Updated: 2021, Jan 30

Top Rated Nootropics of 2021

Here's a look at the 4 top nootropics of 2021. Find the right nootropic formula for your brain chemistry and goals.
We live in an era where efficiency is key to survival, and this has resulted in an increase in the popularity of smart drugs called nootropics according to the Observer[1].

In case you are interested in learning more about nootropics and what are the Top Rated Nootropics of 2021 that are available in the market today, then keep reading.

What do you mean by Nootropics?

Nootropics otherwise known as cognitive enhancers are types of drugs meant to treat cognitive problems in certain brain disease or even natural age-related cognitive decline.

When we say cognitive problems, what we mean is issues relating to memory, attention, executive functioning, perception, and even psychomotor functioning.

The term nootropics was coined[2] in 1972 after scientists discovered that piracetam improved cognitive functioning.

While some nootropics are produced in the laboratory, others are derived from natural and herbal sources.

Top Rated Nootropics

Top Rated Nootropics

#1 Geniux

Geniux – Advanced Brain Formula

Know More About Geniux

Geniux is another all-natural brain enhancement supplement designed to improve memory and alertness in relatively healthy individuals experiencing problems with the cognitive performance that might be affecting their work or school.

Geniux improves neurotransmitter levels with Alpha GPC and cerebral blood flow with Bacopa Monnieri. Tyrosine which is a type of amino acid was added in Geniux because it was found to improve working memory in situations requiring multitasking.

Another study[7] found that tyrosine improved cognitive performance and decreased blood pressure in 21 cadets undergoing a military training course.

#2 Lipogen PS Plus

Lipogen ps plus
Lipogen PS Plus – Optimize Brain Energy

Know More About Lipogen PS Plus

Studies[8] on rats have found that stress caused hippocampal atrophy learning impairment. Stress has a strong negative effect on brain health and functioning which is why managing stress is important to preserve your sanity and good cognitive functioning. Lipogen PS Plus was designed to control daily stress levels while also supporting brain health.

The soy-derived phosphatidylserine and phosphatidic acid in Lipogen PS Plus was found in one placebo-controlled study[9] to normalize stress-induced problems with the hypothalamus-pituitary-adrenal axis in male subjects. The researchers found a normalized endocrine stress response from salivary cortisol levels in subjects who took a daily dose of phosphatidylserine and phosphatidic acid.

#3 Cebria

Cebria – Reduce Mental Fuzziness & Brain Fog

Know More About Cebria

Neuropeptides are one of the most important signaling molecules in the brain important for a wide range of brain functions.

The levels of neuropeptides decrease with age causing significant memory problems. Cebria is a nootropic supplement designed to boost the levels of neuropeptides in your body and, in turn, lead to better memory and mental agility.

Cebria contains a patented blend of different neuropeptides that help build new neuron connections which can help improve overall memory functioning. Studies[10] on neuropeptide supplements on brain health have found that these chemicals improve cognitive functioning and reduce neurodegenerative events in older persons.

#4 Synagen IQ

Synagen Iq Review
Synagen IQ – Advanced Cognitive Enhancer

Know More About Synagen IQ

Synagen IQ is another great nootropic supplement designed for almost any age and any cognitive problem.

This nootropic is meant to preserve overall brain health by preventing age-related cognitive decline. Since cognitive decline begins as early as one’s late 20s, taking Synagen IQ at an early age can help you preserve brainpower for much longer.

Just like Lipogen PS Plus, Synagen IQ also contains a naturally-derived phosphatidylserine complex that is meant to preserve your brain health by preventing age-related loss of neuropeptides.

Do Nootropics Boost Concentration and Focus?

According to Curr Med Chem. 2007 study, Nootropics can increase your concentration and focus by improving your brain’s health and neurotransmitter levels.

Some nootropics like caffeine were found in studies[3] to significantly increase alertness, focus, and concentration.

However, caffeine can also cause nervousness when used in its pure form. Wakefulness-promoting nootropics such as modafinil can increase alertness as can psychostimulants such as amphetamines that are used in the treatment of ADHD.

Are Nootropics Really Good?

Nootropics can be good when used accordingly. Some pharmaceutical nootropics were specifically designed for people with cognitive abnormalities such as Alzheimer’s disease and sleep, schizophrenia, and ADHD. Use[4] of these nootropics by healthy people is not advised.

A better alternative for healthy people wishing to improve their cognitive performance is taking natural and herbal nootropics[5] which were also found to be very effective.

Are There Any Side Effects Of Nootropics?

Nootropics are smart pills or can also be recognized as brain enhancement pills that are supposed to protect our brain and improve its functioning.

These are the dietary supplements that one needs after touching a certain age to promote and boost memory retention. But many people worry about its safety and the side effects they can attract, before using these. Being a nootropic, the designers know that this product must be built as 100% natural, safe and non-toxic for the brain.

According to the Time’s report, the brain is the most complicated as well as a sensitive part of our body. There are many supplements that do not come under the bracket of nootropics but they are smart drugs like Adderall and Ritalin.

To consider a nootropic, the supplements pass through the clinically proven tests to establish their safety and a negligible rate of risk or side effects such as Piracetam, Noopept, Choline, Provasil, Geniux and many more. These supplements can boost focus, mental clarity and attention along with the promotion of brain health and communication.

These supports memory and reasoning power and build up motivation level in a person. The dosage and level of risk depend on the supplements.

The use of nootropics is on the rise in today’s society, but more research is needed to better understand their benefits.

How to Choose the Best Nootropic?

The best nootropics are those that a proven to be safe and effective through clinical trials. The best nootropics support the brain’s healthy via reducing oxidative stress, brain cell death, and neurotransmitter deficit and increasing cerebral blood flow, neurotransmitter connections, and improving brain structure.


Those are just but a few of the Top Rated Nootropics of 2021 that are available on the market and that provide a variety of health benefits to the brain.


[1] Nootropic Brain Drugs Rise in Popularity for Today’s Cutthroat Corporate Climbers | | Observer https://observer.com/2015/04/nootropics/
[2] Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes - IOS Press https://content.iospress.com/articles/journal-of-alzheimers-disease/jad121537
[3] J Int Soc Sports Nutr. 2014; 11(Suppl 1): P45. Published online 2014 Dec 1. doi: 10.1186/1550-2783-11-S1-P45. PMCID: PMC4271648. The effects of a multi-ingredient cognitive formula on alertness, focus, motivation, calmness and psychomotor performance in comparison to caffeine and placebo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271648/
[4] J Med Ethics. 2009 Oct;35(10):611-5. doi: 10.1136/jme.2009.030882. Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology. https://www.ncbi.nlm.nih.gov/pubmed/19793941
[5] Pharmacogn Rev. 2012 Jul-Dec; 6(12): 147–153. doi: 10.4103/0973-7847.99949. PMCID: PMC3459457. PMID: 23055641. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459457/
[6] Neurotransmitter - Wikipedia https://en.wikipedia.org/wiki/Neurotransmitter
[7] Brain Res Bull. 1999 Jan 15;48(2):203-9. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. https://www.ncbi.nlm.nih.gov/pubmed/10230711
[8] Nat Rev Neurosci. 2004 Dec;5(12):917-30. Stress, cognitive impairment and cell adhesion molecules. https://www.ncbi.nlm.nih.gov/pubmed/15550947
[9] A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study | Lipids in Health and Diseasehttps://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-121
[10] Methods Find Exp Clin Pharmacol. 2005 Sep;27(7):483-7. Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects. https://www.ncbi.nlm.nih.gov/pubmed/16258593
Instagram linkedin

Lauren Ann, MS

Lauren has dual graduate degrees in Clinical Psychotherapy and Nutrition, espousing an integrative approach to optimizing overall healt

**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

Disclosure of Material connection: Some of the links in the post above are "associate sales links."This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."