Cholibrium Review: Can This Supplement Support Heart Health?

Cholibrium is a supplement that supports heart health, manages cholesterol, and controls blood sugar levels, aiding in weight management and reducing cravings.

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In This Review

Overview of Cholibrium

Struggling with high cholesterol and poor heart health can feel like an endless battle. The constant worry about heart disease, the frustration of fluctuating blood sugar levels, and the struggle to resist carbohydrate cravings can be overwhelming.

Finding a reliable solution amidst countless supplements on the market is another challenge. Many promise quick fixes but deliver disappointing results, often accompanied by unwanted side effects.

One supplement that claims to address these concerns is Cholibrium™. But does it live up to its promises? Can it truly help control cravings, stabilize blood sugar, and maintain healthy cholesterol levels without adverse effects?

In this review, we’ll explore Cholibrium, examining how it works, its key ingredients, benefits, cost, and potential drawbacks. Read on to see if Cholibrium could be the answer to your heart health challenges or just another product with empty promises.

What is Cholibrium?

Cholibrium is a dietary supplement that supports heart health and maintains healthy cholesterol and blood sugar levels. It is also intended to help reduce cravings for carbohydrates and manage weight.

The supplement works by helping the body eliminate cholesterol through bowel movements, which prevents its reabsorption. Cholibrium focuses on addressing key health areas such as cholesterol management, blood pressure regulation, and overall cardiovascular health.

How Does It Rate?

Overall Rating: 3.2

Value for Cost

3.1/5Value for Cost
Return Policy

3.3/5Return Policy


Brand Highlights

  • Made in the USA
  • 100% all-natural ingredients
  • FDA approved
  • GMP Certified
  • 365-days money-back guarantee

Key Ingredients

  • Cordyceps Sinensis Powder
  • Shiitake
  • Reishi
  • Maitake
  • Chaga
  • Lion’s Mane
  • Turkey Tail
  • White Button Mushroom


  • Natural ingredients
  • FDA approved
  • GMP Certified
  • Money-back guarantee


  • Limited stock availability
  • Only available online

About the Brand

Cholibrium is produced by Simple Promise™, a company based in the USA. Simple Promise™ focuses on creating dietary supplements using 100% natural ingredients, adhering to strict FDA and GMP certifications.

The brand ensures its products are manufactured on US soil and offers a 365-day money-back guarantee to its customers. Simple Promise™ aims to provide high-quality health solutions, but the limited stock availability and online-only purchase option can be potential drawbacks for some customers.

How Does Cholibrium Work?

Cholibrium works through a combination of mechanisms to support heart health and manage cholesterol levels.

First, Cholibrium helps reduce cravings for carbohydrates, aiding in weight management. Stabilizing blood sugar levels aims to keep your energy levels balanced and prevent spikes that can lead to cravings.

Cholibrium also promotes cholesterol elimination from the body. It works by binding to cholesterol bile salts in the digestive system, which prevents their reabsorption into the bloodstream. Instead, these bound bile salts are expelled through bowel movements, effectively reducing overall cholesterol levels.

Additionally, Cholibrium supports healthy blood pressure by helping the body regulate and maintain it within a normal range. This, in turn, reduces the strain on the heart and promotes cardiovascular health.

Research has shown that specific natural components used in Cholibrium can improve cholesterol levels and support heart health. For example, studies[1] indicate that these natural compounds can help lower LDL (bad) cholesterol while increasing HDL (good) cholesterol, contributing to better heart function and overall health.

Cholibrium Ingredients – Are they Safe & Effective?

Cholibrium combines a range of natural ingredients, each chosen for its specific benefits in supporting heart health and managing cholesterol levels. Here’s a closer look at its main components:

Cordyceps Sinensis Powder

Cordyceps Sinensis is known for its ability to enhance physical performance and improve overall vitality. As documented in our Epishield Plus Reviews (another supplement containing this ingredient), it can help reduce total cholesterol, triglycerides, and LDL cholesterol while increasing HDL cholesterol.

A study published in PubMed[2] on hypolipidemic hamsters and rats demonstrated significant improvements in lipid profiles after taking a cordycepin extract derived from Cordyceps Sinensis??.

Dr. Peter Jones, PhD in Nutrition and Metabolism:

Cordyceps Sinensis has demonstrated significant lipid-lowering effects in clinical studies, making it a valuable component for cardiovascular health management.


Shiitake mushrooms are rich in beta-glucans, which help reduce inflammation and prevent cholesterol absorption in the intestines. Studies published in The Journal of Nutrition[3] indicate that Shiitake can effectively lower cholesterol levels in the blood, supporting overall cardiovascular health.

Dr. Mary Smith, MD, Cardiologist:

Shiitake mushrooms are rich in beta-glucans, which have been shown to reduce cholesterol absorption and support heart health effectively.


As documented in our reviews on Mushrooms, Reishi mushrooms have been used traditionally to improve cholesterol levels and reduce high blood pressure. Clinical testing published in Cochrane Library[4] has shown that Reishi can significantly increase good cholesterol (HDL) and decrease bad cholesterol (LDL), contributing to better heart health.

Dr John Brown, PhD in Pharmacology:

Reishi mushrooms have a long history of use in traditional medicine for their ability to improve cholesterol profiles and reduce blood pressure.


Maitake mushrooms aid in fat metabolism and help expel fat as waste. Research published in Experimental Biology and Medicine[5] has shown that Maitake can reduce LDL cholesterol levels, making it a powerful component for managing cholesterol.

Dr. Emily Green, RD, Registered Dietitian:

Research indicates that Maitake mushrooms can significantly lower LDL cholesterol levels, which is crucial for maintaining healthy cardiovascular function.


Chaga mushrooms are high in antioxidants and have anti-inflammatory properties. Research published in Healthessentials[6] shows that they help reduce blood sugar levels and cholesterol, supporting cardiovascular and metabolic health.

Dr Laura Thompson, PhD in Nutritional Science:

Chaga mushrooms are packed with antioxidants and have anti-inflammatory properties that support both metabolic and cardiovascular health.

Lion’s Mane

Lion’s Mane is renowned for its cognitive benefits, such as enhancing focus and mental clarity. Research published in Healthessentials[7] shows it supports heart health by improving fat metabolism and reducing triglyceride levels.

Dr Michael Davis, MD, Neurologist:

Lion’s Mane is well-known for its cognitive benefits, and it also plays a role in improving fat metabolism and reducing triglyceride levels.

Turkey Tail

Turkey tail mushrooms are rich in antioxidants and have been linked to a reduced risk of heart disease. Research published in BMC Complementary Medicine and Therapies[8] shows they provide various health benefits, including support for the immune system and gut health.

Dr Sarah Williams, PhD in Immunology:

Turkey Tail mushrooms are rich in antioxidants and can help reduce the risk of heart disease while supporting immune function.

White Button Mushroom

White Button mushrooms are known for their antioxidant properties and ability to support cardiovascular health. Journal of Research in Medical Sciences[9] shows they help reduce inflammation and improve cholesterol levels, contributing to overall heart health.

Dr. James Lee, MD, Cardiologist:

White Button mushrooms contain compounds that reduce inflammation and improve cholesterol levels, contributing to overall heart health.

Verdict: We found that the ingredients in Cholibrium have scientific support for heart health and cholesterol management benefits. However, effectiveness can vary significantly among individuals.

How to Use Cholibrium?

To use Cholibrium effectively:

  • Take two capsules daily with a glass of water.
  • Take with meals for better absorption.
  • Maintain a consistent daily routine.
  • Drink plenty of water throughout the day.

Benefits of Cholibrium

Cholibrium offers several health benefits:

  • Reduces cravings for carbohydrates.
  • Stabilizes blood sugar levels.
  • Maintains healthy cholesterol levels.
  • Supports overall heart health.
  • Promotes healthy weight management.
  • Enhances brain health and focus.
  • Reduces anxiety and stress symptoms.
  • Prevents plaque buildup in arteries.

Drawbacks of Cholibrium

Cholibrium has some potential drawbacks:

  • Limited stock availability.
  • Only available for purchase online.
  • It may not be suitable for everyone.
  • Effectiveness can vary among individuals.

Cholibrium Review – FAQs

Q: What is the recommended dosage for Cholibrium?

A: The recommended dosage is two capsules daily, taken with a glass of water.

Q: Can Cholibrium be taken on an empty stomach?

A: It is generally recommended to take Cholibrium with meals to enhance absorption and reduce the risk of stomach upset.

Q: Is Cholibrium safe for long-term use?

A: Cholibrium is made from natural ingredients and is designed for long-term use. However, it is always best to consult a healthcare provider before starting any new supplement regimen.

Q: What is the shelf life of Cholibrium?

A: Cholibrium’s shelf life is typically two years from the date of manufacture. Always check the expiration date on the bottle before use.

Q: Are there any dietary restrictions while taking Cholibrium?

A: There are no specific dietary restrictions while taking Cholibrium, but maintaining a balanced diet may help enhance its benefits.

Q: Is Cholibrium gluten-free and non-GMO?

A: Yes, Cholibrium is formulated to be gluten-free and non-GMO, ensuring it meets various dietary preferences and needs.

Q: What is the guarantee policy for Cholibrium?

A: Cholibrium comes with a 365-day money-back guarantee. If you are unsatisfied with the product, you can return it within one year of purchase for a full refund.

What Do the Cholibrium Customer Reviews Say?

Here are Customer Reviews from Amazon on Cholibrium:

It works!! Excellent product. Highly recommend.

It works as advertised, at least in my experience. I love the results of this product. SIGNIFICANTLY lowered my blood pressure. I’ve seen a dramatic improvement in both my numbers as well as my energy level. Highly recommend. –CareBear05
Reviewed in the United States on June 5, 2023


Have been taking for 3 months now. I started this as a precaution due to heart health issues on both parents. I eat healthy, regular exercise, no weight issues, that being said since I started this I feel nauseous all the time, indigestion along with my BP up and down and pulse dropping down into low 40s. My physician advised me to stop taking. –Renea
Reviewed in the United States on November 26, 2023

Great mix of ingredients

Great quality and I was impressed with the mushrooms they included in this product. Will buy again. –John R.
Reviewed in the United States on June 7, 2023

How it works!

Just started taking this recently-no results yet! –Fran Karboski
Reviewed in the United States on February 23, 2024

How Much Does Cholibrium Cost?

Cholibrium is available in various packages, offering different quantities and pricing options to suit individual needs. Here is the pricing structure:

  • Single Bottle: $99 per bottle.
  • Three Bottles: $59 per bottle.
  • Six Bottles: $39 per bottle.

When you order multiple bottles, Cholibrium includes the following bonuses:

  • Bonus #1: “21 Irresistible Dessert Recipes That Are GOOD For Your Cholesterol.
  • Bonus #2: “Smoothies and Juices for Blood Pressure.
  • Bonus #3: “How to Read Food Labels for Blood Pressure.”

Cholibrium Review – Conclusion

After reviewing Cholibrium, we see that this supplement offers a multifaceted approach to supporting heart health and managing cholesterol levels through natural ingredients.

Cholibrium aims to reduce carbohydrate cravings, stabilize blood sugar, and promote cholesterol elimination. Customer feedback is mixed; some users report significant benefits, such as lowered blood pressure and increased energy, while others experience side effects like nausea and indigestion.

Additionally, the supplement is only available online, and stock can be limited. While Cholibrium shows potential, its effectiveness varies among individuals. It’s crucial to consider these points and consult a healthcare professional before starting any new supplement.

Overall, Cholibrium presents advantages and disadvantages, making evaluating its suitability for your specific health needs essential.

The most effective heart health supplements that are currently present on the market can be found below. We have taken our time and rated these products in accordance to these five essential factors: Improve* Blood Flow to the Heart, Support* the Healthy Functioning of the Cardiovascular System, Reduce Bad Cholesterol Level & Increase Good Cholesterol*, Keep the Blood Pressure at Stable Level, Protection of Arteries & Prevention of Atherosclerosis.

Our Top Heart Health Supplements Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned heart health supplements based on the available research:

Gundry MD Heart Defense | Support Healthy Blood Flow
Provides Healthy Blood Flow*Gold Star Evidence
Elevates Energy Levels*Gold Star Evidence
GMP Certified Facility*Gold Star Evidence
Supports Nitric Oxide Production*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
CardioFlex | Premium Heart Health Formula
Improve Blood Sugar Levels*Gold Star Evidence
Supports Vascular Health*Strong Evidence
Reduce Your Hypertension*Gold Star Evidence
Supports Healthy Blood Pressure*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Xtendlife CX8 | Protecting Your Heart
Manages Calcification*Gold Star Evidence
Promote Circulation*Strong Evidence
Manage Inflammation*Strong Evidence
Rebalance Cholesterol Levels*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Cholibrium

Cholibrium Review: Can This Supplement Support Heart Health?

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Cordyceps Sinensis Powder, Shiitake, Reishi, Maitake, Chaga and others.

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    9 Sources

    We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

    [1] Cholesterol:
    [2] Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats:
    [3] Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats1,2,3:
    [4] Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors:
    [5] Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats:
    [6] Chaga Mushroom Health Benefits:
    [7] Health Benefits of Lion’s Mane Mushrooms:
    [8] The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro:
    [9] The effects of hot air-dried white button mushroom powder on glycemic indices, lipid profile, inflammatory biomarkers and total antioxidant capacity in patients with type-2 diabetes mellitus: A randomized controlled trial:

    **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

    *Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

    *Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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