Phenibut Reviews: Does Phenibut Work on Depression?

Depression supplements are combined with other natural compounds or herbs in supplements designed to alleviate anxiety and promote relaxation in humans.

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In This Review

Phenibut Overview

Phenibut or beta-phenyl-gamma-aminobutyric acid is a compound commonly sold as a dietary supplement. It is a derivative of GABA (gamma-aminobutyric acid). It is different from GABA since it easily passes through the blood-brain barrier making it work faster.

This supplement is mixed with other natural compounds or herbs in supplements designed to address anxiety and promote relaxation. It can be purchased online or from health retail establishments. However, Phenibut is only available with a prescription in certain countries like Russia.

How Does It Rate?

Overall Rating: 3.7
ingredient

3.6/5Ingredients
Value for Cost

3.7/5Value for Cost
Return Policy

3.6/5Return Policy
Safety

3.7/5Safety

Brand Highlights

  • Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA capable of passing the blood-brain barrier and has been used as a nootropic, relaxation aid, and a sleep promoter.
  • Many athletes find Phenibut helpful when searching for restful sleep, especially after physically and mentally exhausting training days

Key Ingredients

  • Phenibut

Pros

  • Improving Sleep
  • Improving Mental Performance
  • Treat Anxiety and Improve Overall Well-Being

Cons

  • There are some experiences wherein users suffered from withdrawal symptoms (insomnia, anxiety, depression, hallucinations) when they abruptly discontinue intake of the compound.

How Does Phenibut Work?

Phenibut works by binding to the GABA receptors in a person’s brain. Compounds that bind to these receptors like alcohol and benzodiazepines have a significant effect in reducing anxiety while at the same time having a moderate euphoria effect. In higher doses, these compounds typically cause sleepiness which is the reason they are commonly used for treating insomnia and other sleep problems. One of the best features of phenibut is that it doesn’t just relieve stress and anxiety, but can also be used to improve cognitive function, memory, sleep quality and overall sense of well-being.

Phenibut Ingredients – Are They Safe & Effective?

Phenyl Aminobutyric Acid

– Phenibut (?-phenyl-?-aminobutyric acid) is a synthetic nootropic that is a GABA analogue. It was initially introduced and used in Clinical practice in Russia in the 1960s to treat depression, posttraumatic stress, stuttering, and vestibular disorders and as a pre- and postoperative medication [1]

Phenibut FAQ’s

Q : What You Can Expect From Phenibut?

A : Phenibut is a top-rated depression medication, unlike many so-called natural remedies for anxiety, stress, and sleep problems. It is a moderately powerful compound that is not legal in certain countries. Here are some of the most popular uses for the compound:

Since it is a compound that binds to GABA receptors, with higher doses, it can cause sleepiness. Phenibut is one of the most popular natural treatments for insomnia. However, some users claim that tolerance to the compounds builds up fast and withdrawal symptoms can be experienced when you suddenly stop intake. This is the reason most users recommend tapering off if you want to stop the intake of the compound.

There is a lot of clinical evidence that Phenibut improves cognitive function, memory and neurological functions. Although there is still no specific explanation, it is suggested that this effect is due to the compound’s action on GABA-A, GABA-B and dopamine receptors. A recent study also found that the compound increased transcallosal response amplitude in the brain which enhances the communication between the left and right hemispheres of the brain.

Phenibut is also known to improve mood and overall well-being. This is because of the compound’s ability to stimulate dopamine receptors. Again, it has an anxiolytic effect or the ability to relieve anxiety since it is a GABA agonist. This is also the reason it can be used for treating depression, high stress and other psychological problems. Just remember to follow the recommended intake in order to prevent side effects.

Q : What is the Dosage/Dosing Schedule of Phenibut?

A : One of the primary disadvantages of Phenibut is that tolerance builds up quickly so to maintain effectiveness, it would be best used on occasion only or cycled. Dietary supplements usually recommend taking phenibut for 5 days then taking 2days off. It can also be cycled wherein the compound is taken for two weeks, followed by two weeks off before starting the cycle again. The dosage varies depending on your primary goal (improved sleep, treating anxiety, etc.). The dosage range is around 250 to 1500 mg twice daily or as needed.

You May Also Like To ReadMin-Tran and Nature’s Way St John’s Wort

Phenibut – Final Verdict

Phenibut is known to enhance sleep quality and cognitive function while being regarded as best pills for depression and anxiety; however, its not completely safe in countries such as Russia, it is considered a potentially dangerous drug.

If you’re planning to take this supplement, you have to be very careful and follow the recommended dosage cautiously. If you’re planning to use it for anxiety or any other reason, there may be the <>safest antidepressant available.

Depression and anxiety are common disorders that can make daily tasks extremely challenging. Some estimates allege that approximately one in ten Americans suffer from some level of depression and/or anxiety. Symptoms of anxiety and depression include ongoing feelings of sadness accompanied by unease, irritability, tension, and nervousness. While some people require medication to deal with these occasionally crippling symptoms, others may find an all-natural product helpful. An all natural relaxation supplement should promote healthy neurological function. All ingredients should be clinically proven to reduce feelings of anxiousness, sadness, unease, irritability, tension, and nervousness.

Below you'll find some of the most effective natural nervousness relief supplements on the market today, in our opinion.

Rating
Our Top Depression Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned depression supplements based on the available research:

VitaPost Stress Support | Ashwagandha & Chamomile
Seal
Supports Daily Stress*Gold Star Evidence
Keeps Mind Positive*Gold Star Evidence
Prevents Chronic Stress*Gold Star Evidence
Provides Relaxation*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Restilen | Stress Relief and Relaxation
Maintains a Positive Mood*Gold Star Evidence
Reduces Stress Symptoms*Strong Evidence
Combats Fatigue*Gold Star Evidence
Boosts Energy Levels*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
NuviaLab Relax | Stress Relief Mood Support
Promotes Relaxation*Gold Star Evidence
Supports Calmness*Strong Evidence
Improves Quality of Sleep*Strong Evidence
Enhances Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

1
Customer Reviews for Phenibut

Phenibut Reviews: Does Phenibut Work on Depression?

Customer Reviews & Ratings

1.0 out of 5

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  1. Janet G.




    Not what I was expecting
    I have been taking this now for a little over weeks and haven’t noticed any results at all for mood and memory enhancement! I have taken the capsules as per the directions and will not be buying again after I finish. I experienced horrible anxiety after taking them. Highly disappointed with this product.

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PRODUCT NAME
Phenibut
PRODUCT BRAND
PrimaForce
PRICE (in USD)
$11.80
ITEM FORM
Capsules
UNIT COUNT
90 capsules
INGREDIENTS
Phenyl Aminobutyric Acid

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    1 Sources

    We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

    [1] Phenibut (?-Phenyl-?-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952553/

    **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

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