Synerflex Joint Supplement Reviews: Is it Worth Your Money?

Synerflex is a joint support supplement with a unique ingredient designed for people who suffer from daily joint pain and inflammation.

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In This Review

Synerflex Joint Supplement Overview

While there is a good amount of information on the official website for the joint pain reliever, Synerflex it is unfortunate that the tone of the site gives it a poor impression. Written in the form of a ‘personal’ letter to the customer, this North Star Nutritionals’ brand seems ‘too good to be true’ and very gimmicky.

SynerFlex is only available from the company website which has a secure ordering page. The customer can opt to enroll in the auto-shipping program, whereby they can receive Synerflex at discount prices and, as with most products of this type, the company offers deals on larger orders.

How Does It Rate?

Overall Rating: 3.5
synerflex joint supplementSynerflex Joint Supplement


Value for Cost

3.4/5Value for Cost
Return Policy

3.8/5Return Policy


Brand Highlights

  • SynerFlex is manufactured by NorthStar Nutritionals.
  • A company that has been producing high-quality products since 1991.
  • They use a variety of nutritional supplements and related products to promote health and wellness.
  • NorthStar Nutritionals is headquartered in Maryland, USA.



*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Hyal-Joint (hyaluronic acid and collagen)
  • Hops flower extract
  • Boswellia serrata extract
  • Boron
  • Bio-enhancer blend with ginger, black pepper, and long pepper


  • A 60 day money back guarantee is provided
  • The ordering site is secure
  • Customer discounts are offered
  • The active ingredients are shown
  • Full company contact details are provided
  • Discounts are offered on certain orders


  • The product does not contain Glucosamine or Chondroitin
  • No clinical trials are shown
  • Not all ingredients are known
  • The website is not professionally presented

How Does SynerFlex Work?

The key active ingredient in SynerFlex is Hyal-joint, a formula that consists of Hyaluronic acid, a substance that increases the production of protective synovial fluid in the joint.

The formula also uses Hops extract, which has antioxidant and anti-inflammatory properties, plus concentrated Boswellia.

The Boswellia can inhibit Cox-2, an enzyme that contributes to pain in the body.

By reducing this enzyme, inflammation is decreased, and the joint can repair itself more efficiently.

There is a lot of information regarding the key ingredients in the SynerFlex formula, although a full ingredient list is not shown, and while it is stated that clinical tests have been performed, no results are published.

Synerflex Joint Supplement Ingredients – Are they Safe & Effective?

Hyal-Joint (hyaluronic acid and collagen)

– Hyal-Joint is made up of hyaluronic acid, collagen, and a few other glycosaminoglycans. This helps replenish hyaluronic acid stores that diminish with age. Collagen, on the other hand, may help reduce joint pain, particularly during movement, according to research. [1]

Hops flower extract

– Hops flowers are widely used in Eastern medicine. There have been few studies on their anti-inflammatory properties for bones and cartilage. [2]

Boswellia serrata extract

– As discussed in our comprehensive Joint Pro Review, Boswellia extract, derived from the Boswellia serrata tree, is recognized for its potential to alleviate joint pain and inflammation. The gum-resin extracts of the Boswellia serrata tree have been used as medicine in various cultures for various types of inflammation in the body. Cox-2 is an enzyme that adds to the pain in the body; therefore, if this enzyme is reduced, inflammation is decreased, and the joint can repair itself more efficiently.

A double-blind, randomized, placebo-controlled clinical study evaluates that 100mg of Boswellia was able to reduce all measured parameters of osteoarthritis in persons over 30 days. [3]


– Studies show that consuming enough boron in your diet can help prevent the development of osteoarthritis by modulating your body’s inflammatory response. [4]

Bio-enhancer blend with ginger, black pepper, and long pepper

– According to a recent study, ginger and pepper are natural products that may help treat osteoarthritis. Pepper contains
, a flavonoid that aids in the reduction of an overactive immune response in the body, resulting in anti-inflammatory properties. Ginger, on the other hand, may alleviate joint pain [5]
The main ingredient in Synerflex is Hyal-joint; this contains an acid known as hyaluronic acid. It is said that Synerflex is tested, but there are no published results. Synerflex is a perfect approach to keep your joints healthy.

It helps to turn on the synovial fluid that is trapped in the joints and helps in movement. Thus you can easily stretch, crouch, flex, and bend without experiencing piercing pain in knees, elbows, and knuckles.

Rich ingredients found in best supplement for knee pain are helpful in increasing synovial fluid in joints through which joints can be protected.

READ NEXTArthrozene Review and ProOmega Joint Xtra

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Synerflex FAQ’s

Q: How to use Synerflex?

A: Initially, it is recommended that you use 3-5 pills of Synerflex, depending on the pain. If the pain is severe, then a daily intake of 3 pills of Synerflex is recommended for a period of 3 to 5 weeks. This is an ideal treatment for relieving yourself of joint pains.

The dose can be reduced over time if the pain decreases and you can shift from 3 capsules daily to 2 capsules per day. Synerflex can also be obtained in powder form from the market; this is useful for those who find it difficult to swallow pills. You can add the powder into water and drink it.

Q: What are the side effects of SynerFlex?

A: There are no known side effects from taking this supplement. However, some users may be allergic to certain ingredients of the joint supplement

Q: How Much Does SynerFlex Cost?

A: The regular cost of Synerflex is $39.95 for a one-month supply.

Q: What is SynerFlex Return Policy?

A: The official site does provide a 60-day money-back guarantee.



*All individuals are unique. Your results can and will vary.

Synerflex Review – Final Verdict

Unlike a lot of other joint pain products like Omega XL, Relief Factor, and Vital 3 on the market, SynerFlex uses the power of Hyaluronic acid as its main ingredient which, while providing lubrication and cushioning, does not help rebuild damaged cartilage.

The addition of Glucosamine and Chondroitin would be beneficial as would a free sample of the product and publication of clinical test results.


Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

BioDynamix Joint Genesis | Doctor Formulated
Reduces Pain and Stiffness*Gold Star Evidence
Improves Joint Lubrication*Gold Star Evidence
Supports Joint Function*Gold Star Evidence
Relieves Inflammation & Discomfort*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
ProJoint Plus - VitaPost | Premium Joint Support
Supports Cartilage Health*Gold Star Evidence
Supports Joint Health*Gold Star Evidence
Lubricates Stiff Joints*Strong Evidence
Supports Joint Mobility*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Relief Factor | Best Pain Relief Supplement
Relief Aches and Pains*Gold Star Evidence
Reduces Inflammation*Strong Evidence
Protect Joints Damage*Strong Evidence
Support Immune System*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Heal-n-Soothe | Best Joint Pain Formula
Supports Healhty Joints*Gold Star Evidence
Promotes Joint Mobility*Gold Star Evidence
Help in Relieving Joint Pain*Strong Evidence
Supporting Reduction in Joint Pain*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Turmeric Curcumin Plus | High Quality Joint & Muscle Health Formula
Supports Joint Health*Gold Star Evidence
Supports Immune System*Strong Evidence
Antioxidant Support*Strong Evidence
Supports Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for SynerFlex

Synerflex Joint Supplement Reviews: Is it Worth Your Money?

Customer Reviews & Ratings

2.0 out of 5

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  1. Barbara K

    Useless. Nothing but a money sinkhole.
    Synerflex has so many positive reviews that’s why I was encouraged to try it. I didn’t mind that it lacked important ingredients like glucosamine or chondroitin, both of which are staple in joint health supplements. Maybe that’s why the product hasn’t produced any noticeable difference even after finishing a whole bottle. My hip and knee joints are still as painful and stiff as before. Long story short, it didn’t do what it’s supposed to do. Useless, so to speak. There are a lot of other joint pain supplements that really works. My daughter was about to buy me another bottle – I stopped her.
  2. David Arkin

    SynerFlex help everyday aches and pains.
    It seems to help everyday aches and pains but SynerFlex is very expensive. Also, it only works if you take it every day which is something I really don’t want to do as I already take a lot of medications.

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North Star Nutritional
60 Capsules
Hyal-Joint (hyaluronic acid and collagen), Hops flower extract, Boswellia serrata extract, Boron, Bio-enhancer blend with ginger, black pepper, and long pepper

5 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Van Cleemput M, Heyerick A, Libert C, Swerts K, Philippé J, De Keukeleire D, Haegeman G, De Bosscher K. Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res. 2009 Sep;53(9):1143-55. doi: 10.1002/mnfr.200800493. PMID: 19655312.
[2] Lerman RH, Chang JL, Konda V, Desai A, Montalto MB. Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integr Med (Encinitas). 2015 Oct;14(5):52-61. PMID: 26770167; PMCID: PMC4712866.
[3] Boswellia serrata Extract Containing 30% 3-Acetyl-11-Keto-Boswellic Acid Attenuates Inflammatory Mediators and Preserves Extracellular Matrix in Collagen-Induced Arthritis:
[4] Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994 Nov;102 Suppl 7(Suppl 7):83-5. doi: 10.1289/ehp.94102s783. PMID: 7889887; PMCID: PMC1566627.
[5] Lodhi S, Vadnere GP, Patil KD, Patil TP. Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats. J Tradit Complement Med. 2019 Feb 27;10(1):60-69. doi: 10.1016/j.jtcme.2019.02.004. PMID: 31956559; PMCID: PMC6957812.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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