Best Joint Pain Supplements of 2017 Reviewed

Editor's Note: This article has been recently updated with latest information and research studies.

Joint pain is most often a result of diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), and other conditions affecting the joints. According to the Centers for Disease Control and Prevention (CDC), approximately 22,7% of people in the U.S. were told by a doctor to have some form of arthritis. But despite its high prevalence, treatment for arthritis is limited to relieving the symptoms such as Osteoarthritis and inflammation without directly addressing the disease. This is exactly why a lot of people turn to alternative remedies such as joint pain supplements in order to find some relief. In order to manage the joint pain, relieves any kind of discomfort, and improve* flexibility people usually opt for the best joint pain supplement.

How to Choose the Best Joint Pain Supplements

Choosing joint pain supplements is not easy. This is mostly because there is an abundance of joint pain supplements on the market with most of them not offering any true measurable benefits. Because most of these products are designed as dietary supplements, they don’t undergo vigorous FDA testing making their ingredient safety and efficiency highly debatable. Furthermore, the studies on common ingredients in joint pain supplements are inconclusive and contradictory as stated in a review on joint pain supplements published in Pharmacy and Therapeutics. So choosing the best joint pain supplements will largely depend on your own research and trust regarding these products.

How do Joint Pain Supplements Work?

Joint pain products contain ingredients that are believed to mainly reduce* inflammation and repair joint structure. The supplements are meant to be taken orally, and the ingredients that enter the bloodstream are believed to improve* collagen synthesis, inhibiting the synthesis of proteins that can cause joint cartilage destruction, and reduce* inflammation and pain. Some supplements also improve* joint lubrication by affecting the synovial fluid of the joints. This efficiency can depend greatly on the quality of the ingredients, their molecular weight, and their ability to enter the bloodstream.

Things to Consider When Taking Joint Pain Supplements

Most joint pain supplements you see on the market are derived from natural ingredients and are completely safe. This also means you probably won’t have any side effects which is common with prescription treatments for arthritis. Talk to your doctor before taking these supplements especially if you are currently taking other medications. Another thing you need to consider before taking supplements is label transparency, i.e. that all ingredients are listed including binding ones. This is important especially if you have certain allergies and want to make sure you don’t have an allergic reaction to any of the ingredients in your joint pain supplement.

Popular Ingredients in Joint Pain Supplements

The two most popular ingredients in joint pain supplements are glucosamine and chondroitin. Both ingredients are important constituents of healthy joint cartilage tissue. Their efficiency in repairing the joints is limited to laboratory studies. Other popular ingredients are hyaluronic acid which is a part of the synovial fluid, diacerein, Avocado–soybean unsaponifiable (ASU), S-adenosylmethionine, Indian frankincense (Boswellia), capsaicin, turmeric, etc. Some of these ingredients are believed to help improve* joint cartilage structure and speed up repair and others function as natural anti-inflammatories and pain relievers.

The 10 Overall Best Joint Pain Supplements

Considering ingredients quality and efficiency, label transparency, product reviews, we’ve picked out 10 of the best joint pain supplements in terms of safety and efficiency.

#1 Flexoplex

Flexoplex is a supplement designed to address all issues that could be affecting arthritic joints. The product claims are that it can repair joint cartilage, improve* joint lubrication, reduce* inflammation, decrease* pain and lead to better joint mobility. The ingredients in this product are chondroitin sulfate which, according to clinical trials, is the best form of chondroitin for OA. The product also contains glucosamine sulfate, Boswellia, hyaluronic acid, rutin, MSM, trypsin, and bromelain. While chondroitin and glucosamine work to repair the structure of joint cartilage, ingredients such as bromelain reduce* pain and inflammation caused by osteoarthritis. Bromealain which is a pineapple extract was extensively studied is considered a safer alternative to NSAIDs in the treatment of arthritis pain. Although the product is pricey, the manufacturers of Flexoplex offer a 60-day money-back guarantee. In case you find the product ineffective, you could just return the bottle and get your money back. Read more about Flexoplex here.

#2 Instaflex

Endorsed by famous football player Doug Flutie, Instaflex is bound to offer at least some benefits to arthritis sufferers. This product contains a unique form of Boswellia extract labeled AprèsFlex, resveratrol, a polyphenol, UC-II Collagen, Black pepper extract, Hyaluronic acid,and, lastly, turmeric was added due to its fairly known anti-inflammatory properties. Read more about Instaflex here.

#3 Osteo Bi-Flex

This product is unique in that it offers benefits not just to the joints but also surrounding muscles. Another thing that makes this product unique is that the product tablets are 80% smaller than other similar joint-supporting supplements. Osteo Bi-Flex is also suitable for those with gluten sensitivity and shellfish allergies. As far as the ingredients are concerned, the product contains glucosamine, type-II collagen, 5-LOXIN Advanced, and MSM. Read more about Osteo Bi-Flex here.

#4 Beneflex

For those who had bad experiences with the most common joint supplement ingredients, namely chondroitin and glucosamine, Beneflex, Turmeric, Boswellia, Hyaluronic acid, and UC-II Collagen. The product has received a lot of positive reviews making this product one of the rare that live up to its claims. The legitimacy of this product is further supported by the fact that Beneflex is a proud sponsor of the Arthritis Foundation. Read more about Beneflex here.

#5 Osteojuv

OsteJuv’s main purpose is to improve* joint lubrication as it contains high concentrations of hyaluronic acid. The manufacturers of OsteoJuv claim the product is capable of treating pain from different types of arthritis and works on all joints in the body. Besides improving* joint lubrication, this product is said to reduce* inflammation which is another contributing factor to pain and joint damage. While this product also contains ingredients such as chondroitin and glucosamine. Read more about OsteoJuv here.

#6 Flexacil Ultra

The manufacturers of Flexacil Ultra that this product contains the best-selling formula for joint pain relief available on the market today. It also contains ginger root and horsetail leaf extracts. This effectiveness is due to the apparent ability of the horsetail plant to downregulate the levels of TNF-? which causes inflammation in RA. Read more about Flexacil Ultra here.

#7 Lyprinol

Lyprinol is another product suitable for those with RA which is a joint disease whose main feature is joint inflammation. The product is a natural anti-inflammatory designed to treat* different disorders whose main feature is inflammation. This product contains a unique blend of these essential fatty acids and the mussels from which the ingredients in this product were extracted were also separately studied for their efficiency of treating knee osteoarthritis, and the results speak in favor of both the mussels and their extract form. Read more about Lyprinol here.

#8 Arthro 7

The manufacturers of Arthro 7 claim their product can help relieve joint discomfort, promote joint mobility, nourish the joint cartilage, and promote joint mobility. The product contains vitamin C, collagen, bromelain, CMO (cetyl myristoleate) which is a type of fatty acid, MSM, lipase, turmeric, Gelatin, silicon dioxide, titanium dioxide, and magnesium stearate. Read more about Arthro 7 here.

#9. Vital 3

Vital 3 is different from other joint pain supplements because it comes in a drop dispenser. This product was also tested in clinical trials and was described as a good addition to other arthritis medication as explained on the product website. The collagen in Vital 3 is said to improve* joint lubrication and cushioning which aids in its repair. Read more about Viral 3 here.

#10 Flexitrinol

Flexitrinol is an innovative health supplement, specially designed to reduce* joint pains, improve* flexibility and promote overall joint health. It is made of powerful and high quality ingredients that help to make your joint strong and reduce* the pains. It also helps to prevent inflammation, which is the main cause of joint pains and swelling. Read more about Flexitrinol here.


Joint pain is a daily reality of the great number of arthritis sufferers. While medical experts are on the search for effective treatments of arthritis, patients rely on natural supplements to find at least some relief. While the effectiveness of dietary supplements in the treatment of arthritis pain is elusive, there are some studies speaking in favor of some of these supplements and ingredients. The best way to truly know if a supplement will work for you is to try it out for yourself.


  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103717/
  • http://www.arthritis.org/living-with-arthritis/treatments/natural/supplements-herbs/9-supplements-arthritis-6.php