In This Review


A joint is a point where two or more bones intersect. Joint is surrounded by synovial fluid for lubrication, cushioning, and shock absorption. Joint pain can occur due to a variety of reasons like injury, illness, or medical conditions. Some possible causes of joint pain include autoimmune diseases like lupus or rheumatoid arthritis, osteoarthritis, tendinitis, bursitis, gout, infections, and fractures. Arthralgia or arthritis are terms used to describe joint discomfort. It might be moderate and provide some discomfort, or it can be severe and debilitating. However, joint pain is usually not an emergency and can be managed at home.

Topical pain relief solutions are a type of over-the-counter drug that is applied directly to the skin to relieve pain and suffering in specific locations of the body. These treatments are available in creams, gels, lotions, and sprays, and contain a variety of active substances that can provide relief for conditions such as arthritis, sore muscles, and joint pain. Topical pain relief products provide a simple, convenient, and non-invasive alternative to managing pain.

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At Consumer Health Digest, we understand that finding the right health and wellness products can be a daunting task. That’s why our team of dedicated health experts and certified dietitians have put in tireless effort to bring you the very best in topical pain relief products. Our team has conducted an extensive and thorough research process, including an in-depth analysis of online reviews and clinical studies, to ensure that the products we recommend are not only effective, but also safe and suitable for our valued customers. You can trust that the products we have carefully selected are backed by science and will meet all of your needs.

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At our company, we are committed to delivering the most accurate and reliable information to our readers. To achieve this, we have implemented a rigorous testing and evaluation process for all of our products. Our team of experts conducts a thorough examination of each product for a minimum of one week to ensure that we are providing unbiased and comprehensive information to our readers.

To ensure that our information is both reliable and medically sound, we have partnered with Robert G. Silverman, founder of Westchester Integrative Health Center, who specializes in treating joint pain using functional nutrition with cutting-edge science-based nonsurgical approaches.

We are dedicated to providing our readers with the best and most accurate information, so that they can make informed decisions about their health and wellness.

Our Top Picks

10 Best Topical Pain Relief Products 2023

Discover the best solution for your pain management needs with our top 10 topical pain relief products of 2023. From creams, gels, sprays, patches, these products are specially formulated for localized pain relief and can treat a variety of conditions like chronic back pain, headaches, sore muscles, and arthritis.


Well Care Botanicals | Best Topical Pain Relief Cream


Well Care Botanicals

(4.9/5) 536 REVIEWS
  • High-Quality Ingredients
  • Risk-free Trial
  • Affordable Price
  • Powerful Testimonials
  • Reputable History
  • Form: Cream
  • Quantity: 1000 mg
  • Dosage: Twice Daily
  • Ingredients: Organic Aloe leaf juice, Organic Coconut Oil, Emulsifying Wax, Organic Arnica Flower Extra
  • Usage: Gets rid of all kinds of aches, inflammation, soreness, and pains instantly
  • Safety: GMP Certified, Lab Tested
  • Refund Policy: 14 Days Return Policy
  • Company Info: Mail: [email protected], Tel: 888-211-2011

This product actually works!star-4.8

“My 80-year-old husband shattered his left ankle almost three years ago and has been in agony and discomfort ever since, despite a good surgery and recovery. He refuses to use painkillers, and Tylenol only helps a little. Your cream has brought him much-needed relief… Every night, I touch his ankle and foot, and he sleeps better and gets up earlier.” -Emily B.



*All individuals are unique. Your results can and will vary.

Well Care Botanicals is a brand that offers a variety of high-quality hemp extract products, including creams and gels for pain relief. These products are specially formulated to promote overall wellness, helping users to sleep better, manage pain and anxiety effectively.

colanAloe leaf extract is one of the organic extracts believed to have a nourishing and protective effect on the skin. It can, therefore, protect your skin from damage while keeping it nourished and moist.

According to the Iranian Journal of Medical Sciences, Aloe Vera is a medicinal herb is packed with anti-inflammatory, anti-bacterial, antiseptic, and wound healing properties and can be used to improve skin integrity.colan-1

Well Care Botanicals Cream is made with all-natural and organic ingredients sourced from sustainably farmed plants. This cream is designed to provide instant relief from pain and discomfort, nourish and protect the skin, reduce swelling, and aid in the healing of bruises. It’s a perfect solution for people looking for a natural remedy for pain relief.

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Penetrex Pain Relief Cream | Best For Joint & Muscle Pain


Penetrex Pain Relief Cream

(4.1/5) 443 REVIEWS
  • Form: Cream
  • Quantity: 114 gm
  • Dosage: 3-4 Times Daily
  • Ingredients: Arnica, Pyridoxine, Methylsulfonylmethane, Boswellia Serrata
  • Usage: Whole Body Relief
  • Safety: Cruelty Free
  • Refund Policy: 365 Days Refund Policy
  • Company Info: 8921 Complex Dr San Diego, CA 92123, Mail: [email protected], Tel: (858) 356-5980

Penetrex is good inflammation product star-3.5-1

“The best anti-inflammatory treatment I have ever used is Penetrex cream, which I will recommend to everyone of my friends and family. After installing a bathroom faucet, I had significant pain in my wrist and was looking for something to assist. At my local Walmart, I saw a man pick up a jar of Penetrex pain relief cream and tell me it actually “WORKS.” I bought it, and it does really work” -Luis DeLaRosa.

Penetrex pain relief cream is a product that utilizes the latest technology and high-quality ingredients to provide effective relief. By incorporating the latest advancements in skin penetration and emulsification, the cream ensures that the active ingredients are effectively absorbed by the outer layer of the skin to the affected area.

An active carrier of the ingredients, Ethoxydiglycol, is used in the cream. This ingredient is both water and oil-soluble, which improves the absorption of all the active ingredients. Arnica Extract, Dipotassium Glycyrrhizinate, and Camphor are also included for their anti-inflammatory and calming properties, providing relief from inflammation and calming pain. The cream’s effectiveness is further enhanced by its topical formulation, which allows the ingredients to work directly at the injured area, bypassing the stomach and intestine.Read Reviews


Tiger Balm | Best For Back Pain


Tiger Balm

(3.8/5) 490 REVIEWS
  • Form: Balm
  • Quantity: 18 Grams
  • Dosage: Twice Daily
  • Ingredients: Camphor, Menthol, Capsicum Extract, Methyl Salicylate
  • Usage: Joint & Muscle Pain Relief
  • Safety: Safe Ingredients
  • Refund Policy: N/A
  • Company Info: Prince of Peace® Enterprises, Inc. 751 North Canyons Parkway Livermore, CA 94551, Mail: [email protected], Tel: 1 (925) 292-3888

Its work for me! star-3.5-1

“I’ve been using Tiger Balm for a long time. There are many formulations for it, and although this one appears to have less menthol than the Ultra Strength version, it nonetheless seems to work. Although it lacks the other formula’s bite, that’s okay. It would be better for me if this worked, and it appears to. I use it on my lower back, knees, and shoulders, and they all seem to feel better afterward, so I’m happy with this product. The cost was reasonable as well. Much less expensive than Walgreens—I saved over $3 each jar by purchasing it from Amazon, and free shipping was a pleasant bonus.” -Susan Cromby.


*All individuals are unique. Your results can and will vary.

A topical lotion or ointment called “Tiger Balm” is used to treat pain, soreness, and discomfort. It is created from a mixture of all-natural components, including cajuput oil, menthol, and camphor. It is frequently used to alleviate joint pain, muscle aches, and headaches. It is supposed to function by producing a warm sensation that aids in relaxing muscles and reducing pain when applied straight to the skin. Some people also use it to treat small burns, bug bites, and chest rubs for the cold and flu.Read Reviews


Aspercreme | Best Topical Pain Relief For Arthritis And Joint Pain


Aspercreme Pain Relieving Cream

(3.6/5) 220 REVIEWS
  • Form: Cream
  • Quantity: 75 Grams
  • Dosage: Twice Daily
  • Ingredients: Lidocaine HCI (4 %), Topical Anesthetic, Aloe Barbadendsis Leaf Juice, Aminomethyl Propanol
  • Usage: Relief Joint & Muscle Pains
  • Safety: Safe Ingredients
  • Refund Policy: N/A
  • Company Info: Chattem, Inc. P.O. Box 2219 Chattanooga, TN 37409-0219, Tel: 1-800-633-1610

Helps take the edge off severe muscle pain star-3.5-1

“I’ve been experiencing horrible pain and muscular strain in my neck, back, and shoulders lately. I’ve tried everything I know to help the muscles relax, but nothing works. While this cream doesn’t totally alleviate the discomfort, it does lessen it to the point where the burning stops. It won’t make me better, but I’ll accept anything that even slightly aids.” -Frederico.

Aspercreme is a clinically established topical salicylate cream (Trolamine Salicylate 10%) used to treat small aches and pains caused by arthritis, basic back discomfort, strains, and joint and muscle difficulties. Aspercreme has anti-inflammatory properties, lowering swelling and inflammation in affected muscles and joints. It immediately diffuses and infuses into painful areas, and its deep-penetrating action provides long-lasting relief. Chattem, Inc., a Sanofi Company, manufactures Aspercreme.

Aspercreme has a number of active substances that are extremely effective for pain relief and the treatment of joint disorders. It is a joint supplement that enhances joint health and is believed to alleviate joint pain. It aids in the relief of arthritis symptoms.Read Reviews


Biofreeze Roll-On | Best For Fast Acting Cold Therapy


Biofreeze Roll-On

(3.5/5) 383 REVIEWS
  • Form: Spray
  • Quantity: 89 mL
  • Dosage: 3 to 4 Times Daily
  • Ingredients: Arnica Montana Flower Extract, Calendula Officinalis Flower Extract, Camellia Sinensis Leaf Extract
  • Usage: Reduce joint pain and discomfort
  • Safety: FSA/HSA eligible
  • Refund Policy: N/A
  • Company Info: Mail: [email protected], Tel: 1-800-228-4722

Fast acting and effective. star-3.5-1

“The 360-degree spray (so you may spray at any angle) helps you reach locations that are difficult to reach on your own if you don’t have someone nearby to assist. A friend who received samples from their chiropractor recommended this product. I also tested the gel form (samples), which was similarly satisfactory. Good for chronic pain, all areas of the back and legs, and helps with sciatic nerve discomfort. It does not eliminate the need for over-the-counter pain medicine, but it works immediately on touch and, in my opinion, is superior to using prescription medication.” -Kim Karas

Biofreeze is a well-known brand of topical pain reliever spray used to treat muscular and joint pain, tightness, and stiffness. It’s especially popular among athletes, fitness buffs, and physical therapy patients. Menthol, a natural chemical originating from mint plants, is the active element in Biofreeze. Menthol generates a cold feeling on the skin, which helps to numb the area and relieve pain and inflammation. Biofreeze spray can be sprayed directly to the area of pain and is reported to provide relief rapidly.

One of the benefits of Biofreeze spray is its ease of application. It is easy to administer to hard-to-reach regions because it may be sprayed directly onto the skin. Furthermore, because Biofreeze is non-greasy and does not stain clothing, it can be used during the day. It is also available in a variety of forms, including sprays, gels, and roll-ons, allowing you to select the form that is most convenient for you.Read Reviews


Theraworx Relief | Best For Foot & Leg Cramps


Theraworx Relief

(3.5/5) 303 REVIEWS
  • Form: Foam
  • Quantity: 210 mL
  • Dosage: 2 to 3 Time Daily
  • Ingredients: Aloe Vera, Allantoin, Vitamin E, Grapefruit Extract, Colloidal Silver, Magnesium Sulfate
  • Usage: Relieves muscle cramps
  • Safety: Safe & Gentle, Made in USA
  • Refund Policy: N/A
  • Company Info: Theraworx Relief 4 Old Patton Cove Road Swannanoa, NC 28778, Mail: [email protected], Tel: 888-282-7353

It beneficial when you have a cramp. star-3.5-1

“I’ve found this product to be extremely useful when I’m traveling and tend to experience more leg or foot cramping due to increased walking. I’ve had success with it many times if I get a cramp, but now I apply it on my feet and legs before going to bed which has lessened the chances of cramping. I appreciate that this set included a smaller, travel-size version as it makes packing it in my suitcase more convenient. Although I did feel the price was a bit high, I believe the product is worth it.” -Maria Dillard

Theraworx Relief is a topical foam used to treat muscle cramps and spasms. It is a quick-acting, easy-to-apply foam that is applied straight to the skin and is supposed to operate by lowering lactic acid buildup in muscles. This can aid in the prevention and relief of muscle cramps and spasms. The solution is also non-greasy and does not stain clothing, making it suitable for usage during the day.

Theraworx Relief is a prescription-only medication that can be used to treat muscle cramps and spasms caused by a range of circumstances, including overuse, injury, or certain medical problems. It is also used to avoid muscle cramps at night.Read Reviews


FlexPower Warm Lotion | Best Hot Therapy Lotion


FlexPower Warm Lotion

(3.4/5) 383 REVIEWS
  • Form: Lotion
  • Quantity: 118 mL
  • Dosage: Twice Daily
  • Ingredients: Trolamine Salicylate, Lecithin, Caprylyl Glycol, Caprylic/Capric Triglyceride Stearate, Phenoxyethanol, Propylene Glycol
  • Usage: Reduce joint pain and discomfort
  • Safety: All Safe Ingredient
  • Refund Policy: N/A
  • Company Info: 2110 Main Street Suite 202 Santa Monica, California 90405, Mail: [email protected], Tel: +1 (310) 402-2199

Easy to use star-3.5-1

“I have been using FlexPower Warm Lotion for a few weeks and I am very pleased with the results. The lotion provides a warm sensation that helps to soothe my sore muscles and joints. I would recommend FlexPower Warm Lotion to anyone looking for a fast-acting, easy-to-use pain relief lotion that provides warmth to the area of pain.” -James M Smith


*All individuals are unique. Your results can and will vary.

FlexPower Warm Lotion is a topical pain reliever intended to treat muscular and joint pain, soreness, and stiffness. It is designed to offer warmth to the area of pain, which can aid in increasing blood flow, reducing muscle spasms, and promoting healing. Menthol and methyl salicylate, both of which have pain-relieving qualities, are active components in FlexPower Warm Lotion. To provide additional advantages, the lotion is infused with natural substances such as Aloe Vera, Arnica, and MSM.

FlexPower Warm Lotion is simple to use; simply apply it to the skin and massage it into the painful area. It is also non-greasy and does not stain clothing, making it suitable for usage during the day. It can be used before or after exercise, as well as to treat pain caused by arthritis, back discomfort, and other ailments.Official Website


Ortho-Nesic | Best Arthritis Topical Pain Relief Gel


Ortho-Nesic Pain-Relieving Gel

(3.4/5) 383 REVIEWS
  • Form: Gel
  • Quantity: 177 mL
  • Dosage: Twice Daily
  • Ingredients: Menthol, Camphor, Carbomer, Isopropyl, Camellia Sinensis
  • Usage: Whole Body Relief
  • Safety: Made in USA
  • Refund Policy: 100% Patient-Direct, Money-Back Guarantee
  • Company Info: 11037 Lockport Place, Santa Fe Springs , CA 90670, Mail: [email protected], Tel: (800)307-8818

Strong Menthol Odor star-3.3-1

“I have been using Ortho-Nesic Pain-Relieving Gel for the past few weeks and have found it to be effective in managing my occasional muscle and joint pain. The gel is easy to apply and absorbs quickly into the skin, providing a cooling sensation that helps to alleviate discomfort. One thing to note is that the gel has a strong menthol odor, which may not be suitable for everyone.” -Deborah J.

Ortho-Nesic Pain-Relieving Gel is a popular choice for individuals looking for a fast-acting and convenient solution for muscle and joint pain. The gel is easy to apply and absorbs quickly into the skin, providing a cooling sensation that helps to alleviate discomfort. The active ingredient in the gel is menthol, which is known to provide a cooling sensation that can help to alleviate discomfort. The gel is non-greasy and doesn’t leave any residue on clothes. It can be used as needed throughout the day, but it is always recommended to follow the recommended dosage. Overall, Ortho-Nesic Pain-Relieving Gel is a good option for those looking for a reliable and effective pain relief solution.Official Website


Penetran Plus | Best For Topical Pain Relief Lotion


Penetran Plus

(3.4/5) 180 REVIEWS
  • Form: Lotion
  • Quantity: 237 mL
  • Dosage: 2 to 3 Times Daily
  • Ingredients: Ammonia Solution, Allantoin, Asorbyl Palminate, Benzethonium Chloride
  • Usage: Reduce Muscle Aches
  • Safety: All Natural Ingredients
  • Refund Policy: 30-Days Return Policy
  • Company Info: Contact Form:

Easy to apply! star-3.5-1

“I recently tried Penetran Plus for my chronic muscle pain and found it to be quite effective. Easy to apply the product directly to the affected area and the formula seemed to penetrate deep into the muscle tissue for targeted relief. One thing to note is that the relief was not immediate, it took some time for me to feel the effects. However, once it kicked in, I noticed a significant reduction in pain and stiffness.” -Charles R.

Penetran Plus is a topical pain relief product that is designed to provide targeted relief for chronic muscle pain. The product comes in a roll-on applicator that allows for easy application to the affected area, making it easy to use and convenient to take with you wherever you go. The formula is absorbed quickly into the skin and is said to penetrate deep into the muscle tissue for targeted relief. The product has a pleasant scent and does not leave any residue on the skin or clothing.

It is important to note that the active ingredients in the product are not specified, which makes it difficult to determine the effectiveness and potential side effects of the product. As with any pain relief product, individual results may vary, and it may not work for everyone. Official Website


Voltaren Arthritis Pain Gel | Best for Arthritis and Joint Pain


Voltaren Arthritis Pain Gel

(3.4/5) 383 REVIEWS
  • Form: Gel
  • Quantity: 50 Grams
  • Dosage: Twice Daily
  • Ingredients: Diclofenac sodium, Nonsteroidal anti-inflammatory drug (NSAID)
  • Usage: Relieve Arthritis Join Pain
  • Safety: Made in USA
  • Refund Policy: N/A
  • Company Info: Mail: [email protected], Tel: 1-855-297-3031

Severe Arthritis in Lower Back – IT HELPSstar-3.1-2

“Despite being taken medication for my hand arthritis, I have significant lower back arthritis. One day, I was in excruciating agony and was out of my regular supply of Sombre from my massage therapist. Nevertheless, I’ll give this a go. I take diclofenac twice daily, but if I am particularly active, sometimes that doesn’t help as much. So I utilise it if I’m not able to take any further tablets.” -Stacey P.

Voltaren Arthritis Pain Gel is a topically applied solution designed to provide direct relief to sore joints, muscles, and other regional aches. The product is well-made and is brought to you by a reputable company, adding credibility to its effectiveness. It contains natural ingredients known to deliver many benefits.

Through its application in gel form, Voltaren Gel delivers a non-steroidal anti-inflammatory product called diclofenac directly to sore tissues, allowing for targeted pain relief where it is needed most, such as the knees, instead of being distributed throughout the bodyRead Reviews

How to Choose the Best Topical Pain Relief Products?

Because of the many side effects of medications for joint pain, most patients prefer other treatments like the natural variety. Topical joint pain relief products are currently one of the most popular. These products basically work by blocking the substances that are responsible for transmitting pain signals in the body.

There are also products that help release endorphins which also help block pain. You just need to find the right product which is both safe and effective (source). Check the ingredients carefully in order to ensure that the product really works and is free of side effects.

Key Ingredients to Look for in Topical Pain Relief Products

Several essential substances are typically found in topical pain treatment medications. These are some examples:


A natural pain reliever that provides a cooling sensation, it can be found in products such as Biofreeze and Flexpower. It is known for its cooling and soothing properties and is often used in topical pain relief products such as Biofreeze, Flexpower, and Icy Hot[1].


Capsaicin is a compound found in chili peppers that is known for its pain-relieving properties. It is responsible for transmitting pain signals to the brain. It can be found in products such as Capzasin and Zostrix[2].


A natural pain reliever that has a cooling effect and can help to reduce inflammation. It can be found in products such as Bengay and Flexpower. It can also be used to relieve itching and discomfort associated with conditions such as poison ivy, eczema, and insect bites[3].


The active ingredient in aspirin, is often used to relieve minor aches and pains. It can be found in products such as Aspercreme and Bengay. They are known for their anti-inflammatory and pain-relieving properties. Aspirin is a well-known example of a salicylate medication[4].


A naturally-occurring nutrient that is often used to reduce inflammation and pain. It can be found in products such as Flexpower and Theraworx Relief. It has been used to relieve pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and back pain. Methyl Sulfonyl Methane (MSM) has also been used to treat conditions such as bursitis, tendonitis, and sprains[5].


A natural herb that has anti-inflammatory properties and can help to reduce pain and swelling. It can be found in products such as Traumeel and Boiron Arnicare. It is also used to relieve muscle soreness and stiffness, sprains, and strains[6].

Also, make sure that the formulation only uses quality ingredients for maximum efficacy. A good sign you should be looking for in a product for joint pain relief is if it comes with a money-back guarantee.

In some cases, joint inflammation supplements can be included in the treatment program for joint pain. It can be used together with physical therapy and other alternative treatments for maximum relief from joint pain.

Product Comparison

Here’s a short comparison of our top 5 recommendations to make your decision easier:

Well Care Botanicals Penetrex Pain Relief Cream Tiger Balm Aspercreme Pain Relieving Cream Biofreeze Roll-On
Cost $69.95 $34.95 $5.88 $7.94 $12.58
Dosage Twice Daily 3 to 4 Times Daily Twice Daily Twice Daily 3 to 4 Times Daily
Usage Gets rid of all kinds of aches Full Body Relief Joint & Muscle Pain Relief Relief Joint & Muscle Pains Reduce joint pain and discomfort
Return Policy 14 Days Return Policy 365 Days Refund Policy N/A N/A N/A
Pros Instant relief of pain and aches Gluten and preservative free Made from natural and potent ingredients. Relief from Muscle and Joint Pain. Relieve muscle soreness
Review Instant relief for chronic back pain. Miracle cream for sore muscles. Effective for both acute and chronic pain. Easy to use. Fast acting and effective.
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Frequently Asked Questions

Q: How do topical pain relievers work?

A: Topical pain relievers work by delivering the active component directly to the site of discomfort via the skin. These solutions, which can be creams, gels, or ointments, can give regional pain relief without the danger of systemic adverse effects associated with oral drugs.

Q: Are topical pain relief products safe to use?

A: Most topical pain relief products are considered safe when used as directed. It is important to always read and follow the instructions on the product label and to consult a healthcare professional if you have any concerns or questions about using a particular product.

Q: How often can I use a topical pain relief product?

A: The frequency of use for topical pain relief products will vary depending on the product and the condition being treated. It is important to follow the instructions on the product label and to consult a healthcare professional if you have any questions about the appropriate frequency of use.

Q: Can topical pain relief products be used with other medications?

A: It is always important to consult with a healthcare professional before using any new medication, including topical pain relief products, in conjunction with other medications. Some topical pain relief products may interact with certain medications, so it is important to be aware of any potential interactions.

Q: What are the active ingredients in topical pain relief products?

A: The active ingredients in topical pain relief products can vary depending on the product. Some common active ingredients include menthol, capsaicin, salicylates, and counterirritants. It is important to read the product label and consult a healthcare professional if you have any questions about the active ingredients in a particular product.

Q: Can topical pain relief products be used for chronic pain?

A: Topical pain relief products can be effective in managing chronic pain, but it is important to consult a healthcare professional for advice and treatment options. Some chronic pain conditions may require a combination of treatments, including oral medications, physical therapy, and lifestyle changes.

Q: Are topical pain relief products safe for children to use?

A: Because some topical pain relievers are not appropriate for children, it is critical to consult with a healthcare practitioner before using them on children.


Finally, when it comes to managing localised pain, topical pain management treatments can be an effective and safe alternative to oral drugs. These solutions function by delivering the active component through the skin to the region of pain. They can help with a variety of diseases, including persistent back pain, headaches, aching muscles, and arthritis.

It is critical to always read and follow the product label instructions, and to consult with a healthcare professional if you have any concerns or questions about using a specific product. There are many different types of topical pain treatment solutions on the market, each with its own combination of active chemicals, so it is critical to select the one that best meets your needs.

Topical pain treatment, when used correctly, can be a significant aid in managing pain and increasing overall quality of life. Before making a decision, it is critical to explore all available options and talk with a healthcare practitioner.

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Robert G. Silverman, MS, CCN, CNS, CSCS

Dr. Robert G. Silverman is a chiropractic doctor, clinical nutritionist, and author of 'Inside-Out Health: A Revolutionary Approach to

6 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Topp R, Brosky JA Jr, Pieschel D. The effect of either topical menthol or a placebo on functioning and knee pain among patients with knee OA. J Geriatr Phys Ther. 2013 Apr-Jun;36(2):92-9. doi: 10.1519/JPT.0b013e318268dde1. PMID: 22976810.
[2] Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA, Verri WA. Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules. 2016 Jun 28;21(7):844. doi: 10.3390/molecules21070844. PMID: 27367653; PMCID: PMC6273101.
[3] Chen W, Vermaak I, Viljoen A. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. doi: 10.3390/molecules18055434. PMID: 23666009; PMCID: PMC6270224.
[4] Runde TJ, Nappe TM. Salicylates Toxicity. [Updated 2022 Jul 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
[5] Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. PMID: 28300758; PMCID: PMC5372953.
[6] Smith AG, Miles VN, Holmes DT, Chen X, Lei W. Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management. Medicines (Basel). 2021 Oct 9;8(10):58. doi: 10.3390/medicines8100058. PMID: 34677487; PMCID: PMC8537440.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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