Deplin Review – What to Expect from This Supplement?

We know how it feels to be depressed! Hence, we dug out a solution for you. Introducing 'Deplin', a prescribed med that could pull you out of depression.

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In This Review

Deplin Overview

Deplin is a prescription medication designed to help treat patients who are suffering from different types of depression.

It is specifically for the dietary management of depression working to regulate all the monoamine neurotransmitters connected to mood.

It provides for the increased folate requirement in the brain on individuals who have depression.

There are several clinical studies indicating a good success rate of prescription medication in people with depression.

One month’s supply of Deplin can cost up to $98 depending on the location.

How Does It Rate?

Overall Rating: 3.7

Value for Cost

3.9/5Value for Cost
Return Policy

3.7/5Return Policy


Brand Highlights

  • Formula is Third-party tested and retested for quality
  • They offer 100%, no questions asked, money-back guarantee
  • Products are made with the highest standard with GMP-certified facilities
  • The brand has legacy of using natural ingredients.

Key Ingredients

  • Phosphatidyl Serine
  • Magnolia Bark
  • Beta-Sitosterol
  • Rhodiolarosea


  • Can help one in reducing stress
  • It may help in boosting your immunity.
  • It can regulate nerve excitability.
  • It calms and relaxes your body both mentally and physically.


  • There is less information about the components in the product.
  • There are no studies which support the working of the product.

Who Is the Manufacturer of Deplin?

The prescription medication was developed and is being manufactured by Pamlab (Pan American Laboratories) which is a growing company that specializes in formulating what are considered “prescription medical foods”.

The company has been around for more than 50 years and has established a reputation for developing and producing this specific type of supplements.

Pamlab is now a trustable supplier of prescription formulations offering high quality and effective products.

The depression supplements is said to address the nutritional imbalance from depression.

It specifically provides the body with more active folate which works together with antidepressant therapy to treat depression and prevent it from recurring.

It can also be used to treat other conditions that cause low folate levels like alcoholism, pregnancy, liver disease, and gastrointestinal problems.

How Does Deplin Work?

Deplin provides the user with folate that is already activated.

Thus, there is no need for the body to perform several processes just to benefit from the primary active ingredient.

This supplement will ensure that the body will utilize the folate effectively to deliver specific nutritional needs caused by depression.

It works together with antidepressants to alleviate depression and prevent the problem from recurring.

Deplin Ingredients – Are they Safe & Effective?

The main active ingredient of Deplin is activated folate which has been shown to be a powerful weapon for treating depression.

Folate fuels the synthesis of important brain messengers like dopamine, serotonin, and norepinephrine.

Deficiency of these chemicals is closely linked to major depression along with other major psychiatric disorders.

It uses an activated form of folate [1] so there is no need for the body to convert it and it would easily pass through the blood-brain barrier for optimum benefit.

Does Deplin Really Work?

The product is claimed to provide the said claims.

However, there is less information about its ingredients and therefore, we cannot ascertain whether it is effective or not.

Deplin – FAQs

Q: What Is The Recommended Dosage Instructions of Deplin?

A – Follow the dosage from your physician very carefully. Altering dosage may lead to adverse effects. If you miss a dose, consult your physician on what you should do.

Q: Are There Any Precautions Associated with Deplin?

A – Before taking this product, make sure you are not allergic to it and inform your physician of your allergies. There is a possibility that the product can cause allergic reactions or other adverse effects due to inactive ingredients. Inform your physician about your medical history especially if you have a vitamin B12 deficiency.

Make sure to inform your physician or dentist about the medications and non-prescription products you are taking before any kind of surgery. Folic acid passes into breast milk, but it is not likely to harm a nursing infant. However, you still need to consult your physician before breastfeeding.

Q: Does It Interact With Other Medication?

A – There is a possibility that Deplin will interact with certain medications, so you need to inform your physician of all the medication you are currently taking.

It can even interact with non-prescription medication and herbal or other supplements, so you need to inform your physician of these as well.

In some cases, your physician will only need to adjust the dosage to prevent interaction with other medication.

Deplin Reviews – Final Verdict

After carefully examining the prescribed antidepressant Deplin, it is a good supplement for people under antidepressant therapy.

There is sufficient evidence that it helps in most cases for treating depression and many people say it is really effective.

The main problem is the high price it is covered by most health insurance policies.

Depression and anxiety are common disorders that can make daily tasks extremely challenging. Some estimates allege that approximately one in ten Americans suffer from some level of depression and/or anxiety. Symptoms of anxiety and depression include ongoing feelings of sadness accompanied by unease, irritability, tension, and nervousness. While some people require medication to deal with these occasionally crippling symptoms, others may find an all-natural product helpful. An all natural relaxation supplement should promote healthy neurological function. All ingredients should be clinically proven to reduce feelings of anxiousness, sadness, unease, irritability, tension, and nervousness.

Below you'll find some of the most effective natural nervousness relief supplements on the market today, in our opinion.

Our Top Depression Choices

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned depression supplements based on the available research:

VitaPost Stress Support | Ashwagandha & Chamomile
Supports Daily Stress*Gold Star Evidence
Keeps Mind Positive*Gold Star Evidence
Prevents Chronic Stress*Gold Star Evidence
Provides Relaxation*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Restilen | Stress Relief and Relaxation
Maintains a Positive Mood*Gold Star Evidence
Reduces Stress Symptoms*Strong Evidence
Combats Fatigue*Gold Star Evidence
Boosts Energy Levels*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
NuviaLab Relax | Stress Relief Mood Support
Promotes Relaxation*Gold Star Evidence
Supports Calmness*Strong Evidence
Improves Quality of Sleep*Strong Evidence
Enhances Cognitive Function*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Deplin

Deplin Review – What to Expect from This Supplement?

Customer Reviews & Ratings

3.5 out of 5

Review this Product

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  1. Charlene Cortez

    No question that I would buy this again!!!
    This medical food helped me so much that, when I had to wait to get a refill due to finances, I hugged the bottle!!! Also, it is much less expensive if you have your doctor send it to Brand Direct to get it filled. Insurance will not pay for it.
  2. Debra H Blixt

    Slight Improvement But There Are Better Choices Than It!
    I was impressed with the scientific data that supported the capabilities of this product formulation to elevate mood and fight symptoms of depression. I take it daily and I have noticed a slight improvement. It’s helpful, but not as effective as other medication prescribed for depression.

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Pan American Laboratories
30 Capsules

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We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Folate is a B-vitamin that is naturally present in many foods. Your body needs folate to make DNA and other genetic material.,foods%20and%20most%20dietary%20supplements.

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

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