In This Review
Neuropathy is not a particular disease, but it is a complication caused by the combination of different underlying medical conditions.
Doctors call it “idiopathic” when the primary cause is not yet diagnosed.
What is neuropathy peripheral? The term neuropathy is actually short for peripheral neuropathy which means that there is nerve damage in parts of the peripheral nervous system.
Take note that peripheral neuropathy doesn’t include nerve damage in parts of the central nervous system.
What is neuropathy nerve damage? It involves nerves outside of the brain and spinal cord.
Types of Neuropathy
There are a number of peripheral neuropathies from different causes.
The range is broad from carpal tunnel syndrome to nerve damage caused by diabetes.
Neuropathies are classified according to the problems they cause or the root of the damage.
1. Mononeuropathy: This is when the damage is only to a single peripheral nerve.
The most common cause is trauma or physical injury like in the case of an accident.
Prolonged nerve pressure from long periods of being sedentary (like in the case of lying in bed) or continuous repetitive motions can cause mononeuropathy.
The most common type is carpal tunnel syndrome.
It affects multiple peripheral nerves in the body which malfunction at the same time.
There is a wide variety of possible causes including toxin exposure (like alcohol abuse), vitamin deficiency and complications from cancer or kidney failure.
Signs and Symptoms of Neuropathy
The possible signs and symptoms of peripheral neuropathy include:
- Numbness or reduced sensitivity.
- A tingling or painful sensation.
- Sharp pains or cramps.
- Increased sensitivity of certain parts of the body.
- The weakness of muscles.
- Reduced reflexes especially in the ankles.
- Loss of coordination and balance.
- Serious problems of the foot including infections, ulcers, deformities and bone/joint pain.
Causes and Risk Factors of Neuropathy
Most causes of neuropathy are caused by metabolic disorder diabetes when it is simply referred to as diabetic neuropathy.
- Diabetes mellitus especially when sugar levels are not controlled correctly
- Abuse of alcohol.
- Vitamin B deficiency.
- Infections like Lyme disease, hepatitis C, HIV and Epstein-Barr virus.
- Autoimmune diseases like lupus and rheumatoid arthritis.
- Toxic exposure.
- Disorders of the liver, thyroid or kidney.
- Family history of neuropathy.
- Repetitive motions.
Must Watch – Everything You Need to Know About Neuropathy
Tests and Diagnosis for Neuropathy
The doctor needs to determine the location of the nerve damage and its cause.
Diagnosis starts with a physical examination that may include blood tests.
Then a full medical history will be needed which will be followed by a neurological examination.
Then other tests may be ordered like:
- Imaging Tests: CT or MRI scans to check for tumors or any other abnormalities.
- Nerve Function Tests: An electromyography may be ordered to determine if symptoms are caused by muscle or nerve damage. Nerve conduction studies may also be done.
- Other Nerve Function Tests: It may include an autonomic reflex screen, sweat test and sensory tests.
- Nerve Biopsy: A small portion of a nerve may be removed for examination.
- Skin Biopsy: This is for examining the number of nerve endings.
Treatments and Medications to Treat Neuropathy
The goal of treatment is to manage the condition that causes neuropathy that will also relieve the symptoms.
If there is no underlying condition, the doctor will observe if the neuropathy improves.
In the case of exposure to toxins or alcohol, such substances should be avoided.
- Medications: For relieving peripheral neuropathy, pain relievers, anti-seizure medications, capsaicin formulations and antidepressants may be prescribed by the physician. .
- Therapies: There are various therapies and procedures that may be used depending on the type and extent of neuropathy. This includes transcutaneous electrical nerve stimulation. , plasma exchange and intravenous immune globulin, physical therapy and surgery.
Precaution and Self Care for Neuropathy
- Take good care of your feet especially if you have diabetes.
- Get regular exercise that helps improve muscle strength, relieve neuropathy symptoms and control blood sugar levels.
- Quit smoking since it negatively affects circulation.
- Follow a healthy diet making sure you get the important vitamins and minerals.
- Limit alcohol intake since it can worsen peripheral neuropathy.
- Monitor your blood glucose level closely.
- You need to be closely monitored by your healthcare provider to see if the neuropathy worsens or improves over time so Neuropathy treatment can be adjusted accordingly.
We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. This ensures the highest standard of scientific accuracy. Peripheral Neuropathy: https://my.clevelandclinic.org/health/diseases/14737-peripheral-neuropathy
 Peripheral Neuropathy Fact Sheet: https://www.ninds.nih.gov/peripheral-neuropathy-fact-sheet
 Hovaguimian A, Gibbons CH. Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep. 2011;15(3):193-200. doi:10.1007/s11916-011-0181-7
 Peripheral neuropathy: https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061
 What is peripheral neuropathy?: https://www.medicalnewstoday.com/articles/147963
 Gibson W, Wand BM, O'Connell NE. Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev. 2017;9(9):CD011976. Published 2017 Sep 14. doi:10.1002/14651858.CD011976.pub2