Phenibut Reviews: Does Phenibut Work on Depression?

Depression supplements are combined with other natural compounds or herbs in supplements designed to alleviate anxiety and promote relaxation in humans.

We independently research, review, and recommend the best products. Healthcare professionals review articles for medical accuracy. When you buy through our links, we may earn a commission. Read more about our process for evaluating brands and products.

In This Review

Phenibut Overview

Phenibut or beta-phenyl-gamma-aminobutyric acid is a compound commonly sold as a dietary supplement. It is a derivative of GABA (gamma-aminobutyric acid). It is different from GABA since it easily passes through the blood-brain barrier making it work faster.

This supplement is mixed with other natural compounds or herbs in supplements designed to address anxiety and promote relaxation. It can be purchased online or from health retail establishments. However, Phenibut is only available with a prescription in certain countries like Russia.

How Does It Rate?

Overall Rating: 3.7

Value for Cost

3.7/5Value for Cost
Return Policy

3.6/5Return Policy


Brand Highlights

  • Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA capable of passing the blood-brain barrier and has been used as a nootropic, relaxation aid, and a sleep promoter.
  • Many athletes find Phenibut helpful when searching for restful sleep, especially after physically and mentally exhausting training days

Key Ingredients

  • Phenibut


  • Improving Sleep
  • Improving Mental Performance
  • Treat Anxiety and Improve Overall Well-Being


  • There are some experiences wherein users suffered from withdrawal symptoms (insomnia, anxiety, depression, hallucinations) when they abruptly discontinue intake of the compound.

How Does Phenibut Work?

Phenibut works by binding to the GABA receptors in a person’s brain. Compounds that bind to these receptors like alcohol and benzodiazepines have a significant effect in reducing anxiety while at the same time having a moderate euphoria effect. In higher doses, these compounds typically cause sleepiness which is the reason they are commonly used for treating insomnia and other sleep problems. One of the best features of phenibut is that it doesn’t just relieve stress and anxiety, but can also be used to improve cognitive function, memory, sleep quality and overall sense of well-being.

Phenibut Ingredients – Are They Safe & Effective?

Phenyl Aminobutyric Acid

– Phenibut (?-phenyl-?-aminobutyric acid) is a synthetic nootropic that is a GABA analogue. It was initially introduced and used in Clinical practice in Russia in the 1960s to treat depression, posttraumatic stress, stuttering, and vestibular disorders and as a pre- and postoperative medication [1]

Phenibut FAQ’s

Q : What You Can Expect From Phenibut?

A : Phenibut is a top-rated depression medication, unlike many so-called natural remedies for anxiety, stress, and sleep problems. It is a moderately powerful compound that is not legal in certain countries. Here are some of the most popular uses for the compound:

Since it is a compound that binds to GABA receptors, with higher doses, it can cause sleepiness. Phenibut is one of the most popular natural treatments for insomnia. However, some users claim that tolerance to the compounds builds up fast and withdrawal symptoms can be experienced when you suddenly stop intake. This is the reason most users recommend tapering off if you want to stop the intake of the compound.

There is a lot of clinical evidence that Phenibut improves cognitive function, memory and neurological functions. Although there is still no specific explanation, it is suggested that this effect is due to the compound’s action on GABA-A, GABA-B and dopamine receptors. A recent study also found that the compound increased transcallosal response amplitude in the brain which enhances the communication between the left and right hemispheres of the brain.

Phenibut is also known to improve mood and overall well-being. This is because of the compound’s ability to stimulate dopamine receptors. Again, it has an anxiolytic effect or the ability to relieve anxiety since it is a GABA agonist. This is also the reason it can be used for treating depression, high stress and other psychological problems. Just remember to follow the recommended intake in order to prevent side effects.

Q : What is the Dosage/Dosing Schedule of Phenibut?

A : One of the primary disadvantages of Phenibut is that tolerance builds up quickly so to maintain effectiveness, it would be best used on occasion only or cycled. Dietary supplements usually recommend taking phenibut for 5 days then taking 2days off. It can also be cycled wherein the compound is taken for two weeks, followed by two weeks off before starting the cycle again. The dosage varies depending on your primary goal (improved sleep, treating anxiety, etc.). The dosage range is around 250 to 1500 mg twice daily or as needed.

You May Also Like To ReadMin-Tran and Nature’s Way St John’s Wort

Phenibut – Final Verdict

Phenibut is currently a very popular supplement for treating anxiety, improving sleep quality, and improving cognitive function. However, it is not completely safe and is even considered to be a dangerous drug in countries like Russia. If you’re planning to take this supplement, you have to be very careful and follow the recommended dosage cautiously. If you’re planning to use it for anxiety or any other reason, there may be the <>safest antidepressant available.

Depression and anxiety are common disorders that can make daily tasks extremely challenging. Some estimates allege that approximately one in ten Americans suffer from some level of depression and/or anxiety. Symptoms of anxiety and depression include ongoing feelings of sadness accompanied by unease, irritability, tension, and nervousness. While some people require medication to deal with these occasionally crippling symptoms, others may find an all-natural product helpful. An all natural relaxation supplement should promote healthy neurological function. All ingredients should be clinically proven to reduce feelings of anxiousness, sadness, unease, irritability, tension, and nervousness.

Below you'll find some of the most effective natural nervousness relief supplements on the market today, in our opinion.

Our Top Depression Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned depression supplements based on the available research:

VitaPost Stress Support | Ashwagandha & Chamomile
Supports Daily Stress*Gold Star Evidence
Keeps Mind Positive*Gold Star Evidence
Prevents Chronic Stress*Gold Star Evidence
Provides Relaxation*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Restilen | Stress Relief and Relaxation
Maintains a Positive Mood*Gold Star Evidence
Reduces Stress Symptoms*Strong Evidence
Combats Fatigue*Gold Star Evidence
Boosts Energy Levels*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
NuviaLab Relax | Stress Relief Mood Support
Promotes Relaxation*Gold Star Evidence
Supports Calmness*Strong Evidence
Improves Quality of Sleep*Strong Evidence
Enhances Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Phenibut

Phenibut Reviews: Does Phenibut Work on Depression?

Customer Reviews & Ratings

1.0 out of 5

Review this Product

Leave a review and share your experience with others.

Write a Review

  1. Janet G.

    Not what I was expecting
    I have been taking this now for a little over weeks and haven’t noticed any results at all for mood and memory enhancement! I have taken the capsules as per the directions and will not be buying again after I finish. I experienced horrible anxiety after taking them. Highly disappointed with this product.

Write a Review

Your email address will not be published. Required fields are marked *

5000 characters remaining.

Explanation ?

Privacy Policy

Submitting this review means that you agree to our Review Guidelines, confirming that you are a verified customer who has purchased the product and may have used the merchandise or experienced the service, and providing only a real interaction and experience without ulterior motives or has an affiliate or business with the company in any way. By ticking this box and submitting this review, you also accept that submitting fake reviews is a violation of Consumer Health Digest’s Terms of Use and such conduct will not be tolerated.


How to Upload your Proof of Purchase:

Please follow the instructions listed below to upload your electronic proof of purchase.

  • To upload your physical paper receipt, simply take a picture of it with your camera or phone. You may also try taking a still picture of it with your computer’s webcam.
  • Once you have taken the picture, save the image as a JPG, TIF, or PDF file.
  • Please note that you cannot upload a file that is larger than 2MB.
  • Then all you have to do is click the Browse button and search for your receipt picture file. You can also drag and drop the file into the provided field.

If you are still not able to upload your proof of purchase, please contact us for further assistance (take a moment to look over the sample bill below).


Have a Question? Please Tell Us What We Are Missing Here!

Note: Consumer Health Digest isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
90 capsules
Phenyl Aminobutyric Acid

1 Sources

We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Phenibut (?-Phenyl-?-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

  1. About Us
  2. Editorial Policy
  3. DMCA Policy

Note: Results may vary about any product effectiveness. The information contained in this website is provided for general informational purposes only. No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition.

3 E Evergreen Road #1193, New City, NY 10956
[email protected]
Phone: +91-712-2543006

Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Your use of this website indicates your agreement to this websites published terms of use and all site policies. Please see our Medical Disclaimer for more information.

Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here.

Do Not Sell My Personal Information

Helping the Cause

Make a Donation

Follow Us


Advertising Disclosure

The content that appears on this page is presented as an overview vs. comparative marketing. The provided information includes product information, overviews, buying guides, and product specifications. All trademarks, registered trademarks and service-marks mentioned on this site are the property of their respective owners. If something is factually inaccurate please contact us and let us know. By contributing your product facts helps to better serve our readers and the accuracy of the content.

The table below does not include all companies or all available products in the market but those that we promote as their affiliates. In full compliance with the FTC guidelines, please assume that any and all links on the table are affiliate links, and we may receive compensation if you click one of these and make a purchase. We are independently owned and the opinions expressed here are our own. All editorial content is written without prejudice or bias, regardless of sponsor or affiliate associations. Read more about our process.