Penetrex Pain Relief Cream Review – Is It Safe to Use Penetrex Cream?

Penetrex is a topical formulation and should be applied directly to external areas where you experience discomfort (pain, tingling, numbing, etc.)

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In This Review

What is Penetrex?

Any kind of pain, whether it is elbow pain, back pain, or neck pain, can be really annoying, and it won’t let you focus on your day-to-day activities.
The statistics taken in 2010-2012 show that 22.7% of the population in the United States has diagnosed with some kind of Arthritis, and this number is predicted to increase further in the upcoming years. Because the rate is so high, many people look for effective medication for their pain.

It will provide quick relief from different types of pain like back pain, elbow pain, shoulder pain, and others. It is also a good choice for people suffering from arthritis.

Without wasting much time, let’s move forward to a detailed review of the product to see if this cream is the right choice for you or not.

How Does It Rate?

Overall Rating: 4.2
Penetrex Pain Relief CreamPenetrex Pain Relief Cream


Value for Cost

4.1/5Value for Cost

4.0/5Return policy


Brand Highlights

  • Penetrex is an effective pain relief cream manufactured by Penetrex. Penetrex is a well-reputed manufacturer with a good consumer base.
  • The manufacturer of this product claims that it is a recommended joint supplement which will provide quick relief from various types of pain.
  • It does not matter whether you are suffering from arthritis, back pain, elbow pain, or some other types of pain; it is capable of providing relief from all these types of pain according to the manufacturer.


Pro Joint Plus

*All individuals are unique. Your results can and will vary.

Key Ingredients

  • Arnica
  • Pyridoxine
  • Methylsulfonylmethane(MSM/DMSO2)
  • Boswellia Serrata
  • Cetyl Myristoleate


  • It utilizes a natural formula
  • It is fast acting
  • Might lower inflammation
  • May boost joint health
  • It is gluten and preservative free


  • It requires daily usage
  • Consumers can only purchase the product online

How Does Penetrex Work?

Penetrex pain relief cream is made up of high-quality, proven ingredients combined with the use of the latest technology. It incorporates the most recent advancements in skin penetration and emulsification technology.

This technology ensures that the proven ingredients are effectively absorbed by the outer layer of the skin to the affected area.

The ingredient like Ethoxydiglycol plays the role of an active carrier of the active ingredients. This ingredient is also water and oil-soluble, which significantly improves the absorption of all the active ingredients.

The Arnica Extract, the Dipotassium Glycyrrhizinate, and the Camphor with their anti-inflammatory and calming properties provide relief from inflammation and calm the pain.

Another reason behind its effectiveness is the use of topical formulations. The ingredients in this cream do not move through the stomach and intestine; it works directly at the injured area.

This is how Penetrex is able to provide quick relief from your pain.

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Penetrex Ingredients – Are they Safe & Effective?

Here are the active ingredients of Penetrex:


: Arnica, a flowering plant native to Europe and North America, has long been prized for its medicinal properties, particularly in the realm of joint health. Extracts from the arnica plant, specifically Arnica montana, are commonly used in topical creams, gels, and ointments to alleviate joint pain, inflammation, and stiffness.

As explored in our comprehensive Arctic Blast Reviews, Arnica contains compounds such as sesquiterpene lactones, flavonoids, and phenolic acids, which exert anti-inflammatory and analgesic effects when applied to the skin. These bioactive constituents work synergistically to inhibit inflammatory pathways, reduce swelling, and relieve pain associated with conditions like osteoarthritis, rheumatoid arthritis, and joint injuries.


: Pyridoxine is also known as vitamin B6; it plays a role in balancing sodium and potassium for the normal functioning of nerves. The deficiency of vitamin B6 might be responsible for arthritis, swelling, and other types of pain.

However, a study conducted by Arthritis Research & Therapy says “Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis”


: It is an active ingredient, which has shown the ability to relieve inflammation and pain. An experiment conducted by, International Journal of Biomedical Science shows improved results on people with joint pain, swelling and arthritis upon usage of MSM supplement.

Boswellia Serrata

It has a long history of therapeutic use, especially in India. It leads to an improvement of blood supply throughout the joints. It also possesses anti-arthritis and anti-inflammatory properties. In fact, a study has showed positive results on adults using Boswellia Serrata for joint pain.

Cetyl Myristoleate

: Cetyl Myristoleate acts as an anti-inflammatory agent and protect against arthritis.

Penetrex pain relief cream side effects

No severe side effects have been found till now, however, there are some mild side effects reported.

  • There might be rashes if your skin is very sensitive.
  • You may experience nausea if you are using it in an abdominal area. It is a very rare side effect seen among the consumers.
  • Rare allergic reactions might be seen.

If you experience any of these side effects, then it is recommended to consult your doctor.



*All individuals are unique. Your results can and will vary.

Penetrex Questions and Answers

Q: How do I use Penetrex?

A: Apply Penetrex cream to the affected area(s) and continue to massage thoroughly for a minute or two until you can see that it has been absorbed through the skin. The appropriate amount of Penetrex to use on each occasion should be enough so that the product massages smoothly & comfortably over the entire area.

Repeat this 3 to 4 times per day over an initial period of at least 7 to 10 days and thereafter on an as-needed basis.

Q: How much does Penetrex cost?

A: You can buy a single bottle of Penetrex of 2 oz for $18.98, 4 oz for $34.95 while a pack of 3 for $97.50.

Q: Is Penetrex available at drug stores?

A: Penetrex is now Available at CVS! Search for Penetrex Cream Walgreens CVS. Thanks to overwhelming customer demand, Penetrex is now available in a Walmart near you! Penetrex is also a #1 Seller on Amazon, or order direct at As always, please do not hesitate to contact customer support if you have any questions, comments, or concerns. Penetrex’s telephone number is (858) 356-5980.

Q: How long should you use Penetrex Cream?

A: You should apply the Penetrex cream for 7 days at least 3 or 4 times each day. If there are no results after the mentioned treatment period, you can continue applying the topical anti-inflammatory cream as needed. According to the manufacturer, no two human bodies assimilate and react to Penetrex in exactly the same way. For these reasons, it is inappropriate to establish time frame expectations. Users should expect that if they use Penetrex as recommended (see above) they will obtain noticeable results within a week or so.

Q: Is Penetrex good for Sciatica Muscle Pain?

A: Read what Penetrex users saying;

I don’t know if you have tried any good chiropractors. I suffered terrible Sciatica Pain for over two years. I tried several Chiropractors, no cure. Until I had one Chiropractor adjust my back and hips after two months on weekly basis, I am all good now. The pain never came back. I didn’t believe in Chiropractors before, I used a lot of these pain release creams, but they only can work temporarily, But now I know you need to find the root of the cause! ~ by Elaine Greene (via Amazon)

One review says, “My wife and I are senior citizens in our seventies. We use Penetrex faithfully when either of us has a Sciatica attack, I also use it for my knee and hip, It helps to eliminate the pain, so we can move about freely without discomfort. It also helps to keep arthritis in check. We will not be without Penetrex in our house. We have also got our children to use it and they love it. They say it really helps them. I highly recommend Penetrex to anyone who wants to eliminate pain. You will not be sorry, and you will get your life back. Penetrex the Leader, All other Products are Followers.” ~ by sonnyimp (via Penetrex Official Website)

Ms. Mildew says, “YES! I use it for multiple types of nerve & muscle pain and IT WORKS. I have sciatica, cubital tunnel syndrome, myofascial trigger points (muscle “knots”), and long-term lower back, leg, & foot pain due to a motion coordinated disorder and I have tried every pain cream/ointment that exists. Most of them did not help or only helped a little- Penetrex is like some kind of “miracle” cream. I know it sounds too good to be true, but in minutes after applying it my pain starts to subside. It was recommended to me by my best friend, who suffers from even more serious injuries/chronic pain issues than I do, and I was skeptical too…until I tried it. Now, I am NEVER without it.” ~ Mildew (via



*All individuals are unique. Your results can and will vary.

Penetrex Review – Final Verdict

It is very common to suffer from various pains like joint pain, back pain, elbow pain, and others. Many of these cases are not so serious; however, it is very important to treat them properly.

These various types of pain will not allow you to work properly. There are many ways to reduce pain, and among them, pain relief cream is one of them.

This is a new topical pain cream which provides immediate relief from the pain.

Penetrex is one of the many pain relief creams available on the market. It is manufactured by a reputed company, and the effectiveness of this cream is proven as well.

According to the Penetrex reviews, There are many satisfied consumers who have gotten relief after using this cream. If it has effectively worked out for so many people, then it can definitely work out for you as well.

Don’t hesitate to try other topical creams such as Biofreeze, Blue-Emu, and Aspercreme in the market before you give this quality pain relief cream a try.

Healthy joints allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. From aging to untreated sports injuries – many conditions lead to joint pain. A quality joint product may help reduce inflammation, repair existing tissue damage, and promote stronger joints, lessening susceptibility to future degeneration.

Below you'll find some of the most effective joint pain supplements on the market today, in our opinion.

Our Top Joint Pain Relief Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned joint pain supplements based on the available research:

BioDynamix Joint Genesis | Doctor Formulated
Reduces Pain and Stiffness*Gold Star Evidence
Improves Joint Lubrication*Gold Star Evidence
Supports Joint Function*Gold Star Evidence
Relieves Inflammation & Discomfort*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
ProJoint Plus - VitaPost | Premium Joint Support
Supports Cartilage Health*Gold Star Evidence
Supports Joint Health*Gold Star Evidence
Lubricates Stiff Joints*Strong Evidence
Supports Joint Mobility*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Relief Factor | Best Pain Relief Supplement
Relief Aches and Pains*Gold Star Evidence
Reduces Inflammation*Strong Evidence
Protect Joints Damage*Strong Evidence
Support Immune System*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Heal-n-Soothe | Best Joint Pain Formula
Supports Healhty Joints*Gold Star Evidence
Promotes Joint Mobility*Gold Star Evidence
Help in Relieving Joint Pain*Strong Evidence
Supporting Reduction in Joint Pain*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Turmeric Curcumin Plus | High Quality Joint & Muscle Health Formula
Supports Joint Health*Gold Star Evidence
Supports Immune System*Strong Evidence
Antioxidant Support*Strong Evidence
Supports Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Penetrex Cream

Penetrex Pain Relief Cream Review – Is It Safe to Use Penetrex Cream?

Customer Reviews & Ratings

4.0 out of 5

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  1. Val

    Finally found relief!!!
    I have tried a lot of products. For years I have taken hydrocodone when necessary for the pain in the arthritic lower back for gardening, golf, work lifting, etc., and only hated the constipation side-effect.

    At 63 I am in love with Penetrex Pain Relief Cream! Not to mention I’ve only been using it for a week!! Praying it keeps working as it works immediately (within 5 minutes) and after a few weeks I’m anxious to see if it keeps working until I get to the ‘only when needed’ stage! Buy it and you won’t be disappointed!

  2. D. Nicole Uscher

    Total waste of money
    Used Penetrex cream for three months at 20.00. A jar and absolutely no Relief! Total waste of money in these hard times. Used for bursitis and arthritis and twice a day! Still no relief at all. Too expensive for nothing!
  3. Bryona L.

    It's FSA eligible and it works!!
    I ordered it during the pandemic because my lower back was a hot mess. I couldn’t sleep comfortably, stand, squat, etc. I was searching for FSA eligible items for back pain and found it on Amazon. I was skeptical but since you can’t get just anything with your FSA account I ordered it. Best decision ever. Penetrex—Well worth the money.
  4. Luis DeLaRosa

    Penetrex Best Inflammation product ever
    Penetrex cream is the best inflammation formulation that I have ever tried, I will be recommended to all my friends and family. I was at my local Walmart looking for something to help me with the severe pain in my wrist after replacing a faucet in my bathroom, then this gentleman picked up a jar of Penetrex pain relief cream and told me it really works, so I bought it and it really ‘WORKS’.
  5. Robert Mabeley

    I was experiencing severe knee pain and nothing seemed to reduce the pain. I started using this product as directed and after about a week all of the pain in my knee has subsided. Fantastic product, am completely satisfied and have recommended it to others. I recently purchased a jar of cream for a friend of mine and she just started using it, I will let you know if it worked for her. THANKS FOR PRODUCING SUCH A GREAT PRODUCT!!!
  6. Kathleen Celestine

    My Free Bottle
    I received an offer for a free roll on bottle of Penetrex as a free gift for being a repeat customer. I hope this offer will be honored. As in my review, Penetrex is an excellent product and I received amazing results in pain relief. Offer verification Number is 1776054. My address is 3300 Palmer Avenue Unit 415- Bronx NY 10475.
  7. Krystal Ouellette

    Amazzzz balls!!!!!!
    Where to start… Going from a skeptic to an absolute believer.. I just started using this product 3 days ago and I so cannot believe the relief I got. I suffer from arthritis, tendinitis, & carpel tunnel bad for not only many, many years of typing and still typing to this day for work, but working on my cars, on my house and cutting hair for 19+ yrs as a hairdresser as well. Popping pain relievers was just not cutting it at all and was getting to the point I was going to go back to my Orthopedist to find relief. So I decided on my break 3 days ago to see just maybe there was something on the market specifically for what my issues were. This came up as the 1’st choice of items for a pain cream reliever. So I search who carried it and surprisingly I noticed Walmart was carrying it. Checked on their site to see if the one in my town had it and was in luck they did. Stopped after work to get it, put it on that night, huge relief instantly to the point I finally got some sleep that night… OMG !!! Yes sleep after years of painful restless nights all because of my hands and wrists. I liked it so much that the next day told one of my cube mate about it and she bought it and couldn’t believe it either. Also told other employees in my office who suffer from similar pain and they plan on getting it as well… All I can say is Thank you! Thank you! Penetrex makers you have a lifer here and much cheaper than going for an surgical procedure for sure… I plan on telling many, many more its worth the $$$ and trying it.. Seriously you need the relief and want to avoid popping pain killers all your life for some kind of relief, you would have to be NUTS not to try this product…. You have nothing to lose for sure… Go for it you won’t regret it!!!!!!!!!!!!!!!!!!!!!!!!!
  8. Doe

    I love your product. The only thing that works.
    I have tried many pain relief products. Penetrex has been the best I have found for arthritis, tendonitis, Carpel tunnel. Especially in the hands. I feel it really penetrates & helps get rid of the inflammation. Therefore allowing the area to heal healing. One must use as directed. You will find all of a sudden the pain has disappeared. I hope everyone has found the relief I have. thx. for a great product. Thrilled, Doe

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Penetrex Cream
Arnica, Pyridoxine, Methylsulfonylmethane, Boswellia Serrata, Cetyl Myristoleate

6 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Arthritis Related Statistics:
[3] Chiang EP, Selhub J, Bagley PJ, Dallal G, Roubenoff R. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Res Ther. 2005;7(6):R1404-R1411. doi:10.1186/ar1839
[4] Xu G, Zhou T, Gu Y, et al. Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. Int J Biomed Sci. 2015;11(2):54-60.
[5] Supplement and Herb Guide for Arthritis Symptoms:
[6] Cetyl myristoleate:

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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