gastroenterologist at Providence Saint John’s Health Center, in Santa Monica, California, digestive deficiency impedes nutrition absorption and causes gastric discomfort.

By taking digestive enzyme supplements, you promote the breakdown of proteins, fats, and carbohydrates from the food we eat and support healthy digestion and proper nutrient absorption, adds Dr. Bedford.

How We Choose the Best Digestive Enzymes

Here is how we choose the best digestive enzymes:

Use of researched ingredients:
When choosing our list of the best protein digestive enzymes we checked the ingredients to ensure they are formulated using high-quality and research-based ingredients.

Brand reputation:
Supplements from reputable brands are usually genuine, safe, and of high quality because the company is keen on protecting its reputation. So, when choosing our best brand of digestive enzymes we made it from reputable brands.

Use of additives and artificial constituents:
Products with additives and artificial constituents have a high chance of causing undesirable side effects. That is, when selecting our list of best digestive enzymes we avoided any products with artificial ingredients and additions that may jeopardize your health.

Accurate labeling and dosage instructions:
To get the most out of any given supplement, it is important that you adhere to the dosage and usage directions. We have ensured that our selected digestive enzyme is properly labeled with clear usage instructions.

Whether or not the formula is GMO-free:
GMO-free products guarantee safety and that is why we ensure that our best digestive enzymes for constipation are non-GMO.

Customer feedback:
The best digestive enzymes for constipation are supported by customer reviews. Customer feedback on any given product is important because it gives more insight into a product.

Our top-selected digest enzyme supplement has customer reviews to help you make a value-added purchase decision.

Types of Digestive Enzymes

The best digestive enzymes for ibs or best digestive enzymes for fodmaps should consist of three categories of enzymes that govern the way the body breaks down nutrients. They include:

Protease – It is the pancreas that produces this enzyme and then releases it into the small intestines. It is responsible for breaking proteins into amino acids for easy absorption.

Amylase – It is a type of enzyme produced by the salivary glands and pancreas and it is responsible for breaking down starches into sugars and carbohydrates.

Lipase – This enzyme is produced in the pancreas and stomach, and is responsible for converting fats into fatty acids and glycerol.

What Key Ingredients to Look for In Best Digestive Enzymes

Digestive enzyme supplements are formulated using a variety of ingredients. Some of the key ingredients to look out for in the best digestive enzyme supplements include:

Fennel Seed

Fennel seeds are obtained from the carrot family and its seeds are rich in nutrients such as Vitamin C, calcium, iron, manganese, potassium, and magnesium. They are high in fiber and crucial for promoting healthy digestion, and easing bloating, among other gastrointestinal symptoms.

A health article published in the African Journal of Biological Sciences[7] by researchers Mohamed A. AbdElwahab et al found out that fennel seeds are packed with potent antioxidants and can effectively support the body’s immune function. It has also been shown to have a positive effect on body mass index and weight.

Another publication the International Journal of Advances in Nursing Management[8] by researcher D. Divya looked into the effect of fennel seeds on the health of women.


Inulin is a form of probiotic present in the bowel and is responsible for feeding probiotic bacteria for proliferation and growth.

It is also a rich source of fiber ideal for promoting satiety and ensures that you take in fewer calories, vital for weight reduction over time.

A study conducted by researcher Nicola D. Guess et al to establish the health benefits of inulin as published in Nutrition and Metabolism[9] concluded that supplementation of inulin can help improve diabetes; balance lipid levels, and promote weight loss.


Turmeric root extract is a medicinal plant packed with powerful bioactive compounds known as curcuminoids. They are packed with antioxidants capable of boosting immunity.

According to a review by researchers Ganesh Chandra Jagetia and Bharat B. Aggarwal in the Journal of Clinical Immunology[10], curcumin from turmeric has the potential to boost immune function.

Another study by researchers Pietro Dulbecco and Vincenzo Savarino to explore the health benefits of turmeric on digestive health was published in the World Journal of Gastroenterology[11]. The results of the study show that curcumin from turmeric can offer therapeutic benefits to a variety of digestive diseases.

Some Natural Sources of Digestive Enzymes

There are natural ways you can increase enzyme intake for those individuals experiencing digestive enzyme deficiency.

Dr. Bedford recommends adding the following types of food to your diet. They have digestive enzymes that may aid in digestion.

  • Pineapple
  • Papaya
  • Mango
  • Avocado,
  • Sauerkraut
  • Ginger
  • Bananas

Key Things to Consider When Buying a Digestive Enzyme

Here are key things to consider when buying a digestive enzyme supplement:

  • Enzyme Strength: Enzyme strength is a key determinant when it comes to digestive enzyme efficiency. The stronger the enzyme, the greater the supplement’s effectiveness.
  • Enzyme Types: When selecting a digestive enzyme supplement, ensure that it contains the type of enzyme designed to address your digestive-specific needs.
  • Additional Ingredients: A digestive supplement with additional ingredients has a high likelihood of offering extra health benefits besides what it is meant to offer.
  • Dosage: Taking the recommended dosage per day increases the chances of achieving the intended health goals. Over-dosing may lead to health risks while under-dosing may lead to product inefficiency.
  • Price: Every person wants value for their money. So, we advise that you research and do a product comparison before making a purchase decision to ensure that you are getting value for your money

Key Benefits of Taking Digestive Enzymes Supplements

Some of the key benefits of taking digestive enzyme supplements are explained below:

Helps break down sugar found in dairy
Enzyme like lactase naturally produced from the small intestine has been found to help in the breakdown of certain sugar particularly those found in the dairy.

May help treat digestive health-related conditions
Digestive enzyme supplements have also been found to aid in the treatment of digestive health-related conditions, including autoimmune conditions that affect the small intestine.

May help manage lactose intolerance
People with lactose intolerance can rely on digestive enzyme supplements to manage the issue. They allow such people to enjoy dairy food without experiencing undesirable side effects.

Product Comparison

Here’s a short comparison of our top recommendations to make your decision easier:

Unbloat Nucific Digestive Enzyme Activated You Active Enzyme 1MD EnzymeMD Biotics 8
Rating star-4.9 star-4.8 star-4.7 star-4.8 star-4.8
Cost $44.99 $49.00 $64.95 $64.95 $64.99
Dosage 2 Capsules Daily 6 Capsules Daily 2 Capsules Per Day 2 Capsules Per Day 3 Capsules Per Day
Usage Bloating Relief, Digestion, Healthy Gut Supports Smoother Digestion, Reduces Bloating Improved digestion, Reduced Inflammation Improved digestion, Reduces Bloating and Gassiness Improve Focus, Support Mental Wellbeing
Return Policy 30-Days 90-Days 90-Days 90-Days 60-Days
Pros Vegetarian, Non-GMO, Gluten Free Allergen Free, Gluten Free Easy-Swallow Capsule, 100% Money Back Guarantee High Quality Ingredients, Plant-based Enzymes GMP-certified, Soy Free, Gluten Free
Review Reasonable Deal Highly Recommended Highly Effective & Safe Good Results Quick Results with No Side Effects
Shop Now

Frequently Asked Questions

Q. Are digestive enzyme supplements different from probiotics?

A: Most people tend to confuse digestive enzymes and probiotics but they are not the same. However, they both do affect digestion, though in different ways.

Digestive enzymes are made of molecules that work to aid in the breakdown of the food we consume. Probiotics, on the other hand, are living microorganisms present in our gut that make up good bacteria.

Probiotics play the role of keeping the digestive tract healthy and have a positive effect on the body’s physiological processes.

In the absence of good gut bacteria, it is easy to experience symptoms resembling those of enzyme insufficiency like gas and bloating.

Q. Do digestive enzymes ease digestion?

A: Digestive enzymes are crucial as they ensure proper nutrient absorption and digestion. Without them, breaking down the food we take and absorbing nutrients that the body requires may be difficult.

However, not all digestive enzymes present in the market will help you achieve this. It requires the strongest digestive enzymes or the best digestive enzyme supplement to be able to experience healthy digestion and proper nutrient absorption.

Q. Can digestive enzymes speed up weight loss?

A: High-quality digestive enzymes can effectively support abdominal issues like pancreatic insufficiency where absorption of nutrients from food becomes difficult.

When combined with the right probiotics, they can help ease digestive system-related symptoms in people with gastrointestinal conditions but they can aid in weight loss.

However, there are arguments that digestive enzyme supplements with lipase enzymes can be helpful in losing weight. According to some studies, lipase can help increase fat metabolism in the body which is somehow linked to weight reduction.

Q. Do digestive enzymes work or they are scam?

A: Digestive enzyme supplements are designed to fix abdominal issues such as heartburn, gas, bloating, bowel irregularity, and overall gut health. However, there is little evidence to support the efficiency claims of these good digestive enzyme supplements.

Some of these best digestive enzymes supplements do offer gut health benefits in certain situations while others are utilized in situations where there is little or no evidence of them working.

A publication by Harvard Medical School[12] warns not to be in a hurry to go for them because insufficient evidence of them having the ability to promote gut health.

Q. Are there risks associated with taking digestive enzymes?

A: Digestive enzyme supplements have been associated with various health risks such as diarrhea, cramps/abdominal pain, nausea, serious allergic reactions, etc.

So, if you are taking digestive enzymes and you happen to experience any of these symptoms and more, we recommend that you talk to your doctor about it.

But if you are taking doctor-prescribed digestive enzymes, it means that your health provider’s judgment is that the benefits are greater compared to the side effects risks.

Q. Any difference between prescription enzymes and over-the-counter digestive enzymes?

A: People diagnosed with enzyme insufficiency require prescription digestive enzymes because such supplements help the body absorb nutrients and process food better.

The best pancreatic enzyme supplements prescription contains three major enzymes; lipase, amylase, and protease. They work to ensure the proper breakdown of fats, carbs, and proteins says Dr. Denhard.

Over-the-counter digestive enzyme supplements, on the other hand, work to address abdominal issues like gas, acid reflux, diarrhea, and bloating. Some of these otc digestive enzymes may contain protease, amylase, and lipase.

Others contain lactase and alpha-galactosidase (an enzyme the body doesn’t produce) even in healthy individuals who do not suffer from enzyme insufficiency.

Alpha-galactosidase aids in the breakdown of non-absorbable fiber known as galactooligosaccharides (GOS), mostly present in root vegetables, beans, and some dairy products.

Q. When should you take your digestive enzymes?

A: While digestive enzyme supplements are meant to help ease digestion and improve nutrient absorption, they come with different usage directions depending on the type of enzymes contained in them.

Some digestive enzymes are to be taken with a meal, before the meal, and others after the meal. The best option would be to check the label and stick to the given usage direction for optimal results.

Q. Can digestive enzyme supplements help with SIBO?

A: Small intestinal bacterial overgrowth (SIBO) is implicated as the main cause of chronic malabsorption, diarrhea, bloating, and constipation.

Good bacteria are known to support healthy digestion and so, it’s contradicting to imagine that they can also be harmful. The truth is that the digestion system requires only enough good bacteria and not excess in order to function properly.

The best digestive enzymes for sibo can, therefore, help people manage SIBO by regulating the production of good bacteria in small intestines by inhibiting excess synthesis.


Best digestive enzymes are some of the sort-after supplements in the health industry today because people are keen on maintaining a healthy gut.

However, not all of the supplements out there will help you address your gut health issues like bloating and gas.

But with the detailed information above, we believe that it will help you make an informed purchase decision.

If you have any gut health issues, it is time to add a digestive enzyme to your health regimen and begin your journey to a healthy digestive system.

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Allison Lansman, RDN, LD

Allison has been practicing dietetics since 2017 and has worked in many settings, including hospitals, clinics, & foodservice industry.

12 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Vitamin B12, Folic Acid, and the Immune System
[2] Proteases: Multifunctional Enzymes in Life and Disease
[3] Bromelain, a Group of Pineapple Proteolytic Complex Enzymes
[4] Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans
[5] Ginger in gastrointestinal disorders: A systematic review of clinical trials
[6] Gastroenterology
[7] Effect of low caloric diet supplemented by fennel (Foeniculum vulgare) seeds or black cumin (Nigella sativa) seeds and its mixture on obese adult female patients
[8] Effect of Fennel seed: On women health
[9] A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes
[10] "Spicing up" of the immune system by curcumin
[11] Therapeutic potential of curcumin in digestive diseases
[12] Gut reaction: A limited role for digestive enzyme supplements

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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