Chlorogenic Acid: Health Benefits, Possible Side Effects & Risks

Chlorogenic acid is a natural antioxidant compound found in coffee beans. Read on to learn more about the potential benefits and side effects of chlorogenic acid.

Coffee beans contain chlorogenic acid, a natural antioxidant molecule. It’s mostly used to help people lose weight and decrease their blood pressure. According to research, it may also help lower blood sugar, enhance mood, and lessen the risk of illnesses including diabetes, cancer, and infections. Continue reading to discover more about chlorogenic acid’s potential health benefits, possible side effects, and risks.

Chlorogenic Acid: Health Benefits, Possible Side Effects & Risks
Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans. Image/Shutterstock

About Chlorogenic Acid

Chlorogenic acid, an antioxidant-rich phytochemicals found in green coffee and coffee beans, is a powerful antioxidant. Phytochemicals are physiologically active compounds found in plants. The etherification of cinnamic acids such as ferulic, p-coumaric acids, and caffeic with (-)-quinic acid produces chlorogenic acid.

Chlorogenic acids have been touted as having the ability to lower blood sugar levels and perhaps reverse or decrease Type 2 Diabetes symptoms. It has also been linked to weight reduction and the prevention of obesity. However, there isn’t enough evidence to back up this claim, and other experts feel it isn’t entirely attributable to chlorogenic acid.

Chlorogenic acid is found in coffee beans and various forms of coffee, including green coffee. Apples, eggplant, blueberries, pears, strawberries, tomatoes, and potatoes are among the food sources of chlorogenic acids.

Chlorogenic Acid

Green coffee extract is the most frequent type of chlorogenic acid supplementation. It offers various health benefits and is most commonly used to lower blood pressure and lose weight. Chlorogenic acid, on the other hand, has been shown in recent research to boost mood, reduce oxidative stress, and lower blood sugar levels.

Chlorogenic Acid Benefits

Chlorogenic Acid – Possible Side Effects

Green coffee bean extract, a natural source of chlorogenic acid, has been linked to some allergies. Asthma attacks were the most common symptom. This effect appears to be caused by coffee components other than chlorogenic acid.

Green coffee bean extract includes caffeine, which may induce some of the adverse effects associated with caffeine. Some side effects include

  • Stimulating effects
  • Laxative effects
  • Interacts with antidepressants or mood stabilizer medications
  • Sleeplessness
  • Anxiety
  • Nausea
  • Vomiting
  • Upset stomach
  • Increased or unbalanced heart rate
  • Rapid breathing
  • Headaches

Although chlorogenic acid (CGA) has stimulant properties, it is believed to be one-third less powerful than coffee. Chlorogenic acid is present in coffee and espresso, but the amount is inconsistent; therefore, the amount of coffee or espresso to drink to reap the benefits is not recommended at this time due to the unreliability of the quantities. Not only does chlorogenic acid have stimulant properties, but it is also a laxative compound found in prunes, which can be helpful to people who suffer from constipation.

On a more serious note, antidepressants and mood stabilizers like bipolar medicines can interact with chlorogenic acid. If you’re taking medication for mood disorders, anxiety, or depression, talk to your doctor before using a chlorogenic acid supplement.

Always remember that too much of a good thing may be harmful; the same symptoms of taking too much traditional coffee or taking too much of a stimulant can cause harm to the stomach, heart, and digestive tract. Consult your doctor if you are experiencing headaches, irritability, vomiting, nausea, sleeplessness, or other symptoms.


If you have any of the following conditions, you should take extra precautions and warnings. Before using chlorogenic acid, talk to your doctor. Caffeine consumption can worsen the following conditions.

Pregnancy and breastfeeding, abnormally high homocysteine levels, bleeding disorders problems, diarrhea, and glaucoma, irritable bowel syndrome (IBS), high blood pressure, and bone thinning (osteoporosis)

Drug Interactions

Chlorogenic acid’s potential blood pressure-lowering impact may cause blood pressure to drop too low in people currently taking blood pressure-lowering medication.

The effect of metformin, a drug used to treat high blood sugar levels, may be enhanced by chlorogenic acid. This effect, however, was only detected in far greater concentrations than those found in human blood following ingestion of chlorogenic acid.

Drug Interactions include:

  • Dipyridamole (Persantine)
  • Alcohol
  • Clozapine (Clozaril)
  • Adenosine (Adenocard)
  • Alendronate (Fosamax)
  • Fluvoxamine (Luvox)
  • Medications for asthma
  • Antibiotics (Quinolone antibiotics)
  • Disulfiram (Antabuse)
  • Ephedrine
  • Medications that slow blood clotting
  • Estrogens
  • Verapamil (Calan, Covera, Isoptin, Verelan)
  • Phenylpropanolamine
  • Lithium
  • Medications for depression (MAOIs)
  • Theophylline
  • Pentobarbital (Nembutal)
  • Riluzole (Rilutek)
  • Stimulant drugs

The caffeine in chlorogenic acid is linked mainly to drug interactions from chlorogenic acid. Before using a chlorogenic acid supplement, talk to your doctor. If you have been instructed not to drink caffeine, it is better to avoid chlorogenic acid.


There is no official dosage because the FDA has not approved chlorogenic acid for any ailment. Unofficial dosages have been determined by users and supplement producers through trial and error. Consult your doctor to see if chlorogenic acid might be beneficial as a supplement in your situation and what dosage you should take.

Green coffee bean supplements may include more or less chlorogenic acid, depending on the brand. Depending on the supplement, the user-recommended dosage for chlorogenic acid ranges from 240 mg to 3,000 mg per day.

Frequently Asked Questions

Q: What Is Chlorogenic Acid?

A: Chlorogenic acid, a component found in coffee beans and various forms of coffee, including green coffee, is a polyphenol compound found in coffee beans and different varieties of coffee. Apples, eggplant, blueberries, pears, strawberries, tomatoes, and potatoes are among the food sources of chlorogenic acids.

Q: How To Take It?

A: The chlorogenic acid supplement appears to be helpful at dosages of 120-300mg orally taken, with larger levels likely being beneficial as well (not tested sufficiently). The effects of these dosages appear to be most beneficial to blood pressure and circulation.

Q: How Much Chlorogenic Acid Is In Coffee?

A: The quantity of chlorogenic acid in coffee varies a lot depending on how long it’s been roasted.

Q: What Food Has Chlorogenic Acid In Them?

A: Can be found in a number of foods and herbs like Apples, eggplant, blueberries, pears, strawberries, tomatoes, and potatoes are among the food sources of chlorogenic acids.


People who have spoken with their doctor before supplementing may notice modest to moderate benefits in glucose metabolism, weight management, heart health, and mental health due to supplementing and/or consuming Chlorogenic Acid.


[1] Adriana Farah, Mariana Monteiro, Carmen M. Donangelo, Sophie Lafay, Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans, The Journal of Nutrition, Volume 138, Issue 12, December 2008, Pages 2309–2315,

Jason Vredenburg, RD

Jason Vredenburg is a nutrition writer with over twenty years of experience as a Registered Dietitian. He has researched and written nu

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