Brintellix (Vortioxetine) – A New Approved Antidepressant


What is Brintellix?

Last September 30, 2013, the US Food and Drug Administration approved Brintellix (generic vortioxetine) to be used for the treatment of major depression, a condition that is characterized by symptoms such as insomnia, low mood, difficulty of concentration, loss of interest, fatigue and changes in appetite. Brintellix is a new class of antidepressant drug that is manufactured by Takeda Pharmaceuticals and H. Lundbeck.

Key Ingredient

Brintellix

The active ingredient in Brintellix is the antidepressant vortioxetine hydrobromide. It appears as a white to slightly beige powder substance that is soluble (slightly) in water. The inactive ingredients in Brintellix are: microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, mannitol, sodium starch glycolate and film coating which consists of titanium dioxide, polyethylene glycol, iron oxide red, iron oxide yellow and hypromellose.

Advantages

  • Research and clinical studies involving this drug show that it is effective in alleviating MDD (Major Depressive Disorder) even for patients who failed to respond to first line drugs
  • As according to a clinical trial called REVIVE, Brintellix is more effective than agomelatine (another type of antidepressant) and is much better tolerated

Disadvantages

  • Has side effects
  • This drug is not yet available in generic form
  • Further research about this drug is necessary since it is still new. Brintellix has not proven itself yet to be better than existing antidepressant therapies
  • As like other antidepressants, Brintellix may also increase the risk for suicidal thoughts

Who Should Take Brintellix?

Brintellix is only indicated for patients diagnosed as having MDD or Major Depressive Disorder. Thus, it is not recommended for patients suffering from other types of psychiatric disorders.

Will Brintellix Show Results?

Although the drug has already been approved by FDA, there is still no 100% guarantee that this drug will perform well in a real clinical setting and in the market as well. As of the moment, results regarding this drug are only from the clinical researches conducted by its manufacturers. Thus far, results show that Brintellix will be a promising antidepressant. According to Lundbeck, during its clinical studies, Brintellix has shown better efficacy versus the placebo used.

Is Brintellix Right for You?

Since Brintellix is a new drug and not much has been exposed to the public and to the entire medical community regarding its effectiveness and action, determining whether Brintellix is right for you can be difficult. You wouldn’t want to guess which drug will work for you, would you? As of this time, Brintellix might not really be a very good first choice for an antidepressant. Even psychiatrists and health care professionals as of the moment are thinking twice before prescribing this drug to their patients, not just because it is expensive but because more clinical findings that support it efficacy must be released.

Side Effects of Brintellix

The most common side effects which were reported with the use of this drug are:

  • Headache
  • Dizziness
  • Diarrhea
  • Vomiting
  • Nausea

Caution

  • Risk for Suicide: Taking Brintellix, as like other antidepressants, may increase the risk for suicidal thoughts and attempts and it may also worsen the clinical symptoms of major depression. Family, friends and caregivers of patients suffering from MDD and who are taking this drug are advised to monitor the patient attentively and to apply suicidal precautions.
  • Risk for Serotonin Syndrome: The use of Brintellix, as with other antidepressants like SNRIs and SSRIs can cause a potentially life threatening condition called as serotonin syndrome which is characterized by mental status changes, neuromuscular symptoms and/or gastrointestinal symptoms. If such symptoms occur, discontinue the drug at once and consult a health professional.
  • Brintellix must not be taken together with MAOIs (another class of antidepressant).
  • Individuals with known hypersensitivity to one of Brintellix’s components should not take the drug.

Final Verdict

Brintellix is a very promising drug in treating major depression. It is different from the other types of drugs used to treat depression and it works using two mechanisms of action which are: a) receptor activity modulation and b) reuptake inhibition. Thus, this drug is a much more improved version of the first line agents used to treat the psychiatric disorder. However, it doesn’t necessarily follow that because this drug is new, it is already effective. This product still has a lot to prove to the public in the following years. As of the moment, until further confirmation from public reviews about the effectiveness of this product has been published, it is wise to stick to what professionals already trust.

On the other hand, for more information regarding products or medications used to treat depression, below is a helpful list of product reviews:

Depression is a common problem today. There are numerous supplements that claim to address this particular problem. Not all brands are created equal, and so reading customer testimonials, thorough research and rigorous evaluation by experts, we have consolidated and ranked today’s top anti-depressants. The criteria we used are: potential to reduce symptoms of depression, potential to reduce anxiety, potential to restore healthy serotonin levels, quality of ingredients and ability to improve overall physical and mental well-being. Below are the finest natural anti-depressants available on the today’s market.

Rating
Our Top Depression Choices
Serelax
Serelax
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
98%
Brintellix
Brintellix
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
92%
True Calm
True Calm
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
91%
Abilify Antidepressant Tablet
Abilify
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
89%
Cymbalta Antidepressant Capsule
Cymbalta
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
88%
A2x
A2X
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
87%
Gabatrol Antidepressant Capsule
Gabatrol
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
87%
Tranquilene
Tranquilene
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
86%
Celexa Antidepressant Pill
Celexa
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
85%
Lumiday
Lumiday
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
85%
Prozac
Prozac
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
84%
Suntheanine Antidepressant Tablet
Suntheanine
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
84%
Zoloft Antidepressant Tablet
Zoloft
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
83%
5 Htp Anxiety Capsule
5-HTP
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
83%
Zanaprin
Zanaprin
Reduce Symptoms of Depression
Reduce Sadness and Stress
Restore Healthy Serotonin Levels
Quality of Ingredients
Improve Physical And Mental Well-Being
82%

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.
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Published Date
October 22, 2013
Last Updated
March 27, 2014

About Joan Raynor
Author

Joan Raynor, a depression health researcher, has written numerous articles on mental health and illness. She is contributing to ConsumerHealthDigest.com since 2011.

46 comments

  • I am 65 years old and suicidal thought troubles me a lot. I have also tried it several times but fortunately I am alive. So for this reason I started using Brintellix as I have read somewhere that it helps to reduce the risk of suicidal thoughts. Now after using it for about a week I have overcome this tendency to some extent. I hope for better results in future.

  • This new brand is hitting the market nowadays. My wife is going through a very difficult condition, recently she has been diagnosed with major depression and I can’t take her to the place where lots of money is required. This product is not very expensive so I thought of buying it and hopefully it is working well beyond my expectations. I am very happy with the results and feel great when my wife behaves normally after so many months. This product is really fantastic!

  • My wife is going through major depression issues and her friend says me to get her this product. She says it will definitely work for her depression. I will order it today. Let’s see how it works!

  • I think I would order this supplement for my sister. She has been through a divorce and my doctor says that she is under depression and needs utmost care and the help of a good anti-depressant. Hope this will not disappoint me.

  • I take 10mg tabs of Brintellix for calming down my frequent anxiety attacks. I was not sure in the beginning that it will work. Then after trying it for several weeks I no more suffer from those terrible attacks. I am back to my work and have become normal enough to marry my beautiful fiancée. Thanks Brintellix for changing my life!

  • I am very disappointed because this product doesn’t work for me. I have mild depression so I was quiet sure that this product will help but no it is not at all useful… It only sucks!

  • I am suffering from major depressive disorder from 7 years. I also feel very low and less energetic. So to improve my physical and mental condition I bought Brintellix. I take the doses regularly and now after 3 weeks my mind has become stable and I feel very energetic and lively. I do my work with great interest without feeling tired and exhausted. I have started liking this product because of its working efficiency.

  • To reduce the level of stress because of the work pressure I started taking this med. But got no significant results, I don’t feel comfortable and can’t enjoy life. I purchased an ineffective product and this creates disappointment in me. I don’t like to recommend it to anybody.

  • I found Brintellix better than placebo after using it for about 4 weeks. It works with the help of its natural ingredients that provides extraordinary results. I feel very relaxed after taking the meds which I think is great for my health. I will use it always for maintaining my life quality.

  • Brintellix gives me terrible side effects. After taking the med I suffer from chronic constipation and usually I do vomiting which is a major drawback of this product. Now I don’t want to continue it further because I can get some other medical illness if I will not quit using it soon. I also don’t want anybody else to suffer from the same problem.

  • My mother used to have depression attacks for which I ordered this product. But with this also she had vomiting and used to feel very much uncomfortable. But this was not the case with other similar product.

  • I am really thankful to my father for having bought this product for me. I was under immense depression and used to get irritated and frustrated very soon. Moreover, there were times when I had thoughts of slapping my children on smallest issues. But then after having this supplement all those symptoms vanished and now I really feel sorry for what I thought against my children.

  • My mother has gone into depression after the death of my father. My father died of heart attack at his working place. Earlier he had no such symptoms that could bother him or my mother. Everything was going very fine, life was going on very smooth when this trauma took place. He died at once without letting anybody take him to the hospital. When my mother came to know about this she was deeply shocked and couldn’t bear this and since then she was under great depression. One of our relatives came to visit us and after seeing my mom’s condition he recommended this product. Then I immediately ordered it and I give her this regularly. I am noticing great changes in her behavior, she is absolutely normal now. I give my thanks to this amazing product; it has saved my mom’s life.

    • Hello Julla, Brintellix consists of several natural ingredients that help to deal with depression issues. It may help you or it may not. So it is better to consult with a physician before consuming this pill. Best Luck!

  • Brintellix works well for the patient of major depressive disorder. My daughter had suicidal tendency because she has experienced one major tragedy in her life. She was sexually harassed for a long time by her own uncle and when we came to know about this it was too late. She tried of doing suicide several times but fortunately she is alive today. She was under depression and got attacks that had completely ruined her life. When we came to know about this we took a strong step and for saving my daughter’s life I searched for an antidepressant and found this medication. Now 4 weeks has passed away and my daughter is taking the tablet daily. She is alright now and slowly coming back towards normal life.

  • Brintellix does not work for me, after taking divorce I am always in depression and lost all the interest in my daily activities and then I came to know about this product and started taking it as directed but till now I didn’t felt any change in my behavior. On top of this I am facing some side effects such as constipation and vomiting. This stuff is really horrible, instead of getting some relief I am now undergoing these new problems. I am feeling that soon I will be suffering from major depression because of this stuff.

  • My son was just 20 years old, and was hit by depression. It was so terrible that I used to cry and pray to God for some help. Nothing seemed to work for him. I tried various anti-depressants but his condition was getting worse every passing day. One day he even made a suicidal attempt and tried to have poison unknowingly. On visit to various psychiatrists I got to know that antidepressants if used below the age of 24 causes suicidal thought in most cases. Then I switched over to various depression therapies and thank God that he came out of it.

  • Brintellix has no positive quality because it doesn’t work for major depression, I didn’t observed any changes in my behavior after using it. It is my fault that I have wasted my money on this product.

  • This product is not safe to use because it gives constant side effects. I ordered it for my friend who is in great depression but now she is having nausea after taking this tablet. I am feeling guilty because I have bought this stuff for her. This situation is really humiliating for me.

  • This product gives terrible side effects and doesn’t perform well to reduce depression. I suffer from severe headache after taking the pills. I had to take medication to keep it in control. So I suggest everyone to better search for another safe product.

  • This product has failed to show its effectiveness as it lacks some important ingredients in it. It doesn’t help to calm down my aggressive feelings. This has made me very upset and now I want an effective product as soon as possible.

  • Even though it is an approved and efficient product, still it did nothing for me. I wasted such a huge amount on this product. My first choice Serelax was a better option!

  • I bought this product for my younger son, but after a month of having this product he had suicidal thoughts. But he shares everything with me and the day he said that I am having such thoughts I flayed this product. Will review Selerax and A2X now!

  • I am looking for something natural to help with minor stress and anxiety while pregnant. Does anyone know if this is safe to use during pregnancy? Or has anyone used it while pregnant? I have asked my doctor and she is not sure.

  • I felt defeated because of my postpartum depression. I stopped going out with my friends and hide this weakness from everybody. But now I am becoming normal and coming back to life. This became possible because of brintellix, I am very fortunate of buying this stuff.

  • I have been on this antidepressant since a very long time. After getting divorced my life had become very tiring and I used to harm my own body when I get anxiety attacks, due to this I have many self – harm scars all over my body. But ever since I am using brintellix everything is under control. I feel relaxed and calm and my anxiety attacks have also reduced.

  • This product doesn’t work very well. I have been using it from the last 4 weeks for my depression. But I am not completely satisfied with it. I want some other product now, to come out of this problem.

  • I am on this product since a week and feeling super cool and relaxed. I am not getting anxiety attacks now. I will definitely recommend this product to anybody struggling from this problem.

  • I feel so grateful to have been given this product by my children. Now I am able to spend a lot of cheerful time with my children, which I missed because of depression. Whenever I think of those bad days I feel sad to have missed a lot of precious time, but then I promise to myself to compensate for all the loss. Really helpful product!

  • This product claims to be a good one for all major depression issues and I need one of this type only for my younger sister only. Since last three months she is in a state of depression and nothing seems to work or provide any kind of relief. Will order this product soon!

  • I get frequent anxiety attacks due to which I am very much disturbed in my life. But this product doesn’t help me in getting rid of it. After purchasing it I came to know that it works only on major depressive disorder. So I was shocked when I came to know about this. This is ridiculously shocking. But now I couldn’t help it. SO sad!

  • Brintellix is not a very promising product for depression. I have been using it for quite a long time without getting any major improvement in my mental health. This is not a right product for getting rid of depression. So think wisely and chose the best product.

  • Brintellix is one such product that provides positive results and satisfies the need of the users. I have used it to overcome my depression but unfortunately failed to get satisfying results.

  • After getting divorced I went into depression and stopped enjoying my life like I used to. Various negative thoughts started affecting my mind which was getting worse. However I try to control myself a lot but couldn’t help it. So I have just bought Brintellix after reading the reviews. I hope that it will help me to bring back my life quality so that I can improve my physical and mental condition. I am eagerly waiting for the results.

  • This product has resolved all my problems. I am very happy and satisfied in my life. It really works well and helps the people who suffer from depression whether mild or severe. I consider this product if anyone wants to improve their mental condition.

  • My daughter is just 21 now and is proceeding towards depression because of her unemployed status now. But I think this is not major depression and this product claims to be suitable for individuals with major depression issues. I am now looking for a natural therapy of an antidepressant with natural ingredients; suitable for mild depression.

  • I seriously regret having bought this product for my mother’s depression issue. After having this product she started having suicidal thoughts and I feel very sad to say this that she did attempt suicide also and that too twice. Thank God! There was someone near around her both the times. Relief! At first we were not aware of the reason, but then later somehow we got to know that this product is the prime reason. Stay away from it!

  • Though this is a recommended product but still it gave me horrible headache and made me land in a soup with depression and miserable headache both together. Plus I had to visit a neurologist and had to spend a lot of money on that also. Stay away from this and save your hard earned money for some other effective product.

  • If you are the one with mild depression, then better go for an antidepressant therapy or a natural antidepressant. Don’t even think of going for this one, it will make your condition even worse with terrible side effects.

  • Now no more drastic swings after using this antidepressant. I am a nurse and now I have lots of energy and I am back to my work. Really brintellix is an amazing product!