Best Antidepressants of 2016 Reviewed

Best Antidepressants
Editor's Note: This article has been recently updated with latest information and research studies.

Fears and Facts about Antidepressants

The percentage of Americans taking antidepressants has nearly doubled between 1999 and 2012 according to a report published in Journal of the American Medical Association (JAMA). What this means is that more and more people are likely to try alternative remedies for their depression. And while antidepressants do help mitigate depression, they do come with their own set of side effects and risks. According to an article published in the Harvard Mental Health Letter, antidepressants can make depressive symptoms even worse in the beginning and may even lead to adverse health outcomes. Antidepressants reduce* the number of blood platelets which increases* a person’s risk of internal bleeding. Furthermore, when taking drugs or even herbs that increase* serotonin levels, antidepressant use may lead to serotonin syndrome which is a potentially fatal condition. For all these and many other reasons, many depression sufferers are looking for other ways to fight depression and a potentially safe and effective way is by using natural antidepressant supplements.

Myths about Antidepressants

Natural antidepressants are made with ingredients such as herbs, amino acids, minerals, and vitamins that were scientifically proven to increase* the levels of serotonin in the brain. However, it’s a common myth that these types of treatments are completely safe just because they are natural. Natural antidepressants are just as likely to cause side-effects as are prescription antidepressants because they manipulate the levels of serotonin in the brain. These changes in your brain chemistry caused by antidepressant use are the main reason why you may experience side effects and the case is the same with natural antidepressants. Another common myth with natural antidepressants is that they will make you feel happy. Antidepressants work mainly by boosting serotonin levels in the brain which can make a person feel less anxious, less tired, and more energetic. But as far as happiness goes, antidepressants can only do so much

Myths about Antidepressants

How Do Antidepressants Work?

As already explained, antidepressants work mainly by boosting the levels of the neurotransmitter serotonin in the brain. Depression is considered, among other things, to be a result of chemical imbalances in the brain with low serotonin being the main culprit. Although this theory no longer holds water, antidepressants paradoxically are able to mitigate the symptoms of depression which can help a person cope and recover more easily. Studies show that antidepressants are effective in moderate and severe cases of depression, but not in milder cases. Those suffering from mild depression may turn to natural antidepressants as a way to mitigate the symptoms associated with mood disorders such as panic attacks, anxiety, insomnia, low mood, low energy, and body aches.

Essential Facts while Choosing Antidepressants

When choosing a natural antidepressant, you should first talk to your doctor about the safety and efficiency of the product you are planning to use. If you are currently taking prescription antidepressants, you should be cautious about taking any other drug or supplement that could increase* the levels of serotonin in your body as this could lead to serotonin syndrome. If, however, you are not taking any treatment for depression or other mood disturbances, you may try natural antidepressants as a safe alternative to prescription antidepressants. Just make sure that the product you are choosing is from a reputable company to avoid ending up with adulterated and tainted supplements.

Mood Disturbances

Best Antidepressants of 2016

To help you fight depression naturally, we’ve compiled a list of the 10 best natural antidepressants and mood-enhancers of 2016. Make sure to read the complete reviews of these products to find a product you believe caters to your specific needs and problem.

#1 Serelax

Serelax was developed by Pharmaxa-Labs to help fight depression and anxiety naturally. The product is said to improve* the levels of serotonin in the brain through its unique blend of natural ingredients. These ingredients include gamma-Aminobutyric acid (GABA), L-Theanine, passionflower, kava kava, valerian, jujube, skullcap, chamomile, and griffonia simplicifolia bean extract. These ingredients work in synergy to calm the central nervous system and improve* mood by boosting serotonin production naturally. Taking Serelax won’t cause any side effects when taken according to directions. You can order a trial offer on the official Serelax website for a $34.50 which is a relatively decent price. Learn more about Serelax by clicking here.

#2 Symetrin

Symetrin is a mood enhancer catering to women and is especially beneficial for mood disturbances caused by menopause or PMS. The product contains patented formulas that were clinically tested for their safety and efficiency, namely Sensoril and Libefem. Sensoril contains the herb Ashwagandha that a clinical study published in the Journal of Alternative and Complementary Medicine found to be effective in reducing* stress and anxiety. Libifem is a specialized extract of the Trigonella foenum-graecum Seed Extract herb that a clinical trial published in Phytotherapy Research found improved* hormonal balance in women and also increased libido and sexual functioning. Symetrin also contains two other ingredients, vitamin B6 and vitamin D which are two of the most important vitamins for normal mood regulation and nervous system functioning. Learn more about Symetrin by clicking here.

#3 A2x

A2x is another natural anti-anxiety and depression relief supplement that is manufactured and sold by the company of the same name. The product contains a couple of serotonin-boosting ingredients such as Passionflower, Ashwagandha, L-Theanine, Vitamins B12 and B6, and the minerals calcium and magnesium. Passionflower is believed to increase* GABA currents in the brain and as such work as an anxiolytic treatment. L-Theanine is a compound found in tea and that studies found that it was able to relax the mind without causing drowsiness. The vitamins B12 and B6 are important precursors for neurotransmitter synthesis and the support brain health in general. Calcium and magnesium are also important nutrients for normal brain signaling. Learn more about A2x by clicking here.

#4 Zanaprin

Zanaprin is manufactured by a company called Lazarus Labs which is a fairly well-known company in the supplement industry. The product was designed to help with social anxiety, stress, insomnia, panic attacks and it is said to increase* mental alertness and cognitive functioning. The main ingredient in this product is phenibut (beta-phenyl-gamma-aminobutyric acid) whose mechanisms are similar to GABA, meaning that it works by calming the central nervous system. However, the product may not work for everyone as evident by a great number of unsatisfied customer testimonials. Nevertheless, those suffering from mild anxiety and depression could benefit from this unique treatment. Learn more about Zanaprin by clicking here.

Taking Depression Pill

#5 Stresstabs

Stresstabs is a nutritional supplement product said to support normal brain functioning with its blend of important nutrients. The ingredients in this product are vitamins C, E, thiamine, riboflavin, niacin, B6, folate, B12, biotin, B5, and the minerals calcium, magnesium, phosphorus, zinc, and copper. These vitamins and minerals were added to the Stresstabs formula because research shows that they are of crucial importance for normal brain signaling, DNA synthesis, and neurotransmitter production. This product is completely safe to use even if you are taking antidepressants as it won’t alter neurotransmitters too much. The product is perfect if you are looking for a formula that will support your brain’s health for better stress relief and sleep. Another great thing about this product is that it is pretty affordable, coming at a price of only $5.37 which is a fraction of the price of other mood-enhancing supplements. Learn more about Stresstabs by clicking here.

#6 Tranquilene

Tranquilene is an all-natural antidepressant manufactured by Tranquility Labs LLC, a US-based company. The company has included a large number of ingredients in the Tranquilene formula for maximum product efficiency. The product is powerful in its ability to reduce* stress and anxiety and can even lead to drowsiness if taken above the recommended dose. The ingredients in this product are mainly botanicals such as Passionflower and Ashwangandha which are able to boost* serotonin production while simultaneously calming the central nervous system and inducing a more positive state of mind. The product can only be ordered through the official Tranquility Labs website and the product also comes with a money-back guarantee. Learn more about Tranquilene by clicking here.

#7 Nuphorin

Unlike most other mood-enhancing supplements that require a long time of consistent use to provide any benefits, Nuphorin works almost instantly. This characteristic makes this product a perfect option for anyone suffering from severe anxiety and panic attacks which are often comorbid conditions with depression. The product contains mainly herbal ingredients and other combinations that the manufacturers of Nuphorin claim were powerful enough to provide instant relief. The product is on the pricier side at $ 199.99 for a bottle of product, but considering the great number of positive reviews, it is probably worth the money. The product can be purchased through the official website or through Amazon. Learn more about Nuphorin by clicking here.

#8 Gabatrol

Another fast-working anti-anxiety supplement, Gabatrol is suitable for those suffering from frequent panic attacks and anxiety associated with depression and other mood disorders. Gabatrol contains a specially-formulated form of the GABA amino acid. You can take the product as needed and don’t have to worry about forgetting your daily dose as is the case with conventional antidepressants and even other mood-enhancing supplements. The product contains the mood-enhancing Phenyl-GABA that increases* the brain’s natural GABA levels and leads to increased feelings of peace and tranquility. The product is said to work between 15 and 30 minutes upon ingestion but can be also taken on a daily basis for anxiety and depression relief. Unfortunately, the manufacturers of Gabatrol do not offer any free samples of this product but considering the many positive reviews this product has received, it is probably worth the investment. Learn more about Gabatrol by clicking here.

#9 Relora

Relora works mainly by controlling your stress levels and we know that stress is the number one cause of both anxiety and depression. The product works mainly by controlling the release of cortisol which is the main stress-response hormone. The two key ingredients in this product are the herbs Magnolia officinalis and Phellodendron amurense bark. These plants contain powerful antioxidants that are believed to help with normal brain functioning and stress adjustment. The product is budget-friendly, coming at a price of only $11 for a month’s worth of product. Although the product is mostly deemed safe and side-effect free, some users have complained of dizziness and stomach upset which is the product’s main downside. Learn more about Relora by clicking here.

#10 True Calm

True Calm is manufactured by a reputable supplement manufacturer, namely Now Foods. True Calm contains mainly a blend of brain-boosting amino acids, but other mood-enhancing ingredients as well. True Calm is sold as both a stress-relieving and mood-enhancing supplement thanks to its unique formula that contains ingredients that support many aspects of brain health and functioning. Some of the ingredients found in this product are GABA, niacin, vitamin B6, magnesium, glycine, and taurine. Unfortunately, this product does not come with a money-back guarantee but considering that the product costs only $ 13.99, it’s probably worth giving the product a try. Learn more about True Calm by clicking here.


Antidepressants are types of drugs that research has yet to show has any effect on depression. What we do know is that they do help with severe cases of depression but not with milder ones. Natural antidepressants usually work through the same mechanisms as do prescription antidepressants -by boosting the levels of serotonin in the brain. But natural antidepressants have an additional advantage of addressing other issues that may be causing depression besides low serotonin levels. Many of these natural antidepressants, for instance, mitigate stress, anxiety, insomnia, and nutritional deficiencies. All these factors could be at the root of depression. The natural antidepressants reviewed here are good examples of products that address depression from multiple angles. These products reduce* stress, central nervous system activity, cortisol release, and enhance* brain neurotransmitter synthesis and support overall brain heath. All this makes natural antidepressants a better and safer alternative to fighting depression.



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Expert Author : Dr. Ahmed Zayed (Consumer Health Digest)

Dr. Ahmed Zayed Helmy holds a baccalaureate of Medicine and Surgery. He has completed his degree in 2011 at the University of Alexandria, Egypt. Dr. Ahmed believes in providing knowledgeable information to readers. Other than his passion for writing, currently he is working as a Plastic surgeon and is doing his masters at Ain shams University.