Synbiotic 365 Review – Is Synbiotic 365 Safe To Use and Worth Buying?

Synbiotic 365 by United Naturals is a probiotic supplement made by United Naturals that is alleged to help you address your digestive issues by combining probiotics and prebiotics.

In This Review

What is Synbiotic 365?

Synbiotic 365 United Naturals is a high-quality probiotic that can ease the discomfort of bloating and other unpleasant digestive issues. This product can help to balance out your gut flora, getting rid of food cravings that cause you to overeat. It contains both probiotics and prebiotics. The product uses only organic ingredients and is very rich in B vitamins.

Synbiotic 365 United Naturals
Synbiotic 365 United Naturals – Colon Cleanser

Who is the Manufacturer of Synbiotic 365?

The Synbiotic 365 supplement is manufactured by United Naturals, which was founded in 2017 by a Canadian owner. This organization aims to produce health supplements, and Synbiotic 365 is their first product.[1]

The founder began the company in an attempt to help his girlfriend, who struggles with digestive issues. Together with renowned doctor Vincent Pedre, they developed these special probiotics.

How does Synbiotic 365 work?

This supplement contains 3 elements: Prebiotics, Probiotics, and B Vitamins. Probiotics are strains of bacteria that are beneficial for digestive functioning and help to strengthen the immune system.

So you may be wondering, what’s the difference between Pre and Probiotics? The prebiotics act like food for the good probiotics to consume and thrive in your gut. This unique mix brings helpful probiotics into your system and keeps them there, while at the same time preventing the growth of harmful bacteria. It is, of course, important to remember that other fruits, vegetables, and grains can act as prebiotics for probiotics in your diet to thrive.

This product is a symbiotic, which Science Direct defines as, “a combination of prebiotics and probiotics that act synergistically promoting gastrointestinal health by improving survival and adherence of live probiotics.”

The B vitamin complex can help to close any deficiencies you may have. B vitamins are crucial to proper human health and functioning. They play essential roles in regular body functions so deficiencies can be problematic. The Harvard School of Public Health says that B vitamins help enzymes function efficiently in the body. Note that B-vitamins are water-soluble and typically present in sufficient quantities in a healthy diet.

Synbiotic 365 Ingredients – Are they Safe and Effective?

Synbiotic 365 Supplement Facts

Synbiotic 365 Supplement Facts

Here is a closer look at some of the specific ingredients:

Lactobacillus Casei – This is one strain of probiotic which is known to be effective at lowering cholesterol levels, and it could also assist with alleviating allergy symptoms.[2] It also helps to regulate your digestive system and could help to reduce some types of diarrhea.[3] Research has also shown that this probiotic can survive transit through the human digestive tract which is an important factor when considering a probiotic.


*All individuals are unique. Your results can and will vary.

Vitamin B12 – This is an essential nutrient in the human body, supporting functions like good brain health, red blood cell, and DNA production.[7] Since our bodies are not capable of producing Vitamin B12, we must derive it from foods such as meat and seafood.

Chicory Root Inulin – This prebiotic is a type of fiber derived from plant foods. Chicory root is rich in inulin, a soluble fiber found in many plants.[6] The small intestine can’t absorb inulin. It goes to the large intestine, where it’s consumed by bacteria. Bacteria found in the colon can be helpful or harmful, so it is important to make sure we get plenty of good probiotics in our diets. This substance in combination with a probiotic, can lessen constipation, promote digestive health, and increase good bacteria in your colon.[4]

ALSO READDr. Tobias Colon 14 Day Quick Cleanse Reviews

What are the Pros of Synbiotic 365?

  • The product promotes excellent digestive health.
  • Helps to fight off bad bacteria in the gut.[5]
  • Synbiotic 365 is very rich in B-vitamins.

What are the Cons of Synbiotic 365?

  • The product contains rice hull concentrate so it should not be used by people with rice allergies.
  • It has a high price point.
  • Synbiotic 365 has large capsules which may be hard to swallow.

SEE ALSOPlexus Bio Cleanse and Thrive Plus Balance

Synbiotic 365 FAQ’s

Q: How should you take Synbiotic 365?

A: The recommended dosage is 1 capsule per day, with a full glass of water. Do not take more than the suggested dosage, as it could harm your body.

Q: How much does Synbiotic 365 cost?

A: You can only purchase this product on the manufacturer’s official website. There are 3 possible purchasing options.

  • 1 box is $45
  • 3 boxes are $119
  • 6 boxes are $229

Q: What is Synbiotic 365’s return policy?

A: The company has a 60-day return policy. If you’re dissatisfied with the product, you must contact the company and return the remainder of the products by 60 days from the date of the original purchase. To receive your full refund, you can only send back 2 empty bottles, and the rest must be sealed or unused. The manufacturer will not pay you back the return shipping costs.

Q: Does Synbiotic 365 offer a free trial?

A: This manufacturer is not offering a free trial offer at the moment, but they acknowledge that they do sometimes offer these deals. When they do, the trial implies that you’ll be signed up for the auto-subscription program without further permission. In this case, you’ll receive and be charged for a bottle every month.

Q: Does Synbiotic 365 have an Expiration Date?

A: Yes, the product comes with an expiration date printed on the side of the container. The duration of viability can vary, depending on when the product was manufactured. Usually, it is at least a year out.

If the 365 Daily Probiotic is in tablet form, these pills must be refrigerated after opening. If left out for long (several hours), they can lose their effectiveness. 365 Daily Probiotic is currently available only in capsule form from stores. The capsules type of product does NOT need to be refrigerated.

Q: What are the side effects of Synbiotic 365?

A: According to the Synbiotic 365 reviews, an excess dosage of a supplement may result in increased appetite, vomiting, and morning sickness problems.


*All individuals are unique. Your results can and will vary.

Q: Where to Buy Synbiotic 365?

A: You can buy Synbiotic 365 directly from official website or it is also available on Walmart.

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Synbiotic 365 Review – Conclusion

This product is very popular among consumers to address digestive health. The majority of online Synbiotic 365 customer reviews and video testimonials are very positive. Users reported this product seemed to calm their digestion and bloating.

Anecdotal reports by consumers say they lost some weight after they started taking this supplement, but remember that those reports are in no way causal evidence.

Synbiotic 365 is an ideal digestive product because it contains probiotics, prebiotics, and a Vitamin B complex. This product is made up of natural ingredients and vitamins, but that doesn’t mean they’re harmless.

You should make an appointment with your doctor before you begin taking them to discuss your digestive issues and make sure this is the most suitable pre and probiotic product for you.

All of the cells and tissues in your body and your major organ of detoxification, the liver rely upon your colon. The colon processes waste and bacteria preparing it for elimination from the body. Colon cleanse products should be determined based on its: potential to clean the colon of harmful waste & toxins, potential to promote better digestion & increase elimination, potential to promote improved immune system function, potential to provide increased energy levels. The quality of the ingredients should be backed by clinical research.

Below you'll find some of the most effective colon cleanse supplements on the market today, in our opinion.

Our Top Gut Health Supplements

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned probiotic supplements and natural colon cleanse supplements based on the available research:

VitaPost Colon Detox Plus | Natural Colon Cleanse Supplement
Supports Natural Body Functions*Gold Star Evidence
Supports Healthy Digestive System*Strong Evidence
Smooth Bowel Movements*Strong Evidence
Relieve Constipation*Moderate Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.7
Morning Complete - ActivatedYou | Best All-Natural Daily Wellness Drink
Regulates Digestion*Gold Star Evidence
Support Healthy Body Weight*Gold Star Evidence
Boost Energy Levels*Strong Evidence
Supports Optimal Health*Gold Star Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.9
Gundry MD Vital Reds | Concentrated Polyphenol Blend
Promotes Improved Digestion*Gold Star Evidence
Supports Weight Management*Strong Evidence
Boost Natural Energy*Gold Star Evidence
Supports Skin Health*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Multi-GI 5 | Best Gut Health Supplement
Balanced Gut Flora*Gold Star Evidence
Supports Healthy Digestion*Gold Star Evidence
Supports Weight Management*Strong Evidence
Healthy GI Lining*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Colon Broom | Strenghten your gut health
Supports Gut Health*Gold Star Evidence
Supports Weight Management*Strong Evidence
Supports Immune Function*Gold Star Evidence
Helps Improve Energy*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.8
Bio Complete 3 - Gundry MD | Natural Probiotic Supplement
Reduces Gas & Bloating*Gold Star Evidence
Supports Weight Loss*Moderate Evidence
Helps Fight Achy Muscles*Moderate Evidence
Boosts Energy*Strong Evidence
Rating Breakdown
Support for Claims:
Ingredient Safety:
Value for the Price:
Brand Transparency:
Overall Rating: 4.7

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Consumer Health Digest. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer. *All individuals are unique. Your results can and will vary.

Customer Reviews for Synbiotic 365

Synbiotic 365 Review – Is Synbiotic 365 Safe To Use and Worth Buying?

Customer Reviews & Ratings

3.8 out of 5

Review this Product

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    Does It Actually Contain Listed Ingredients?
    Is there any independent testing to see if it actually contains the ingredients listed? Any review without this is pretty useless. All it is doing is commenting on the biased producer puts on the ingredients list.
  2. Linda J. Allen

    Real Blessing For My Husband and I
    I had diarrhea for several months and thought I had IBS/IBD. Finally went to my gastro doc and had tests. Turns out I had H Pylori Infection and he prescribed two heavy-duty antibiotics and prazadole (sp) for my stomach. After the course of antibiotics, symptoms subsided for 2-3 weeks and diarrhea came back. I was to go back to the lab for a breathing test, but COVID was running rampant so didn’t want to go to a lab. I have taken a probiotic/prebiotic for several years and decided to try a different one. When I got the video showing Synbiotic 365, I was skeptical to try but it really sounded great, packaging, probiotic & Prebiotic so didn’t think I had anything to lose. It really worked, Regular bowel movement in 2-3 weeks maybe a bit longer BUT, I’m thinking I do have IBS/IBD at any rate this stuff really did the job for me. My husband, daughter (Adult), and I are now all now taking it. It is expensive but as long as I can afford it, I’ll be buying it. Hoping my sister will try it as well as she has been diagnosed with IBS, so am confidant that it will help her as well.
  3. Judy McCullough

    Superb Product Must try!
    This probiotic is, by far, the very best one I’ve ever taken! I’ve taken many different brands over the years and recently happened upon this one. I could not believe how great it made me feel…not just energy but regular bowel movements as well. I highly highly recommend Synbiotic 365.

  4. Gregory Johnston

    Synbiotic 365 works great!
    For the first time in years I have not had bowel issues in months. This stuff works great well worth the money as long as I am feeling good I am going to keep taking it. This is the first time in years I have not had to take antibiotics for bowel infections for months now. I love to trust me if you want something that works to buy it.

    Synbiotic 365...really love it
    I have been taking synbiotic 365 for about 3 weeks. I must say I am pleasantly surprised…I started sleeping better within 2 days. Which I am happiest about! I always have a pretty high energy level so that’s hard for me to measure: but definitely more alert. I don’t have a weight problem and do eat very healthily but do notice that I don’t crave food. Which is a nice bonus? I would definitely recommend giving it a try. I am fortunate to have bloodwork every 4 months and a quick review with my (bioidentical) DR. So I can keep track of the vitamin levels and cholesterol. Curious to see how 365 affects the numbers!

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Relief Factor Ques and Ans

  • Q: Where to return our supply of Synbiotic 365? Both my husband and I are having issues with the product after 4 days?

    A: You can contact United Natural’s via their phone number at 1-844-794-7728. Their address is: United Naturals 1300 Altura Rd Fort Mill SC 29708 You can also reach a representative using their online contact form. If for whatever reason you are not satisfied, the company has a 60 day refund period from the date your credit card was charged. You will have to send back used/unused products to the address listed above. Be sure to read all the terms of their refund/cancelation policy.

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Synbiotic 365
United Naturals
30 Capsules
Lactobacillus Casei, Vitamin B12, Chicory Root Inulin


We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy.

[1] Synbiotic 365: Advanced Probiotic Formula – United Naturals
[2] Lactobacillus | Healthline
[3] Probiotics and Prebiotics: Effects on Diarrhea
[4] Top 12 Foods That Are High in Vitamin B12 | Healthline
[5] What are the most common types of probiotics?
[6] Inulin: Uses and Risks | WebMD
[7] B-Complex Vitamins: Benefits, Side Effects, and Dosage

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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