The 21 Best Mood Enhancer 2025 Vitamins and Supplements

One of the key ingredients in CogniUltra^® is Bacopa Monnieri Extract. This plant extract has been extensively studied and proven to enhance memory and cognitive functioning.

In a 12-week study published in Evidence-Based Complementary and Alternative Medicine ^[1] by Tatimah Peth-Nui, et al, elderly subjects who consumed bacopa extract showed significant improvements in memory and cognitive functioning.

The benefits of CogniUltra^® extend beyond just cognitive enhancement – it also supports overall brain health, reduces oxidative stress, and promotes neural repair. Whether you’re a student struggling to focus during exams or an older adult looking to maintain mental clarity, CogniUltra^® is the ideal supplement for brain function.

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The primary ingredient, Ginkgo Biloba, has been extensively studied for its positive effects on mood regulation.

Research in the British Journal of Pharmacology (2010) found that Ginkgo Biloba can boost serotonin and dopamine levels, leading to better mood stability and reduced anxiety. Additionally, the inclusion of Red Panax Ginseng enhances stress relief, making this supplement a reliable choice for emotional balance.

The WOWMD Ginkgo Biloba Capsules work by enhancing blood flow to the brain, improving oxygen delivery, and supporting neurotransmitter activity. This supplement is safe, non-GMO, and gluten-free, offering a natural way to combat stress and mood swings. It is perfect for adults seeking the best serotonin and dopamine supplements to boost mood and energy.

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One of the standout ingredients in WOWMD Neuro Plus Brain & Focus Formula is Choline Bitartrate. Choline is essential for producing acetylcholine, a neurotransmitter crucial for memory and focus, making it a key ingredient in top brain supplements.

A study published in The Behavioural Neurology found that choline supplementation significantly improved cognitive performance and memory in older adults. This highlights choline’s critical role in supporting brain function and mental sharpness.

The WOWMD Neuro Plus Brain & Focus Formula is designed for adults who want to improve their cognitive abilities, focus, and mental clarity. It works by delivering essential nutrients that support neurotransmitter function, improve brain blood flow, and reduce oxidative stress. This supplement is safe for most people, offering benefits like enhanced memory retention, reduced mental fatigue, and better stress management. It’s an excellent choice for students, professionals, and seniors seeking to maintain their cognitive health. Take 1-2 capsules daily for optimal results.
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The key ingredient, organic Ashwagandha root, is a powerful adaptogen celebrated for its ability to reduce cortisol levels and support mood stability.

A study published in the National Institute of Health highlights Ashwagandha’s role in improving resilience to stress, promoting relaxation, and enhancing serotonin activity. The formula is enhanced with organic Black Pepper extract, which contains piperine to improve the absorption of Ashwagandha, ensuring optimal effectiveness.

WOWMD Ashwagandha Extra Strength Formula is designed to reduce mood swings, support focus, and alleviate anxiety. With a gluten-free, non-GMO formula, it is third-party tested for safety and purity. This supplement is ideal for adults managing stress, individuals seeking vitamins for mood swings and anxiety, and anyone aiming for mood enhancers for depression. Taken daily, WOWMD Ashwagandha Extra Strength Formula helps restore emotional balance and supports long-term mental resilience.

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ProMind Complex isn’t just another memory supplement; it’s a carefully crafted solution for those seeking to boost their cognitive health. Backed by years of research, the brand brings together some of the most effective mood enhancers available to support brain performance, memory, and mental clarity. ProMind Complex has earned recognition as one of the best brain supplements available. It is designed to elevate brain function while boosting overall mood, making it a must-have for individuals seeking to enhance their mental agility and emotional well-being.

A standout ingredient in ProMind Complex is Huperzine A, a compound known for its profound effect on memory enhancement. Studies have shown that Huperzine A helps increase acetylcholine levels, an essential neurotransmitter in cognition.

In a study published in the Journal of the Chinese Medical Association, Huperzine A has demonstrated significant improvements in cognitive performance, making it one of the most reliable mood enhancers for depression available today. This ingredient helps your brain work more efficiently, so you can feel more mentally clear and focused throughout your day.

The real strength of ProMind Complex lies in its unique formulation that combines scientifically proven ingredients to support memory, focus, and overall brain health. Safe and non-habit forming, ProMind Complex is suitable for individuals of all ages looking to improve their cognitive functions and overall mood. Thanks to its powerful blend of natural ingredients, it’s an excellent option for anyone seeking natural mood enhancers for depression or simply looking to boost mental clarity and focus.

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When it comes to weight loss, Helix-4 stands out for its no-nonsense approach, offering users a way to shed stubborn fat without having to overhaul their entire lifestyle. Unlike many other weight loss products, Helix-4 takes a straightforward approach to fat burning, combining a blend of natural mood enhancers and metabolism-boosting ingredients. With the Helix-4 supplement, the focus is on helping your body naturally break down fat while supporting overall well-being.

One of the key ingredients in Helix-4 is Green Thai Dessert, a natural plant extract that has been shown to aid in fat loss.

According to research conducted by the National Library of Medicine, compounds found in this extract may help enhance the body’s ability to burn fat while also supporting mental clarity and mood regulation. This makes it an ideal ingredient for anyone looking for natural energy and mood boosters.

The extract works by increasing metabolic activity, which leads to more efficient fat burning without the need for restrictive diets or strenuous exercise routines.

Helix-4 is more than just a fat-burning supplement—it’s a mood booster pill that supports overall emotional well-being. By helping you burn fat efficiently, it also reduces the physical stress often associated with weight loss journeys. Safe and effective, this supplement is perfect for individuals who want to kick-start their weight loss goals while also enhancing their mental state. With its potent combination of natural energy and mood boosters, Helix-4 is an excellent choice for anyone looking for an instant mood boost while working toward a healthier body.

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Onnit New Mood is a supplement that promises to deliver calm and relaxation in a hectic world. This brand, known for its focus on enhancing human performance, combines science and nature to craft products that help you feel at your best. New Mood, in particular, stands out as one of the best mood boosting supplements, offering a natural way to enhance your mood and unwind after a long day. Whether you are struggling with stress or need help transitioning into a restful night’s sleep, New Mood helps you regain your balance with its potent yet gentle formulation.

One of the main ingredients in Onnit New Mood is 5-HTP (5-Hydroxytryptophan), a naturally occurring compound that is a precursor to serotonin, the “feel-good” neurotransmitter.

According to a study published in the International Journal of Molecular Sciences, 5-HTP has been shown to improve serotonin levels, which can significantly help reduce feelings of anxiety and depression. This makes 5-HTP one of the most effective natural mood enhancers for those seeking an emotional boost without the need for prescription mood enhancers.span class=”colan1″>

By increasing serotonin production, 5-HTP helps stabilize your mood, making it a perfect choice for individuals dealing with occasional stress.

Onnit New Mood works by supporting the natural production of serotonin, which is essential for regulating mood and stress. Onnit New Mood is safe for everyday use and is free from caffeine, gluten, and soy, making it an excellent option for those looking for a natural mood enhancer. Whether you’re an overworked professional, a student preparing for exams, or anyone who simply needs a mental break, New Mood is designed to provide an emotional lift and a sense of calm. It’s a mood booster pill that supports emotional stability, reduces stress, and promotes relaxation, helping you feel at ease throughout the day and night.

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Sovereignty Purpose takes a holistic approach to stress management and emotional well-being. Crafted with Ayurvedic-inspired ingredients, this supplement stands out in a crowded market by offering a natural mood enhancer that also supports balance and clarity. The brand emphasizes the importance of natural healing, aiming to provide users with a sense of inner calm while boosting their mood naturally. Sovereignty Purpose offers a refreshing alternative to traditional mood enhancers for depression, improving your mood and also combating physical and emotional stress.

One of the most powerful ingredients in Sovereignty Purpose is Ashwagandha, an adaptogen revered for its ability to reduce cortisol levels and support mental clarity.

Research published in Journal of Alternative and Complementary Medicine highlights Ashwagandha’s ability to enhance the body’s resilience to stress while also promoting a stable mood. As a natural mood booster, Ashwagandha has been shown to lower anxiety, support cognitive function, and contribute to overall emotional well-being.

Sovereignty Purpose is designed for anyone who wants to regain emotional balance, manage stress, and improve their overall mood. pharmaceutical options. By using a potent combination of adaptogens and botanicals, it works by calming the mind, boosting mood, and improving resilience to stress. Safe, effective, and naturally derived, Sovereignty Purpose is perfect for people of all ages who want to feel their best and maintain a healthy mood throughout the day.

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One of the primary ingredients in Clean Nutraceuticals Mellomood is Rhodiola Rosea, an adaptogen known for its ability to combat stress and fatigue while boosting mood.

According to studies published in the British Journal of Nutrition, Rhodiola has been shown to significantly improve mood, reduce anxiety, and increase mental performance.

As one of the top mood boosting adaptogens, Rhodiola works by reducing the body’s stress response and enhancing the brain’s ability to focus and remain calm under pressure.

Clean Nutraceuticals Mellomood works by reducing mental fatigue, balancing stress hormones, and improving mood. Its carefully crafted formula supports mental clarity, energy, and overall emotional well-being without causing drowsiness. Safe and effective for daily use, it’s a perfect choice for individuals looking for a mood enhancer pill to support mental wellness. Ideal for both men and women, Clean Nutraceuticals Mellomood is a mood enhancer for women and men who need support to face life’s challenges.

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The key ingredient in 5-HTP Plus is 5-Hydroxytryptophan (5-HTP), a naturally occurring amino acid that the body uses to produce serotonin.

Studies, such as those published in the Pharmaceutics, have shown that 5-HTP can significantly improve serotonin levels, which in turn helps to reduce symptoms of depression, anxiety, and poor sleep.

As a potent natural mood enhancer, it supports emotional stability and enhances overall mood without the harsh side effects of prescription mood enhancers.

Dr. Emil Nutrition 5-HTP Plus works by naturally boosting serotonin levels, supporting brain function, and improving mood. It’s an ideal supplement for individuals seeking mood enhancers for depression or anyone looking to enhance emotional well-being in a natural way. It is safe for regular use and offers benefits such as reduced anxiety, improved sleep, and an overall sense of calm.

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The main ingredient in Nature’s Craft Kava Kava is Kava Kava itself, derived from the root of the Piper methysticum plant. Kava has been extensively studied for its ability to reduce stress and promote a sense of tranquility.

According to research published in Nutrients, Kava is known to target key regions in the brain related to stress, such as the GABA receptors, which help regulate feelings of anxiety.

Nature’s Craft Kava Kava works by easing the body and mind, helping you navigate stressful situations more calmly. Safe for regular use, it’s a perfect addition to anyone’s routine who is looking for natural stress relief. With its potent formula, Nature’s Craft Kava Kava also doubles as an effective sleep aid, helping users achieve deeper, more restorative rest without the use of sedatives or sleep medications.

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The star ingredient in Lifted Naturals Mood Boosting Probiotic is the combination of nine probiotic strains and prebiotics like GOS (Galacto-oligosaccharides), which have been shown to significantly improve mood and stress management.

According to research published in Clinics and Practice a healthy gut microbiome is directly linked to better mental health, with probiotics playing a key role in reducing symptoms of anxiety and depression.

Lifted Naturals Probiotics works by restoring balance to the gut microbiome, which in turn has a direct impact on emotional regulation. Lifted Naturals mood boosting probiotic helps to reduce stress, anxiety, and even promotes better sleep patterns. Safe for daily use, it’s perfect for individuals who struggle with emotional fluctuations or digestive issues. Whether you’re experiencing mood swings or seeking to improve your emotional resilience, Lifted Naturals mood boosting probiotic supports your body’s natural systems, enhancing both gut health and mood stability.

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Natural Stacks has built a reputation for creating clean, science-backed supplements that help optimize the body’s natural processes. Their Serotonin Brain Food is a perfect example of this, designed to boost mood, reduce stress, and improve overall emotional well-being. Natural Stacks Serotonin takes a unique approach by focusing on enhancing serotonin levels, the brain’s primary “feel-good” neurotransmitter.

One of the key ingredients in Serotonin Brain Food is L-Tryptophan, an essential amino acid that the body uses to produce serotonin.

According to research published in the Journal of Dietary Supplements , L-Tryptophan supplementation is a powerful method to support serotonin production, helping to alleviate symptoms of mood disorders and anxiety.

When combined with other ingredients like Magnesium Glycinate and Rhodiola Rosea, Natural Stacks Serotonin provides comprehensive support for both mood and relaxation.

Natural Stacks Serotonin works by enhancing the body’s ability to produce serotonin, which has been shown to promote relaxation, reduce stress, and improve overall mood. It’s a natural mood enhancer for anyone looking to boost emotional stability and maintain a calm, positive outlook throughout the day. Safe for daily use, Natural Stacks Serotonin is ideal for those who want a gentle, natural solution to stress management and mood improvement. Whether you’re dealing with occasional anxiety or simply need a mood boosting vitamin, Serotonin Brain Food is a powerful, effective option.
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Considering the lifestyle we have today, managing stress and maintaining a balanced mood can feel impossible, but Benevolent Nourishment offers a solution with their Mood Booster supplement. This brand is dedicated to providing natural, effective ways to elevate emotional well-being and manage stress. The Mood Booster is designed to help you regain control over your emotional balance with a potent blend of natural ingredients. With its carefully selected herbs and adaptogens, Benevolent Nourishment Mood Booster works to reduce stress, improve mood, and promote overall well-being.

The primary ingredient in this mood enhancer is KSM-66 Ashwagandha, a powerful adaptogen known for its ability to help the body respond to stress and anxiety.

According to a study published on ResearchGate, Ashwagandha has shown significant promise in reducing cortisol levels and improving overall stress resilience.

This makes Benevolent Nourishment Mood Booster an excellent choice for anyone looking for natural mood enhancers for depression or general anxiety relief.

Benevolent Nourishment’s Mood Booster Supplement is ideal for anyone dealing with the everyday stresses of life. Benevolent Nourishment Mood Booster works by balancing the body’s cortisol levels, enhancing mood, and supporting a sense of calm and focus. It’s a natural mood enhancer perfect for people looking for a gentle yet effective way to boost their emotional health.

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OLLY is a well-known brand that combines fun with functional wellness in their wide range of dietary supplements. Their mood boosting gummies, such as the Hello Happy Gummy Worms, are perfect for anyone looking to improve their mood in a lighthearted and easy-to-consume way. Each gummy delivers a delicious tropical zing flavor while providing support to help elevate your mood naturally. OLLY Hello gummies are designed for those who seek an effective natural mood enhancer without having to swallow pills.

The main ingredient in OLLY Hello gummies is Saffron Extract, a highly-prized spice known for its mood-balancing benefits.

Numerous studies, such as one published in the Journal of Integrative Medicine, have shown that saffron can significantly improve symptoms of depression and anxiety.

By boosting serotonin levels in the brain, saffron helps manage the stress response and provides a more balanced emotional state. This makes it a standout natural mood enhancer among other ingredients in mood-boosting supplements.

OLLY Hello mood boost gummies are formulated with Vitamin D, another essential nutrient that supports mood and overall brain health. The combination of saffron and Vitamin D works synergistically to provide an uplifted and balanced mood throughout the day. Safe for most adults, it’s ideal for those who experience occasional dips in mood and want a quick, non-prescription solution. Whether you’re feeling a little off or need a consistent mood lift, this product offers an easy and over-the-counter mood enhancer for everyday use.

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Happy Healthy Hippie is a brand that truly embodies the natural path to mental wellness. With their Joy-Filled Mood Support Supplement, they offer a plant-based, holistic solution to tackle stress, anxiety, and low energy. Their supplements are carefully crafted to support mental clarity and emotional balance, making them an excellent option for those looking for natural mood enhancers for depression or general mood imbalances.

The standout ingredient in Joy-Filled Mood Support supplement is Ashwagandha, an ancient herb known for its adaptogenic properties.

According to a study in the National Library of Medicine , ashwagandha has been shown to reduce stress and anxiety by balancing cortisol levels in the body.

This powerful herb works alongside other ingredients like Ginkgo Biloba to enhance overall cognitive function, providing a gentle, effective mood enhancer for women and men alike.

This natural mood enhancer for women is ideal for anyone who faces daily emotional turbulence, whether from stress at work or life’s demanding challenges. It’s safe and effective for both short-term stress relief and long-term emotional balance. People seeking a more herbal mood enhancer that’s free from synthetic chemicals or medications will find Joy-Filled Mood Support a reliable ally in their mental health journey.

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NOW Foods has been a leader in the natural supplement industry for years, offering a wide variety of products aimed at improving health. Their Mood Support Vegan Capsules are a comprehensive solution for those looking to improve emotional balance naturally. Packed with vitamins, minerals, and herbal mood enhancers like St. John’s Wort, NOW Foods Mood Support supplement provides a simple yet powerful tool for anyone looking for an easy, over-the-counter mood enhancer.

One of the main ingredients in NOW Foods Mood Support supplement is St. John’s Wort, a herb with well-documented effects on mood.

Multiple studies, including a systematic review in Systematic Reviews of BMC, have found that St. John’s Wort can be just as effective as pharmaceutical mood enhancer medication for treating mild to moderate depression. Its ability to balance serotonin and dopamine levels in the brain makes it an excellent choice for anyone seeking a mood booster pill.

NOW Foods’ mood boosting pills are ideal for individuals who want an alternative to prescription medications or more invasive treatments. This well-rounded formula combines the best vitamins for anxiety with herbal extracts to support mental clarity and emotional well-being. Safe and effective for most adults, it’s a great option for those experiencing mood enhancers for depression without the side effects commonly found in prescription drugs.
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The key ingredient in NaturaLife Labs’ Organic Ashwagandha supplement is Ashwagandha, an ancient herb that has been used for thousands of years in Ayurvedic medicine for its adaptogenic properties.

Numerous studies, including one published by the National Institutes of Health, have shown that Ashwagandha can significantly reduce cortisol levels, helping to alleviate stress and improve mood. As a powerful natural mood enhancer for depression, it works by balancing the body’s stress response and promoting a feeling of calm.

NaturaLife Labs’ Organic Ashwagandha offers a safe, all-natural solution for those seeking relief from stress and mood fluctuations. The supplement works effectively by balancing cortisol, reducing anxiety, and supporting a more positive emotional state. NaturaLife Labs’ mood-enhancing supplement is safe for long-term use and can benefit both men and women seeking a natural mood enhancer for depression.

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Genius Brand has earned a reputation for its high-quality, research-backed nootropic supplements. Their Genius Joy Nootropic Mood Enhancer is designed to elevate mood, improve cognitive performance, and provide stress relief all in one. Packed with ingredients like SAM-e, Rhodiola, and Ginseng, Genius Joy offers a powerful solution for those seeking a natural mood booster and enhanced mental clarity. Unlike typical mood supplements, Genius Joy supports not just emotional well-being, but also cognitive function, making it ideal for those looking to boost both their mood and mental performance simultaneously.

One of the key ingredients in Genius Joy is SAM-e (S-Adenosyl-Methionine), a compound involved in the production of neurotransmitters like serotonin and dopamine.

Research, including studies published in The Journal of Psychiatry, has shown that SAM-e can be as effective as prescribed mood enhancers for treating depression. This powerful mood-enhancing compound helps improve mood by promoting healthy levels of serotonin and dopamine, crucial neurotransmitters for emotional well-being.

Genius Joy Nootropic Mood Enhancer works by balancing the brain’s chemical systems, promoting mental clarity, focus, and calm. The combination of SAM-e, Rhodiola, and other mood-boosting ingredients helps reduce stress, fight fatigue, and improve overall mental health. Genius Joy is particularly beneficial for those dealing with anxiety, low mood, or lack of motivation. Safe for long-term use, it’s ideal for individuals seeking a mood boosting pill that not only enhances mood but also supports cognitive function and focus.

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Natrol is a trusted name in dietary supplements, offering products that support overall well-being. Their Mood Positive 5-HTP is a mood boosting vitamin designed to naturally enhance serotonin production, helping to improve mood and reduce stress. With its time-release formula, Natrol Mood Positive 5-HTP ensures a steady supply of 5-HTP, a precursor to serotonin, throughout the day.

The key ingredient in Natrol Mood Positive 5-HTP is 5-HTP (5-hydroxytryptophan), a naturally occurring compound derived from the Griffonia seed. 5-HTP plays a crucial role in the production of serotonin, a neurotransmitter that regulates mood, anxiety, and sleep.

Research, including studies published in Trends in Pharmacological Sciences, has shown that 5-HTP can be as effective as mood enhancer medication in treating depression and anxiety.

Mood Positive 5-HTP works by boosting serotonin levels in the brain, which helps to improve mood, alleviate stress, and promote overall emotional balance. It’s safe for long-term use and ideal for individuals who experience occasional mood dips or those dealing with chronic stress. Natrol Mood Positive 5-HTP offers an easy, over the counter mood enhancer that provides steady support for emotional well-being. It’s perfect for those who need a gentle yet effective solution for mood boosting vitamins.

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The main ingredient in Happy Camper is Kava Kava, a plant known for its calming properties.

A study published in Nutrients found that Kava is effective in reducing symptoms of anxiety and promoting relaxation, making it one of the best herbal mood enhancers.

It works by interacting with the brain’s neurotransmitters, helping to reduce tension and foster a more balanced emotional state. Combined with other ingredients like Passion Flower, which has been shown to reduce anxiety and promote restful sleep, Kava Kava is the star of Happy Camper.

Happy Camper works by helping to ease stress, calm the mind, and uplift mood naturally. Its formula is designed to support mental clarity and emotional balance, which is why it’s an excellent choice for individuals dealing with stressful situations or seeking a more peaceful emotional state. Safe for most adults, Happy Camper offers a mood booster pill that is both effective and non-habit forming.

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Futurebiotics is a well-known brand in the supplement world, and their Chill Pill + Ashwagandha is designed to support stress relief, mood enhancement, and overall emotional well-being. With a potent combination of Ashwagandha, Rhodiola, and St. John’s Wort, this supplement offers a natural solution for managing anxiety and boosting mood. Feel more relaxed and balanced without the need for prescription drugs and with Futurebiotics Chill Pill’s carefully selected herbal ingredients.

The primary ingredient in Chill Pill + is Ashwagandha, an adaptogenic herb that has been shown to reduce stress and improve mood.

A study published in Nutrition & Metabolism found that Ashwagandha supplementation resulted in significant reductions in stress levels, improved mood, and enhanced energy levels. This makes Ashwagandha one of the most reliable mood boosters for those experiencing chronic stress or anxiety.

Futurebiotics Chill Pill works by providing the body with natural adaptogens that regulate the stress response. The combination of Rhodiola, St. John’s Wort, and Ashwagandha helps promote a relaxed mood, reduce feelings of tension, and restore balance. Whether you’re struggling with stress at work or just need help relaxing after a busy day, Chill Pill + is an effective mood booster pill that supports both mental clarity and emotional stability.

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